Margaret A. Goodell

Publications

• Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo
  Cell Reports. Apr, 2018  |   Pubmed ID: 29617651
• Loss of Capicua Alters Early T Cell Development and Predisposes Mice to T Cell Lymphoblastic Leukemia/lymphoma
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2018  |   Pubmed ID: 29382756
• DNA Epigenome Editing Using CRISPR-Cas SunTag-directed DNMT3A
  Genome Biology. Sep, 2017  |   Pubmed ID: 28923089
• Genome-Wide Analysis of DNA Methylation in Hematopoietic Cells: DNA Methylation Analysis by WGBS
  Methods in Molecular Biology (Clifton, N.J.). 2017  |   Pubmed ID: 28735485
• Targeted DNA Methylation in Vivo Using an Engineered DCas9-MQ1 Fusion Protein
  Nature Communications. Jul, 2017  |   Pubmed ID: 28695892
• DNMT3A in Leukemia
  Cold Spring Harbor Perspectives in Medicine. Feb, 2017  |   Pubmed ID: 28003281
• Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9
  Cell Reports. 10, 2016  |   Pubmed ID: 27783956
• Oncometabolite D-2-hydroxyglutarate Impairs α-ketoglutarate Dehydrogenase and Contractile Function in Rodent Heart
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2016  |   Pubmed ID: 27582470
• DNMT3A and TET2 Compete and Cooperate to Repress Lineage-specific Transcription Factors in Hematopoietic Stem Cells
  Nature Genetics. 09, 2016  |   Pubmed ID: 27428748
• DOT1L As a Therapeutic Target for the Treatment of DNMT3A-mutant Acute Myeloid Leukemia
  Blood. 08, 2016  |   Pubmed ID: 27335278
• DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias
  Cancer Cell. 06, 2016  |   Pubmed ID: 27300438
• Mixed-phenotype Acute Leukemia (MPAL) Exhibits Frequent Mutations in DNMT3A and Activated Signaling Genes
  Experimental Hematology. 08, 2016  |   Pubmed ID: 27208809
• Noncoding Regulatory RNAs in Hematopoiesis
  Current Topics in Developmental Biology. 2016  |   Pubmed ID: 27137659
• Stem Cells and Healthy Aging
  Science (New York, N.Y.). Dec, 2015  |   Pubmed ID: 26785478
• Acute Loss of TET Function Results in Aggressive Myeloid Cancer in Mice
  Nature Communications. Nov, 2015  |   Pubmed ID: 26607761
• Comparison of Cesium-137 and X-ray Irradiators by Using Bone Marrow Transplant Reconstitution in C57BL/6J Mice
  Comparative Medicine. Jun, 2015  |   Pubmed ID: 26141441
• Comparative Long-term Effects of Interferon α and Hydroxyurea on Human Hematopoietic Progenitor Cells
  Experimental Hematology. Oct, 2015  |   Pubmed ID: 26072330
• Somatic Stem Cell Heterogeneity: Diversity in the Blood, Skin and Intestinal Stem Cell Compartments
  Nature Reviews. Molecular Cell Biology. May, 2015  |   Pubmed ID: 25907613
• Long Non-coding RNAs Control Hematopoietic Stem Cell Function
  Cell Stem Cell. Apr, 2015  |   Pubmed ID: 25772072
• DNMT3A in Haematological Malignancies
  Nature Reviews. Cancer. Mar, 2015  |   Pubmed ID: 25693834
• Dnmt3a Loss Predisposes Murine Hematopoietic Stem Cells to Malignant Transformation
  Blood. Jan, 2015  |   Pubmed ID: 25416277
• Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells
  Cell Stem Cell. Sep, 2014  |   Pubmed ID: 25130491
• New Answers to Old Questions from Genome-wide Maps of DNA Methylation in Hematopoietic Cells
  Experimental Hematology. Aug, 2014  |   Pubmed ID: 24993071
• A Gallon of Sweat to Make a Pint of Blood
  The Journal of Experimental Medicine. Jun, 2014  |   Pubmed ID: 24980745
• MTORC1 Controls the Adaptive Transition of Quiescent Stem Cells from G0 to G(Alert)
  Nature. Jun, 2014  |   Pubmed ID: 24870234
• Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes During Aging That Reinforce Self-renewal
  Cell Stem Cell. May, 2014  |   Pubmed ID: 24792119
• MOABS: Model Based Analysis of Bisulfite Sequencing Data
  Genome Biology. Feb, 2014  |   Pubmed ID: 24565500
• Hematopoietic Stem Cell Development: an Epigenetic Journey
  Current Topics in Developmental Biology. 2014  |   Pubmed ID: 24439802
• Large Conserved Domains of Low DNA Methylation Maintained by Dnmt3a
  Nature Genetics. Jan, 2014  |   Pubmed ID: 24270360
• A DNMT3A Mutation Common in AML Exhibits Dominant-negative Effects in Murine ES Cells
  Blood. Dec, 2013  |   Pubmed ID: 24167195
• Parental Permissions: H19 and Keeping the Stem Cell Progeny Under Control
  Cell Stem Cell. Aug, 2013  |   Pubmed ID: 23910078
• Ten-eleven Translocation 1 (Tet1) is Regulated by O-linked N-acetylglucosamine Transferase (Ogt) for Target Gene Repression in Mouse Embryonic Stem Cells
  The Journal of Biological Chemistry. Jul, 2013  |   Pubmed ID: 23729667
• Rising from the Crypt: Decreasing DNA Methylation During Differentiation of the Small Intestine
  Genome Biology. May, 2013  |   Pubmed ID: 23714004
• Perspectives and Future Directions for Epigenetics in Hematology
  Blood. Jun, 2013  |   Pubmed ID: 23692857
• Ataxin1L is a Regulator of HSC Function Highlighting the Utility of Cross-tissue Comparisons for Gene Discovery
  PLoS Genetics. Mar, 2013  |   Pubmed ID: 23555280
• Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association Between Hypomethylation and Genomic Instability
  PLoS Genetics. 2013  |   Pubmed ID: 23468659
• Isolation and Characterization of Mouse Side Population Cells
  Methods in Molecular Biology (Clifton, N.J.). 2013  |   Pubmed ID: 23179831
• Gpr171, a Putative P2Y-like Receptor, Negatively Regulates Myeloid Differentiation in Murine Hematopoietic Progenitors
  Experimental Hematology. Jan, 2013  |   Pubmed ID: 23022127
• Flow Cytometry Analysis of Murine Hematopoietic Stem Cells
  Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Jan, 2013  |   Pubmed ID: 22736515
• Less is More: Unveiling the Functional Core of Hematopoietic Stem Cells Through Knockout Mice
  Cell Stem Cell. Sep, 2012  |   Pubmed ID: 22958929
• The Transcription Factor Lyl-1 Regulates Lymphoid Specification and the Maintenance of Early T Lineage Progenitors
  Nature Immunology. Jul, 2012  |   Pubmed ID: 22772404
• Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome
  PLoS Genetics. 2012  |   Pubmed ID: 22615578
• The Hematopoietic Expression Viewer: Expanding Mobile Apps As a Scientific Tool
  Bioinformatics (Oxford, England). Jul, 2012  |   Pubmed ID: 22576171
• Rantes/Ccl5 Influences Hematopoietic Stem Cell Subtypes and Causes Myeloid Skewing
  Blood. Mar, 2012  |   Pubmed ID: 22289892
• Dnmt3a is Essential for Hematopoietic Stem Cell Differentiation
  Nature Genetics. Jan, 2012  |   Pubmed ID: 22138693
• Imprinted Genes That Regulate Early Mammalian Growth Are Coexpressed in Somatic Stem Cells
  PloS One. 2011  |   Pubmed ID: 22039481
• Bridge over Troubled Stem Cells
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011  |   Pubmed ID: 21964307
• CD81 is Essential for the Re-entry of Hematopoietic Stem Cells to Quiescence Following Stress-induced Proliferation Via Deactivation of the Akt Pathway
  PLoS Biology. Sep, 2011  |   Pubmed ID: 21931533
• Inflammatory Modulation of HSCs: Viewing the HSC As a Foundation for the Immune Response
  Nature Reviews. Immunology. Sep, 2011  |   Pubmed ID: 21904387
• Irgm1 Protects Hematopoietic Stem Cells by Negative Regulation of IFN Signaling
  Blood. Aug, 2011  |   Pubmed ID: 21633090
• Hematopoietic Stem Cell Characterization and Isolation
  Methods in Molecular Biology (Clifton, N.J.). 2011  |   Pubmed ID: 21618082
• CD48 on Hematopoietic Progenitors Regulates Stem Cells and Suppresses Tumor Formation
  Blood. Jul, 2011  |   Pubmed ID: 21576698
• TIMP-1 Deficiency Subverts Cell-cycle Dynamics in Murine Long-term HSCs
  Blood. Jun, 2011  |   Pubmed ID: 21521782
• Investigating the Role of Hematopoietic Stem and Progenitor Cells in Regulating the Osteogenic Differentiation of Mesenchymal Stem Cells in Vitro
  Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Oct, 2011  |   Pubmed ID: 21495066
• A New Allele of Lyl1 Confirms Its Important Role in Hematopoietic Stem Cell Function
  Genesis (New York, N.Y. : 2000). Jun, 2011  |   Pubmed ID: 21387538
• Direct Conversion of Skin Cells into Blood: Alchemy or Science?
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2011  |   Pubmed ID: 21289635
• Polymorphic Allele of Human IRGM1 is Associated with Susceptibility to Tuberculosis in African Americans
  PloS One. Jan, 2011  |   Pubmed ID: 21283700
• Inflammatory Signals Regulate Hematopoietic Stem Cells
  Trends in Immunology. Feb, 2011  |   Pubmed ID: 21233016
• The Expansion of T-cells and Hematopoietic Progenitors As a Result of Overexpression of the Lymphoblastic Leukemia Gene, Lyl1 Can Support Leukemia Formation
  Leukemia Research. Mar, 2011  |   Pubmed ID: 20705338
• The Orphan Nuclear Receptor Nurr1 Restricts the Proliferation of Haematopoietic Stem Cells
  Nature Cell Biology. Dec, 2010  |   Pubmed ID: 21076412
• LYL1 Degradation by the Proteasome is Directed by a N-terminal PEST Rich Site in a Phosphorylation-independent Manner
  PloS One. Sep, 2010  |   Pubmed ID: 20844761
• Quiescent Haematopoietic Stem Cells Are Activated by IFN-gamma in Response to Chronic Infection
  Nature. Jun, 2010  |   Pubmed ID: 20535209
• Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-beta1
  Cell Stem Cell. Mar, 2010  |   Pubmed ID: 20207229
• Runx1 Isoforms Show Differential Expression Patterns During Hematopoietic Development but Have Similar Functional Effects in Adult Hematopoietic Stem Cells
  Experimental Hematology. May, 2010  |   Pubmed ID: 20206228
• Selective Elimination of a Chemoresistant Side Population of B-CLL Cells by Cytotoxic T Lymphocytes in Subjects Receiving an Autologous HCD40L/IL-2 Tumor Vaccine
  Leukemia. Mar, 2010  |   Pubmed ID: 20072155
• Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis
  PloS One. Jan, 2010  |   Pubmed ID: 20052416
• Mechanisms of Hematopoietic Stem Cell Aging
  Experimental Gerontology. Apr, 2010  |   Pubmed ID: 20034552
• Enhanced Generation of Myeloid Lineages in Hematopoietic Differentiation from Embryonic Stem Cells by Silencing Transcriptional Repressor Twist-2
  Cloning and Stem Cells. Dec, 2009  |   Pubmed ID: 20025523
• Selective Depletion of a Minor Subpopulation of B-chronic Lymphocytic Leukemia Cells is Followed by a Delayed but Progressive Loss of Bulk Tumor Cells and Disease Regression
  Molecular Cancer. Nov, 2009  |   Pubmed ID: 19922650
• Adult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival
  Cell Stem Cell. Feb, 2009  |   Pubmed ID: 19200805
• Identification and Characterization of Side Population Cells in Embryonic Stem Cell Cultures
  Stem Cells and Development. Oct, 2009  |   Pubmed ID: 19113897
• Mouse Hematopoietic Stem Cell Identification and Analysis
  Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Jan, 2009  |   Pubmed ID: 19023891
• Promiscuous Expression of H2B-GFP Transgene in Hematopoietic Stem Cells
  PloS One. Jun, 2008  |   Pubmed ID: 18523660
• CD150- Side Population Cells Represent a Functionally Distinct Population of Long-term Hematopoietic Stem Cells
  Blood. Feb, 2008  |   Pubmed ID: 18055867
• Efficacy of Delayed Administration of Post-chemotherapy Granulocyte Colony-stimulating Factor: Evidence from Murine Studies of Bone Marrow Cell Kinetics
  Experimental Hematology. Jan, 2008  |   Pubmed ID: 17949891
• Hematopoietic Fingerprints: an Expression Database of Stem Cells and Their Progeny
  Cell Stem Cell. Nov, 2007  |   Pubmed ID: 18371395
• An Argument Against a Role for Oct4 in Somatic Stem Cells
  Cell Stem Cell. Oct, 2007  |   Pubmed ID: 18371372
• Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
  PLoS Biology. Aug, 2007  |   Pubmed ID: 17676974
• Molecular Profiling of Hematopoietic Stem Cells
  Methods in Molecular Medicine. 2007  |   Pubmed ID: 17666739
• Pluripotentiality and Conditional Transgene Regulation in Human Embryonic Stem Cells Expressing Insulated Tetracycline-ON Transactivator
  Stem Cells (Dayton, Ohio). Oct, 2007  |   Pubmed ID: 17628023
• Retroviral Vector Insertion Sites Associated with Dominant Hematopoietic Clones Mark "stemness" Pathways
  Blood. Mar, 2007  |   Pubmed ID: 17119121
• The Impact of Altered P53 Dosage on Hematopoietic Stem Cell Dynamics During Aging
  Blood. Feb, 2007  |   Pubmed ID: 17032926
• Purification of Hematopoietic Stem Cells Using the Side Population
  Methods in Enzymology. 2006  |   Pubmed ID: 17161700
• Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells
  PLoS Genetics. Sep, 2006  |   Pubmed ID: 17009876
• Differential MRNA Processing in Hematopoietic Stem Cells
  Stem Cells (Dayton, Ohio). Mar, 2006  |   Pubmed ID: 16373690
• Hematopoietic Stem Cells Do Not Engraft with Absolute Efficiencies
  Blood. Jan, 2006  |   Pubmed ID: 16204316
• Stem Cell Identification and Sorting Using the Hoechst 33342 Side Population (SP)
  Current Protocols in Cytometry. Nov, 2005  |   Pubmed ID: 18770827
• Plasticity and Tissue Regenerative Potential of Bone Marrow-derived Cells
  Stem Cell Reviews. 2005  |   Pubmed ID: 17132877
• Roles of Sca-1 in Hematopoietic Stem/progenitor Cell Function
  Experimental Hematology. Jul, 2005  |   Pubmed ID: 15963860
• Isolation and Characterization of Side Population Cells
  Methods in Molecular Biology (Clifton, N.J.). 2005  |   Pubmed ID: 15361673
• Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells
  PLoS Biology. Oct, 2004  |   Pubmed ID: 15459755
• Circulating Hematopoietic Stem Cells Do Not Efficiently Home to Bone Marrow During Homeostasis
  Experimental Hematology. Sep, 2004  |   Pubmed ID: 15345289
• Hematopoietic Myelomonocytic Cells Are the Major Source of Hepatocyte Fusion Partners
  The Journal of Clinical Investigation. May, 2004  |   Pubmed ID: 15124017
• Myeloproliferative Disease in Mice with Reduced Presenilin Gene Dosage: Effect of Gamma-secretase Blockage
  Biochemistry. May, 2004  |   Pubmed ID: 15122901
• Skeletal Muscle Fiber-specific Green Autofluorescence: Potential for Stem Cell Engraftment Artifacts
  Stem Cells (Dayton, Ohio). 2004  |   Pubmed ID: 14990857
• An in Vivo Propagated Human Acute Myeloid Leukemia Expressing ABCA3
  Leukemia Research. Mar, 2004  |   Pubmed ID: 14687625
• Primitive Adult Hematopoietic Stem Cells Can Function As Osteoblast Precursors
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003  |   Pubmed ID: 14673088
• Single Hematopoietic Stem Cells Generate Skeletal Muscle Through Myeloid Intermediates
  Nature Medicine. Dec, 2003  |   Pubmed ID: 14625546
• Isolation and Characterization of Functional Mammary Gland Stem Cells
  Cell Proliferation. Oct, 2003  |   Pubmed ID: 14521513
• Altered Phenotype and Reduced Function of Muscle-derived Hematopoietic Stem Cells
  Experimental Hematology. Sep, 2003  |   Pubmed ID: 12962727
• Transient RNA Interference in Hematopoietic Progenitors with Functional Consequences
  Genesis (New York, N.Y. : 2000). Aug, 2003  |   Pubmed ID: 12929091
• Phenotype and Hematopoietic Potential of Side Population Cells Throughout Embryonic Development
  Blood. Oct, 2003  |   Pubmed ID: 12805065
• Complement-fixing CD45 Monoclonal Antibodies to Facilitate Stem Cell Transplantation in Mouse and Man
  Annals of the New York Academy of Sciences. May, 2003  |   Pubmed ID: 12799286
• Stem-cell "plasticity": Befuddled by the Muddle
  Current Opinion in Hematology. May, 2003  |   Pubmed ID: 12690288
• Adenoviral Transduction of Mouse Hematopoietic Stem Cells
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2003  |   Pubmed ID: 12668129
• Techniques for the Study of Adult Stem Cells: Be Fruitful and Multiply
  BioTechniques. Mar, 2003  |   Pubmed ID: 12661162
• Tracing the Origin of Non-hematopoietic Cells Using CD45 PCR Restriction Fragment Length Polymorphisms
  BioTechniques. Jan, 2003  |   Pubmed ID: 12545553
• Distinct Progenitor Populations in Skeletal Muscle Are Bone Marrow Derived and Exhibit Different Cell Fates During Vascular Regeneration
  The Journal of Clinical Investigation. Jan, 2003  |   Pubmed ID: 12511590
• Anti-CD45-mediated Cytoreduction to Facilitate Allogeneic Stem Cell Transplantation
  Blood. Mar, 2003  |   Pubmed ID: 12433683
• Failure of Bone Marrow Cells to Transdifferentiate into Neural Cells in Vivo
  Science (New York, N.Y.). Aug, 2002  |   Pubmed ID: 12193778
• The Therapeutic Potential of Stem Cells from Adults
  BMJ (Clinical Research Ed.). Aug, 2002  |   Pubmed ID: 12183311
• Use of CD9 Expression to Enrich for Porcine Hematopoietic Progenitors
  Experimental Hematology. Jul, 2002  |   Pubmed ID: 12135680
• Stem Cells: a Minireview
  Journal of Cellular Biochemistry. Supplement. 2002  |   Pubmed ID: 12046843
• Sca-1(pos) Cells in the Mouse Mammary Gland Represent an Enriched Progenitor Cell Population
  Developmental Biology. May, 2002  |   Pubmed ID: 11969254
• Muscle-derived Hematopoietic Stem Cells Are Hematopoietic in Origin
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002  |   Pubmed ID: 11830662
• Regeneration of Ischemic Cardiac Muscle and Vascular Endothelium by Adult Stem Cells
  The Journal of Clinical Investigation. Jun, 2001  |   Pubmed ID: 11390421
• Hematopoietic Potential of Stem Cells Isolated from Murine Skeletal Muscle
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 1999  |   Pubmed ID: 10588731