Articles by Mark M. Magharious in JoVE
Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System Mark M. Magharious*1, Philippe M. D'Onofrio*1, Paulo D. Koeberle1 1Department of Surgery, University of Toronto Optic Nerve transection is a widely used model of adult CNS injury. Ninety percent of retinal ganglion cells (RGCs) whose axons are completely transected (axotomy) die within 14 days after axotomy. This model is easily amenable to experimental manipulations and highly reproducible.
Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS Philippe M. D'Onofrio*1, Mark M. Magharious*1, Paulo D. Koeberle1 1Department of Surgery, University of Toronto Optic Nerve transection is a widely used model of adult CNS injury. This model is ideal for performing a number of experimental manipulations that target the retina globally or directly target the injured neuronal population of retinal ganglion cells.