Mark R. Cookson

Publications

• Genetic Analysis of Amyotrophic Lateral Sclerosis Identifies Contributing Pathways and Cell Types
  Science Advances. Jan, 2021  |   Pubmed ID: 33523907
• Combined Knockout of Lrrk2 and Rab29 Does Not Result in Behavioral Abnormalities in Vivo
  Journal of Parkinson's Disease. Jan, 2021  |   Pubmed ID: 33523017
• Extracellular Clusterin Limits the Uptake of α-synuclein Fibrils by Murine and Human Astrocytes
  Glia. Mar, 2021  |   Pubmed ID: 33045109
• LRRK2 Mediates Tubulation and Vesicle Sorting from Lysosomes
  Science Advances. Nov, 2020  |   Pubmed ID: 33177079
• Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
  Cells. 10, 2020  |   Pubmed ID: 33105882
• LRRK2 Mediates Microglial Neurotoxicity Via NFATc2 in Rodent Models of Synucleinopathies
  Science Translational Medicine. Oct, 2020  |   Pubmed ID: 33055242
• Sequential Screening Nominates the Parkinson's Disease Associated Kinase LRRK2 As a Regulator of Clathrin-mediated Endocytosis
  Neurobiology of Disease. 07, 2020  |   Pubmed ID: 32434048
• Can Leucine-Rich Repeat Kinase 2 Inhibition Benefit GBA-Parkinson's Disease?
  Movement Disorders : Official Journal of the Movement Disorder Society. 05, 2020  |   Pubmed ID: 32415718
• The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the Trans-Golgi Network
  Cell Reports. 05, 2020  |   Pubmed ID: 32375042
• Pathways of Protein Synthesis and Degradation in PD Pathogenesis
  Progress in Brain Research. 2020  |   Pubmed ID: 32247365
• APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
  Scientific Reports. 03, 2020  |   Pubmed ID: 32152337
• In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets
  Scientific Reports. 02, 2020  |   Pubmed ID: 32103062
• Correction To: Molecular Mechanism of Olesoxime-mediated Neuroprotection Through Targeting α-synuclein Interaction with Mitochondrial VDAC
  Cellular and Molecular Life Sciences : CMLS. 09, 2020  |   Pubmed ID: 31919572
• Molecular Mechanism of Olesoxime-mediated Neuroprotection Through Targeting α-synuclein Interaction with Mitochondrial VDAC
  Cellular and Molecular Life Sciences : CMLS. Sep, 2020  |   Pubmed ID: 31760463
• Genetic Modifiers of Risk and Age at Onset in GBA Associated Parkinson's Disease and Lewy Body Dementia
  Brain : a Journal of Neurology. 01, 2020  |   Pubmed ID: 31755958
• DNAJC Proteins and Pathways to Parkinsonism
  The FEBS Journal. 08, 2019  |   Pubmed ID: 31120186
• Transcriptome Analysis of LRRK2 Knock-out Microglia Cells Reveals Alterations of Inflammatory- and Oxidative Stress-related Pathways Upon Treatment with α-synuclein Fibrils
  Neurobiology of Disease. 09, 2019  |   Pubmed ID: 31102768
• The Role of Rab GTPases in the Pathobiology of Parkinson' Disease
  Current Opinion in Cell Biology. 08, 2019  |   Pubmed ID: 31054512
• Proteomics; Applications in Familial Parkinson's Disease
  Journal of Neurochemistry. 11, 2019  |   Pubmed ID: 31022302
• Glial Phagocytic Clearance in Parkinson's Disease
  Molecular Neurodegeneration. 04, 2019  |   Pubmed ID: 30953527
• LRRK2 Links Genetic and Sporadic Parkinson's Disease
  Biochemical Society Transactions. 04, 2019  |   Pubmed ID: 30837320
• Assessment of APOE in Atypical Parkinsonism Syndromes
  Neurobiology of Disease. 07, 2019  |   Pubmed ID: 30798004
• The Endocytic Membrane Trafficking Pathway Plays a Major Role in the Risk of Parkinson's Disease
  Movement Disorders : Official Journal of the Movement Disorder Society. 04, 2019  |   Pubmed ID: 30675927
• Genetic Analysis of Neurodegenerative Diseases in a Pathology Cohort
  Neurobiology of Aging. 04, 2019  |   Pubmed ID: 30528841
• The Role of Monogenic Genes in Idiopathic Parkinson's Disease
  Neurobiology of Disease. 04, 2019  |   Pubmed ID: 30448284
• Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2
  Neurochemical Research. Jun, 2019  |   Pubmed ID: 30291536
• Leucine-rich Repeat Kinase 2 Controls Protein Kinase A Activation State Through Phosphodiesterase 4
  Journal of Neuroinflammation. Oct, 2018  |   Pubmed ID: 30368241
• Converging Pathways in Neurodegeneration, from Genetics to Mechanisms
  Nature Neuroscience. 10, 2018  |   Pubmed ID: 30258237
• A Comprehensive Analysis of SNCA-related Genetic Risk in Sporadic Parkinson Disease
  Annals of Neurology. 07, 2018  |   Pubmed ID: 30146727
• Finding Useful Biomarkers for Parkinson's Disease
  Science Translational Medicine. 08, 2018  |   Pubmed ID: 30111645
• Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease
  JAMA Neurology. 11, 2018  |   Pubmed ID: 30039155
• Proteomic Analysis Reveals Co-ordinated Alterations in Protein Synthesis and Degradation Pathways in LRRK2 Knockout Mice
  Human Molecular Genetics. 09, 2018  |   Pubmed ID: 29917075
• Detection of Endogenous S1292 LRRK2 Autophosphorylation in Mouse Tissue As a Readout for Kinase Activity
  NPJ Parkinson's Disease. 2018  |   Pubmed ID: 29707617
• MTOR Independent Alteration in ULK1 Ser758 Phosphorylation Following Chronic LRRK2 Kinase Inhibition
  Bioscience Reports. Apr, 2018  |   Pubmed ID: 29563162
• Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins
  Proteomics. May, 2018  |   Pubmed ID: 29513927
• Parkinson Disease-associated Mutations in LRRK2 Cause Centrosomal Defects Via Rab8a Phosphorylation
  Molecular Neurodegeneration. 01, 2018  |   Pubmed ID: 29357897
• The LRRK2 Signalling System
  Cell and Tissue Research. Jul, 2018  |   Pubmed ID: 29308544
• LRRK2 Phosphorylates Membrane-bound Rabs and is Activated by GTP-bound Rab7L1 to Promote Recruitment to the Trans-Golgi Network
  Human Molecular Genetics. 01, 2018  |   Pubmed ID: 29177506
• The Endosomal-Lysosomal Pathway Is Dysregulated by Expression
  Frontiers in Neuroscience. 2017  |   Pubmed ID: 29311783
• Transcriptomic Profiling of the Human Brain Reveals That Altered Synaptic Gene Expression is Associated with Chronological Aging
  Scientific Reports. 12, 2017  |   Pubmed ID: 29203886
• Hexokinases Link DJ-1 to the PINK1/parkin Pathway
  Molecular Neurodegeneration. 09, 2017  |   Pubmed ID: 28962651
• The DYT6 Dystonia Protein THAP1 Regulates Myelination Within the Oligodendrocyte Lineage
  Developmental Cell. 07, 2017  |   Pubmed ID: 28697333
• Gene Linkage and Systems Biology
  Advances in Neurobiology. 2017  |   Pubmed ID: 28674994
• Mechanisms of Mutant LRRK2 Neurodegeneration
  Advances in Neurobiology. 2017  |   Pubmed ID: 28353287
• The G2385R Risk Factor for Parkinson's Disease Enhances CHIP-dependent Intracellular Degradation of LRRK2
  The Biochemical Journal. 04, 2017  |   Pubmed ID: 28320779
• Novel Genetic Loci Associated with Hippocampal Volume
  Nature Communications. Jan, 2017  |   Pubmed ID: 28098162
• RNA-binding Proteins Implicated in Neurodegenerative Diseases
  Wiley Interdisciplinary Reviews. RNA. 01, 2017  |   Pubmed ID: 27659605
• The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes Along with Evidence for Their Pathogenicity
  Current Protein & Peptide Science. 2017  |   Pubmed ID: 26965687
• LRRK2 at the Interface of Autophagosomes, Endosomes and Lysosomes
  Molecular Neurodegeneration. 12, 2016  |   Pubmed ID: 27927216
• Cellular Functions of LRRK2 Implicate Vesicular Trafficking Pathways in Parkinson's Disease
  Biochemical Society Transactions. 12, 2016  |   Pubmed ID: 27913668
• The Impact of Fraudulent and Irreproducible Data to the Translational Research Crisis - Solutions and Implementation
  Journal of Neurochemistry. 10, 2016  |   Pubmed ID: 27797406
• Novel Genetic Loci Underlying Human Intracranial Volume Identified Through Genome-wide Association
  Nature Neuroscience. Dec, 2016  |   Pubmed ID: 27694991
• Structure, Function, and Leucine-rich Repeat Kinase 2: On the Importance of Reproducibility in Understanding Parkinson's Disease
  Proceedings of the National Academy of Sciences of the United States of America. 07, 2016  |   Pubmed ID: 27422551
• The Function of Orthologues of the Human Parkinson's Disease Gene LRRK2 Across Species: Implications for Disease Modelling in Preclinical Research
  The Biochemical Journal. Feb, 2016  |   Pubmed ID: 26811536
• ADAR2 Affects MRNA Coding Sequence Edits with Only Modest Effects on Gene Expression or Splicing in Vivo
  RNA Biology. 2016  |   Pubmed ID: 26669816
• Genes Associated with Parkinson's Disease: Regulation of Autophagy and Beyond
  Journal of Neurochemistry. 10, 2016  |   Pubmed ID: 26223426
• The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice
  ENeuro. Jan-Feb, 2015  |   Pubmed ID: 26464968
• Pathways to Parkinsonism Redux: Convergent Pathobiological Mechanisms in Genetics of Parkinson's Disease
  Human Molecular Genetics. Oct, 2015  |   Pubmed ID: 26101198
• Common Genetic Variants Influence Human Subcortical Brain Structures
  Nature. Apr, 2015  |   Pubmed ID: 25607358
• Genetic Variability in the Regulation of Gene Expression in Ten Regions of the Human Brain
  Nature Neuroscience. Oct, 2014  |   Pubmed ID: 25174004
• Lardy Brains Make Parkinson's Disease Mice Worse
  Journal of Neurochemistry. Dec, 2014  |   Pubmed ID: 25142063
• Heterogeneity of Leucine-rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications
  Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2014  |   Pubmed ID: 24957201
• Differential Protein-protein Interactions of LRRK1 and LRRK2 Indicate Roles in Distinct Cellular Signaling Pathways
  Journal of Neurochemistry. Oct, 2014  |   Pubmed ID: 24947832
• Downregulation of Pink1 Influences Mitochondrial Fusion-fission Machinery and Sensitizes to Neurotoxins in Dopaminergic Cells
  Neurotoxicology. Sep, 2014  |   Pubmed ID: 24792327
• Post-translational Decrease in Respiratory Chain Proteins in the Polg Mutator Mouse Brain
  PloS One. 2014  |   Pubmed ID: 24722488
• Mutations in the Matrin 3 Gene Cause Familial Amyotrophic Lateral Sclerosis
  Nature Neuroscience. May, 2014  |   Pubmed ID: 24686783
• LRRK2: Dropping (kinase) Inhibitions and Seeking an (immune) Response
  Journal of Neurochemistry. Jun, 2014  |   Pubmed ID: 24661004
• Unbiased Screen for Interactors of Leucine-rich Repeat Kinase 2 Supports a Common Pathway for Sporadic and Familial Parkinson Disease
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014  |   Pubmed ID: 24510904
• Genetic Comorbidities in Parkinson's Disease
  Human Molecular Genetics. Feb, 2014  |   Pubmed ID: 24057672
• Age-associated MiRNA Alterations in Skeletal Muscle from Rhesus Monkeys Reversed by Caloric Restriction
  Aging. Sep, 2013  |   Pubmed ID: 24036467
• MRNA Expression, Splicing and Editing in the Embryonic and Adult Mouse Cerebral Cortex
  Nature Neuroscience. Apr, 2013  |   Pubmed ID: 23416452
• Age-associated Changes in Gene Expression in Human Brain and Isolated Neurons
  Neurobiology of Aging. Apr, 2013  |   Pubmed ID: 23177596
• Cell Population-specific Expression Analysis of Human Cerebellum
  BMC Genomics. Nov, 2012  |   Pubmed ID: 23145530
• Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways
  Cold Spring Harbor Perspectives in Medicine. Sep, 2012  |   Pubmed ID: 22951446
• The G2385R Variant of Leucine-rich Repeat Kinase 2 Associated with Parkinson's Disease is a Partial Loss-of-function Mutation
  The Biochemical Journal. Aug, 2012  |   Pubmed ID: 22612223
• Integration of GWAS SNPs and Tissue Specific Expression Profiling Reveal Discrete EQTLs for Human Traits in Blood and Brain
  Neurobiology of Disease. Jul, 2012  |   Pubmed ID: 22433082
• Is Inhibition of Kinase Activity the Only Therapeutic Strategy for LRRK2-associated Parkinson's Disease?
  BMC Medicine. Feb, 2012  |   Pubmed ID: 22361010
• Mitochondrial Quality Control and Dynamics in Parkinson's Disease
  Antioxidants & Redox Signaling. May, 2012  |   Pubmed ID: 21568830
• Role of LRRK2 Kinase Dysfunction in Parkinson Disease
  Expert Reviews in Molecular Medicine. Jun, 2011  |   Pubmed ID: 21676337
• DJ-1 Regulation of Mitochondrial Function and Autophagy Through Oxidative Stress
  Autophagy. May, 2011  |   Pubmed ID: 21317550
• DJ-1 Acts in Parallel to the PINK1/parkin Pathway to Control Mitochondrial Function and Autophagy
  Human Molecular Genetics. Jan, 2011  |   Pubmed ID: 20940149
• The Role of Leucine-rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease
  Nature Reviews. Neuroscience. Dec, 2010  |   Pubmed ID: 21088684
• Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain
  PLoS Genetics. May, 2010  |   Pubmed ID: 20485568
• Parkinson's Disease: Insights from Pathways
  Human Molecular Genetics. Apr, 2010  |   Pubmed ID: 20421364
• Deep Sequencing of Coding and Non-coding RNA in the CNS
  Brain Research. Jun, 2010  |   Pubmed ID: 20307502
• The Parkinson's Disease Associated LRRK2 Exhibits Weaker in Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation
  PloS One. 2010  |   Pubmed ID: 20090955
• Genome-wide Association Study Reveals Genetic Risk Underlying Parkinson's Disease
  Nature Genetics. Dec, 2009  |   Pubmed ID: 19915575
• Leucine-rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions
  ASN Neuro. Apr, 2009  |   Pubmed ID: 19570025
• Post-transcriptional Regulation of MRNA Associated with DJ-1 in Sporadic Parkinson Disease
  Neuroscience Letters. Mar, 2009  |   Pubmed ID: 19146923
• DYT16, a Novel Young-onset Dystonia-parkinsonism Disorder: Identification of a Segregating Mutation in the Stress-response Protein PRKRA
  The Lancet. Neurology. Mar, 2008  |   Pubmed ID: 18243799
• Deletion at ITPR1 Underlies Ataxia in Mice and Spinocerebellar Ataxia 15 in Humans
  PLoS Genetics. Jun, 2007  |   Pubmed ID: 17590087
• Amyotrophic Lateral Sclerosis 2-deficiency Leads to Neuronal Degeneration in Amyotrophic Lateral Sclerosis Through Altered AMPA Receptor Trafficking
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006  |   Pubmed ID: 17093100
• Dystonia and the Nuclear Envelope
  Neuron. Dec, 2005  |   Pubmed ID: 16364891
• How Genetics Research in Parkinson's Disease is Enhancing Understanding of the Common Idiopathic Forms of the Disease
  Current Opinion in Neurology. Dec, 2005  |   Pubmed ID: 16280683
• Molecules That Cause or Prevent Parkinson's Disease
  PLoS Biology. Nov, 2004  |   Pubmed ID: 15547643
• Dominant TorsinA Mutations in Cellular Systems
  Advances in Neurology. 2004  |   Pubmed ID: 14509657
• Crystallizing Ideas About Parkinson's Disease
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003  |   Pubmed ID: 12886009
• Microarray Analysis Reveals Induction of Heat Shock Proteins MRNAs by the Torsion Dystonia Protein, TorsinA
  Neuroscience Letters. May, 2003  |   Pubmed ID: 12749984
• Pathways to Parkinsonism
  Neuron. Jan, 2003  |   Pubmed ID: 12526767