In JoVE (1)

Other Publications (80)

Articles by Luis Lassaletta in JoVE

 JoVE Biology

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

1Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM, 2Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), 3Instituto de Investigación Sanitaria La Paz (IdiPAZ), 4Facultad de Veterinaria, Universidad Complutense de Madrid, 5Departmento de Otorrino laringología, Hospital Universitario La Paz


JoVE 54951

Other articles by Luis Lassaletta on PubMed

Surgical Management of Recurrent Parathyroid Cyst

Auris, Nasus, Larynx. Jan, 2002  |  Pubmed ID: 11772497

Parathyroid cysts are rare lesions of uncertain embryological origin, usually presenting as a painless mass in the lower part of the neck. Clinical presentation usually mimics a thyroid nodule, and fine needle aspiration with demonstration of high parathyroid hormone levels in fluid is often required to establish the diagnosis. In addition to difficulty in diagnosis, the best treatment for these uncommon lesions remains controversial. We present a case of recurrent parathyroid cyst after several fine needle aspirations managed by surgery, and discuss the relevant associated literature.

Functional Neck Dissection for the Clinically Negative Neck: Effectiveness and Controversies

The Annals of Otology, Rhinology, and Laryngology. Feb, 2002  |  Pubmed ID: 11860071

This study was performed to evaluate the effectiveness of functional neck dissection in controlling metastasis to the clinically negative (cN0) neck, focusing on recurrences in the pathologically negative (pN0) neck and the role of extracapsular spread in the cN0 neck. A series of 172 patients (253 dissected fields) treated for cN0 laryngeal or hypopharyngeal cancer with a 5-year minimum follow-up is presented. Occult metastasis was observed in 30% of the patients. Extracapsular spread was present in 39% of the positive nodes. The neck recurrence rate was 5.2%. Surgical specimens from cases of neck recurrence in pN0 necks were reevaluated for micrometastasis by immunostaining with antibody for cytokeratins. The immunohistochemical findings were positive in 1 of 4 cases. Functional neck dissection provides good neck control and survival rates for the cN0 neck. The accurate prognostic significance of extracapsular spread in cN0 necks is still unknown. Micrometastasis alone may be insufficient to explain recurrences in pN0 necks.

Facial Nerve Schwannoma of the Cerebellopontine Angle: a Diagnostic Challenge

Skull Base : Official Journal of North American Skull Base Society ... [et Al.]. Nov, 2002  |  Pubmed ID: 17167683

Facial nerve schwannomas are rare lesions that may involve any segment of the facial nerve. Because of their rarity and the lack of a consistent clinical and radiological pattern, facial nerve schwannomas located at the cerebellopontine angle (CPA) and internal auditory canal (IAC) represent a diagnostic and therapeutic challenge for clinicians. In this report, a case of a CPA/IAC facial nerve schwannoma is presented. Contemporary diagnosis and management of this rare lesion are analyzed.

Oncologic and Functional Results of Near-total Laryngectomy

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. May, 2003  |  Pubmed ID: 12748564

To report the oncologic and functional outcome of patients undergoing near-total laryngectomy.

Avoiding Misdiagnosis in Ceruminous Gland Tumours

Auris, Nasus, Larynx. Aug, 2003  |  Pubmed ID: 12927294

Ceruminous gland tumours are infrequent lesions of the external auditory canal (EAC). Controversy still exists about nomenclature, classification, tissue of origin, and accurate diagnosis of these tumours. We present three cases of ceruminous gland tumours, including benign eccrine cylindroma, ceruminous adenoma, and adenoid cystic carcinoma. Superficial biopsy led to an initial erroneous diagnosis of adenocarcinoma in the latter. All cases were positive for cytokeratin and S-100 protein, supporting a ceruminous gland origin. The benign eccrine cylindroma should be included in the ceruminous gland tumour classification. A wide excisional biopsy should be performed in every EAC lesion. The terms 'ceruminoma' and 'cylindroma' should be avoided.

Hearing Preservation with the Retrosigmoid Approach for Vestibular Schwannoma: Myth or Reality?

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Oct, 2003  |  Pubmed ID: 14574295

The purpose of this study is to present our experience with the retrosigmoid approach for vestibular schwannoma resection, emphasizing our hearing results, discussing selection and reporting results criteria.Study design and setting The notes of 65 consecutive cases of vestibular schwannoma undergoing the retrosigmoid approach were reviewed. Hearing data were reported according to the recommendations of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS). In addition, the terms normal, serviceable, useful, and measurable hearing were considered.

CpG Island Methylation in Sporadic and Neurofibromatis Type 2-associated Schwannomas

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2003  |  Pubmed ID: 14654541

The purpose of this research was to examine the DNA methylation profile of schwannomas.

Hypermethylation of the DNA Repair Gene MGMT: Association with TP53 G:C to A:T Transitions in a Series of 469 Nervous System Tumors

Mutation Research. Oct, 2004  |  Pubmed ID: 15450401

O6-methylguanine-DNA methyltransferase (MGMT) plays a major role in repairing DNA damage from alkylating agents. By removing alkyl groups from the O6-position in guanine, MGMT can prevent G:C to A:T transition mutations, a type of variation frequently involving TP53 mutations in brain tumors. Promoter hypermethylation of CpG islands in tumor-related genes can lead to their transcriptional inactivation, and this epigenetic mechanism has been shown to participate in MGMT silencing in some cancers, including those affecting the nervous system. Accordingly, a link between both genetic and epigenetic anomalies may exist in these neoplasms. To determine the relevance of defective MGMT function due to aberrant methylation in relation to the presence of TP53 mutations, we studied 469 nervous system tumors (including all major histological subtypes) for MGMT promoter methylation and TP53 mutations at exons 5-8. Overall, aberrant methylation occurred in 38% of the samples (180/469), with values higher than 50% in the more malignant forms such as glioblastomas and anaplastic gliomas including those with astrocytic, oligodendroglial and ependymal differentiation. In contrast, the non-glial tumors displayed an overall aberrant MGMT promoter methylation of 26%, even though this group includes highly malignant tumors such as neuroblastomas, medulloblastomas and brain metastases. Overall, TP53 mutations were found in 25% of the methylated MGMT tumors (45/180), whereas only 10% of the unmethylated MGMT tumors (30/289) showed TP53 changes (P < 0.001). G:C to A:T changes occurred at CpG sites in 9% of methylated tumors, and in 0.7% of the unmethylated samples. This type of transition at non-CpG dinucleotides was also more frequent in the tumors with aberrant MGMT methylation (5%) than the unmethylated tumors (0.7%). These data suggest that MGMT silencing as a result of promoter hypermethylation may lead to G:C to A:T transition mutations in the TP53 gene of some histological nervous system tumor subtypes.

Internal Auditory Canal Hyperostosis in Myotonic Dystrophy

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Mar, 2005  |  Pubmed ID: 15793424

Pancreatic Regeneration After Near-total Pancreatectomy in Children with Nesidioblastosis

Pediatric Radiology. Nov, 2005  |  Pubmed ID: 16003534

Nesidioblastosis is often resistant to medical therapy and requires near-total pancreatectomy. There is little information on the postoperative imaging findings of these patients.

Smooth Muscle Choristoma of the Internal Auditory Meatus

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Oct, 2005  |  Pubmed ID: 16187135

Choristomas of the internal auditory meatus are very uncommon tumors. Because of their rarity and the lack of a consistent clinical and radiological pattern, they are usually misdiagnosed as vestibular schwannomas. Surgical exploration usually shows involvement of the vestibular, cochlear or facial nerve by the tumor, representing a diagnostic and therapeutic challenge to the surgeon. In this report, a case of a smooth muscle choristoma of the internal auditory meatus is presented. The lesion involved the vestibular and cochlear nerves and was extremely adherent to the facial nerve. Microscopic examination of the tumor revealed nerve fibers, smooth muscle and a small amount of adipose tissue. No striated muscle was found. The contemporary terminology, diagnosis and management of this infrequent lesion are analyzed.

Quality of Life in Postlingually Deaf Patients Following Cochlear Implantation

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Mar, 2006  |  Pubmed ID: 16025257

Most cochlear implant studies are focused on improvement of speech perception associated with implantation. The goal of this study was to assess the impact of cochlear implantation on quality of life changes in Spanish users. Thirty postlingually deaf patients fitted with a cochlear implant completed the Glasgow Benefit Inventory, a questionnaire dealing with communication abilities, and an open-ended questionnaire. The Glasgow Benefit Inventory revealed a positive effect in 93% of patients. The use of a cochlear implant significantly enhanced discrimination ability, telephone use and self-confidence. A high degree of satisfaction was achieved in all situations except with background noise. Ninety-six percent of patients would recommend the operation to a friend. A dramatic improvement in quality of life following cochlear implantation is revealed by a great majority of patients. The results cannot only be explained by enhancements to auditory perception.

Teratomas of the Neck and Mediastinum in Children

Pediatric Surgery International. Aug, 2006  |  Pubmed ID: 16838188

This retrospective study reviews a series of teratomas of the neck and mediastinum aiming at defining the features of these particular locations. We recorded prenatal diagnosis, perinatal management, clinical and radiologic features, pathology, surgical strategies and results in cervical and mediastinal teratomas treated over the last 10 years. During this period we treated 66 children with teratoma of which 11 (6 male and 5 female) had cervicomediastinal locations. Five babies had cervical teratomas extended into the anterior mediastinum in two cases. Prenatal diagnosis was made in three (two with polyhydramnios). Four babies were born by C-section and only one had a successful EXIT procedure. The diagnosis was confirmed by imaging and increased AFP. Surgical treatment involved total tumor removal and in one case subsequent removal of lymph node metastases. All children survived except one in whom airway could not be cleared at birth. Two children bear mild hypothyroidism. During the same period six patients aged 0-17 years were treated for mediastinal teratoma. Only one was prenatally diagnosed and only two had some dyspnea. Removal was performed either by median sternotomy, thoracotomy, or thoracoscopy. They all survive and are free of disease. Teratomas of the neck may cause fetal disease and unmanageable neonatal airway obstruction. Prenatal diagnosis and planned multidisciplinary management are mandatory at birth. In contrast, only some mediastinal tumors cause respiratory embarrassment. Although benign, these tumors are sometimes immature and may metastasize to regional lymph nodes. Total surgical removal is curative. Thyroid insufficiency may be present at birth in cervical teratomas and may be aggravated by surgery.

DNA Methylation of Multiple Genes in Vestibular Schwannoma: Relationship with Clinical and Radiological Findings

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Dec, 2006  |  Pubmed ID: 16983315

The purpose of this study was to examine the DNA methylation profile of several genes in a series of vestibular schwannomas, and to analyze its relationship with clinical and radiological features.

Impact of Facial Dysfunction on Quality of Life After Vestibular Schwannoma Surgery

The Annals of Otology, Rhinology, and Laryngology. Sep, 2006  |  Pubmed ID: 17044542

This study was performed to evaluate the impact of facial dysfunction on quality of life in patients who underwent surgery for vestibular schwannoma. Other factors with a possible impact on quality of life were also assessed.

DNA Methylation Pattern in 16 Tumor-related Genes in Schwannomas

Cancer Genetics and Cytogenetics. Jan, 2007  |  Pubmed ID: 17175387

Petrous Bone Langerhans Cell Histiocytosis Treated with Radiosurgery

Stereotactic and Functional Neurosurgery. 2007  |  Pubmed ID: 17228179

Langerhans cell histiocytosis (LCH) is a rare disease that may show as a solitary or multifocal lesion of bone, soft tissue or viscera. Involvement of the temporal bone has been described in 15-61% of patients with LCH, usually in association with multisystemic involvement. We report the case of a 30-year-old man presenting with vertigo and fluctuating hearing loss caused by monosystemic LCH of the left petrous bone. The patient was treated with radiosurgery (covering dose 10 Gy at 85% isodose, maximum dose 11.76 Gy). Two years after treatment, no evidence of recurrent disease was found in the CT scan or MRI. We discuss the treatment of temporal bone LCH, traditionally based on surgery, low-dose radiation therapy and intralesional steroids. To our knowledge, this is the first reported case of LCH of the petrous bone successfully treated with radiosurgery. This approach may be interesting in cases of LCH located on nonaccessible areas of the temporal bone.

[Quality of Life Following Vestibular Schwannoma Surgery]

Acta Otorrinolaringologica Espanola. Feb, 2007  |  Pubmed ID: 17371684

This study evaluates quality of life (QOL) in patients following surgery for vestibular schwannoma (VS) using the Glasgow Benefit Inventory (GBI), and a pain questionnaire.

[Facial Nerve Repair Techniques]

Acta Otorrinolaringologica Espanola. Apr, 2007  |  Pubmed ID: 17428408

Post-operative facial function was analyzed in 14 patients undergoing different techniques for facial nerve repair.

Does Music Perception Have an Impact on Quality of Life Following Cochlear Implantation?

Acta Oto-laryngologica. Jul, 2007  |  Pubmed ID: 17573562

Despite the decrease in listening habits, about half of the patients still enjoy music post implantation. Better quality of sound through the implant improves music enjoyment and contributes to achievement of better postoperative quality of life (QOL).

RASSF1A Methylation and Cyclin D1 Expression in Vestibular Schwannomas

Acta Neuropathologica. Oct, 2007  |  Pubmed ID: 17668224

[Quality of Life of Patients with BAHA]

Acta Otorrinolaringologica Espanola. Aug-Sep, 2007  |  Pubmed ID: 17683699

The aim of this study is to quantify changes in quality of life due to the use of BAHA.

[Haemangiomas of the Geniculate Ganglion]

Acta Otorrinolaringologica Espanola. Aug-Sep, 2007  |  Pubmed ID: 17683701

About 60 cases have been published since Pulec first described hemangiomas of the geniculate ganglion. They usually cause facial weakness even when they are very small. In cases of insidious evolution of facial paralysis, MRI, and CT are very helpful to rule out these tumors. The treatment is based on complete surgical removal, although it has to be individualized, depending on preoperative facial function and the possibility of complete surgical removal with preservation of the facial nerve.

Cyclin D1 Expression and Histopathologic Features in Vestibular Schwannomas

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Oct, 2007  |  Pubmed ID: 17704717

To evaluate cyclin D1 expression in vestibular schwannoma and its relationship with histologic, clinical, and radiologic features.

[On the Clinical Expressiveness of Proliferative Lesions of the Cerebello-pontine Angle]

Acta Otorrinolaringologica Espanola. Oct, 2007  |  Pubmed ID: 17949669

Changes in Listening Habits and Quality of Musical Sound After Cochlear Implantation

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Mar, 2008  |  Pubmed ID: 18312886

To evaluate listening habits and quality of musical sound after cochlear implantation.

[Hemi-hypoglossal-facial Intratemporal Side to Side Anastomosis]

Acta Otorrinolaringologica Espanola. Mar, 2008  |  Pubmed ID: 18364205

Conventional hypoglossal-facial anastomosis and the interposition jump graft variation are the most popular techniques for facial nerve reconstruction resulting from proximal facial nerve injury. We present a modification of this technique, the hemi-hypoglossal facial intratemporal side to side anastomosis, which overcomes many of the failings of previous techniques. The method involves mobilization of the intratemporal facial nerve, which is anastomosed to a partially incised hypoglossal nerve. It is especially indicated in patients with multiple cranial nerve palsies.

[Musical Perception and Enjoyment in Post-lingual Patients with Cochlear Implants]

Acta Otorrinolaringologica Espanola. May, 2008  |  Pubmed ID: 18501158

To evaluate music perception and enjoyment following cochlear implantation and its impact on quality of life (QOL).

Benefits from a Mobile Telephone Adapter in Combi40+ Cochlear Implant Users

Acta Oto-laryngologica. Jun, 2008  |  Pubmed ID: 18568501

Telephone adapters can help cochlear implanted patients to enhance their telephonic conversations. However, these devices should be further developed to be useful for daily life.

Spontaneous Hearing Improvement in a Patient with an Inflammatory Myofibroblastic Tumor of the Temporal Bone

Skull Base : Official Journal of North American Skull Base Society ... [et Al.]. Nov, 2008  |  Pubmed ID: 19412412

Inflammatory myofibroblastic tumor (IMT) is a rare lesion of unknown etiology and difficult diagnosis. The treatment of IMT is controversial. We report a case of IMT of the temporal bone in a young man presenting with a progressive hearing loss. Three years after diagnosis, partial hearing improvement has been documented.

Inflammatory Pseudotumor of the Petrous Apex with Spontaneous Improvement of the Lesion

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Feb, 2009  |  Pubmed ID: 18520631

Meningiomas and Schwannomas: Molecular Subgroup Classification Found by Expression Arrays

International Journal of Oncology. Feb, 2009  |  Pubmed ID: 19148485

Microarray gene expression profiling is a high-throughput system used to identify differentially expressed genes and regulation patterns, and to discover new tumor markers. As the molecular pathogenesis of meningiomas and schwannomas, characterized by NF2 gene alterations, remains unclear and suitable molecular targets need to be identified, we used low density cDNA microarrays to establish expression patterns of 96 cancer-related genes on 23 schwannomas, 42 meningiomas and 3 normal cerebral meninges. We also performed a mutational analysis of the NF2 gene (PCR, dHPLC, Sequencing and MLPA), a search for 22q LOH and an analysis of gene silencing by promoter hypermethylation (MS-MLPA). Results showed a high frequency of NF2 gene mutations (40%), increased 22q LOH as aggressiveness increased, frequent losses and gains by MLPA in benign meningiomas, and gene expression silencing by hypermethylation. Array analysis showed decreased expression of 7 genes in meningiomas. Unsupervised analyses identified 2 molecular subgroups for both meningiomas and schwannomas showing 38 and 20 differentially expressed genes, respectively, and 19 genes differentially expressed between the two tumor types. These findings provide a molecular subgroup classification for meningiomas and schwannomas with possible implications for clinical practice.

[Clinical Implications of Iatrogenic Lesion in the Chorda Tympani Nerve During Otosclerosis Surgery]

Acta Otorrinolaringologica Espanola. Mar-Apr, 2009  |  Pubmed ID: 19401076

Damage to the chorda tympani nerve is frequent during otologic surgery. This article studies the clinical outcomes of the nerve's section versus its conservation in otosclerosis surgery.

[An Update on the Treatment of Vestibular Schwannoma]

Acta Otorrinolaringologica Espanola. Mar-Apr, 2009  |  Pubmed ID: 19401081

The increase in the diagnosis of ever smaller vestibular schwannomas (VS), the fact that many tumours can be observed with serial MRI, and the development of radiosurgery as an alternative to microsurgery have led the neurotologic surgeon to a new global approach to patients with VS. On the other hand, the spread of internet-based information sources, often with biased or incomplete information, makes counselling patients with VS a challenging task. This study provides an overview of the natural history of these tumours and the main therapeutic options: observation, surgery and radiosurgery, with comments on their indications, advantages and disadvantages. Due to the completely different approach and peculiar features of bilateral VS in patients with type II neurofibromatosis, these are excluded.

Agriculture-induced Increase in Nitrate Concentrations in Stream Waters of a Large Mediterranean Catchment over 25 Years (1981-2005)

The Science of the Total Environment. Nov, 2009  |  Pubmed ID: 19737674

Anthropogenic activities influence past and present nitrate levels recorded in European stream waters, posing a threat to aquatic biota and human beings. Scarce information on temporal trends of nitrate concentration and its causes is available for Mediterranean catchments. This study presents the evolution of nitrate concentrations over 25 years in stream waters of the Ebro River Basin (Spain), a large Mediterranean catchment involving 85,566 km(2). Nitrate concentration increased with time in 46% of the 65 sites involved in the study. Agricultural cover of 30 hydrologically independent sub-catchments was the main land use related to nitrate concentration (R(2)=0.69). Throughout the 25 year-period, the sites showing increased nitrate concentrations with time (trend sites) also presented an enhanced influence of agricultural cover on nitrate concentrations along the time frame of the study. As a result of these temporal changes, at the end of the studied period nitrate concentrations in stream waters responded similarly to agricultural cover in both trend and non-trend sites, showing non significant differences in the slope of the resultant regression models. At this time, agricultural cover explained 82% of the variability found in nitrate levels. If these trends remain unchanged, in 2015 many of the water bodies considered in this study would not comply with the requirements of the European Union Water Framework Directive (WFD). Therefore management decisions, mainly associated to agricultural practices, should be implemented as soon as possible at the catchment level to meet WFD objectives.

CDNA Microarray Expression Profile in Vestibular Schwannoma: Correlation with Clinical and Radiological Features

Cancer Genetics and Cytogenetics. Oct, 2009  |  Pubmed ID: 19781445

[CSF Fistulae Following Surgery for Cerebellopontine Angle Tumours and Their Relationship with the Body Mass Index]

Acta Otorrinolaringologica Espanola. Sep-Oct, 2009  |  Pubmed ID: 19814983

The most frequent complication after vestibular schwannoma surgery is cerebrospinal fluid (CSF) fistula.

Osteoblastoma of the Temporal Bone

Skull Base : Official Journal of North American Skull Base Society ... [et Al.]. Sep, 2009  |  Pubmed ID: 20190944

Benign osteoblastoma is an uncommon primary tumor of the bone. Any area of the skeleton may be affected by this tumor, but its occurrence in the temporal bone and middle ear is extremely rare. Clinical symptoms are nonspecific, even in the middle ear, and the diagnosis is often difficult in spite a complete physical and radiological examination. A biopsy is usually necessary for definitive diagnosis. Because of its potential for recurrence, local invasion, and, rarely, malignant transformation, a complete surgical excision remains the treatment of choice for osteoblastoma. We report a case of benign osteoblastoma involving the temporal bone and the middle ear and a review of the literature.

Genomic Deletions at 1p and 14q Are Associated with an Abnormal CDNA Microarray Gene Expression Pattern in Meningiomas but Not in Schwannomas

Cancer Genetics and Cytogenetics. Jan, 2010  |  Pubmed ID: 19963129

The molecular pathology of meningiomas and shwannomas involve the inactivation of the NF2 gene to generate grade I tumors. Genomic losses at 1p and 14q are observed in both neoplasms, although more frequently in meningiomas. The inactivation of unidentified genes located in these regions appears associated with tumor progression in meningiomas, but no clues to its molecular/clinical meaning are available in schwannomas. Recent microarray gene expression studies have demonstrated the existence of molecular subgroups in both entities. In the present study, we correlated the presence of genomic deletions at 1p, 14q, and 22q with the expression patterns of 96 tumor-related genes obtained by cDNA low-density microarrays in a series of 65 tumors including 42 meningiomas and 23 schwannomas. Two expression pattern groups were identified by cDNA mycroarray analysis when compared to the expression pattern in normal control RNA in both meningiomas and schwannomas, each one with patterns similar and different from the normal control. Meningioma and schwannoma subgroups differed in the expression of 38 and 16 genes, respectively. Using MLPA and microsatellites, we identified genomic losses at 1p, 14q, and 22q at nonrandom frequencies (12.5-69%) in meningiomas and schwannomas. Losses at 22q were almost equally frequent in both molecular expression subgroups in both neoplasms. However, deletions at 1p and 14q accumulated in meningiomas with a gene expression pattern different from the normal pattern, whereas the inverse situation occurred in schwannomas. Those anomalies characterized the schwannomas with expression pattern similar to the normal control. These findings suggest that deletions at 1p and 14q enhance the development of an abnormal tumor-related gene expression pattern in meningiomas, but this fact is not corroborated in schwannomas.

Colonic Interposition for Esophageal Replacement in Children Remains a Good Choice: 33-year Median Follow-up of 65 Patients

Journal of Pediatric Surgery. Feb, 2010  |  Pubmed ID: 20152348

Gastric pull-up has become the predominant technique for esophageal replacement because of allegedly deficient results of colon grafts. This retrospective study examines the long-term results in a large series of colonic interpositions.

Cyclin D1 Expression and Facial Function Outcome After Vestibular Schwannoma Surgery

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Jan, 2011  |  Pubmed ID: 21131888

The proto-oncogen cyclin D1 has been implicated in the development and behavior of vestibular schwannoma. This study evaluates the association between cyclin D1 expression and other known prognostic factors in facial function outcome 1 year after vestibular schwannoma surgery.

Reversible Posterior Leukoencephalopathy Syndrome After Lateral Skull Base Surgery

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Jul, 2011  |  Pubmed ID: 21659926

To describe the clinical course, diagnostic features and management of a case of reversible posterior leukoencephalopathy syndrome after a lateral cranial base removal.

The Role of Insulin-like Growth Factor-I in the Physiopathology of Hearing

Frontiers in Molecular Neuroscience. 2011  |  Pubmed ID: 21845174

Insulin-like growth factor-I (IGF-I) belongs to the family of polypeptides of insulin, which play a central role in embryonic development and adult nervous system homeostasis by endocrine, autocrine, and paracrine mechanisms. IGF-I is fundamental for the regulation of cochlear development, growth, and differentiation, and its mutations are associated with hearing loss in mice and men. Low levels of IGF-I have been shown to correlate with different human syndromes showing hearing loss and with presbyacusis. Animal models are fundamental to understand the genetic, epigenetic, and environmental factors that contribute to human hearing loss. In the mouse, IGF-I serum levels decrease with aging and there is a concomitant hearing loss and retinal degeneration. In the Igf1(-/-) null mouse, hearing loss is due to neuronal loss, poor innervation of the sensory hair cells, and age-related stria vascularis alterations. In the inner ear, IGF-I actions are mediated by intracellular signaling networks, RAF, AKT, and p38 MAPK protein kinases modulate the expression and activity of transcription factors, as AP1, MEF2, FoxM1, and FoxP3, leading to the regulation of cell cycle and metabolism. Therapy with rhIGF-I has been approved in humans for the treatment of poor linear growth and certain neurodegenerative diseases. This review will discuss these findings and their implications in new IGF-I-based treatments for the protection or repair of hearing loss.

Cochlear Implantation in Patients with Neurofibromatosis Type 2 and Patients with Vestibular Schwannoma in the Only Hearing Ear

International Journal of Otolaryngology. 2012  |  Pubmed ID: 22518152

Cochlear implants are a new surgical option in the hearing rehabilitation of patients with neurofibromatosis type 2 (NF2) and patients with vestibular schwannoma (VS) in the only hearing ear. Auditory brainstem implant (ABI) has been the standard surgical treatment for these patients. We performed a literature review of patients with NF2 and patients with VS in the only hearing ear. Cochlear implantation (CI) provided some auditory benefit in all patients. Preservation of cochlear nerve integrity is crucial after VS resection. Results ranged from environmental sound awareness to excellent benefit with telephone use. Promontory stimulation is recommended although not crucial. MRI can be performed safely in cochlear implanted patients.

The Molecular Biology of Vestibular Schwannomas and Its Association with Hearing Loss: a Review

Genetics Research International. 2012  |  Pubmed ID: 22567403

Hearing loss is the most common symptom in patients with vestibular schwannoma (VS). In the past, compressive mechanisms caused by the tumoral mass and its growth have been regarded as the most likely causes of the hearing loss associated with VS. Interestingly, new evidence proposes molecular mechanisms as an explanation for such hearing loss. Among the molecular mechanisms proposed are methylation of TP73, negative expression of cyclin D1, expression of B7-H1, increased expression of the platelet-derived growth factor A, underexpression of PEX5L, RAD54B, and PSMAL, and overexpression of CEA. Many molecular mechanisms are involved in vestibular schwannoma development; we review some of these mechanisms with special emphasis on hearing loss associated with vestibular schwannoma.

A New Entity in the Differential Diagnosis of Geniculate Ganglion Tumours: Fibrous Connective Tissue Lesion of the Facial Nerve

Acta Otorrinolaringologica Espanola. May-Jun, 2013  |  Pubmed ID: 22425205

Differential diagnosis of geniculate ganglion tumours includes chiefly schwannomas, haemangiomas and meningiomas. We report the case of a patient whose clinical and imaging findings mimicked the presentation of a facial nerve schwannoma.Pathological studies revealed a lesion with nerve bundles unstructured by intense collagenisation. Consequently, it was called fibrous connective tissue lesion of the facial nerve.

Fine Structure Processing Improves Telephone Speech Perception in Cochlear Implant Users

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Mar, 2013  |  Pubmed ID: 22766835

The objective of this study was to compare telephone speech perception and subjective preferences in cochlear implant users with two different speech-processing strategies: high-definition continuous interleaved sampling (HDCIS) and fine structure processing (FSP). A randomized double-blind study was designed for intra-individual comparison of HDCIS and FSP. Twenty-five post-lingually deafened patients with either the PulsarCI(100) or SonataTI(100) and Opus2 acoustic processor were tested consecutively with both coding strategies, assigned in a random order. Disyllabic word speech perception was tested 6 weeks after each fitting under the following conditions: landline use with (LWN) and without (LWoN) background noise, mobile use with (MWN), and without (MWoN) background noise and mobile use with a Bluetooth magnetic field transmitter necklace (MB). Changes in health-related quality of life (QoL) were assessed using the Glasgow Benefit Inventory (GBI) and Faber's questionnaire. Personal preferences between strategies were surveyed upon completion of the study. All subjects included in this study performed better with FSP in the landline tests. There was an improvement of 11.5 % in LWN use (p = 0.014; CI 95 % = 3-20 %) and 10 % in LWoN use (p = 0.001; CI 95 % = 5-15 %). MWoN showed an improvement of 6.3 % with FSP (p = 0.03; CI 95 % = 0-13 %). MB tests showed an improvement of 11 % with FSP (p < 0.05; CI 95 % = 1.5-22 %). Quality of life was significantly better using FSP. Eighty-four percent of participants preferred FSP. The FSP speech coding strategy improved the speech recognition of cochlear implant users when using the telephone compared to HDCIS. Cochlear implantation with FSP coding improved QoL.

[Quality of Life in Patients Implanted with the BAHA Device Depending on the Aetiology]

Acta Otorrinolaringologica Espanola. Jan-Feb, 2013  |  Pubmed ID: 22884429

Assess the improvement of quality of life in osseointegrated implanted patients, taking into account the indication as well as the use of the implant, and the presence of pre- and postoperative tinnitus.

Expression Analysis of Tumor-related Genes Involved in Critical Regulatory Pathways in Schwannomas

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. May, 2013  |  Pubmed ID: 23054753

Gene expression array analysis is providing key data on the potential candidate genes and biological pathways involved in schwannoma origin and development. In this way we performed expression array studies on tumor-related genes in schwannomas.

DNA Copy Gains of Tumor-related Genes in Vestibular Schwannoma

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Sep, 2013  |  Pubmed ID: 23179934

DNA copy gains are a common event in tumor growth. This study determines the gene dosage/amplification of seven tumor-related genes in patients undergoing vestibular schwannoma (VS) surgery and analyzes its clinical implications. Thirty-three patients undergoing surgery for VS were studied. Seven genes (EGFR, ERBB2, ERBB3, ERBB4, MDM2, MDM4, and NMYC) were analyzed by Quantitative real-time PCR. Copy gains were correlated with demographic, clinical and radiological data. Of the 33 samples, 48 % were positive for copy gains in at least one gene. There were no positive samples for gene amplification. A clinical correlation between tumor size and copy gains of ERBB2 was found. Patients with copy gains of this gene had larger tumors measured by diameter (p = 0.027) and volume (p = 0.005). Copy gains of EGFR, ERBB2, ERBB4, and MDM4 were associated with preoperative tinnitus. Contrary to other tumors of the central nervous system, development of VS does not appear to involve gene amplification. However, copy gains of certain tumor-related genes may play a role in the biological behavior of these neoplasms. Our findings support the role of ERBB2 in VS development and growth.

Radiology Quiz Case 1: Glomus Facialis Paraganglioma

JAMA Otolaryngology-- Head & Neck Surgery. Jan, 2013  |  Pubmed ID: 23329103

Microarray Analysis of Gene Expression in Vestibular Schwannomas Reveals SPP1/MET Signaling Pathway and Androgen Receptor Deregulation

International Journal of Oncology. Mar, 2013  |  Pubmed ID: 23354516

Vestibular schwannomas are benign neoplasms that arise from the vestibular nerve. The hallmark of these tumors is the biallelic inactivation of neurofibromin 2 (NF2). Transcriptomic alterations, such as the neuregulin 1 (Nrg1)/ErbB2 pathway, have been described in schwannomas. In this study, we performed a whole transcriptome analysis in 31 vestibular schwannomas and 9 control nerves in the Affymetrix Gene 1.0 ST platform, validated by quantitative real-time PCR (qRT-PCR) using TaqMan low density arrays. We performed a mutational analysis of NF2 by PCR/denaturing high-performance liquid chromatography (dHPLC) and multiplex ligation-dependent probe amplification (MLPA), as well as a microsatellite marker analysis of the loss of heterozygosity (LOH) of chromosome 22q. The microarray analysis demonstrated that 1,516 genes were deregulated and 48 of the genes were validated by qRT-PCR. At least 2 genetic hits (allelic loss and/or gene mutation) in NF2 were found in 16 tumors, seven cases showed 1 hit and 8 tumors showed no NF2 alteration. MET and associated genes, such as integrin, alpha 4 (ITGA4)/B6, PLEXNB3/SEMA5 and caveolin-1 (CAV1) showed a clear deregulation in vestibular schwannomas. In addition, androgen receptor (AR) downregulation may denote a hormonal effect or cause in this tumor. Furthermore, the osteopontin gene (SPP1), which is involved in merlin protein degradation, was upregulated, which suggests that this mechanism may also exert a pivotal role in schwannoma merlin depletion. Finally, no major differences were observed among tumors of different size, histological type or NF2 status, which suggests that, at the mRNA level, all schwannomas, regardless of their molecular and clinical characteristics, may share common features that can be used in their treatment.

Is There an Age Limit for Cochlear Implantation?

The Annals of Otology, Rhinology, and Laryngology. Apr, 2013  |  Pubmed ID: 23697318

We evaluated the quality of life following cochlear implantation in elderly postlingually deaf adults.

The Nitrogen Cascade from Agricultural Soils to the Sea: Modelling Nitrogen Transfers at Regional Watershed and Global Scales

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2013  |  Pubmed ID: 23713121

The nitrogen cycle of pre-industrial ecosystems has long been remarkably closed, in spite of the high mobility of this element in the atmosphere and hydrosphere. Inter-regional and international commercial exchanges of agricultural goods, which considerably increased after the generalization of the use of synthetic nitrogen fertilizers, introduced an additional type of nitrogen mobility, which nowadays rivals the atmospheric and hydrological fluxes in intensity, and causes their enhancement at the local, regional and global scales. Eighty-five per cent of the net anthropogenic input of reactive nitrogen occurs on only 43 per cent of the land area. Modern agriculture based on the use of synthetic fertilizers and the decoupling of crop and animal production is responsible for the largest part of anthropogenic losses of reactive nitrogen to the environment. In terms of levers for better managing the nitrogen cascade, beyond technical improvement of agricultural practices tending to increase nitrogen use efficiency, or environmental engineering management measures to increase nitrogen sinks in the landscape, the need to better localize crop production and livestock breeding, on the one hand, and agriculture and food demand on the other hand, is put forward as a condition to being able to supply food to human populations while preserving environmental resources.

Global Profiling in Vestibular Schwannomas Shows Critical Deregulation of MicroRNAs and Upregulation in Those Included in Chromosomal Region 14q32

PloS One. 2013  |  Pubmed ID: 23776562

Vestibular schwannomas are benign tumors that arise from Schwann cells in the VIII cranial pair and usually present NF2 gene mutations and/or loss of heterozygosity on chromosome 22q. Deregulation has also been found in several genes, such as ERBB2 and NRG1. MicroRNAs are non-coding RNAs approximately 21 to 23 nucleotides in length that regulate mRNAs, usually by degradation at the post-transcriptional level.

NF2 Genetic Alterations in Sporadic Vestibular Schwannomas: Clinical Implications

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Sep, 2013  |  Pubmed ID: 23921927

NF2 gene alterations may have a clinical impact in non-NF2 vestibular schwannomas (VSs).

Gene Expression Analysis of Aberrant Signaling Pathways in Meningiomas

Oncology Letters. Jul, 2013  |  Pubmed ID: 23946817

Examining aberrant pathway alterations is one method for understanding the abnormal signals that are involved in tumorigenesis and tumor progression. In the present study, expression arrays were performed on tumor-related genes in meningiomas. The GE Array Q Series HS-006 was used to determine the expression levels of 96 genes that corresponded to six primary biological regulatory pathways in a series of 42 meningiomas, including 32 grade I, four recurrent grade I and six grade II tumors, in addition to three normal tissue controls. Results showed that 25 genes that were primarily associated with apoptosis and angiogenesis functions were downregulated and 13 genes frequently involving DNA damage repair functions were upregulated. In addition to the inactivation of the neurofibromin gene, NF2, which is considered to be an early step in tumorigenesis, variations of other biological regulatory pathways may play a significant role in the development of meningioma.

End-to-Side Interposed Donor Grafting As a Facial Nerve Reinforcement Technique After Vestibular Schwannoma Surgery

The Annals of Otology, Rhinology, and Laryngology. Aug, 2013  |  Pubmed ID: 24027862

This retrospective case review was performed to determine the facial function outcome of an end-to-side interposed donor grafting technique in patients who had a nonresponsive and partially injured facial nerve during a translabyrinthine approach for vestibular schwannoma resection.

Retrosigmoid Implantation of an Active Bone Conduction Stimulator in a Patient with Chronic Otitis Media

Auris, Nasus, Larynx. Feb, 2014  |  Pubmed ID: 23722197

Percutaneous bone conduction implants are widely used in patients with conductive and mixed hearing loss with no benefit from conventional air conduction hearing aids. These devices have several complications including skin reaction, wound infection, growth of skin over the abutment, and implant extrusion. We describe a case of a transcutaneous bone conduction implantation (Bonebridge, Med-el) in a patient with conductive hearing loss due to chronic otitis media. Surgical planification was performed with the software 3D slicer 4.1. According to this program, the implant transductor was positioned in the retrosigmoid area. Aided thresholds demonstrate a significant benefit, with an improvement from 68dB to 25dB. Speech discrimination scores improved 35dB. The patient is very happy and uses her device daily. The Bonebridge implant is a promising transcutaneous bone conduction implant for patients with conductive hearing loss. Retrosigmoid implantation may be useful in cases with mastoid pathology or previous surgery.

Global Expression Profile in Low Grade Meningiomas and Schwannomas Shows Upregulation of PDGFD, CDH1 and SLIT2 Compared to Their Healthy Tissue

Oncology Reports. Dec, 2014  |  Pubmed ID: 25333347

Schwannomas and grade I meningiomas are non‑metastatic neoplasms that share the common mutation of gene NF2. They usually appear in neurofibromatosis type 2 patients. Currently, there is no drug treatment available for both tumors, thus the use of wide expression technologies is crucial to identify therapeutic targets. Affymetrix Human Gene 1.0 ST was used to test global gene expression in 22 meningiomas, 31 schwannomas and, as non-tumoral controls, 3 healthy meningeal tissues, 8 non-tumoral nerves and 1 primary Schwann cell culture. A non-stringent P-value cut-off and fold change were used to establish deregulated genes. We identified a subset of genes that were upregulated in meningiomas and schwannomas when compared to their respectively healthy tissues, including PDGFD, CDH1 and SLIT2. Thus, these genes should be thoroughly studied as targets in a possible combined treatment.

Reliability and Validity of the Spanish Glasgow Benefit Inventory After Cochlear Implant Surgery in Adults

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Feb, 2015  |  Pubmed ID: 24337876

In recent years, the outcome assessment of subjects undergoing otorhinolaryngological (ORL) intervention has relied increasingly upon patient-reported questionnaires. The English Glasgow Benefit Inventory (GBI) is a reliable, sensitive and validated post-intervention questionnaire that is used to determine health-related quality-of-life (QoL) in patients following ORL intervention. The GBI has been translated into eight languages including Spanish. The present study aimed to determine the internal consistency and validity of the Spanish version of the GBI in patients with a cochlear implant (CI). 121 adult Spanish speaking patients with a CI were questioned retrospectively using the Spanish GBI. Reliability of the questionnaire was determined using Cronbach's α coefficient; factor analyses were performed using principal component extraction with orthogonal rotation; and validity was confirmed using Pearson's correlation coefficient. The mean total score (mean ± standard deviation) of the GBI was 35.1 ± 23.6, 47.6 ± 28.9 for General Health, 17.9 ± 33.2 for Social Benefit and 1.7 ± 27.9 for Physical Health. The reliability was above 0.70 in all test domains. Using factor analyses a 4-factor solution that explained 63.2% of the variance was reached. The objective measures: bisyllables tested without lip-reading and without masking were correlated with the total score and the General Health subscales. The Spanish GBI is a reliable and practicable instrument for the assessment of health-related QoL in Spanish adult CI users.

Reliability and Validity of the Nijmegen Cochlear Implant Questionnaire in Spanish

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Jul, 2015  |  Pubmed ID: 24609736

The Nijmegen Cochlear Implant Questionnaire (NCIQ) is a specific and quantifiable self-assessment health-related quality of life (QoL) questionnaire. It was developed to determine the subjective benefits of a cochlear implant (CI). The present study aimed to determine the validity and reliability of the NCIQ in Spanish. Seventy-six adult, Spanish speaking, CI users and 28 control subjects answered the NCIQ. Reliability of the questionnaire was determined using Cronbach's α coefficient and the validity established using Pearson's correlation coefficient. All questionnaire respondents performed significantly better in all sub-domains with a cochlear implant than before cochlear implantation. The Cronbach's α score exceeded 0.70 in most sub-domains and the total score. The objective measures: bisyllables tested without lip-reading and with masking; and bisyllables, tested without lip-reading and without masking were correlated with the sub-domain 'advanced sound perception'. To determine health-related QoL the NCIQ in Spanish is a reliable self-assessment questionnaire and a valuable instrument in determining the subjective benefit of a CI.

Erratum To: Reliability and Validity of the Nijmegen Cochlear Implant Questionnaire in Spanish

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Jul, 2015  |  Pubmed ID: 24718915

Genome-wide Methylation Analysis in Vestibular Schwannomas Shows Putative Mechanisms of Gene Expression Modulation and Global Hypomethylation at the HOX Gene Cluster

Genes, Chromosomes & Cancer. Apr, 2015  |  Pubmed ID: 25533176

Schwannomas are tumors that develop from Schwann cells in the peripheral nerves and commonly arise from the vestibular nerve. Vestibular schwannomas can present unilaterally and sporadically or bilaterally when the tumor is associated with neurofibromatosis Type 2 (NF2) syndrome. The molecular hallmark of the disease is biallelic inactivation of the NF2 gene. The epigenetic signature of schwannomas remains poorly understood and is mostly limited to DNA methylation of the NF2 gene, whose altered expression due to epigenetic factors in this tumor is controversial. In this study, we tested the genomewide DNA methylation pattern of schwannomas to shed light on this epigenetic alteration in these particular tumors. The methodology used includes Infinium Human Methylation 450K BeadChip microarrays in a series of 36 vestibular schwannomas, 4 nonvestibular schwannomas, and 5 healthy nerves. Our results show a trend toward hypomethylation in schwannomas. Furthermore, homeobox (HOX) genes, located at four clusters in the genome, displayed hypomethylation in several CpG sites in the vestibular schwannomas but not in the nonvestibular schwannomas. Several microRNA (miRNA) and protein-coding genes were also found to be hypomethylated at promoter regions and were confirmed as upregulated by expression analysis; including miRNA-21, Met Proto-Oncogene (MET), and PMEPA1. We also detected methylation patterns that might be involved in alternative transcripts of several genes such as NRXN1 or MBP, which would increase the complexity of the methylation and expression patterns. Overall, our results show specific epigenetic signatures in several coding genes and miRNAs that could potentially be used as therapeutic targets.

Soil Carbon Sequestration is a Climate Stabilization Wedge: Comments on Sommer and Bossio (2014)

Journal of Environmental Management. Apr, 2015  |  Pubmed ID: 25646676

Sommer and Bossio (2014) model the potential soil organic carbon (SOC) sequestration in agricultural soils (croplands and grasslands) during the next 87 years, concluding that this process cannot be considered as a climate stabilization wedge. We argue, however, that the amounts of SOC potentially sequestered in both scenarios (pessimistic and optimistic) fulfil the requirements for being considered as wedge because in both cases at least 25 GtC would be sequestered during the next 50 years. We consider that it is precisely in the near future, and meanwhile other solutions are developed, when this stabilization effort is most urgent even if after some decades the sequestration rate is significantly reduced. Indirect effects of SOC sequestration on mitigation could reinforce the potential of this solution. We conclude that the sequestration of organic carbon in agricultural soils as a climate change mitigation tool still deserves important attention for scientists, managers and policy makers.

Pros and Cons of Round Window Vibroplasty in Open Cavities: Audiological, Surgical, and Quality of Life Outcomes

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Jul, 2015  |  Pubmed ID: 25839978

To evaluate the audiological, surgical, quality of life, and quality of sound outcomes in adults with open cavities implanted with the Vibrant Soundbridge (VSB) implant using round window (RW) vibroplasty approach.

Fibrous Dysplasia of the Temporal Bone Secondary to Ear Surgery: a Case Report

Journal of Medical Case Reports. Jun, 2015  |  Pubmed ID: 26031688

In this report, we describe the clinical course, diagnostic features and management of a patient with fibrous dysplasia of the temporal bone 7 years after middle ear surgery on the same side.

Quality Standards for Bone Conduction Implants

Acta Oto-laryngologica. 2015  |  Pubmed ID: 26223816

Bone conduction implants are useful in patients with conductive and mixed hearing loss for whom conventional surgery or hearing aids are no longer an option. They may also be used in patients affected by single-sided deafness.

Which Ear Should We Choose for Cochlear Implantation in the Elderly: The Poorer or the Better? Audiometric Outcomes, Quality of Sound, and Quality-of-life Results

Acta Oto-laryngologica. 2015  |  Pubmed ID: 26493303

Cochlear implantation in the poorer ear of an elderly patient does not predict poorer post-operative audiological, quality-of-life (QoL), and quality of sound results.

Facial Nerve Reconstruction Following Radical Parotidectomy and Subtotal Petrosectomy for Advanced Malignant Parotid Neoplasms

Annals of Maxillofacial Surgery. Jul-Dec, 2015  |  Pubmed ID: 26981471

To describe the oncological management and functional outcome of patients with advanced parotid malignant tumors undergoing facial nerve reconstruction after radical parotidectomy and subtotal petrosectomy.

Ipsilateral Cochlear Implantation in Patients with Sporadic Vestibular Schwannoma in the Only or Best Hearing Ear and in Patients with NF2

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Jan, 2016  |  Pubmed ID: 25537817

The aim of this study was to evaluate the cochlear implant (CI) performances in neurofibromatosis type 2 (NF2) patients with bilateral vestibular schwannoma (VS) and in patients with sporadic VS in the only or better hearing ear. All patients with bilateral VS or sporadic VS in the only or better hearing ear who underwent cochlear implantation, either simultaneous to VS surgery or staged after treatment for VS, in the tumor side were chosen for the study. Postimplantation audiometric scores (sound detection, closed-set and open-set discrimination scores) and device use patterns were the main outcome measures. 15 patients were implanted. Eight patients (53 %) were NF2 and seven patients had VS in the only or better hearing ear. One patient was explanted for cerebrospinal fluid leak. In the CI-only condition, the other 14 patients obtained sound detection, 64 % of them achieving open-set discrimination (mean 70 ± 38 %) and 85 % achieving closed-set discrimination (mean 41 ± 33 %). At the last follow-up 10 patients (67 %) were using the CI. Cochlear implantation provides hearing in particular cases of patients with bilateral VS or VS in the only or better hearing ear. As long as anatomic preservation of the cochlear nerve is achieved, cochlear implantation may offer improvement in communication skills for most patients.

Validation of the Hearing Implant Sound Quality Index (HISQUI19) to Assess Spanish-speaking Cochlear Implant Users' Auditory Abilities in Everyday Communication Situations

Acta Oto-laryngologica. 2016  |  Pubmed ID: 26406547

The Spanish-language HISQUI19 is a reliable and easy-to-use tool for quantifying the self-perceived level of auditory benefit that cochlear implant (CI) users experience in everyday listening situations.

Using the HISQUI29 to Assess the Sound Quality Levels of Spanish Adults with Unilateral Cochlear Implants and No Contralateral Hearing

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Sep, 2016  |  Pubmed ID: 26440105

To evaluate cochlear implant (CI) users' self-reported level of sound quality and quality of life (QoL). Sound quality was self-evaluated using the hearing implant sound quality index (HISQUI29). HISQUI29 scores were further examined in three subsets. QoL was self-evaluated using the glasgow benefit inventory (GBI). GBI scores were further examined in three subsets. Possible correlations between the HISQUI29 and GBI were explored. Additional possible correlations between these scores and subjects' pure tone averages, speech perception scores, age at implantation, duration of hearing loss, duration of CI use, gender, and implant type were explored. Subjects derived a "moderate" sound quality level from their CI. Television, radio, and telephone tasks were easier in quiet than in background noise. 89 % of subjects reported their QoL benefited from having a CI. Mean total HISQUI29 score significantly correlated with all subcategories of the GBI. Age at implantation inversely correlated with the total HISQUI29 score and with television and radio understanding. Sentence in noise scores significantly correlated with all sound perception scores. Women had a better mean score in music perception and in telephone use than did men. CI users' self-reported levels of sound quality significantly correlated with their QoL. Cochlear implantation had a beneficial impact on subjects' QoL. Understanding speech is easier in quiet than in noise. Music perception remains a challenge for many CI users. The HISQUI29 and the GBI can provide useful information about the everyday effects of future treatment modalities, rehabilitation strategies, and technical developments.

Subtotal Petrosectomy for Cochlear Implantation: Lessons Learned After 110 Cases

The Annals of Otology, Rhinology, and Laryngology. Jun, 2016  |  Pubmed ID: 26658067

The purpose of this study was to review the indications for subtotal petrosectomy for cochlear implantation, report our management of complications, as well as review those technical factors that are critical for successful implantation.

Evolution of Patients With Immediate Complete Facial Paralysis Secondary to Acoustic Neuroma Surgery

The Annals of Otology, Rhinology, and Laryngology. Jun, 2016  |  Pubmed ID: 26719351

To study the evolution of patients with immediate complete facial paralysis after acoustic neuroma surgery in different scenarios and assess different facial reanimations techniques.

Postoperative Pain in Patients Undergoing a Transcutaneous Active Bone Conduction Implant (Bonebridge)

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Dec, 2016  |  Pubmed ID: 26968179

The objective of the study was to evaluate postoperative pain following a transcutaneous active conductive hearing implant. 27 patients undergoing Bonebridge (BB) bone conduction implantation were evaluated with two pain-related questionnaires. The Headache Impact Test (HIT-6) was used to measure the degree of disability including none or little impact (≤49), mild (50-55), moderate (56-59), and severe (≥60). The Brief Pain Inventory (BPI) was used to assess pain severity score and function interference (0 = no pain to 10 = worst pain); meaningful pain was considered to be ≥3. The impact of surgical factors on postoperative pain was analyzed. Postoperative BB pain results were compared with 11 Vibrant Soundbridge™ (VSB) and 103 cochlear implant (CI) users. The mean pre- and postoperative HIT-6 scores for BB implantation were 42.6 and 41.8, respectively and the mean preoperative BPI pain severity score changed from 0.6 to 0.9 postoperatively, whereas the preoperative interference score changed from 0.1 to 0.3. None of the mean postoperative values revealed significant pain. The retrosigmoid approach, the need for dural or sinus compression, and the use of bone conduction implant lifts had no significant impact on pain scores. The mean postoperative HIT-6 pain scores for patients with BB, VSB, and CI were 41.8, 46.4, and 42.8, respectively, with the differences not being significant. BB implantation causes no significant postoperative pain irrespective of sinus or dura compression. Pain scores were similar to those experienced by patients with other transcutaneous auditory implants such as middle ear or CIs.

Patient Management for Cochlear Implant Recipients in Audiology Departments: A Practice Review

Cochlear Implants International. May, 2016  |  Pubmed ID: 27078519

To determine and evaluate the time clinics needed to complete the sub-processes involved in the first-fitting and follow-up fitting of people with a cochlear implant.

Bilateral Synchronous Ectopic Ethmoid Sinus Olfactory Neuroblastoma: A Case Report

The American Journal of Case Reports. Apr, 2016  |  Pubmed ID: 27097989

Olfactory neuroblastoma (ONB), also known as esthesioneuroblastoma, is a rare malignant head and neck cancer thought to originate from the olfactory epithelium. It typically invades contiguous structures at presentation. We report a very rare case of multifocal and ectopic ONB.

Water Management Practices Exacerbate Nitrogen Retention in Mediterranean Catchments

The Science of the Total Environment. Dec, 2016  |  Pubmed ID: 27572535

Nitrogen (N) retention sensu lato refers to all processes preventing new reactive nitrogen brought into watersheds through agricultural or industrial activities to be exported by river systems to the sea. Although such processes protect marine systems from the threat of eutrophication and anoxia, they raise other environmental issues, including the acidification of soils, the emission of ammonia and greenhouse gases, and the pollution of aquifers. Despite these implications, the factors involved in N retention are still poorly controlled, particularly in arid and semi-arid systems. The present study evaluates the N fluxes of 38 catchments in the Iberian Peninsula with contrasting climatic characteristics (temperate and Mediterranean), land uses, and water management practices. This diversity allows addressing the contribution of physical and socioecological factors in N retention, and more specifically, exploring the relation between N retention and water regulation. We hypothesise that the extreme flow regulation implemented in the Mediterranean enhances the high N retention values associated with arid and semi-arid regions. The results show that reservoirs and irrigation channels account for >50% of the variability in N retention values, and above a certain regulation threshold, N retention peaks to values >85-90%. Future climate projections forecast a decrease in rainfall and an increase in agricultural intensification and irrigation practices in many world regions, most notably in arid and semi-arid areas. Increased water demand will likely lead to greater flow regulation, and the situation in many areas may resemble that of Iberian Mediterranean catchments. High N retention and the associated environmental risks must therefore be considered and adequately addressed.

Electrically Evoked Compound Action Potentials Are Different Depending on the Site of Cochlear Stimulation

Cochlear Implants International. Nov, 2016  |  Pubmed ID: 27900916

One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea. ECAP measurements were performed in the apical, middle, and basal region of the cochlea at fixed sites of stimulation with varying recording electrodes. One hundred and forty one adult subjects with severe to profound sensorineural hearing loss fitted with a Standard or FLEX(SOFT) electrode were included in this study. ECAP responses were captured using MAESTRO System Software (MED-EL). The ECAP amplitude, threshold, and slope were determined using amplitude growth sequences. The 50% recovery rate was assessed using independent single sequences that have two stimulation pulses (a masker and a probe pulse) separated by a variable inter-pulse interval. For all recordings, ECAP peaks were annotated semi-automatically. ECAP amplitudes were greater upon stimulation of the apical region compared to the basal region of the cochlea. ECAP slopes were steeper in the apical region compared to the basal region of the cochlea and ECAP thresholds were lower in the middle region compared to the basal region of the cochlea. The incidence of double peaks was greater upon stimulation of the apical region compared to the basal region of the cochlea. This data indicates that the site and intensity of cochlear stimulation affect ECAP properties.

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