In JoVE (1)
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Articles by Lourenço Sbragia in JoVE
A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model Marianne S. Carlon*1, Jaan Toelen*2, Marina Mori da Cunha2, Dragana Vidović1, Anke Van der Perren3, Steffi Mayer2, Lourenço Sbragia2, Johan Nuyts4, Uwe Himmelreich5, Zeger Debyser1, Jan Deprest2 1Molecular Virology and Gene Therapy, KU Leuven, 2Department of Woman and Child, KU Leuven, 3Neurobiology and Gene Therapy, KU Leuven, 4Division of Nuclear Medicine, KU Leuven, 5Biomedical NMR Unit/ MoSAIC, KU Leuven We developed a novel surgical approach for intratracheal administration of bioactive agents into the mouse fetus. The delivery route is more efficient in targeting the fetal mouse lungs than the commonly used intra-amniotic injection. This procedure has to date not been described in a mouse model.