Luc Bertrand Department of Biochemistry and Molecular Biology, Miller School of Medicine University of Miami Biography Publications Institution JoVE Articles Luc Bertrand has not added a biography. If you are Luc Bertrand and would like to personalize this page please email our Author Liaison for assistance. Publications Sodium-myoinositol Cotransporter-1, SMIT1, Mediates the Production of Reactive Oxygen Species Induced by Hyperglycemia in the Heart Scientific Reports. Jan, 2017 | Pubmed ID: 28128227 Extracellular Vesicles of the Blood-brain Barrier: Role in the HIV-1 Associated Amyloid Beta Pathology Molecular and Cellular Neurosciences. Dec, 2016 | Pubmed ID: 28040512 Antiretroviral Treatment with Efavirenz Disrupts the Blood-Brain Barrier Integrity and Increases Stroke Severity Scientific Reports. Dec, 2016 | Pubmed ID: 28008980 Nuclear Respiratory Factor 1 and Endurance Exercise Promote Human Telomere Transcription Science Advances. Jul, 2016 | Pubmed ID: 27819056 AMPK in Cardiovascular Diseases EXS. 2016 | Pubmed ID: 27812981 Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK EXS. 2016 | Pubmed ID: 27812975 Fifteen Days of 3,200 M Simulated Hypoxia Marginally Regulates Markers for Protein Synthesis and Degradation in Human Skeletal Muscle Hypoxia (Auckland, N.Z.). 2016 | Pubmed ID: 27800505 O-GlcNAcylation, Enemy or Ally During Cardiac Hypertrophy Development? Biochimica Et Biophysica Acta. Dec, 2016 | Pubmed ID: 27544701 Solving the Blood-Brain Barrier Challenge for the Effective Treatment of HIV Replication in the Central Nervous System Current Pharmaceutical Design. 2016 | Pubmed ID: 27464720 Regulation of Viral Gene Expression by the Herpes Simplex Virus 1UL24 Protein (HSV-1UL24 Inhibits Accumulation of Viral Transcripts) Virology. Aug, 2016 | Pubmed ID: 27214229 AMPK in Cardiac Fibrosis and Repair: Actions Beyond Metabolic Regulation Journal of Molecular and Cellular Cardiology. Feb, 2016 | Pubmed ID: 26772531 Hypothermic Continuous Machine Perfusion Enables Preservation of Energy Charge and Functional Recovery of Heart Grafts in an Ex Vivo Model of Donation Following Circulatory Death European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. May, 2016 | Pubmed ID: 26604296 Occludin Controls HIV Transcription in Brain Pericytes Via Regulation of SIRT-1 Activation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2016 | Pubmed ID: 26601824 Even is Better Than Odd: One Fat May Conceal Another American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2015 | Pubmed ID: 26297227 Dysregulation of Endoplasmic Reticulum Stress and Autophagic Responses by the Antiretroviral Drug Efavirenz Molecular Pharmacology. Aug, 2015 | Pubmed ID: 25987489 Hypothermic Continuous Machine Perfusion Improves Metabolic Preservation and Functional Recovery in Heart Grafts Transplant International : Official Journal of the European Society for Organ Transplantation. Feb, 2015 | Pubmed ID: 25265884 Metformin: from Mechanisms of Action to Therapies Cell Metabolism. Dec, 2014 | Pubmed ID: 25456737 AMPK Activation by Glucagon-like Peptide-1 Prevents NADPH Oxidase Activation Induced by Hyperglycemia in Adult Cardiomyocytes American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2014 | Pubmed ID: 25128166 Reduced Scar Maturation and Contractility Lead to Exaggerated Left Ventricular Dilation After Myocardial Infarction in Mice Lacking AMPKα1 Journal of Molecular and Cellular Cardiology. Sep, 2014 | Pubmed ID: 24805196 A-769662 Potentiates the Effect of Other AMP-activated Protein Kinase Activators on Cardiac Glucose Uptake American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2014 | Pubmed ID: 24748590 Disruption of Epithelial Barrier by Quorum-sensing N-3-(oxododecanoyl)-homoserine Lactone is Mediated by Matrix Metalloproteinases American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2014 | Pubmed ID: 24742991 Catalase Expression in MCF-7 Breast Cancer Cells is Mainly Controlled by PI3K/Akt/mTor Signaling Pathway Biochemical Pharmacology. May, 2014 | Pubmed ID: 24630930 Enhanced Activation of Cellular AMPK by Dual-small Molecule Treatment: AICAR and A769662 American Journal of Physiology. Endocrinology and Metabolism. Mar, 2014 | Pubmed ID: 24425763 Enhanced Expression of β3-adrenoceptors in Cardiac Myocytes Attenuates Neurohormone-induced Hypertrophic Remodeling Through Nitric Oxide Synthase Circulation. Jan, 2014 | Pubmed ID: 24190960 Role of AMP-activated Protein Kinase in Regulating Hypoxic Survival and Proliferation of Mesenchymal Stem Cells Cardiovascular Research. Jan, 2014 | Pubmed ID: 24104879 Connection Between Cardiac Vascular Permeability, Myocardial Edema, and Inflammation During Sepsis: Role of the α1AMP-activated Protein Kinase Isoform Critical Care Medicine. Dec, 2013 | Pubmed ID: 23963133 The Onecut Transcription Factor HNF-6 Contributes to Proper Reorganization of Purkinje Cells During Postnatal Cerebellum Development Molecular and Cellular Neurosciences. Sep, 2013 | Pubmed ID: 23669529 Differential Regulation of EEF2 and P70S6K by AMPKalpha2 in Heart Biochimica Et Biophysica Acta. Jun, 2013 | Pubmed ID: 23466593 Overexpression of AMP-activated Protein Kinase or Protein Kinase D Prevents Lipid-induced Insulin Resistance in Cardiomyocytes Journal of Molecular and Cellular Cardiology. Feb, 2013 | Pubmed ID: 23159540 AMP-activated Protein Kinase in the Control of Cardiac Metabolism and Remodeling Current Heart Failure Reports. Sep, 2012 | Pubmed ID: 22767403 Role of the Ductal Transcription Factors HNF6 and Sox9 in Pancreatic Acinar-to-ductal Metaplasia Gut. Dec, 2012 | Pubmed ID: 22271799 Urotensin II and Urocortin Trigger the Expression of Myostatin, a Negative Regulator of Cardiac Growth, in Cardiomyocytes Peptides. Feb, 2012 | Pubmed ID: 22244812 Urocortin-induced Cardiomyocytes Hypertrophy is Associated with Regulation of the GSK-3β Pathway Heart and Vessels. Mar, 2012 | Pubmed ID: 21505854 NADPH Oxidase Activation by Hyperglycaemia in Cardiomyocytes is Independent of Glucose Metabolism but Requires SGLT1 Cardiovascular Research. Nov, 2011 | Pubmed ID: 21859816 Cardiac and Neurological Assessment of Normothermia/warm Blood Cardioplegia Vs Hypothermia/cold Crystalloid Cardioplegia in Pediatric Cardiac Surgery: Insight from a Prospective Randomized Trial European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Dec, 2011 | Pubmed ID: 21752665 ER Stress Induces Anabolic Resistance in Muscle Cells Through PKB-induced Blockade of MTORC1 PloS One. 2011 | Pubmed ID: 21698202 The Ribonucleotide Reductase R1 Subunits of Herpes Simplex Virus 1 and 2 Protect Cells Against Poly(I · C)-induced Apoptosis Journal of Virology. Sep, 2011 | Pubmed ID: 21697465 Inhibition of the MTOR/p70S6K Pathway is Not Involved in the Insulin-sensitizing Effect of AMPK on Cardiac Glucose Uptake American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2011 | Pubmed ID: 21602475 AMPK Activation, a Preventive Therapeutic Target in the Transition from Cardiac Injury to Heart Failure Cardiovascular Research. May, 2011 | Pubmed ID: 21285292 Heart 6-phosphofructo-2-kinase Activation by Insulin Requires PKB (protein Kinase B), but Not SGK3 (serum- and Glucocorticoid-induced Protein Kinase 3) The Biochemical Journal. Oct, 2010 | Pubmed ID: 20687898 Activation of the Cardiac MTOR/p70(S6K) Pathway by Leucine Requires PDK1 and Correlates with PRAS40 Phosphorylation American Journal of Physiology. Endocrinology and Metabolism. Apr, 2010 | Pubmed ID: 20051528 Conserved Residues in the UL24 Protein of Herpes Simplex Virus 1 Are Important for Dispersal of the Nucleolar Protein Nucleolin Journal of Virology. Jan, 2010 | Pubmed ID: 19864385 Loss of AMPK Exacerbates Experimental Autoimmune Encephalomyelitis Disease Severity Biochemical and Biophysical Research Communications. Aug, 2009 | Pubmed ID: 19486896 AMPK: Lessons from Transgenic and Knockout Animals Frontiers in Bioscience (Landmark Edition). Jan, 2009 | Pubmed ID: 19273052 Crucial Role for LKB1 to AMPKalpha2 Axis in the Regulation of CD36-mediated Long-chain Fatty Acid Uptake into Cardiomyocytes Biochimica Et Biophysica Acta. Mar, 2009 | Pubmed ID: 19159696 Myocardial Injury Induced by Ultrasound-targeted Microbubble Destruction: Evidence for the Contribution of Myocardial Ischemia Ultrasound in Medicine & Biology. Apr, 2009 | Pubmed ID: 19110365 Comparison Between Adenoviral and Retroviral Vectors for the Transduction of the Thymidine Kinase PET Reporter Gene in Rat Mesenchymal Stem Cells Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Nov, 2008 | Pubmed ID: 18984872 AMPKalpha2 Counteracts the Development of Cardiac Hypertrophy Induced by Isoproterenol Biochemical and Biophysical Research Communications. Nov, 2008 | Pubmed ID: 18812163 The Conserved N-terminal Domain of Herpes Simplex Virus 1 UL24 Protein is Sufficient to Induce the Spatial Redistribution of Nucleolin The Journal of General Virology. May, 2008 | Pubmed ID: 18420791 Insulin Signalling in the Heart Cardiovascular Research. Jul, 2008 | Pubmed ID: 18390897 The Relationship Between P38 Mitogen-activated Protein Kinase and AMP-activated Protein Kinase During Myocardial Ischemia Cardiovascular Research. Dec, 2007 | Pubmed ID: 17765884 Creatine Enhances Differentiation of Myogenic C2C12 Cells by Activating Both P38 and Akt/PKB Pathways American Journal of Physiology. Cell Physiology. Oct, 2007 | Pubmed ID: 17652429 Dual Cardiac Contractile Effects of the Alpha2-AMPK Deletion in Low-flow Ischemia and Reperfusion American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2007 | Pubmed ID: 17337600 High-resolution X-ray Structures of Human Apoferritin H-chain Mutants Correlated with Their Activity and Metal-binding Sites Journal of Molecular Biology. Jan, 2007 | Pubmed ID: 17070541 IGF-I Does Not Prevent Myotube Atrophy Caused by Proinflammatory Cytokines Despite Activation of Akt/Foxo and GSK-3beta Pathways and Inhibition of Atrogin-1 MRNA American Journal of Physiology. Endocrinology and Metabolism. Jan, 2007 | Pubmed ID: 16926385 Evaluation of the Role of Protein Kinase Czeta in Insulin-induced Heart 6-phosphofructo-2-kinase Activation Cellular Signalling. Jan, 2007 | Pubmed ID: 16829026 Role of the Alpha2-isoform of AMP-activated Protein Kinase in the Metabolic Response of the Heart to No-flow Ischemia American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2006 | Pubmed ID: 16877552 Optical and EPR Spectroscopic Studies of Demetallation of Hemin by L-chain Apoferritins Journal of Inorganic Biochemistry. Aug, 2006 | Pubmed ID: 16781777 Activation of AMP-activated Protein Kinase in the Liver: a New Strategy for the Management of Metabolic Hepatic Disorders The Journal of Physiology. Jul, 2006 | Pubmed ID: 16644802 [Regulation of Energy Metabolism by AMPK: a Novel Therapeutic Approach for the Treatment of Metabolic and Cardiovascular Diseases] Medecine Sciences : M/S. Apr, 2006 | Pubmed ID: 16597407 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-activated Protein Kinase-independent Effect on Glucokinase Translocation Diabetes. Apr, 2006 | Pubmed ID: 16567505 AMPK Activation Restores the Stimulation of Glucose Uptake in an in Vitro Model of Insulin-resistant Cardiomyocytes Via the Activation of Protein Kinase B American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2006 | Pubmed ID: 16489105 H11 Kinase Prevents Myocardial Infarction by Preemptive Preconditioning of the Heart Circulation Research. Feb, 2006 | Pubmed ID: 16373598 Identification of in Vivo Phosphorylation Sites on Human Deoxycytidine Kinase. Role of Ser-74 in the Control of Enzyme Activity The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16361699 Deficiency of LKB1 in Heart Prevents Ischemia-mediated Activation of AMPKalpha2 but Not AMPKalpha1 American Journal of Physiology. Endocrinology and Metabolism. May, 2006 | Pubmed ID: 16332922 Myocardial Delivery of Colloid Nanoparticles Using Ultrasound-targeted Microbubble Destruction European Heart Journal. Jan, 2006 | Pubmed ID: 16166101 6-Phosphofructo-2-kinase and Fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular Characterization, Database Searches, Modelling Studies and Evolutionary Analysis The FEBS Journal. Jul, 2005 | Pubmed ID: 16008555 Activation of Deoxycytidine Kinase by Protein Kinase Inhibitors and Okadaic Acid in Leukemic Cells Biochemical Pharmacology. Jul, 2004 | Pubmed ID: 15183121 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: Head-to-head with a Bifunctional Enzyme That Controls Glycolysis The Biochemical Journal. Aug, 2004 | Pubmed ID: 15170386 Deficiency of PDK1 in Cardiac Muscle Results in Heart Failure and Increased Sensitivity to Hypoxia The EMBO Journal. Sep, 2003 | Pubmed ID: 12970179 The Stimulation of Heart Glycolysis by Increased Workload Does Not Require AMP-activated Protein Kinase but a Wortmannin-sensitive Mechanism FEBS Letters. Nov, 2002 | Pubmed ID: 12417335 Insulin and Ischemia Stimulate Glycolysis by Acting on the Same Targets Through Different and Opposing Signaling Pathways Journal of Molecular and Cellular Cardiology. Sep, 2002 | Pubmed ID: 12392881 Activation of AMP-activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis Current Biology : CB. Aug, 2002 | Pubmed ID: 12194824 Control of P70 Ribosomal Protein S6 Kinase and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase and Protein Phosphatases in Isolated Hepatocytes European Journal of Biochemistry. Aug, 2002 | Pubmed ID: 12153572 Signalling Pathways and Combinatory Effects of Insulin and Amino Acids in Isolated Rat Hepatocytes European Journal of Biochemistry. Aug, 2002 | Pubmed ID: 12153571 The Stimulation of Glycolysis by Hypoxia in Activated Monocytes is Mediated by AMP-activated Protein Kinase and Inducible 6-phosphofructo-2-kinase The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12065600 Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area Luc Bertrand1,2, Levi Dygert2, Michal Toborek1,3 1Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, 2Miller School of Medicine, University of Miami, 3Jerzy Kukuczka Academy of Physical Education JoVE 54805 Medicine Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery Ana R. Leda1, Levy Dygert1, Luc Bertrand1, Michal Toborek1,2 1Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, 2The Jerzy Kukuczka Academy of Physical Education JoVE 54804 Neuroscience
Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area Luc Bertrand1,2, Levi Dygert2, Michal Toborek1,3 1Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, 2Miller School of Medicine, University of Miami, 3Jerzy Kukuczka Academy of Physical Education JoVE 54805 Medicine
Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery Ana R. Leda1, Levy Dygert1, Luc Bertrand1, Michal Toborek1,2 1Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, 2The Jerzy Kukuczka Academy of Physical Education JoVE 54804 Neuroscience
