Manu O. Platt Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology & Emory University School of Medicine Biography Publications Institution JoVE Articles Manu O. Platt has not added a biography. If you are Manu O. Platt and would like to personalize this page please email our Author Liaison for assistance. Publications Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model Annals of Biomedical Engineering. Jan, 2015 | Pubmed ID: 25558848 Identification of Therapeutic Covariant MicroRNA Clusters in Hypoxia-treated Cardiac Progenitor Cell Exosomes Using Systems Biology Circulation Research. Jan, 2015 | Pubmed ID: 25344555 Acid Sphingomyelinase is Activated in Sickle Cell Erythrocytes and Contributes to Inflammatory Microparticle Generation in SCD Blood. Sep, 2014 | Pubmed ID: 25075126 Pro-atherogenic Shear Stress and HIV Proteins Synergistically Upregulate Cathepsin K in Endothelial Cells Annals of Biomedical Engineering. Jun, 2014 | Pubmed ID: 24719048 Crohn's Disease: a Review of Treatment Options and Current Research Cellular Immunology. Nov-Dec, 2013 | Pubmed ID: 24321565 From GRID to Gridlock: the Relationship Between Scientific Biomedical Breakthroughs and HIV/AIDS Policy in the US Congress Journal of the International AIDS Society. 2013 | Pubmed ID: 24286556 Azidothymidine (AZT) Leads to Arterial Stiffening and Intima-media Thickening in Mice Journal of Biomechanics. May, 2013 | Pubmed ID: 23623314 Systematic Optimization of Multiplex Zymography Protocol to Detect Active Cathepsins K, L, S, and V in Healthy and Diseased Tissue: Compromise Among Limits of Detection, Reduced Time, and Resources Molecular Biotechnology. Jul, 2013 | Pubmed ID: 23532386 Endothelial Dysfunction, Arterial Stiffening, and Intima-media Thickening in Large Arteries from HIV-1 Transgenic Mice Annals of Biomedical Engineering. Apr, 2013 | Pubmed ID: 23180031 Patient Specific Proteolytic Activity of Monocyte-derived Macrophages and Osteoclasts Predicted with Temporal Kinase Activation States During Differentiation Integrative Biology : Quantitative Biosciences from Nano to Macro. Dec, 2012 | Pubmed ID: 23114878 Cathepsin S Cannibalism of Cathepsin K As a Mechanism to Reduce Type I Collagen Degradation The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22730330 Tumor Necrosis Factor Alpha Stimulates Cathepsin K and V Activity Via Juxtacrine Monocyte-endothelial Cell Signaling and JNK Activation Molecular and Cellular Biochemistry. Aug, 2012 | Pubmed ID: 22562303 Sickle Cell Disease Activates Peripheral Blood Mononuclear Cells to Induce Cathepsins K and V Activity in Endothelial Cells Anemia. 2012 | Pubmed ID: 22550569 T-cell Phosphokinome As a Fingerprint of Effective Graft Versus Leukemia Frontiers in Bioscience (Elite Edition). 2012 | Pubmed ID: 22201908 Manipulating Substrate and PH in Zymography Protocols Selectively Distinguishes Cathepsins K, L, S, and V Activity in Cells and Tissues Archives of Biochemistry and Biophysics. Dec, 2011 | Pubmed ID: 21982919 VEGF Internalization is Not Required for VEGFR-2 Phosphorylation in Bioengineered Surfaces with Covalently Linked VEGF Integrative Biology : Quantitative Biosciences from Nano to Macro. Sep, 2011 | Pubmed ID: 21826315 Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer Journal of Translational Medicine. 2011 | Pubmed ID: 21756348 Sickle Cell Biomechanics Annual Review of Biomedical Engineering. Aug, 2010 | Pubmed ID: 20455701 Detection of Femtomole Quantities of Mature Cathepsin K with Zymography Analytical Biochemistry. Jun, 2010 | Pubmed ID: 20206119 Multipathway Kinase Signatures of Multipotent Stromal Cells Are Predictive for Osteogenic Differentiation: Tissue-specific Stem Cells Stem Cells (Dayton, Ohio). Nov, 2009 | Pubmed ID: 19750537 Sustained Epidermal Growth Factor Receptor Levels and Activation by Tethered Ligand Binding Enhances Osteogenic Differentiation of Multi-potent Marrow Stromal Cells Journal of Cellular Physiology. Nov, 2009 | Pubmed ID: 19544388 Expression of Cathepsin K is Regulated by Shear Stress in Cultured Endothelial Cells and is Increased in Endothelium in Human Atherosclerosis American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2007 | Pubmed ID: 17098827 Cyclic Pressure and Shear Stress Regulate Matrix Metalloproteinases and Cathepsin Activity in Porcine Aortic Valves The Journal of Heart Valve Disease. Sep, 2006 | Pubmed ID: 17044366 Laminar Shear Stress Inhibits Cathepsin L Activity in Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2006 | Pubmed ID: 16709945 Simulated Microgravity Using the Random Positioning Machine Inhibits Differentiation and Alters Gene Expression Profiles of 2T3 Preosteoblasts American Journal of Physiology. Cell Physiology. Jun, 2005 | Pubmed ID: 15689415 Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Induces Monocyte Adhesion by Stimulating Reactive Oxygen Species Production from a Nox1-based NADPH Oxidase Circulation Research. Oct, 2004 | Pubmed ID: 15388638 Heat Shock and Cold Shock in Deinococcus Radiodurans Cell Biochemistry and Biophysics. 2004 | Pubmed ID: 15211028 Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Stimulates an Inflammatory Response The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12766166 Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States Natalie K. Fan1, Philip M. Keegan1, Manu O. Platt1,2, Rodney D. Averett2,3 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University School of Medicine, 2Parker H. Petit Institute for Bioengineering & Bioscience, Georgia Institute of Technology, 3George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology JoVE 52019 Medicine
Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States Natalie K. Fan1, Philip M. Keegan1, Manu O. Platt1,2, Rodney D. Averett2,3 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University School of Medicine, 2Parker H. Petit Institute for Bioengineering & Bioscience, Georgia Institute of Technology, 3George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology JoVE 52019 Medicine
