Mario Losen School for Mental Health and Neuroscience Maastricht University Biography Publications Institution JoVE Articles Mario Losen has not added a biography. If you are Mario Losen and would like to personalize this page please email our Author Liaison for assistance. Publications Detection of Peptide-based Nanoparticles in Blood Plasma by ELISA PloS One. 2015 | Pubmed ID: 25996618 Standardization of the Experimental Autoimmune Myasthenia Gravis (EAMG) Model by Immunization of Rats with Torpedo Californica Acetylcholine Receptors - Recommendations for Methods and Experimental Designs Experimental Neurology. Mar, 2015 | Pubmed ID: 25796590 Guidelines for Pre-clinical Assessment of the Acetylcholine Receptor-specific Passive Transfer Myasthenia Gravis Model-Recommendations for Methods and Experimental Designs Experimental Neurology. Mar, 2015 | Pubmed ID: 25743217 IL-17-producing CD4(+) T Cells Contribute to the Loss of B-cell Tolerance in Experimental Autoimmune Myasthenia Gravis European Journal of Immunology. May, 2015 | Pubmed ID: 25676041 Ex Vivo and in Vivo Administration of Fluorescent CNA35 Specifically Marks Cardiac Fibrosis Molecular Imaging. 2014 | Pubmed ID: 25249247 Glycine Receptor Antibodies in PERM: a New Channelopathy Brain : a Journal of Neurology. Aug, 2014 | Pubmed ID: 25057131 Proteasome Inhibition with Bortezomib Depletes Plasma Cells and Specific Autoantibody Production in Primary Thymic Cell Cultures from Early-onset Myasthenia Gravis Patients Journal of Immunology (Baltimore, Md. : 1950). Aug, 2014 | Pubmed ID: 24973445 Delivery of DNA into the Central Nervous System Via Electroporation Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24510821 Clonal Heterogeneity of Thymic B Cells from Early-onset Myasthenia Gravis Patients with Antibodies Against the Acetylcholine Receptor Journal of Autoimmunity. Aug, 2014 | Pubmed ID: 24439114 Complement Activation by Ceramide Transporter Proteins Journal of Immunology (Baltimore, Md. : 1950). Feb, 2014 | Pubmed ID: 24395916 Muscle Disuse Atrophy is Not Accompanied by Changes in Skeletal Muscle Satellite Cell Content Clinical Science (London, England : 1979). Apr, 2014 | Pubmed ID: 24215591 MuSK IgG4 Autoantibodies Cause Myasthenia Gravis by Inhibiting Binding Between MuSK and Lrp4 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013 | Pubmed ID: 24297891 Autoantibodies to Neurotransmitter Receptors and Ion Channels: from Neuromuscular to Neuropsychiatric Disorders Frontiers in Genetics. 2013 | Pubmed ID: 24065983 Proteomic Analysis of Rat Tibialis Anterior Muscles at Different Stages of Experimental Autoimmune Myasthenia Gravis Journal of Neuroimmunology. Aug, 2013 | Pubmed ID: 23791150 Autoantigen Induced Clonal Expansion in Immortalized B Cells from the Peripheral Blood of Multiple Sclerosis Patients Journal of Neuroimmunology. Aug, 2013 | Pubmed ID: 23746373 Pathophysiology of Myasthenia Gravis with Antibodies to the Acetylcholine Receptor, Muscle-specific Kinase and Low-density Lipoprotein Receptor-related Protein 4 Autoimmunity Reviews. Jul, 2013 | Pubmed ID: 23535160 Targeting Plasma Cells with Proteasome Inhibitors: Possible Roles in Treating Myasthenia Gravis? Annals of the New York Academy of Sciences. Dec, 2012 | Pubmed ID: 23252897 MuSK Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome in the Same Patient Clinical Neurology and Neurosurgery. Jul, 2012 | Pubmed ID: 22421253 Goodpasture Antigen-binding Protein/ceramide Transporter Binds to Human Serum Amyloid P-component and is Present in Brain Amyloid Plaques The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22396542 Muscle-specific Kinase Myasthenia Gravis IgG4 Autoantibodies Cause Severe Neuromuscular Junction Dysfunction in Mice Brain : a Journal of Neurology. Apr, 2012 | Pubmed ID: 22396395 The Lipid Droplet Coat Protein Perilipin 5 Also Localizes to Muscle Mitochondria Histochemistry and Cell Biology. Feb, 2012 | Pubmed ID: 22127648 Unchanged Expression of the Ceramide Transfer Protein in the Acute 6-OHDA Neurodegenerative Model Neuroscience Letters. Jan, 2012 | Pubmed ID: 22040672 Neuropathy-induced Spinal GAP-43 Expression is Not a Main Player in the Onset of Mechanical Pain Hypersensitivity Journal of Neurotrauma. Dec, 2011 | Pubmed ID: 21671799 Paradoxical Increase in TAG and DAG Content Parallel the Insulin Sensitizing Effect of Unilateral DGAT1 Overexpression in Rat Skeletal Muscle PloS One. 2011 | Pubmed ID: 21264296 Proteasome Inhibition with Bortezomib Depletes Plasma Cells and Autoantibodies in Experimental Autoimmune Myasthenia Gravis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2011 | Pubmed ID: 21239719 Reduced Thymic Expression of ErbB Receptors Without Auto-antibodies Against Synaptic ErbB in Myasthenia Gravis Journal of Neuroimmunology. Mar, 2011 | Pubmed ID: 21168922 In Vivo Electroporation of the Central Nervous System: a Non-viral Approach for Targeted Gene Delivery Progress in Neurobiology. Nov, 2010 | Pubmed ID: 20937354 Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2010 | Pubmed ID: 20389292 Antibody Effector Mechanisms in Myasthenia Gravis-pathogenesis at the Neuromuscular Junction Autoimmunity. Aug, 2010 | Pubmed ID: 20380584 The Auto-antigen Repertoire in Myasthenia Gravis Autoimmunity. Aug, 2010 | Pubmed ID: 20380581 The Ceramide Transporter and the Goodpasture Antigen Binding Protein: One Protein--one Function? Journal of Neurochemistry. Jun, 2010 | Pubmed ID: 20236389 Main Immunogenic Region Structure Promotes Binding of Conformation-dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2009 | Pubmed ID: 19890000 The Effect of Plasma from Muscle-specific Tyrosine Kinase Myasthenia Patients on Regenerating Endplates The American Journal of Pathology. Oct, 2009 | Pubmed ID: 19745065 The Expression of the Goodpasture Antigen-binding Protein (ceramide Transporter) in Adult Rat Brain Journal of Chemical Neuroanatomy. Oct, 2009 | Pubmed ID: 19555756 Silencing Rapsyn in Vivo Decreases Acetylcholine Receptors and Augments Sodium Channels and Secondary Postsynaptic Membrane Folding Neurobiology of Disease. Jul, 2009 | Pubmed ID: 19344765 Immunosuppression of Experimental Autoimmune Myasthenia Gravis by Mycophenolate Mofetil Journal of Neuroimmunology. Sep, 2008 | Pubmed ID: 18667242 Treatment of Myasthenia Gravis by Preventing Acetylcholine Receptor Modulation Annals of the New York Academy of Sciences. 2008 | Pubmed ID: 18567867 Generation of Polyclonal Antibodies Directed Against G Protein-coupled Receptors Using Electroporation-aided DNA Immunization Journal of Pharmacological and Toxicological Methods. Jul-Aug, 2008 | Pubmed ID: 18261934 Anti-inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange Science (New York, N.Y.). Sep, 2007 | Pubmed ID: 17872445 Improvement of in Vivo Transfer of Plasmid DNA in Muscle: Comparison of Electroporation Versus Ultrasound Drug Delivery. Jul, 2007 | Pubmed ID: 17613014 Overexpression of Rapsyn in Rat Muscle Increases Acetylcholine Receptor Levels in Chronic Experimental Autoimmune Myasthenia Gravis The American Journal of Pathology. Feb, 2007 | Pubmed ID: 17255332 Increased Expression of Rapsyn in Muscles Prevents Acetylcholine Receptor Loss in Experimental Autoimmune Myasthenia Gravis Brain : a Journal of Neurology. Oct, 2005 | Pubmed ID: 16150851 DGAT1 Overexpression in Muscle by in Vivo DNA Electroporation Increases Intramyocellular Lipid Content Journal of Lipid Research. Feb, 2005 | Pubmed ID: 15576838 Effect of Oxygen Limitation and Medium Composition on Escherichia Coli Fermentation in Shake-flask Cultures Biotechnology Progress. Jul-Aug, 2004 | Pubmed ID: 15296430 Effect of Oxygen Supply on Passaging, Stabilising and Screening of Recombinant Hansenula Polymorpha Production Strains in Test Tube Cultures FEMS Yeast Research. Nov, 2003 | Pubmed ID: 14613884 Erzeugung von rekombinanten humanen IgG monoklonalen Antikörpern aus Immortalisierte Sortiert B Cells Gisela Nogales-Gadea*1,2, Abhishek Saxena*1, Carolin Hoffmann*1, Judith Hounjet1, Daniëlle Coenen1, Peter Molenaar1, Mario Losen1, Pilar Martinez-Martinez1 1School for Mental Health and Neuroscience, Maastricht University, 2Department of Neurosciences, Institut d'Investigació Germans Trias i Pujol Immunology and Infection
Erzeugung von rekombinanten humanen IgG monoklonalen Antikörpern aus Immortalisierte Sortiert B Cells Gisela Nogales-Gadea*1,2, Abhishek Saxena*1, Carolin Hoffmann*1, Judith Hounjet1, Daniëlle Coenen1, Peter Molenaar1, Mario Losen1, Pilar Martinez-Martinez1 1School for Mental Health and Neuroscience, Maastricht University, 2Department of Neurosciences, Institut d'Investigació Germans Trias i Pujol Immunology and Infection
