Marie Stiborova

Publications

• The Impact of Chemotherapeutic Drugs on the CYP1A1-catalysed Metabolism of the Environmental Carcinogen Benzo[a]pyrene: Effects in Human Colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) Cells
  Toxicology. Feb, 2018  |   Pubmed ID: 29471073
• Comparative Gene Expression Profiling of Human Metallothionein-3 Up-regulation in Neuroblastoma Cells and Its Impact on Susceptibility to Cisplatin
  Oncotarget. Jan, 2018  |   Pubmed ID: 29435113
• Cytochrome Bimpacts on Cytochrome P450-mediated Metabolism of Benzo[a]pyrene and Its DNA Adduct Formation: Studies in Hepatic Cytochrome B/P450 Reductase Null (HBRN) Mice
  Archives of Toxicology. Jan, 2018  |   Pubmed ID: 29368147
• Differentiation-associated Urothelial Cytochrome P450 Oxidoreductase Predicates the Xenobiotic-metabolizing Activity of "luminal" Muscle-invasive Bladder Cancers
  Molecular Carcinogenesis. Jan, 2018  |   Pubmed ID: 29323757
• The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells
  International Journal of Molecular Sciences. Jan, 2018  |   Pubmed ID: 29304031
• Sarcosine Influences Apoptosis and Growth of Prostate Cells Via Cell-type Specific Regulation of Distinct Sets of Genes
  The Prostate. Feb, 2018  |   Pubmed ID: 29105933
• Cytochromeplays a Dual Role in the Reaction Cycle of Cytochrome P450 3A4 During Oxidation of the Anticancer Drug Ellipticine
  Monatshefte Fur Chemie. 2017  |   Pubmed ID: 29104319
• Comparison of the Oxidation of Carcinogenic Aristolochic Acid I and II by Microsomal Cytochromes P450 in Vitro: Experimental and Theoretical Approaches
  Monatshefte Fur Chemie. 2017  |   Pubmed ID: 29104318
• Comparison of Human Cytochrome P450 1A1-catalysed Oxidation of Benzo[]pyrene in Prokaryotic and Eukaryotic Expression Systems
  Monatshefte Fur Chemie. 2017  |   Pubmed ID: 29104317
• DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer
  International Journal of Molecular Sciences. Oct, 2017  |   Pubmed ID: 29036902
• An Insight into the Complex Roles of Metallothioneins in Malignant Diseases with Emphasis on (sub)isoforms/isoforms and Epigenetics Phenomena
  Pharmacology & Therapeutics. Oct, 2017  |   Pubmed ID: 28987322
• DNA Interaction with Platinum-based Cytostatics Revealed by DNA Sequencing
  Analytical Biochemistry. Sep, 2017  |   Pubmed ID: 28970072
• VPA Does Not Enhance Platinum Binding to DNA in Cisplatin-resistant Neuroblastoma Cancer Cells
  Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Sep, 2017  |   Pubmed ID: 28945187
• Histone Deacetylase Inhibitors As Anticancer Drugs
  International Journal of Molecular Sciences. Jul, 2017  |   Pubmed ID: 28671573
• The Capacity and Effectiveness of Diosmectite and Charcoal in Trapping the Compounds Causing the Most Frequent Intoxications in Acute Medicine: A Comparative Study
  Environmental Toxicology and Pharmacology. Jun, 2017  |   Pubmed ID: 28445845
• Apoferritin As an Ubiquitous Nanocarrier with Excellent Shelf Life
  International Journal of Nanomedicine. 2017  |   Pubmed ID: 28392686
• Impact of Genetic Modulation of SULT1A Enzymes on DNA Adduct Formation by Aristolochic Acids and 3-nitrobenzanthrone
  Archives of Toxicology. Apr, 2017  |   Pubmed ID: 27557898
• Effectiveness of Human Cytochrome P450 3A4 Present in Liposomal and Microsomal Nanoparticles in Formation of Covalent DNA Adducts by Ellipticine
  Neuro Endocrinology Letters. Dec, 2016  |   Pubmed ID: 28263536
• Exposure of Rats to Exogenous Endocrine Disruptors 17alpha-ethinylestradiol and Benzo(a)pyrene and an Estrogenic Hormone Estradiol Induces Expression of Cytochromes P450 Involved in Their Metabolism
  Neuro Endocrinology Letters. Dec, 2016  |   Pubmed ID: 28263535
• Fully Automated Two-step Assay for Detection of Metallothionein Through Magnetic Isolation Using Functionalized γ-Fe2O3 Particles
  Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Dec, 2016  |   Pubmed ID: 27825623
• Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer
  PloS One. 2016  |   Pubmed ID: 27824899
• Prostate Tumor Attenuation in the Nu/nu Murine Model Due to Anti-sarcosine Antibodies in Folate-targeted Liposomes
  Scientific Reports. Sep, 2016  |   Pubmed ID: 27646588
• Zinc and Zinc-containing Biomolecules in Childhood Brain Tumors
  Journal of Molecular Medicine (Berlin, Germany). Nov, 2016  |   Pubmed ID: 27638340
• Correction to NADH:Cytochrome B5 Reductase and Cytochrome B5 Can Act As Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene
  Chemical Research in Toxicology. Sep, 2016  |   Pubmed ID: 27575721
• Balkan Endemic Nephropathy: an Update on Its Aetiology
  Archives of Toxicology. Nov, 2016  |   Pubmed ID: 27538407
• NADH:Cytochrome B5 Reductase and Cytochrome B5 Can Act As Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene
  Chemical Research in Toxicology. 08, 2016  |   Pubmed ID: 27404282
• Site-Directed Conjugation of Antibodies to Apoferritin Nanocarrier for Targeted Drug Delivery to Prostate Cancer Cells
  ACS Applied Materials & Interfaces. Jun, 2016  |   Pubmed ID: 27219717
• Induced Expression of Microsomal Cytochrome B5 Determined at MRNA and Protein Levels in Rats Exposed to Ellipticine, Benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I)
  Monatshefte Fur Chemie. 2016  |   Pubmed ID: 27110040
• Heterologous Expression of Human Cytochrome P450 2S1 Inand Investigation of Its Role in Metabolism of Benzo[]pyrene and Ellipticine
  Monatshefte Fur Chemie. 2016  |   Pubmed ID: 27110039
• NADPH- and NADH-dependent Metabolism of and DNA Adduct Formation by Benzo[]pyrene Catalyzed with Rat Hepatic Microsomes and Cytochrome P450 1A1
  Monatshefte Fur Chemie. 2016  |   Pubmed ID: 27110038
• Fluorescence Characterization of Gold Modified Liposomes with Antisense N-myc DNA Bound to the Magnetisable Particles with Encapsulated Anticancer Drugs (Doxorubicin, Ellipticine and Etoposide)
  Sensors (Basel, Switzerland). Feb, 2016  |   Pubmed ID: 26927112
• The Impact of Individual Cytochrome P450 Enzymes on Oxidative Metabolism of Benzo[a]pyrene in Human Livers
  Environmental and Molecular Mutagenesis. Apr, 2016  |   Pubmed ID: 26919089
• Electrochemical Sensing of Etoposide Using Carbon Quantum Dot Modified Glassy Carbon Electrode
  The Analyst. Apr, 2016  |   Pubmed ID: 26882954
• Active Site Mutations As a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1
  International Journal of Molecular Sciences. Feb, 2016  |   Pubmed ID: 26861298
• Relation of Exposure to Amino Acids Involved in Sarcosine Metabolic Pathway on Behavior of Non-tumor and Malignant Prostatic Cell Lines
  The Prostate. May, 2016  |   Pubmed ID: 26847870
• Induction of Cytochromes P450 1A1 and 1A2 Suppresses Formation of DNA Adducts by Carcinogenic Aristolochic Acid I in Rats in Vivo
  Toxicology. Feb, 2016  |   Pubmed ID: 26845733
• The Impact of P53 on DNA Damage and Metabolic Activation of the Environmental Carcinogen Benzo[a]pyrene: Effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) Mice
  Archives of Toxicology. Apr, 2016  |   Pubmed ID: 25995008
• The Effects of Heavy Metal Ions, Phthalates and Ochratoxin A on Oxidation of Carcinogenic Aristolochic Acid I Causing Balkan Endemic Nephropathy
  Neuro Endocrinology Letters. 2015  |   Pubmed ID: 26757129
• Role of Dihydromyricetin in Cytochrome P450-mediated Metabolism and Carcinogen Activation
  Neuro Endocrinology Letters. 2015  |   Pubmed ID: 26757127
• Preparation and Application of Anti-peptide Antibodies for Detection of Orphan Cytochromes P450
  Neuro Endocrinology Letters. 2015  |   Pubmed ID: 26757124
• Ferrous and Ferric State of Cytochromes P450 in Intact Escherichia Coli Cells: a Possible Role of Cytochrome P450-flavodoxin Interactions
  Neuro Endocrinology Letters. 2015  |   Pubmed ID: 26757119
• Cytotoxicity of and DNA Adduct Formation by Ellipticine and Its Micellar Form in Human Leukemia Cells in Vitro
  Neuro Endocrinology Letters. 2015  |   Pubmed ID: 26757112
• A Study on 17alpha-ethinylestradiol Metabolism in Rat and Pleurotus Ostreatus
  Neuro Endocrinology Letters. 2015  |   Pubmed ID: 26757108
• A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches
  International Journal of Molecular Sciences. Nov, 2015  |   Pubmed ID: 26593908
• Photo-initiated Crosslinking Extends Mapping of the Protein-protein Interface to Membrane-embedded Portions of Cytochromes P450 2B4 and B₅
  Methods (San Diego, Calif.). Nov, 2015  |   Pubmed ID: 26235815
• Vacuolar-ATPase-mediated Intracellular Sequestration of Ellipticine Contributes to Drug Resistance in Neuroblastoma Cells
  International Journal of Oncology. Sep, 2015  |   Pubmed ID: 26134421
• The Synergistic Effects of DNA-damaging Drugs Cisplatin and Etoposide with a Histone Deacetylase Inhibitor Valproate in High-risk Neuroblastoma Cells
  International Journal of Oncology. Jul, 2015  |   Pubmed ID: 25963435
• Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene
  Toxicological Sciences : an Official Journal of the Society of Toxicology. Aug, 2015  |   Pubmed ID: 25911668
• Doxorubicin Interactions with Bovine Serum Albumin Revealed by Microdialysis with On-line Laser-induced Fluorescence Detection at Subpicogram Level
  Electrophoresis. Jun, 2015  |   Pubmed ID: 25808901
• Fluorescent Cellular Assay for Screening Agents Inhibiting Pseudomonas Aeruginosa Adherence
  Sensors (Basel, Switzerland). Jan, 2015  |   Pubmed ID: 25602268
• The Influence of Ochratoxin A on DNA Adduct Formation by the Carcinogen Aristolochic Acid in Rats
  Archives of Toxicology. Nov, 2015  |   Pubmed ID: 25209566
• Enzymes Oxidizing the Azo Dye 1-phenylazo-2-naphthol (Sudan I) and Their Contribution to Its Genotoxicity and Carcinogenicity
  Current Drug Metabolism. 2014  |   Pubmed ID: 25658126
• The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats, Hepatic Cytochrome P450 Reductase Null (HRN™) Mice and Pure Enzymes
  International Journal of Molecular Sciences. Dec, 2014  |   Pubmed ID: 25547492
• Modulation of Induced Cytotoxicity of Doxorubicin by Using Apoferritin and Liposomal Cages
  International Journal of Molecular Sciences. Dec, 2014  |   Pubmed ID: 25514405
• Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats - a Comparative Study
  Sensors (Basel, Switzerland). Dec, 2014  |   Pubmed ID: 25479328
• Role of Rat Cytochromes P450 in the Oxidation of 17α-ethinylestradiol
  Environmental Toxicology and Pharmacology. Nov, 2014  |   Pubmed ID: 25461545
• Flexible Docking-based Molecular Dynamics/steered Molecular Dynamics Calculations of Protein-protein Contacts in a Complex of Cytochrome P450 1A2 with Cytochrome B5
  Biochemistry. Oct, 2014  |   Pubmed ID: 25313797
• Introduction of Water into the Heme Distal Side by Leu65 Mutations of an Oxygen Sensor, YddV, Generates Verdoheme and Carbon Monoxide, Exerting the Heme Oxygenase Reaction
  Journal of Inorganic Biochemistry. Nov, 2014  |   Pubmed ID: 25046385
• Mechanisms of Enzyme-catalyzed Reduction of Two Carcinogenic Nitro-aromatics, 3-nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches
  International Journal of Molecular Sciences. Jun, 2014  |   Pubmed ID: 24918288
• The Application of an Emerging Technique for Protein-protein Interaction Interface Mapping: the Combination of Photo-initiated Cross-linking Protein Nanoprobes with Mass Spectrometry
  International Journal of Molecular Sciences. May, 2014  |   Pubmed ID: 24865487
• The Effect of Aristolochic Acid I on Expression of NAD(P)H:quinone Oxidoreductase in Mice and Rats--a Comparative Study
  Mutation Research. Genetic Toxicology and Environmental Mutagenesis. Jul, 2014  |   Pubmed ID: 24769487
• The Influence of Dicoumarol on the Bioactivation of the Carcinogen Aristolochic Acid I in Rats
  Mutagenesis. May, 2014  |   Pubmed ID: 24598128
• Cytochrome B5 and Epoxide Hydrolase Contribute to Benzo[a]pyrene-DNA Adduct Formation Catalyzed by Cytochrome P450 1A1 Under Low NADPH:P450 Oxidoreductase Conditions
  Toxicology. Apr, 2014  |   Pubmed ID: 24530354
• Hypoxia-mediated Histone Acetylation and Expression of N-myc Transcription Factor Dictate Aggressiveness of Neuroblastoma Cells
  Oncology Reports. Apr, 2014  |   Pubmed ID: 24481548
• Cisplatin-resistant Prostate Cancer Model: Differences in Antioxidant System, Apoptosis and Cell Cycle
  International Journal of Oncology. Mar, 2014  |   Pubmed ID: 24366574
• Histone Deacetylase Inhibitors in Cancer Therapy. A Review
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jun, 2014  |   Pubmed ID: 24263215
• Knockout and Humanized Mice As Suitable Tools to Identify Enzymes Metabolizing the Human Carcinogen Aristolochic Acid
  Xenobiotica; the Fate of Foreign Compounds in Biological Systems. Jan, 2014  |   Pubmed ID: 24152141
• Ellipticines As DNA-targeted Chemotherapeutics
  Current Medicinal Chemistry. 2014  |   Pubmed ID: 24059226
• Alcoholic Liver Cirrhosis Increases the Risk of Left Ventricular Diastolic Dysfunction
  Neuro Endocrinology Letters. 2013  |   Pubmed ID: 24362094
• Oxidation of Carcinogenic Benzo[a]pyrene by Human and Rat Cytochrome P450 1A1 and Its Influencing by Cytochrome B5 - a Comparative Study
  Neuro Endocrinology Letters. 2013  |   Pubmed ID: 24362093
• The Effect of Benzo[a]pyrene on Metabolic Activation of Anticancer Drug Ellipticine in Mice
  Neuro Endocrinology Letters. 2013  |   Pubmed ID: 24362092
• A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
  International Journal of Molecular Sciences. Oct, 2013  |   Pubmed ID: 24185911
• The Relationship Between DNA Adduct Formation by Benzo[a]pyrene and Expression of Its Activation Enzyme Cytochrome P450 1A1 in Rat
  Environmental Toxicology and Pharmacology. Nov, 2013  |   Pubmed ID: 24095716
• Sarcosine As a Potential Prostate Cancer Biomarker--a Review
  International Journal of Molecular Sciences. Jul, 2013  |   Pubmed ID: 23880848
• Apoferritin Modified Magnetic Particles As Doxorubicin Carriers for Anticancer Drug Delivery
  International Journal of Molecular Sciences. Jun, 2013  |   Pubmed ID: 23807501
• Enzymes Metabolizing Aristolochic Acid and Their Contribution to the Development of Aristolochic Acid Nephropathy and Urothelial Cancer
  Current Drug Metabolism. Jul, 2013  |   Pubmed ID: 23701164
• The Role of Metallothionein in Oxidative Stress
  International Journal of Molecular Sciences. Mar, 2013  |   Pubmed ID: 23502468
• Induced Expression of Cytochrome P450 1A and NAD(P)H:quinone Oxidoreductase Determined at MRNA, Protein, and Enzyme Activity Levels in Rats Exposed to the Carcinogenic Azo Dye 1-phenylazo-2-naphthol (Sudan I)
  Chemical Research in Toxicology. Feb, 2013  |   Pubmed ID: 23289503
• Effects of Cytochrome P450 Inhibitors on Peroxidase Activity
  Neuro Endocrinology Letters. 2012  |   Pubmed ID: 23353841
• Theoretical Investigation of Differences in Nitroreduction of Aristolochic Acid I by Cytochromes P450 1A1, 1A2 and 1B1
  Neuro Endocrinology Letters. 2012  |   Pubmed ID: 23353840
• Impact of Histone Deacetylase Inhibitor Valproic Acid on the Anticancer Effect of Etoposide on Neuroblastoma Cells
  Neuro Endocrinology Letters. 2012  |   Pubmed ID: 23353839
• Activation and Detoxification Metabolism of Urban Air Pollutants 2-nitrobenzanthrone and Carcinogenic 3-nitrobenzanthrone by Rat and Mouse Hepatic Microsomes
  Neuro Endocrinology Letters. 2012  |   Pubmed ID: 23353838
• Modern Micro and Nanoparticle-based Imaging Techniques
  Sensors (Basel, Switzerland). Nov, 2012  |   Pubmed ID: 23202187
• NAD(P)H:quinone Oxidoreductase Expression in Cyp1a-knockout and CYP1A-humanized Mouse Lines and Its Effect on Bioactivation of the Carcinogen Aristolochic Acid I
  Toxicology and Applied Pharmacology. Dec, 2012  |   Pubmed ID: 22982977
• Ellipticine Oxidation and DNA Adduct Formation in Human Hepatocytes is Catalyzed by Human Cytochromes P450 and Enhanced by Cytochrome B5
  Toxicology. Dec, 2012  |   Pubmed ID: 22917556
• Analysis of Covalent Ellipticine- and Doxorubicin-derived Adducts in DNA of Neuroblastoma Cells by the ³²P-postlabeling Technique
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jun, 2012  |   Pubmed ID: 22837132
• Formation, Persistence, and Identification of DNA Adducts Formed by the Carcinogenic Environmental Pollutant O-anisidine in Rats
  Toxicological Sciences : an Official Journal of the Society of Toxicology. Jun, 2012  |   Pubmed ID: 22403159
• Cytochrome B5 Increases Cytochrome P450 3A4-mediated Activation of Anticancer Drug Ellipticine to 13-hydroxyellipticine Whose Covalent Binding to DNA is Elevated by Sulfotransferases and N,O-acetyltransferases
  Chemical Research in Toxicology. May, 2012  |   Pubmed ID: 22390216
• Bioactivation Versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2
  Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2012  |   Pubmed ID: 22086975
• Mechanisms of Ellipticine-mediated Resistance in UKF-NB-4 Neuroblastoma Cells
  Cancer Science. Feb, 2012  |   Pubmed ID: 22040216
• Role of Cytochromes P450 in Metabolism of Carcinogenic Aristolochic Acid I: Evidence of Their Contribution to Aristolochic Acid I Detoxication and Activation in Rat Liver
  Neuro Endocrinology Letters. 2011  |   Pubmed ID: 22167220
• Isolation and Partial Characterization of Extracellular NADPH-dependent Phenol Hydroxylase Oxidizing Phenol to Catechol in Comamonas Testosteroni
  Neuro Endocrinology Letters. 2011  |   Pubmed ID: 22167219
• Impact of Beta-naphthoflavone on Genotoxicity of Food-derived Carcinogens
  Neuro Endocrinology Letters. 2011  |   Pubmed ID: 22167217
• Comparison of Activation of Aristolochic Acid I and II with NADPH:quinone Oxidoreductase, Sulphotransferases and N-acetyltranferases
  Neuro Endocrinology Letters. 2011  |   Pubmed ID: 22167209
• Anticancer Agent Ellipticine Combined with Histone Deacetylase Inhibitors, Valproic Acid and Trichostatin A, is an Effective DNA Damage Strategy in Human Neuroblastoma
  Neuro Endocrinology Letters. 2011  |   Pubmed ID: 22167207
• Human Cytochrome-P450 Enzymes Metabolize N-(2-methoxyphenyl)hydroxylamine, a Metabolite of the Carcinogens O-anisidine and O-nitroanisole, Thereby Dictating Its Genotoxicity
  Mutation Research. Dec, 2011  |   Pubmed ID: 21946300
• Ellipticine Cytotoxicity to Cancer Cell Lines - a Comparative Study
  Interdisciplinary Toxicology. Jun, 2011  |   Pubmed ID: 21753906
• Cytochrome B(5) Shifts Oxidation of the Anticancer Drug Ellipticine by Cytochromes P450 1A1 and 1A2 from Its Detoxication to Activation, Thereby Modulating Its Pharmacological Efficacy
  Biochemical Pharmacology. Sep, 2011  |   Pubmed ID: 21683692
• The Human Carcinogen Aristolochic Acid I is Activated to Form DNA Adducts by Human NAD(P)H:quinone Oxidoreductase Without the Contribution of Acetyltransferases or Sulfotransferases
  Environmental and Molecular Mutagenesis. Jul, 2011  |   Pubmed ID: 21370283
• Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:cytochrome P450 Reductase Null (HRN) Mouse Model
  Toxicological Sciences : an Official Journal of the Society of Toxicology. May, 2011  |   Pubmed ID: 21362632
• Induction of Biotransformation Enzymes by the Carcinogenic Air-pollutant 3-nitrobenzanthrone in Liver, Kidney and Lung, After Intra-tracheal Instillation in Rats
  Mutation Research. Feb, 2011  |   Pubmed ID: 21167309
• DNA and Histone Deacetylases As Targets for Neuroblastoma Treatment
  Interdisciplinary Toxicology. Jun, 2010  |   Pubmed ID: 21217872
• Identification of Rat Cytochromes P450 Metabolizing N-(2-methoxyphenyl)hydroxylamine, a Human Metabolite of the Environmental Pollutants and Carcinogens O-anisidine and O-nitroanisole
  Neuro Endocrinology Letters. 2010  |   Pubmed ID: 21187827
• Role of Cytochromes P450 and Peroxidases in Metabolism of the Anticancer Drug Ellipticine: Additional Evidence of Their Contribution to Ellipticine Activation in Rat Liver, Lung and Kidney
  Neuro Endocrinology Letters. 2010  |   Pubmed ID: 21187821
• Glycosylation Protects Proteins Against Free Radicals Generated from Toxic Xenobiotics
  Toxicological Sciences : an Official Journal of the Society of Toxicology. Oct, 2010  |   Pubmed ID: 20616208
• The Binding Affinity of Carcinogenic N-nitrosodimethylamine and N-nitrosomethylaniline to Cytochromes P450 2B4, 2E1 and 3A6 Does Not Dictate the Rate of Their Enzymatic N-demethylation
  General Physiology and Biophysics. Jun, 2010  |   Pubmed ID: 20577029
• Mechanisms of the Different DNA Adduct Forming Potentials of the Urban Air Pollutants 2-nitrobenzanthrone and Carcinogenic 3-nitrobenzanthrone
  Chemical Research in Toxicology. Jul, 2010  |   Pubmed ID: 20545351
• Analysis of Benzo[a]pyrene Metabolites Formed by Rat Hepatic Microsomes Using High Pressure Liquid Chromatography: Optimization of the Method
  Interdisciplinary Toxicology. Dec, 2009  |   Pubmed ID: 21217860
• Histone Deacetylase Inhibitors Valproate and Trichostatin A Are Toxic to Neuroblastoma Cells and Modulate Cytochrome P450 1A1, 1B1 and 3A4 Expression in These Cells
  Interdisciplinary Toxicology. Sep, 2009  |   Pubmed ID: 21217856
• The Effects of Selected Flavonoids on Cytochromes P450 in Rat Liver and Small Intestine
  Interdisciplinary Toxicology. Sep, 2009  |   Pubmed ID: 21217855
• Oxidation of the Carcinogenic Non-aminoazo Dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by Cytochromes P450 and Peroxidases: a Comparative Study
  Interdisciplinary Toxicology. Sep, 2009  |   Pubmed ID: 21217854
• Genotoxic Mechanisms for the Carcinogenicity of the Environmental Pollutants and Carcinogens O-anisidine and 2-nitroanisole Follow from Adducts Generated by Their Metabolite N-(2-methoxyphenyl)-hydroxylamine with Deoxyguanosine in DNA
  Interdisciplinary Toxicology. Mar, 2009  |   Pubmed ID: 21217841
• Isolation and Partial Characterization of Catechol 1,2-dioxygenase of Phenol Degrading Yeast Candida Tropicalis
  Neuro Endocrinology Letters. 2009  |   Pubmed ID: 20027149
• Preparation of Apo-cytochrome B5 Utilizing Heme Transfer to Apo-myoglobin
  Neuro Endocrinology Letters. 2009  |   Pubmed ID: 20027148
• Modulation of Cytochrome P450 Enzyme System by Selected Flavonoids
  Neuro Endocrinology Letters. 2009  |   Pubmed ID: 20027147
• Cytotoxicity of and DNA Adduct Formation by Ellipticine in Human U87MG Glioblastoma Cancer Cells
  Neuro Endocrinology Letters. 2009  |   Pubmed ID: 20027146
• Oxidation of 3-aminobenzanthrone, a Human Metabolite of Carcinogenic Environmental Pollutant 3-nitrobenzanthrone, by Cytochromes P450 - Similarity Between Human and Rat Enzymes
  Neuro Endocrinology Letters. 2009  |   Pubmed ID: 20027145
• Rat Cytochromes P450 Oxidize 2-nitrophenol, a Human Metabolite of Carcinogenic 2-nitroanisole
  Neuro Endocrinology Letters. 2009  |   Pubmed ID: 20027144
• The Mechanism of Cytotoxicity and DNA Adduct Formation by the Anticancer Drug Ellipticine in Human Neuroblastoma Cells
  Biochemical Pharmacology. May, 2009  |   Pubmed ID: 19426684
• 3-aminobenzanthrone, a Human Metabolite of the Carcinogenic Environmental Pollutant 3-nitrobenzanthrone, Induces Biotransformation Enzymes in Rat Kidney and Lung
  Mutation Research. May, 2009  |   Pubmed ID: 19398038
• The Role of Biotransformation Enzymes in the Development of Renal Injury and Urothelial Cancer Caused by Aristolochic Acid: Urgent Questions and Difficult Answers
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Mar, 2009  |   Pubmed ID: 19365519
• Preparation of a Biologically Active Apo-cytochrome B5 Via Heterologous Expression in Escherichia Coli
  Protein Expression and Purification. Aug, 2009  |   Pubmed ID: 19358889
• Isolation of Cytoplasmic NADPH-dependent Phenol Hydroxylase and Catechol-1,2-dioxygenase from Candida Tropicalis Yeast
  Interdisciplinary Toxicology. Dec, 2008  |   Pubmed ID: 21218120
• Cytochrome P450-mediated Metabolism of N-(2-methoxyphenyl)-hydroxylamine, a Human Metabolite of the Environmental Pollutants and Carcinogens O-anisidine and O-nitroanisole
  Interdisciplinary Toxicology. Dec, 2008  |   Pubmed ID: 21218119
• Optimalization of Preparation of Apo-cytochrome B(5) Utilizing Apo-myoglobin
  Interdisciplinary Toxicology. Sep, 2008  |   Pubmed ID: 21218111
• The Comparison of Cytotoxicity of the Anticancer Drugs Doxorubicin and Ellipticine to Human Neuroblastoma Cells
  Interdisciplinary Toxicology. Sep, 2008  |   Pubmed ID: 21218110
• Oxidation of Carcinogenic 2-nitroanisole by Rat Cytochromes P450 - Similarity Between Human and Rat Enzymes
  Interdisciplinary Toxicology. Sep, 2008  |   Pubmed ID: 21218109
• Ellipticine and Benzo(a)pyrene Increase Their Own Metabolic Activation Via Modulation of Expression and Enzymatic Activity of Cytochromes P450 1A1 and 1A2
  Interdisciplinary Toxicology. Sep, 2008  |   Pubmed ID: 21218107
• Experimental Approaches to Evaluate Activities of Cytochromes P450 3A
  Interdisciplinary Toxicology. Sep, 2008  |   Pubmed ID: 21218106
• Rat Cytochromes P450 Oxidize 3-aminobenzanthrone, a Human Metabolite of the Carcinogenic Environmental Pollutant 3-nitrobenzanthrone
  Interdisciplinary Toxicology. Sep, 2008  |   Pubmed ID: 21218105
• Contribution of Biotransformation Enzymes to the Development of Renal Injury and Urothelial Cancer Caused by Aristolochic Acid: Urgent Questions, Difficult Answers
  Interdisciplinary Toxicology. Jun, 2008  |   Pubmed ID: 21218097
• A One-electron Oxidation of Carcinogenic Nonaminoazo Dye Sudan I by Horseradish Peroxidase
  Neuro Endocrinology Letters. Oct, 2008  |   Pubmed ID: 18987613
• Human Cytochromes P450 1A1 and 1A2 Participate in Detoxication of Carcinogenic Aristolochic Acid
  Neuro Endocrinology Letters. Oct, 2008  |   Pubmed ID: 18987598
• Induction of Cytochromes P450 in Small Intestine by Chemopreventive Compounds
  Neuro Endocrinology Letters. Oct, 2008  |   Pubmed ID: 18987596
• Isolation and Partial Characterization of the Adduct Formed by 13-hydroxyellipticine with Deoxyguanosine in DNA
  Neuro Endocrinology Letters. Oct, 2008  |   Pubmed ID: 18987592
• Structural Analysis of Binding of a Diamantoid Substrate to Cytochrome P450 2B4: Possible Role of Arg 133 in Modulation of Function and Activity of This Enzyme
  Neuro Endocrinology Letters. Oct, 2008  |   Pubmed ID: 18987581
• Macleaya Cordata Extract and Sangrovit Genotoxicity. Assessment in Vivo
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jun, 2008  |   Pubmed ID: 18795072
• Redox Cycling in the Metabolism of the Environmental Pollutant and Suspected Human Carcinogen O-anisidine by Rat and Rabbit Hepatic Microsomes
  Chemical Research in Toxicology. Aug, 2008  |   Pubmed ID: 18624415
• The Environmental Pollutant and Carcinogen 3-nitrobenzanthrone Induces Cytochrome P450 1A1 and NAD(P)H:quinone Oxidoreductase in Rat Lung and Kidney, Thereby Enhancing Its Own Genotoxicity
  Toxicology. May, 2008  |   Pubmed ID: 18329153
• Role of Hepatic Cytochromes P450 in Bioactivation of the Anticancer Drug Ellipticine: Studies with the Hepatic NADPH:cytochrome P450 Reductase Null Mouse
  Toxicology and Applied Pharmacology. Feb, 2008  |   Pubmed ID: 17976674
• Metabolic Activation of Carcinogenic Aristolochic Acid, a Risk Factor for Balkan Endemic Nephropathy
  Mutation Research. Jan-Feb, 2008  |   Pubmed ID: 17851120
• Utilizing of Square Wave Voltammetry to Detect Flavonoids in the Presence of Human Urine
  Sensors (Basel, Switzerland). Oct, 2007  |   Pubmed ID: 28903234
• Mapping of Cytochrome P450 2B4 Substrate Binding Sites by Photolabile Probe 3-azidiamantane: Identification of Putative Substrate Access Regions
  Archives of Biochemistry and Biophysics. Dec, 2007  |   Pubmed ID: 17961497
• The Anticancer Drug Ellipticine is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Oct, 2007  |   Pubmed ID: 17656468
• Formation and Persistence of DNA Adducts of Anticancer Drug Ellipticine in Rats
  Toxicology. Jul, 2007  |   Pubmed ID: 17482743
• DNA Adduct Formation by the Anticancer Drug Ellipticine in Human Leukemia HL-60 and CCRF-CEM Cells
  Cancer Letters. Jul, 2007  |   Pubmed ID: 17306925
• Mammalian Peroxidases Activate Anticancer Drug Ellipticine to Intermediates Forming Deoxyguanosine Adducts in DNA Identical to Those Found in Vivo and Generated from 12-hydroxyellipticine and 13-hydroxyellipticine
  International Journal of Cancer. Jan, 2007  |   Pubmed ID: 17066455
• Modulation of CYP1A1-mediated Oxidation of Carcinogenic Azo Dye Sudan I and Its Binding to DNA by Cytochrome B5
  Neuro Endocrinology Letters. Dec, 2006  |   Pubmed ID: 17159775
• Cytochromes P450 Reconstituted with NADPH: P450 Reductase Mimic the Activating and Detoxicating Metabolism of the Anticancer Drug Ellipticine in Microsomes
  Neuro Endocrinology Letters. Dec, 2006  |   Pubmed ID: 17159771
• Toxicological Aspects of Flavonoid Interaction with Biomacromolecules
  Neuro Endocrinology Letters. Dec, 2006  |   Pubmed ID: 17159770
• Oxidative Detoxication of Carcinogenic 2-nitroanisole by Human, Rat and Rabbit Cytochrome P450
  Neuro Endocrinology Letters. Dec, 2006  |   Pubmed ID: 17159769
• Molecular Mechanisms of Antineoplastic Action of an Anticancer Drug Ellipticine
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jul, 2006  |   Pubmed ID: 16936898
• The Environmental Pollutant and Carcinogen 3-nitrobenzanthrone and Its Human Metabolite 3-aminobenzanthrone Are Potent Inducers of Rat Hepatic Cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone Oxidoreductase
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Aug, 2006  |   Pubmed ID: 16714372
• Oxidation of an Antitumor Drug Ellipticine by Peroxidases
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Dec, 2005  |   Pubmed ID: 16601808
• Carcinogenic Pollutants O-nitroanisole and O-anisidine Are Substrates and Inducers of Cytochromes P450
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Dec, 2005  |   Pubmed ID: 16601807
• Antitumor Drug Ellipticine Inhibits the Activities of Rat Hepatic Cytochromes P450
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Dec, 2005  |   Pubmed ID: 16601806
• Molecular Mechanism of Genotoxicity of the Environmental Pollutant 3-nitrobenzanthrone
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Dec, 2005  |   Pubmed ID: 16601755
• The Binding of Aristolochic Acid I to the Active Site of Human Cytochromes P450 1A1 and 1A2 Explains Their Potential to Reductively Activate This Human Carcinogen
  Cancer Letters. Nov, 2005  |   Pubmed ID: 16125300
• Structural Requirements for Inhibitors of Cytochromes P450 2B: Assessment of the Enzyme Interaction with Diamondoids
  Journal of Enzyme Inhibition and Medicinal Chemistry. Feb, 2005  |   Pubmed ID: 15895681
• Identification of a Genotoxic Mechanism for the Carcinogenicity of the Environmental Pollutant and Suspected Human Carcinogen O-anisidine
  International Journal of Cancer. Sep, 2005  |   Pubmed ID: 15828049
• Expression of Cytochrome P450 1A1 and Its Contribution to Oxidation of a Potential Human Carcinogen 1-phenylazo-2-naphthol (Sudan I) in Human Livers
  Cancer Letters. Apr, 2005  |   Pubmed ID: 15766589
• Human Hepatic and Renal Microsomes, Cytochromes P450 1A1/2, NADPH:cytochrome P450 Reductase and Prostaglandin H Synthase Mediate the Formation of Aristolochic Acid-DNA Adducts Found in Patients with Urothelial Cancer
  International Journal of Cancer. Jan, 2005  |   Pubmed ID: 15386410
• The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, Through Metabolism to 13-hydroxyellipticine and Ellipticine N2-oxide
  Cancer Research. Nov, 2004  |   Pubmed ID: 15548707
• Enzymes Involved in the Metabolism of the Carcinogen 2-nitroanisole: Evidence for Its Oxidative Detoxication by Human Cytochromes P450
  Chemical Research in Toxicology. May, 2004  |   Pubmed ID: 15144223
• Identification of a Genotoxic Mechanism for 2-nitroanisole Carcinogenicity and of Its Carcinogenic Potential for Humans
  Carcinogenesis. May, 2004  |   Pubmed ID: 14729594
• DNA Adduct Formation by the Anticancer Drug Ellipticine in Rats Determined by 32P Postlabeling
  International Journal of Cancer. Dec, 2003  |   Pubmed ID: 14601046
• Human Cytosolic Enzymes Involved in the Metabolic Activation of Carcinogenic Aristolochic Acid: Evidence for Reductive Activation by Human NAD(P)H:quinone Oxidoreductase
  Carcinogenesis. Oct, 2003  |   Pubmed ID: 12869422
• Rat Microsomes Activating the Anticancer Drug Ellipticine to Species Covalently Binding to Deoxyguanosine in DNA Are a Suitable Model Mimicking Ellipticine Bioactivation in Humans
  Chemical Research in Toxicology. Jan, 2003  |   Pubmed ID: 12693029
• Sudan I is a Potential Carcinogen for Humans: Evidence for Its Metabolic Activation and Detoxication by Human Recombinant Cytochrome P450 1A1 and Liver Microsomes
  Cancer Research. Oct, 2002  |   Pubmed ID: 12384524
• DNA Adduct Formation from Quaternary Benzo[c]phenanthridine Alkaloids Sanguinarine and Chelerythrine As Revealed by the 32P-postlabeling Technique
  Chemico-biological Interactions. Aug, 2002  |   Pubmed ID: 12204579
• New Selective Inhibitors of Cytochromes P450 2B and Their Application to Antimutagenesis of Tamoxifen
  Archives of Biochemistry and Biophysics. Jul, 2002  |   Pubmed ID: 12061800
• Carcinogenic Aristolochic Acids Upon Activation by DT-diaphorase Form Adducts Found in DNA of Patients with Chinese Herbs Nephropathy
  Carcinogenesis. Apr, 2002  |   Pubmed ID: 11960915
• Mechanism of Peroxidase-mediated Oxidation of Carcinogenic O-anisidine and Its Binding to DNA
  Mutation Research. Mar, 2002  |   Pubmed ID: 11890934
• Flavonoids-potent and Versatile Biologically Active Compounds Interacting with Cytochromes P450
  Chemico-biological Interactions. Jan, 2002  |   Pubmed ID: 11803026