Maria Fernanda Laranjeira-Silva Department of Physiology University of Sao Paulo Biography Publications Institution JoVE Articles Maria Fernanda Laranjeira-SilvaPhD Dr. Maria Fernanda Laranjeira-Silva is a Young Researcher in the Department of Physiology at the University of Sao Paulo, Brazil. She received her undergraduate degree in Molecular Sciences and a Ph.D. from the University of Sao Paulo, Brazil.Throughout her research career, Dr. Laranjeira-Silva developed a keen focus on host-parasite interactions and the Leishmania´s mechanisms of subverting host defense responses. During her postdoctoral training and a subsequent Research Associate position at the University of Maryland-College Park, U.S.A. with Prof. Norma Andrews and Prof. Iqbal Hamza, she began to investigate iron and heme metabolism pathways in both the parasite and mammalian host. She identified and characterized the first iron exporter (LIR1) in a trypanosomatid parasite answering an important question about how Leishmania prevents accumulation of free iron to avoid cytotoxicity.Moving back to Brazil, Dr. Laranjeira-Silva was given a highly prestigious award from The State of Sao Paulo Research Foundation (FAPESP) and began her independent career as an Early-Stage Investigator at the University of Sao Paulo. Her ultimate research goal is to further understand Leishmania pathogenesis to define better therapeutic targets for leishmaniasis treatment. Publications Iron and Heme Metabolism at the Leishmania-Host Interface Trends in Parasitology. Jan, 2020 | Pubmed ID: 32005611 Ascorbate-Dependent Peroxidase (APX) from Leishmania Amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence Infection and Immunity. 12, 2019 | Pubmed ID: 31527128 Intracellular Iron Availability Modulates the Requirement for Leishmania Iron Regulator 1 (LIR1) During Macrophage Infections International Journal for Parasitology. 05, 2019 | Pubmed ID: 30910463 A MFS-like plasma membrane transporter required for Leishmania virulence protects the parasites from iron toxicity PLOS Pathogens. Jun, 2018 | Pubmed ID: 29906288 RNA-seq Transcriptional Profiling of Leishmania Amazonensis Reveals an Arginase-dependent Gene Expression Regulation PLoS Neglected Tropical Diseases. Oct, 2017 | Pubmed ID: 29077741 In Vivo Infecção com Leishmania amazonensis avaliará virulence parasita em camundongos Juliana Ide Aoki1, Ahyun Hong1, Ricardo Andrade Zampieri1, Lucile Maria Floeter-Winter1, Maria Fernanda Laranjeira-Silva1 1Department of Physiology, Institute of Bioscience, University of Sao Paulo JoVE 60617 Immunology and Infection Quantificação de crescimento intracelular dentro de macrófagos é um rápido e confiável método para avaliar a virulência de Leishmania parasitas Amrita Sarkar1, Yousuf A. Khan1, Maria Fernanda Laranjeira-Silva1, Norma W. Andrews1, Bidyottam Mittra1 1Department of Cell Biology and Molecular Genetics, University of Maryland JoVE 57486 Immunology and Infection
In Vivo Infecção com Leishmania amazonensis avaliará virulence parasita em camundongos Juliana Ide Aoki1, Ahyun Hong1, Ricardo Andrade Zampieri1, Lucile Maria Floeter-Winter1, Maria Fernanda Laranjeira-Silva1 1Department of Physiology, Institute of Bioscience, University of Sao Paulo JoVE 60617 Immunology and Infection
Quantificação de crescimento intracelular dentro de macrófagos é um rápido e confiável método para avaliar a virulência de Leishmania parasitas Amrita Sarkar1, Yousuf A. Khan1, Maria Fernanda Laranjeira-Silva1, Norma W. Andrews1, Bidyottam Mittra1 1Department of Cell Biology and Molecular Genetics, University of Maryland JoVE 57486 Immunology and Infection
