Marcel Leist Department of Biology University of Konstanz Biography Publications Institution JoVE Articles Marcel Leist has not added a biography. If you are Marcel Leist and would like to personalize this page please email our Author Liaison for assistance. Publications Prevention of Human Dopaminergic Neurodegeneration in an Astrocytes Co-culture System Allowing Endogenous Drug Metabolism British Journal of Pharmacology. May, 2015 | Pubmed ID: 25989025 From Smoking Guns to Footprints: Mining for Critical Events of Toxicity Pathways in Transcriptome Data Archives of Toxicology. May, 2015 | Pubmed ID: 25851820 Systems Toxicology: The Future of Risk Assessment International Journal of Toxicology. Mar, 2015 | Pubmed ID: 25804424 International STakeholder NETwork (ISTNET): Creating a Developmental Neurotoxicity (DNT) Testing Road Map for Regulatory Purposes Archives of Toxicology. Feb, 2015 | Pubmed ID: 25618548 Toxicogenomics Directory of Chemically Exposed Human Hepatocytes Archives of Toxicology. Dec, 2014 | Pubmed ID: 25399406 Alpha-synuclein Binds to the Inner Membrane of Mitochondria in an α-helical Conformation Chembiochem : a European Journal of Chemical Biology. Nov, 2014 | Pubmed ID: 25209675 Spatial Control of Cdc42 Signalling by a GM130-RasGRF Complex Regulates Polarity and Tumorigenesis Nature Communications. 2014 | Pubmed ID: 25208761 Impairment of Glutamate Signaling in Mouse Central Nervous System Neurons in Vitro by Tri-ortho-cresyl Phosphate at Noncytotoxic Concentrations Toxicological Sciences : an Official Journal of the Society of Toxicology. Nov, 2014 | Pubmed ID: 25199799 Consensus Report on the Future of Animal-free Systemic Toxicity Testing ALTEX. 2014 | Pubmed ID: 25061899 Lineage-specific Regulation of Epigenetic Modifier Genes in Human Liver and Brain PloS One. 2014 | Pubmed ID: 25054330 State-of-the-art of 3D Cultures (organs-on-a-chip) in Safety Testing and Pathophysiology ALTEX. 2014 | Pubmed ID: 25027500 Current Approaches and Future Role of High Content Imaging in Safety Sciences and Drug Discovery ALTEX. 2014 | Pubmed ID: 25027442 From Transient Transcriptome Responses to Disturbed Neurodevelopment: Role of Histone Acetylation and Methylation As Epigenetic Switch Between Reversible and Irreversible Drug Effects Archives of Toxicology. Jul, 2014 | Pubmed ID: 24935251 Identification and Affinity-quantification of ß-amyloid and α-synuclein Polypeptides Using On-line SAW-biosensor-mass Spectrometry Journal of the American Society for Mass Spectrometry. Aug, 2014 | Pubmed ID: 24845351 Acrylamide Alters Neurotransmitter Induced Calcium Responses in Murine ESC-derived and Primary Neurons Neurotoxicology. Jul, 2014 | Pubmed ID: 24726791 Developmental Neurotoxicity - Challenges in the 21st Century and in Vitro Opportunities ALTEX. 2014 | Pubmed ID: 24687333 Instruments for Assessing Risk of Bias and Other Methodological Criteria of Animal Studies: Omission of Well-established Methods Environmental Health Perspectives. Mar, 2014 | Pubmed ID: 24583401 Epigenetics and Transcriptomics to Detect Adverse Drug Effects in Model Systems of Human Development Basic & Clinical Pharmacology & Toxicology. Jul, 2014 | Pubmed ID: 24476462 Design Principles of Concentration-dependent Transcriptome Deviations in Drug-exposed Differentiating Stem Cells Chemical Research in Toxicology. Mar, 2014 | Pubmed ID: 24383497 Targeting Chelatable Iron As a Therapeutic Modality in Parkinson's Disease Antioxidants & Redox Signaling. Jul, 2014 | Pubmed ID: 24251381 Test Systems of Developmental Toxicity: State-of-the Art and Future Perspectives Archives of Toxicology. Dec, 2013 | Pubmed ID: 24190503 A Roadmap for Hazard Monitoring and Risk Assessment of Marine Biotoxins on the Basis of Chemical and Biological Test Systems ALTEX. 2013 | Pubmed ID: 24173170 Generation of Genetically-modified Human Differentiated Cells for Toxicological Tests and the Study of Neurodegenerative Diseases ALTEX. 2013 | Pubmed ID: 24173167 Monocrotophos in Gandaman Village: India School Lunch Deaths and Need for Improved Toxicity Testing Archives of Toxicology. Oct, 2013 | Pubmed ID: 23943209 Evaluation of a Human Neurite Growth Assay As Specific Screen for Developmental Neurotoxicants Archives of Toxicology. Dec, 2013 | Pubmed ID: 23670202 Inflammatory Findings on Species Extrapolations: Humans Are Definitely No 70-kg Mice ALTEX. 2013 | Pubmed ID: 23665808 Metabolomics in Toxicology and Preclinical Research ALTEX. 2013 | Pubmed ID: 23665807 Inflammatory Findings on Species Extrapolations: Humans Are Definitely No 70-kg Mice Archives of Toxicology. Apr, 2013 | Pubmed ID: 23503654 Oxidative and Nitrative Alpha-synuclein Modifications and Proteostatic Stress: Implications for Disease Mechanisms and Interventions in Synucleinopathies Journal of Neurochemistry. May, 2013 | Pubmed ID: 23452040 A 3-dimensional Human Embryonic Stem Cell (hESC)-derived Model to Detect Developmental Neurotoxicity of Nanoparticles Archives of Toxicology. Apr, 2013 | Pubmed ID: 23203475 Human Embryonic Stem Cell-derived Test Systems for Developmental Neurotoxicity: a Transcriptomics Approach Archives of Toxicology. Jan, 2013 | Pubmed ID: 23179753 Control of Aβ Release from Human Neurons by Differentiation Status and RET Signaling Neurobiology of Aging. Jan, 2013 | Pubmed ID: 22534065 The Use of Biomarkers of Toxicity for Integrating in Vitro Hazard Estimates into Risk Assessment for Humans ALTEX. 2012 | Pubmed ID: 23138511 Novel Technologies and an Overall Strategy to Allow Hazard Assessment and Risk Prediction of Chemicals, Cosmetics, and Drugs with Animal-free Methods ALTEX. 2012 | Pubmed ID: 23138508 Characterization of Mouse Cell Line IMA 2.1 As a Potential Model System to Study Astrocyte Functions ALTEX. 2012 | Pubmed ID: 22847254 Epigenetic Changes and Disturbed Neural Development in a Human Embryonic Stem Cell-based Model Relating to the Fetal Valproate Syndrome Human Molecular Genetics. Sep, 2012 | Pubmed ID: 22723015 Compound Selection for in Vitro Modeling of Developmental Neurotoxicity Frontiers in Bioscience (Landmark Edition). 2012 | Pubmed ID: 22652791 Extensive Transcriptional Regulation of Chromatin Modifiers During Human Neurodevelopment PloS One. 2012 | Pubmed ID: 22590590 Autocatalytic Nitration of Prostaglandin Endoperoxide Synthase-2 by Nitrite Inhibits Prostanoid Formation in Rat Alveolar Macrophages Antioxidants & Redox Signaling. Nov, 2012 | Pubmed ID: 22578329 Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells Environmental Health Perspectives. Aug, 2012 | Pubmed ID: 22571897 Locally Resolved Membrane Binding Affinity of the N-terminus of α-synuclein Biochemistry. May, 2012 | Pubmed ID: 22494024 A Roadmap for the Development of Alternative (non-animal) Methods for Systemic Toxicity Testing - T4 Report* ALTEX. 2012 | Pubmed ID: 22307314 Uncoupling of ATP-depletion and Cell Death in Human Dopaminergic Neurons Neurotoxicology. Aug, 2012 | Pubmed ID: 22206971 Highlight Report: Towards the Replacement of in Vivo Repeated Dose Systemic Toxicity Testing Archives of Toxicology. Jan, 2012 | Pubmed ID: 22187068 GFAP-independent Inflammatory Competence and Trophic Functions of Astrocytes Generated from Murine Embryonic Stem Cells Glia. Feb, 2012 | Pubmed ID: 22072312 Autoproteolytic Fragments Are Intermediates in the Oligomerization/aggregation of the Parkinson's Disease Protein Alpha-synuclein As Revealed by Ion Mobility Mass Spectrometry Chembiochem : a European Journal of Chemical Biology. Dec, 2011 | Pubmed ID: 22162214 A Framework Program for the Teaching of Alternative Methods (replacement, Reduction, Refinement) to Animal Experimentation ALTEX. 2011 | Pubmed ID: 22130484 Critical Evaluation of the Use of Dogs in Biomedical Research and Testing in Europe ALTEX. 2011 | Pubmed ID: 22130483 Translating Neurobehavioural Endpoints of Developmental Neurotoxicity Tests into in Vitro Assays and Readouts Neurotoxicology. Oct, 2011 | Pubmed ID: 22008243 Rapid, Complete and Large-scale Generation of Post-mitotic Neurons from the Human LUHMES Cell Line Journal of Neurochemistry. Dec, 2011 | Pubmed ID: 21434924 Sensitivity of Dopaminergic Neuron Differentiation from Stem Cells to Chronic Low-dose Methylmercury Exposure Toxicological Sciences : an Official Journal of the Society of Toxicology. Jun, 2011 | Pubmed ID: 21385734 Assessment of Chemical-induced Impairment of Human Neurite Outgrowth by Multiparametric Live Cell Imaging in High-density Cultures Toxicological Sciences : an Official Journal of the Society of Toxicology. May, 2011 | Pubmed ID: 21342877 TLR2 Hypersensitivity of Astrocytes As Functional Consequence of Previous Inflammatory Episodes Journal of Immunology (Baltimore, Md. : 1950). Mar, 2011 | Pubmed ID: 21282508 Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21081502 Food for Thought ... Considerations and Guidelines for Basic Test Method Descriptions in Toxicology ALTEX. 2010 | Pubmed ID: 21240472 Reduced Immunoproteasome Formation and Accumulation of Immunoproteasomal Precursors in the Brains of Lymphocytic Choriomeningitis Virus-infected Mice Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20881186 Erythropoietin: Not Just About Erythropoiesis Lancet. Jun, 2010 | Pubmed ID: 20609950 The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a Transatlantic Bridge for the Paradigm Shift in Toxicology ALTEX. 2010 | Pubmed ID: 20390240 Markers of Murine Embryonic and Neural Stem Cells, Neurons and Astrocytes: Reference Points for Developmental Neurotoxicity Testing ALTEX. 2010 | Pubmed ID: 20390237 The Network Formation Assay: a Spatially Standardized Neurite Outgrowth Analytical Display for Neurotoxicity Screening Lab on a Chip. Mar, 2010 | Pubmed ID: 20221557 Food for Thought ... on Education in Alternative Methods in Toxicology ALTEX. 2009 | Pubmed ID: 20383471 Requirement of a Dopaminergic Neuronal Phenotype for Toxicity of Low Concentrations of 1-methyl-4-phenylpyridinium to Human Cells Toxicology and Applied Pharmacology. Nov, 2009 | Pubmed ID: 19647008 The Suitability of BV2 Cells As Alternative Model System for Primary Microglia Cultures or for Animal Experiments Examining Brain Inflammation ALTEX. 2009 | Pubmed ID: 19565166 Measurement of Cellular Beta-site of APP Cleaving Enzyme 1 Activity and Its Modulation in Neuronal Assay Systems Analytical Biochemistry. Apr, 2009 | Pubmed ID: 19454261 The Biological and Ethical Basis of the Use of Human Embryonic Stem Cells for in Vitro Test Systems or Cell Therapy ALTEX. 2008 | Pubmed ID: 18841314 The Dawning of a New Age of Toxicology ALTEX. 2008 | Pubmed ID: 18551234 Food for Thought ... on the Evolution of Toxicology and the Phasing out of Animal Testing ALTEX. 2008 | Pubmed ID: 18551232 High-dose Erythropoietin Alters Platelet Reactivity and Bleeding Time in Rodents in Contrast to the Neuroprotective Variant Carbamyl-erythropoietin (CEPO) Thrombosis and Haemostasis. Apr, 2008 | Pubmed ID: 18392330 Food for Thought... on the Real Success of 3R Approaches ALTEX. 2008 | Pubmed ID: 18360724 Molecular Basis for Detection of Invading Pathogens in the Brain Journal of Neuroscience Research. May, 2008 | Pubmed ID: 18061944 Vesicular Monoamine Transporter 2 Regulates the Sensitivity of Rat Dopaminergic Neurons to Disturbed Cytosolic Dopamine Levels Brain Research. Dec, 2007 | Pubmed ID: 18028884 The Sonic Hedgehog Pathway Mediates Carbamylated Erythropoietin-enhanced Proliferation and Differentiation of Adult Neural Progenitor Cells The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17804404 Functional and Immunochemical Characterisation of Different Antibodies Against the Erythropoietin Receptor Journal of Neuroscience Methods. Aug, 2007 | Pubmed ID: 17524492 Pathological Apoptosis in the Developing Brain Apoptosis : an International Journal on Programmed Cell Death. May, 2007 | Pubmed ID: 17453164 Wide Spectrum Modulation by KP-544 in Models Relevant for Neuronal Survival Neuroreport. Apr, 2007 | Pubmed ID: 17413659 Attenuated Amyloid-beta Aggregation and Neurotoxicity Owing to Methionine Oxidation Neuroreport. Apr, 2007 | Pubmed ID: 17413657 Comparison of Neuroprotective Effects of Erythropoietin (EPO) and Carbamylerythropoietin (CEPO) Against Ischemia-like Oxygen-glucose Deprivation (OGD) and NMDA Excitotoxicity in Mouse Hippocampal Slice Cultures Experimental Neurology. Mar, 2007 | Pubmed ID: 17157835 Reduced Functional Deficits, Neuroinflammation, and Secondary Tissue Damage After Treatment of Stroke by Nonerythropoietic Erythropoietin Derivatives Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2007 | Pubmed ID: 16835629 Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration in Vitro and in Vivo Molecular Medicine (Cambridge, Mass.). Jul-Aug, 2006 | Pubmed ID: 17088947 [What Can a Chair on Alternatives to Animal Experimentation Effectuate?] ALTEX. 2006 | Pubmed ID: 17086353 The Dynamics of the LPS Triggered Inflammatory Response of Murine Microglia Under Different Culture and in Vivo Conditions Journal of Neuroimmunology. Nov, 2006 | Pubmed ID: 16996144 Neuroprotective Properties of Memantine in Different in Vitro and in Vivo Models of Excitotoxicity The European Journal of Neuroscience. May, 2006 | Pubmed ID: 16817864 A Role for Mixed Lineage Kinases in Granule Cell Apoptosis Induced by Cytoskeletal Disruption Journal of Neurochemistry. Mar, 2006 | Pubmed ID: 16478524 Decrease in Parvalbumin-expressing Neurons in the Hippocampus and Increased Phencyclidine-induced Locomotor Activity in the Rat Methylazoxymethanol (MAM) Model of Schizophrenia The European Journal of Neuroscience. Jan, 2006 | Pubmed ID: 16420437 The Inflammatory Transcriptome of Reactive Murine Astrocytes and Implications for Their Innate Immune Function Journal of Neurochemistry. Feb, 2006 | Pubmed ID: 16405499 Progressive Degeneration of Human Mesencephalic Neuron-derived Cells Triggered by Dopamine-dependent Oxidative Stress is Dependent on the Mixed-lineage Kinase Pathway The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2005 | Pubmed ID: 16000623 CEP-11004, an Inhibitor of the SAPK/JNK Pathway, Reduces TNF-alpha Release from Lipopolysaccharide-treated Cells and Mice European Journal of Pharmacology. May, 2005 | Pubmed ID: 15904918 Inhibition of Microglial Inflammation by the MLK Inhibitor CEP-1347 Journal of Neurochemistry. Mar, 2005 | Pubmed ID: 15748162 Botulinum Neurotoxin C Initiates Two Different Programs for Neurite Degeneration and Neuronal Apoptosis The Journal of Cell Biology. Feb, 2005 | Pubmed ID: 15716378 The Nonerythropoietic Asialoerythropoietin Protects Against Neonatal Hypoxia-ischemia As Potently As Erythropoietin Journal of Neurochemistry. Nov, 2004 | Pubmed ID: 15525344 Poly(ADP-ribose) Glycohydrolase As a Target for Neuroprotective Intervention: Assessment of Currently Available Pharmacological Tools European Journal of Pharmacology. Aug, 2004 | Pubmed ID: 15321729 Specific Modulation of Astrocyte Inflammation by Inhibition of Mixed Lineage Kinases with CEP-1347 Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15294995 Sensitization to the Lysosomal Cell Death Pathway Upon Immortalization and Transformation Cancer Research. Aug, 2004 | Pubmed ID: 15289336 Derivatives of Erythropoietin That Are Tissue Protective but Not Erythropoietic Science (New York, N.Y.). Jul, 2004 | Pubmed ID: 15247477 Asialoerythropoietin is Not Effective in the R6/2 Line of Huntington's Disease Mice BMC Neuroscience. May, 2004 | Pubmed ID: 15134587 Lysosomes in Cell Death Oncogene. Apr, 2004 | Pubmed ID: 15077151 Improvement of Embryonic Dopaminergic Neurone Survival in Culture and After Grafting into the Striatum of Hemiparkinsonian Rats by CEP-1347 Journal of Neurochemistry. Feb, 2004 | Pubmed ID: 14720219 Defined Inflammatory States in Astrocyte Cultures: Correlation with Susceptibility Towards CD95-driven Apoptosis Journal of Neurochemistry. Jan, 2004 | Pubmed ID: 14675162 Asialoerythropoietin is a Nonerythropoietic Cytokine with Broad Neuroprotective Activity in Vivo Proceedings of the National Academy of Sciences of the United States of America. May, 2003 | Pubmed ID: 12746497 Overexpression of Heat Shock Protein 70 in R6/2 Huntington's Disease Mice Has Only Modest Effects on Disease Progression Brain Research. Apr, 2003 | Pubmed ID: 12706247 Eradication of Glioblastoma, and Breast and Colon Carcinoma Xenografts by Hsp70 Depletion Cancer Research. Dec, 2002 | Pubmed ID: 12499245 Burning Up TNF Toxicity for Cancer Therapy Nature Medicine. Jul, 2002 | Pubmed ID: 12091900 Mitogen-activated Protein Kinase-activated Protein Kinase 2-deficient Mice Show Increased Susceptibility to Listeria Monocytogenes Infection Journal of Immunology (Baltimore, Md. : 1950). May, 2002 | Pubmed ID: 11971016 रासायनिक सुरक्षा स्क्रीनिंग और सिस्टम्स बायोलॉजी डेटा पीढ़ी के लिए विकासात्मक विषाक्तता Assays के आधार पर मानव स्टेम सेल Vaibhav Shinde*1, Stefanie Klima*2, Perumal Srinivasan Sureshkumar1, Kesavan Meganathan1, Smita Jagtap1, Eugen Rempel3, Jörg Rahnenführer3, Jan Georg Hengstler4, Tanja Waldmann2, Jürgen Hescheler1, Marcel Leist*2, Agapios Sachinidis*1 1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund JoVE 52333 Developmental Biology
रासायनिक सुरक्षा स्क्रीनिंग और सिस्टम्स बायोलॉजी डेटा पीढ़ी के लिए विकासात्मक विषाक्तता Assays के आधार पर मानव स्टेम सेल Vaibhav Shinde*1, Stefanie Klima*2, Perumal Srinivasan Sureshkumar1, Kesavan Meganathan1, Smita Jagtap1, Eugen Rempel3, Jörg Rahnenführer3, Jan Georg Hengstler4, Tanja Waldmann2, Jürgen Hescheler1, Marcel Leist*2, Agapios Sachinidis*1 1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund JoVE 52333 Developmental Biology
