Markus Heilig Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine Linköping University Biography Publications Institution JoVE Articles Markus Heilig has not added a biography. If you are Markus Heilig and would like to personalize this page please email our Author Liaison for assistance. Publications Distinction of Self-produced Touch and Social Touch at Cortical and Spinal Cord Levels Proceedings of the National Academy of Sciences of the United States of America. Feb, 2019 | Pubmed ID: 30670645 Striatal Dopamine Deficits Predict Reductions in Striatal Functional Connectivity in Major Depression: a Concurrent C-raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation Translational Psychiatry. Nov, 2018 | Pubmed ID: 30504860 Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula Neuromodulation : Journal of the International Neuromodulation Society. Oct, 2018 | Pubmed ID: 30370983 Science-Based Actions Can Help Address the Opioid Crisis Trends in Pharmacological Sciences. 11, 2018 | Pubmed ID: 30343726 Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. Dec, 2018 | Pubmed ID: 30143454 Protective Effects of Elevated Anandamide on Stress and Fear-related Behaviors: Translational Evidence from Humans and Mice Molecular Psychiatry. Aug, 2018 | Pubmed ID: 30120421 Putting a Good Face on Touch: Facial Expression Reflects the Affective Valence of Caress-like Touch Across Modalities Biological Psychology. 09, 2018 | Pubmed ID: 30003943 A Molecular Mechanism for Choosing Alcohol over an Alternative Reward Science (New York, N.Y.). 06, 2018 | Pubmed ID: 29930131 The Novel Ghrelin Receptor Inverse Agonist PF-5190457 Administered with Alcohol: Preclinical Safety Experiments and a Phase 1b Human Laboratory Study Molecular Psychiatry. May, 2018 | Pubmed ID: 29728704 The Salience of Self, Not Social Pain, is Encoded by Dorsal Anterior Cingulate and Insula Scientific Reports. Apr, 2018 | Pubmed ID: 29670166 Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use Alcoholism, Clinical and Experimental Research. Jun, 2018 | Pubmed ID: 29667742 Preclinical Evaluation of the Kappa-opioid Receptor Antagonist CERC-501 As a Candidate Therapeutic for Alcohol Use Disorders Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 08, 2018 | Pubmed ID: 29463912 Several Behavioral Traits Relevant for Alcoholism Are Controlled by ɣ2 Subunit Containing GABA Receptors on Dopamine Neurons in Mice Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 06, 2018 | Pubmed ID: 29463910 Neural Responses to Cues Paired with Methamphetamine in Healthy Volunteers Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 07, 2018 | Pubmed ID: 29463908 Insula Sensitivity to Unfairness in Alcohol Use Disorder Alcohol and Alcoholism (Oxford, Oxfordshire). May, 2018 | Pubmed ID: 29309499 A Cannabinoid Receptor Antagonist Attenuates Ghrelin-induced Activation of the Mesolimbic Dopamine System in Mice Physiology & Behavior. 02, 2018 | Pubmed ID: 29221808 Deep TMS of the Insula Using the H-coil Modulates Dopamine Release: a Crossover [C] PHNO-PET Pilot Trial in Healthy Humans Brain Imaging and Behavior. Oct, 2018 | Pubmed ID: 29170944 Addiction Research and Theory: a Commentary on the Surgeon General's Report on Alcohol, Drugs, and Health Addiction Biology. Jan, 2018 | Pubmed ID: 28224686 Early Rearing History Influences Oxytocin Receptor Epigenetic Regulation in Rhesus Macaques Proceedings of the National Academy of Sciences of the United States of America. 10, 2017 | Pubmed ID: 29078292 Substance P and the Neurokinin-1 Receptor: The New CRF International Review of Neurobiology. 2017 | Pubmed ID: 29056150 MTORC and ProSAPiP1: How Alcohol Changes Synapses of Reward Circuitry Neuron. Sep, 2017 | Pubmed ID: 28957677 The GABA Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Aug, 2017 | Pubmed ID: 28294133 Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): A Pilot Study in Alcohol-dependent Women Journal of Addiction Medicine. Jan, 2017 | Pubmed ID: 28079572 Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2016 | Pubmed ID: 27810934 FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence Alcoholism, Clinical and Experimental Research. Nov, 2016 | Pubmed ID: 27716956 Erratum To: The Melanin-concentrating Hormone-1 Receptor Modulates Alcohol-induced Reward and DARPP-32 Phosphorylation Psychopharmacology. Oct, 2016 | Pubmed ID: 27650828 Effect of the CRF1-receptor Antagonist Pexacerfont on Stress-induced Eating and Food Craving Psychopharmacology. Dec, 2016 | Pubmed ID: 27595147 Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake Alcoholism, Clinical and Experimental Research. Oct, 2016 | Pubmed ID: 27579857 The Nociceptin/orphanin FQ Receptor Agonist SR-8993 As a Candidate Therapeutic for Alcohol Use Disorders: Validation in Rat Models Psychopharmacology. Oct, 2016 | Pubmed ID: 27515665 OPRM1 Genotype Interacts with Serotonin System Dysfunction to Predict Alcohol-heightened Aggression in Primates Addiction Biology. Aug, 2016 | Pubmed ID: 27484010 The MGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Nov, 2016 | Pubmed ID: 27339394 Time to Connect: Bringing Social Context into Addiction Neuroscience Nature Reviews. Neuroscience. Sep, 2016 | Pubmed ID: 27277868 Proinflammatory Signaling Regulates Voluntary Alcohol Intake and Stress-induced Consumption After Exposure to Social Defeat Stress in Mice Addiction Biology. Jun, 2016 | Pubmed ID: 27273552 The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research Current Topics in Behavioral Neurosciences. 2016 | Pubmed ID: 27240677 Characterization of Comorbid PTSD in Treatment-seeking Alcohol Dependent Inpatients: Severity and Personality Trait Differences Drug and Alcohol Dependence. Jun, 2016 | Pubmed ID: 27114205 The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But Not of Anti-Craving Effects Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Nov, 2016 | Pubmed ID: 27109623 The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers Alcoholism, Clinical and Experimental Research. May, 2016 | Pubmed ID: 27062270 The Melanin-concentrating Hormone-1 Receptor Modulates Alcohol-induced Reward and DARPP-32 Phosphorylation Psychopharmacology. Jun, 2016 | Pubmed ID: 27044354 Tunable Diffractive Optical Elements Based on Shape-Memory Polymers Fabricated Via Hot Embossing ACS Applied Materials & Interfaces. Apr, 2016 | Pubmed ID: 26998646 MRNA GPR162 Changes Are Associated with Decreased Food Intake in Rat, and Its Human Genetic Variants with Impairments in Glucose Homeostasis in Two Swedish Cohorts Gene. May, 2016 | Pubmed ID: 26827797 What the Alcohol Doctor Ordered from the Neuroscientist: Theragnostic Biomarkers for Personalized Treatments Progress in Brain Research. 2016 | Pubmed ID: 26822368 Circumspectives: Cannabis and Psychiatric Illness: Blunt Thoughts Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2016 | Pubmed ID: 26555278 Glutamatergic Transmission in the Central Nucleus of the Amygdala is Selectively Altered in Marchigian Sardinian Alcohol-preferring Rats: Alcohol and CRF Effects Neuropharmacology. Mar, 2016 | Pubmed ID: 26519902 Neurokinin 1 Receptor Blockade in the Medial Amygdala Attenuates Alcohol Drinking in Rats with Innate Anxiety but Not in Wistar Rats British Journal of Pharmacology. Nov, 2015 | Pubmed ID: 26275374 Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers The International Journal of Neuropsychopharmacology. Jul, 2015 | Pubmed ID: 26209857 Circumspectives: The Replacements Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jul, 2015 | Pubmed ID: 26068571 Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Oct, 2015 | Pubmed ID: 25881115 DNA Methylation in the Medial Prefrontal Cortex Regulates Alcohol-induced Behavior and Plasticity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2015 | Pubmed ID: 25878287 The Role of Expectation in the Therapeutic Outcomes of Alcohol and Drug Addiction Treatments Alcohol and Alcoholism (Oxford, Oxfordshire). May, 2015 | Pubmed ID: 25761920 PPARc Activation Attenuates Opioid Consumption and Modulates Mesolimbic Dopamine Transmission Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2015 | Pubmed ID: 25668637 A Pharmacogenetic Determinant of Mu-opioid Receptor Antagonist Effects on Alcohol Reward and Consumption: Evidence from Humanized Mice Biological Psychiatry. May, 2015 | Pubmed ID: 25442002 The Corticotropin Releasing Hormone-1 (CRH1) Receptor Antagonist Pexacerfont in Alcohol Dependence: a Randomized Controlled Experimental Medicine Study Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2015 | Pubmed ID: 25409596 Hypocretin Receptor 2 Antagonism Dose-dependently Reduces Escalated Heroin Self-administration in Rats Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2015 | Pubmed ID: 25367502 Reduced Anterior Insula, Enlarged Amygdala in Alcoholism and Associated Depleted Von Economo Neurons Brain : a Journal of Neurology. Jan, 2015 | Pubmed ID: 25367022 PPARγ Activation Attenuates Opioid Consumption and Modulates Mesolimbic Dopamine Transmission Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2015 | Pubmed ID: 25311134 Polymorphism in the Corticotropin-releasing Factor Receptor 1 (CRF1-R) Gene Plays a Role in Shaping the High Anxious Phenotype of Marchigian Sardinian Alcohol-preferring (msP) Rats Psychopharmacology. Mar, 2015 | Pubmed ID: 25260340 The Neurokinin-1 Receptor Antagonist Aprepitant in Co-morbid Alcohol Dependence and Posttraumatic Stress Disorder: a Human Experimental Study Psychopharmacology. Jan, 2015 | Pubmed ID: 25030801 Methods for Inducing Alcohol Craving in Individuals with Co-morbid Alcohol Dependence and Posttraumatic Stress Disorder: Behavioral and Physiological Outcomes Addiction Biology. Jul, 2015 | Pubmed ID: 24806358 Effects of Naltrexone on Neural and Subjective Response to Alcohol in Treatment-seeking Alcohol-dependent Patients Alcoholism, Clinical and Experimental Research. Dec, 2014 | Pubmed ID: 25581657 Daniel W. Hommer Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Dec, 2014 | Pubmed ID: 25381706 Chronic Treatment with Novel Brain-penetrating Selective NOP Receptor Agonist MT-7716 Reduces Alcohol Drinking and Seeking in the Rat Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Oct, 2014 | Pubmed ID: 24863033 Kappa-opioid Receptor Antagonism: a Mechanism for Treatment of Relief Drinking? Biological Psychiatry. May, 2014 | Pubmed ID: 24780009 Cerebrospinal Fluid Monocyte Chemoattractant Protein-1 in Alcoholics: Support for a Neuroinflammatory Model of Chronic Alcoholism Alcoholism, Clinical and Experimental Research. May, 2014 | Pubmed ID: 24689518 MicroRNA-206 in Rat Medial Prefrontal Cortex Regulates BDNF Expression and Alcohol Drinking The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2014 | Pubmed ID: 24672003 Stress and Alcohol Interactions: Animal Studies and Clinical Significance Trends in Neurosciences. Apr, 2014 | Pubmed ID: 24636458 Alcohol-preferring Rats Show Decreased Corticotropin-releasing Hormone-2 Receptor Expression and Differences in HPA Activation Compared to Alcohol-nonpreferring Rats Alcoholism, Clinical and Experimental Research. May, 2014 | Pubmed ID: 24611993 FKBP5 Moderates Alcohol Withdrawal Severity: Human Genetic Association and Functional Validation in Knockout Mice Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jul, 2014 | Pubmed ID: 24603855 Acamprosate: an Alcoholism Treatment That May Not Be What We Thought Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2014 | Pubmed ID: 24518272 Restraint Stress Alters Nociceptin/orphanin FQ and CRF Systems in the Rat Central Amygdala: Significance for Anxiety-like Behaviors The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2014 | Pubmed ID: 24403138 Gender Differences in Neural-behavioral Response to Self-observation During a Novel FMRI Social Stress Task Neuropsychologia. Jan, 2014 | Pubmed ID: 24316200 The Role of the Neurokinin-1 Receptor in Stress-induced Reinstatement of Alcohol and Cocaine Seeking Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Apr, 2014 | Pubmed ID: 24173499 Binge-like Ethanol Consumption Increases Corticosterone Levels and Neurodegneration Whereas Occupancy of Type II Glucocorticoid Receptors with Mifepristone is Neuroprotective Addiction Biology. Jan, 2014 | Pubmed ID: 22500955 [Opioid Dependence: New National Guidelines Must Allow Maintenance Treatment] Lakartidningen. Oct 23-29, 2013 | Pubmed ID: 24340431 Structure-activity Relationship of Imidazopyridinium Analogues As Antagonists of Neuropeptide S Receptor Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24171469 Loss of Metabotropic Glutamate Receptor 2 Escalates Alcohol Consumption Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013 | Pubmed ID: 24082084 β-Arrestin 2 Knockout Mice Exhibit Sensitized Dopamine Release and Increased Reward in Response to a Low Dose of Alcohol Psychopharmacology. Dec, 2013 | Pubmed ID: 23779257 A Novel Brain Penetrant NPS Receptor Antagonist, NCGC00185684, Blocks Alcohol-induced ERK-phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-administration in Rats The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2013 | Pubmed ID: 23761908 Role of a Genetic Polymorphism in the Corticotropin-releasing Factor Receptor 1 Gene in Alcohol Drinking and Seeking Behaviors of Marchigian Sardinian Alcohol-preferring Rats Frontiers in Psychiatry. 2013 | Pubmed ID: 23630503 Activation of PPARγ by Pioglitazone Potentiates the Effects of Naltrexone on Alcohol Drinking and Relapse in MsP Rats Alcoholism, Clinical and Experimental Research. Aug, 2013 | Pubmed ID: 23550625 Tacr1 Gene Variation and Neurokinin 1 Receptor Expression is Associated with Antagonist Efficacy in Genetically Selected Alcohol-preferring Rats Biological Psychiatry. Apr, 2013 | Pubmed ID: 23419547 Conditioned Preference to a Methamphetamine-associated Contextual Cue in Humans Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2013 | Pubmed ID: 23416857 Rescue of Infralimbic MGluR2 Deficit Restores Control over Drug-seeking Behavior in Alcohol Dependence The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2013 | Pubmed ID: 23407939 Low Vitamin D Status and Suicide: a Case-control Study of Active Duty Military Service Members PloS One. 2013 | Pubmed ID: 23308099 The NK1 Receptor Antagonist L822429 Reduces Heroin Reinforcement Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2013 | Pubmed ID: 23303056 Behavioral, Biological, and Chemical Perspectives on Targeting CRF(1) Receptor Antagonists to Treat Alcoholism Drug and Alcohol Dependence. Mar, 2013 | Pubmed ID: 23294766 Childhood Trauma Exposure and Alcohol Dependence Severity in Adulthood: Mediation by Emotional Abuse Severity and Neuroticism Alcoholism, Clinical and Experimental Research. Jun, 2013 | Pubmed ID: 23278300 Enhanced GABAergic Transmission in the Central Nucleus of the Amygdala of Genetically Selected Marchigian Sardinian Rats: Alcohol and CRF Effects Neuropharmacology. Apr, 2013 | Pubmed ID: 23220399 Effects of the NK1 Antagonist, Aprepitant, on Response to Oral and Intranasal Oxycodone in Prescription Opioid Abusers Addiction Biology. Mar, 2013 | Pubmed ID: 22260216 Translational Approaches to Medication Development Current Topics in Behavioral Neurosciences. 2013 | Pubmed ID: 21590390 Stress-related Neuropeptides and Addictive Behaviors: Beyond the Usual Suspects Neuron. Oct, 2012 | Pubmed ID: 23040815 Melanin-concentrating Hormone Receptor 1 (MCH1-R) Antagonism: Reduced Appetite for Calories and Suppression of Addictive-like Behaviors Pharmacology, Biochemistry, and Behavior. Sep, 2012 | Pubmed ID: 22705492 Corticosteroid-dependent Plasticity Mediates Compulsive Alcohol Drinking in Rats The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2012 | Pubmed ID: 22649234 The Kappa Opioid Receptor Antagonist JDTic Attenuates Alcohol Seeking and Withdrawal Anxiety Addiction Biology. May, 2012 | Pubmed ID: 22515275 Medications Development to Treat Alcohol Dependence: a Vision for the Next Decade Addiction Biology. May, 2012 | Pubmed ID: 22458728 Impact of Multiple Types of Childhood Trauma Exposure on Risk of Psychiatric Comorbidity Among Alcoholic Inpatients Alcoholism, Clinical and Experimental Research. Jun, 2012 | Pubmed ID: 22420670 Reduced Alcohol Intake and Reward Associated with Impaired Endocannabinoid Signaling in Mice with a Deletion of the Glutamate Transporter GLAST Neuropharmacology. Aug, 2012 | Pubmed ID: 22342743 The Serotonin Transporter Gene Linked Polymorphic Region is Associated with the Behavioral Response to Repeated Stress Exposure in Infant Rhesus Macaques Development and Psychopathology. Feb, 2012 | Pubmed ID: 22293001 Brain-specific Inactivation of the Crhr1 Gene Inhibits Post-dependent and Stress-induced Alcohol Intake, but Does Not Affect Relapse-like Drinking Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2012 | Pubmed ID: 22113086 Pharmacological Blockade of Corticotropin-releasing Hormone Receptor 1 (CRH1R) Reduces Voluntary Consumption of High Alcohol Concentrations in Non-dependent Wistar Rats Pharmacology, Biochemistry, and Behavior. Jan, 2012 | Pubmed ID: 22036774 Relationship Between Liver Function and Brain Shrinkage in Patients with Alcohol Dependence Alcoholism, Clinical and Experimental Research. Apr, 2012 | Pubmed ID: 21995416 The Biometric Measurement of Alcohol Consumption Alcoholism, Clinical and Experimental Research. Feb, 2012 | Pubmed ID: 21895709 Pharmacogenetic Approaches to the Treatment of Alcohol Addiction Nature Reviews. Neuroscience. Oct, 2011 | Pubmed ID: 22011682 The G Protein Coupled Receptor Gpr153 Shares Common Evolutionary Origin with Gpr162 and is Highly Expressed in Central Regions Including the Thalamus, Cerebellum and the Arcuate Nucleus The FEBS Journal. Dec, 2011 | Pubmed ID: 21981325 Pharmacological Consequence of the A118G μ Opioid Receptor Polymorphism on Morphine- and Fentanyl-mediated Modulation of Ca²⺠Channels in Humanized Mouse Sensory Neurons Anesthesiology. Nov, 2011 | Pubmed ID: 21926562 Translational and Reverse Translational Research on the Role of Stress in Drug Craving and Relapse Psychopharmacology. Nov, 2011 | Pubmed ID: 21494792 A Welcome Change That Stops Short of Being Fully Satisfying Addiction (Abingdon, England). May, 2011 | Pubmed ID: 21477231 OPRM1 Gene Variation Influences Hypothalamic-pituitary-adrenal Axis Function in Response to a Variety of Stressors in Rhesus Macaques Psychoneuroendocrinology. Oct, 2011 | Pubmed ID: 21459516 Exposure to Nicotine During Periadolescence or Early Adulthood Alters Aversive and Physiological Effects Induced by Ethanol Pharmacology, Biochemistry, and Behavior. Jul, 2011 | Pubmed ID: 21420998 Stress-induced Reinstatement of Alcohol-seeking in Rats is Selectively Suppressed by the Neurokinin 1 (NK1) Antagonist L822429 Psychopharmacology. Nov, 2011 | Pubmed ID: 21340476 Child μ-opioid Receptor Gene Variant Influences Parent-child Relations Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2011 | Pubmed ID: 21326192 Pharmacologically Induced Alcohol Craving in Treatment Seeking Alcoholics Correlates with Alcoholism Severity, but is Insensitive to Acamprosate Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2011 | Pubmed ID: 21289601 Activation of Nuclear PPARγ Receptors by the Antidiabetic Agent Pioglitazone Suppresses Alcohol Drinking and Relapse to Alcohol Seeking Biological Psychiatry. Apr, 2011 | Pubmed ID: 21276964 Dissociation of Antidepressant-like Activity of Escitalopram and Nortriptyline on Behaviour and Hippocampal BDNF Expression in Female Rats Journal of Psychopharmacology (Oxford, England). Oct, 2011 | Pubmed ID: 21262856 Genetic Moderators and Psychiatric Mediators of the Link Between Sexual Abuse and Alcohol Dependence Drug and Alcohol Dependence. Jun, 2011 | Pubmed ID: 21193270 The Novel, Selective, Brain-penetrant Neuropeptide Y Y2 Receptor Antagonist, JNJ-31020028, Tested in Animal Models of Alcohol Consumption, Relapse, and Anxiety Alcohol (Fayetteville, N.Y.). Sep, 2011 | Pubmed ID: 21145691 Chronic Alcohol Neuroadaptation and Stress Contribute to Susceptibility for Alcohol Craving and Relapse Pharmacology & Therapeutics. Feb, 2011 | Pubmed ID: 20951730 Addiction Research Centres and the Nurturing of Creativity: the National Institute on Alcohol Abuse and Alcoholism Addiction (Abingdon, England). Jun, 2011 | Pubmed ID: 20569230 Increased MRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain International Journal of Alzheimer's Disease. Dec, 2010 | Pubmed ID: 21234373 Selective Modulation of Gq/Gs Pathways by Naphtho Pyrano Pyrimidines As Antagonists of the Neuropeptide S Receptor ACS Chemical Neuroscience. Aug, 2010 | Pubmed ID: 21116448 Neuropeptide S Facilitates Cue-induced Relapse to Cocaine Seeking Through Activation of the Hypothalamic Hypocretin System Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20974945 Effect of Acamprosate on Magnetic Resonance Spectroscopy Measures of Central Glutamate in Detoxified Alcohol-dependent Individuals: a Randomized Controlled Experimental Medicine Study Archives of General Psychiatry. Oct, 2010 | Pubmed ID: 20921123 Reversibility of Object Recognition but Not Spatial Memory Impairment Following Binge-like Alcohol Exposure in Rats Neurobiology of Learning and Memory. Nov, 2010 | Pubmed ID: 20849966 Human NPY Promoter Variation Rs16147:T>C As a Moderator of Prefrontal NPY Gene Expression and Negative Affect Human Mutation. Aug, 2010 | Pubmed ID: 20648632 Suppression of Alcohol Self-administration and Reinstatement of Alcohol Seeking by Melanin-concentrating Hormone Receptor 1 (MCH1-R) Antagonism in Wistar Rats Psychopharmacology. Sep, 2010 | Pubmed ID: 20628734 Ethanol-induced Activation of AKT and DARPP-32 in the Mouse Striatum Mediated by Opioid Receptors Addiction Biology. Jul, 2010 | Pubmed ID: 20456289 Functional NPY Variation As a Factor in Stress Resilience and Alcohol Consumption in Rhesus Macaques Archives of General Psychiatry. Apr, 2010 | Pubmed ID: 20368518 Long-term Suppression of Forebrain Neurogenesis and Loss of Neuronal Progenitor Cells Following Prolonged Alcohol Dependence in Rats The International Journal of Neuropsychopharmacology. Jun, 2010 | Pubmed ID: 20334723 A Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists Assay and Drug Development Technologies. Jun, 2010 | Pubmed ID: 20230302 Early Onset Alcohol Dependence with High Density of Family History is Not "male Limited" Alcohol (Fayetteville, N.Y.). Mar, 2010 | Pubmed ID: 20193873 Effects of Early-life Stress on Serotonin(1A) Receptors in Juvenile Rhesus Monkeys Measured by Positron Emission Tomography Biological Psychiatry. Jun, 2010 | Pubmed ID: 20172506 Acute Withdrawal, Protracted Abstinence and Negative Affect in Alcoholism: Are They Linked? Addiction Biology. Apr, 2010 | Pubmed ID: 20148778 Reward Sensitivity: Issues of Measurement, and Achieving Consilience Between Human and Animal Phenotypes Addiction Biology. Apr, 2010 | Pubmed ID: 20148777 Ethanol Consumption: How Should We Measure It? Achieving Consilience Between Human and Animal Phenotypes Addiction Biology. Apr, 2010 | Pubmed ID: 20148775 Alcohol-induced Neurodegeneration, Suppression of Transforming Growth Factor-beta, and Cognitive Impairment in Rats: Prevention by Group II Metabotropic Glutamate Receptor Activation Biological Psychiatry. May, 2010 | Pubmed ID: 20132926 Alcohol Response and Consumption in Adolescent Rhesus Macaques: Life History and Genetic Influences Alcohol (Fayetteville, N.Y.). Feb, 2010 | Pubmed ID: 20113875 Neurokinin-1 Receptors (NK1R:s), Alcohol Consumption, and Alcohol Reward in Mice Psychopharmacology. Mar, 2010 | Pubmed ID: 20112009 D2 Dopamine Receptor Internalization Prolongs the Decrease of Radioligand Binding After Amphetamine: a PET Study in a Receptor Internalization-deficient Mouse Model NeuroImage. May, 2010 | Pubmed ID: 20097293 Gene-environment Interactions and Response to Social Intrusion in Male and Female Rhesus Macaques Biological Psychiatry. Feb, 2010 | Pubmed ID: 20015482 Neuropeptide Y (NPY) Suppresses Yohimbine-induced Reinstatement of Alcohol Seeking Psychopharmacology. Feb, 2010 | Pubmed ID: 20012021 Translating the Neuroscience of Alcoholism into Clinical Treatments: from Blocking the Buzz to Curing the Blues Neuroscience and Biobehavioral Reviews. Nov, 2010 | Pubmed ID: 19941895 Rimonabant (SR141716) Has No Effect on Alcohol Self-administration or Endocrine Measures in Nontreatment-seeking Heavy Alcohol Drinkers Psychopharmacology. Jan, 2010 | Pubmed ID: 19902183 Suppression of Alcohol Preference by Naltrexone in the Rhesus Macaque: a Critical Role of Genetic Variation at the Micro-opioid Receptor Gene Locus Biological Psychiatry. Jan, 2010 | Pubmed ID: 19748082 Stress-related Neuropeptides and Alcoholism: CRH, NPY, and Beyond Alcohol (Fayetteville, N.Y.). Nov, 2009 | Pubmed ID: 19913192 Functional CRH Variation Increases Stress-induced Alcohol Consumption in Primates Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19706546 Requirement of Central Ghrelin Signaling for Alcohol Reward Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009 | Pubmed ID: 19564604 Persistent Increase of Alcohol-seeking Evoked by Neuropeptide S: an Effect Mediated by the Hypothalamic Hypocretin System Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Aug, 2009 | Pubmed ID: 19322167 Arrestin3 Mediates D(2) Dopamine Receptor Internalization Synapse (New York, N.Y.). Jul, 2009 | Pubmed ID: 19309759 Assessment of Glutamate Transporter GLAST (EAAT1)-deficient Mice for Phenotypes Relevant to the Negative and Executive/cognitive Symptoms of Schizophrenia Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2009 | Pubmed ID: 19078949 Suppressed Neuroendocrine Stress Response in Depressed Women on Job-stress-related Long-term Sick Leave: a Stable Marker Potentially Suggestive of Preexisting Vulnerability Biological Psychiatry. May, 2009 | Pubmed ID: 19058782 Acute Ethanol Challenge Inhibits Glycogen Synthase Kinase-3beta in the Rat Prefrontal Cortex The International Journal of Neuropsychopharmacology. Mar, 2009 | Pubmed ID: 19007447 [New Guidelines Against Unfair Treatment of Narcotic Addicts Necessary] Lakartidningen. Oct 29-Nov 4, 2008 | Pubmed ID: 19031975 CRH Haplotype As a Factor Influencing Cerebrospinal Fluid Levels of Corticotropin-releasing Hormone, Hypothalamic-pituitary-adrenal Axis Activity, Temperament, and Alcohol Consumption in Rhesus Macaques Archives of General Psychiatry. Aug, 2008 | Pubmed ID: 18678798 Loss of Glial Glutamate and Aspartate Transporter (excitatory Amino Acid Transporter 1) Causes Locomotor Hyperactivity and Exaggerated Responses to Psychotomimetics: Rescue by Haloperidol and Metabotropic Glutamate 2/3 Agonist Biological Psychiatry. Nov, 2008 | Pubmed ID: 18550032 Rapid Tolerance and Locomotor Sensitization in Ethanol-naïve Adolescent Rhesus Macaques Alcoholism, Clinical and Experimental Research. Jul, 2008 | Pubmed ID: 18482160 Neuroplasticity in Brain Reward Circuitry Following a History of Ethanol Dependence The European Journal of Neuroscience. Apr, 2008 | Pubmed ID: 18412612 Variation at the Mu-opioid Receptor Gene (OPRM1) Influences Attachment Behavior in Infant Primates Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18378897 Dysregulation of Nociceptin/orphanin FQ Activity in the Amygdala is Linked to Excessive Alcohol Drinking in the Rat Biological Psychiatry. Aug, 2008 | Pubmed ID: 18367152 Buprenorphine and Methadone Treatment of Opiate Dependence During Pregnancy: Comparison of Fetal Growth and Neonatal Outcomes in Two Consecutive Case Series Drug and Alcohol Dependence. Jul, 2008 | Pubmed ID: 18355989 Neurokinin 1 Receptor Antagonism As a Possible Therapy for Alcoholism Science (New York, N.Y.). Mar, 2008 | Pubmed ID: 18276852 Association Between the Nociceptin Receptor Gene (OPRL1) Single Nucleotide Polymorphisms and Alcohol Dependence Addiction Biology. Mar, 2008 | Pubmed ID: 18269382 The Neuropeptide Y Y1 Receptor Subtype is Necessary for the Anxiolytic-like Effects of Neuropeptide Y, but Not the Antidepressant-like Effects of Fluoxetine, in Mice Psychopharmacology. Jan, 2008 | Pubmed ID: 17891380 Mood and Neuroendocrine Response to a Chemical Stressor, Metyrapone, in Buprenorphine-maintained Heroin Dependence Biological Psychiatry. Jan, 2008 | Pubmed ID: 17850768 Long-lasting Tolerance to Alcohol Following a History of Dependence Addiction Biology. Mar, 2008 | Pubmed ID: 17850416 Upregulation of Voluntary Alcohol Intake, Behavioral Sensitivity to Stress, and Amygdala Crhr1 Expression Following a History of Dependence Biological Psychiatry. Jan, 2008 | Pubmed ID: 17585886 Imagen: Implications for Addiction Science and Science Policy Addiction (Abingdon, England). Nov, 2007 | Pubmed ID: 17935578 Association Between the Recombinant Human Serotonin Transporter Linked Promoter Region Polymorphism and Behavior in Rhesus Macaques During a Separation Paradigm Development and Psychopathology. 2007 | Pubmed ID: 17931429 Changes in the Occurrences of Coercive Interventions and Staff Injuries on a Psychiatric Intensive Care Unit Archives of Psychiatric Nursing. Oct, 2007 | Pubmed ID: 17904484 A Key Role for Corticotropin-releasing Factor in Alcohol Dependence Trends in Neurosciences. Aug, 2007 | Pubmed ID: 17629579 Effect of the Adenosine A2a Receptor Antagonist 3,7-dimethyl-propargylxanthine on Anxiety-like and Depression-like Behavior and Alcohol Consumption in Wistar Rats Alcoholism, Clinical and Experimental Research. Aug, 2007 | Pubmed ID: 17550371 A Stepped Care Strategy Using Buprenorphine and Methadone Versus Conventional Methadone Maintenance in Heroin Dependence: a Randomized Controlled Trial The American Journal of Psychiatry. May, 2007 | Pubmed ID: 17475739 Region-specific Down-regulation of Crhr1 Gene Expression in Alcohol-preferring MsP Rats Following Ad Lib Access to Alcohol Addiction Biology. Mar, 2007 | Pubmed ID: 17407495 Hazardous Alcohol Users During Pregnancy: Psychiatric Health and Personality Traits Drug and Alcohol Dependence. Jul, 2007 | Pubmed ID: 17363194 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a Novel Brain-penetrant, Orally Available Corticotropin-releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2007 | Pubmed ID: 17344409 Association of a Functional Polymorphism in the Mu-opioid Receptor Gene with Alcohol Response and Consumption in Male Rhesus Macaques Archives of General Psychiatry. Mar, 2007 | Pubmed ID: 17339526 Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/orphanin FQ-NOP Receptor System Biological Psychiatry. Jan, 2007 | Pubmed ID: 16533497 Genetic Impairment of Frontocortical Endocannabinoid Degradation and High Alcohol Preference Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2007 | Pubmed ID: 16482090 Neuroendocrine, Cognitive and Structural Imaging Characteristics of Women on Longterm Sickleave with Job Stress-induced Depression Biological Psychiatry. Oct, 2006 | Pubmed ID: 16934773 Identifying Hazardous Alcohol Consumption During Pregnancy: Implementing a Research-based Model in Real Life Acta Obstetricia Et Gynecologica Scandinavica. 2006 | Pubmed ID: 16752255 Pharmacological Treatment of Alcohol Dependence: Target Symptoms and Target Mechanisms Pharmacology & Therapeutics. Sep, 2006 | Pubmed ID: 16545872 NPY in Alcoholism and Psychiatric Disorders EXS. 2006 | Pubmed ID: 16383007 Addiction and Its Brain Science Addiction (Abingdon, England). Dec, 2005 | Pubmed ID: 16367982 Gene Discovery in Neuropharmacological and Behavioral Studies Using Affymetrix Microarray Data Methods (San Diego, Calif.). Nov, 2005 | Pubmed ID: 16308151 Unexpectedly High Prevalence of Alcohol Use Among Pregnant Swedish Women: Failed Detection by Antenatal Care and Simple Tools That Improve Detection Journal of Studies on Alcohol. Mar, 2005 | Pubmed ID: 15957666 A Novel Single Nucleotide Polymorphism of the Neuropeptide Y (NPY) Gene Associated with Alcohol Dependence Alcoholism, Clinical and Experimental Research. May, 2005 | Pubmed ID: 15897713 Cannabinoid CB1 Receptor Antagonism Reduces Conditioned Reinstatement of Ethanol-seeking Behavior in Rats The European Journal of Neuroscience. Apr, 2005 | Pubmed ID: 15869521 Anxiolytic-like Actions of Centrally-administered Neuropeptide Y, but Not Galanin, in C57BL/6J Mice Pharmacology, Biochemistry, and Behavior. Mar, 2005 | Pubmed ID: 15740785 Suppression of Ethanol Self-administration by the Neuropeptide Y (NPY) Y2 Receptor Antagonist BIIE0246: Evidence for Sensitization in Rats with a History of Dependence Neuroscience Letters. Feb, 2005 | Pubmed ID: 15670655 Increased Attributable Risk Related to a Functional Mu-opioid Receptor Gene Polymorphism in Association with Alcohol Dependence in Central Sweden Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Feb, 2005 | Pubmed ID: 15525999 Functional Genomics Strategies to Identify Susceptibility Genes and Treatment Targets in Alcohol Dependence Neurotoxicity Research. 2004 | Pubmed ID: 15545019 The NPY System in Stress, Anxiety and Depression Neuropeptides. Aug, 2004 | Pubmed ID: 15337373 High Trait Anxiety and Hyporeactivity to Stress of the Dorsomedial Prefrontal Cortex: a Combined PhMRI and Fos Study in Rats NeuroImage. Sep, 2004 | Pubmed ID: 15325386 Beliefs and Reality: Detection and Prevention of High Alcohol Consumption in Swedish Antenatal Clinics Acta Obstetricia Et Gynecologica Scandinavica. Sep, 2004 | Pubmed ID: 15315589 Analysis of 5-hydroxytryptamine 2c Receptor Gene Promoter Variants As Alcohol-dependence Risk Factors Alcohol and Alcoholism (Oxford, Oxfordshire). Sep-Oct, 2004 | Pubmed ID: 15304380 Decreased Cerebrospinal Fluid Neuropeptide Y (NPY) in Patients with Treatment Refractory Unipolar Major Depression: Preliminary Evidence for Association with PreproNPY Gene Polymorphism Journal of Psychiatric Research. Mar-Apr, 2004 | Pubmed ID: 14757324 Attenuation of Ethanol Self-administration and of Conditioned Reinstatement of Alcohol-seeking Behaviour by the Antiopioid Peptide Nociceptin/orphanin FQ in Alcohol-preferring Rats Psychopharmacology. Mar, 2004 | Pubmed ID: 14624331 Corticotropin-releasing Hormone (CRH) MRNA Expression in Rat Central Amygdala in Cannabinoid Tolerance and Withdrawal: Evidence for an Allostatic Shift? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2004 | Pubmed ID: 12968131 Fetus at Risk: Prevalence of Alcohol Consumption During Pregnancy Estimated with a Simple Screening Method in Swedish Antenatal Clinics Addiction (Abingdon, England). Nov, 2003 | Pubmed ID: 14616177 Neuropeptide Systems As Novel Therapeutic Targets for Depression and Anxiety Disorders Trends in Pharmacological Sciences. Nov, 2003 | Pubmed ID: 14607081 [Reduced Drug Craving and Better Social Function with Buprenorphine Therapy. Combination Therapy As an Alternative to Methadone Therapy in Heroin Addiction] Lakartidningen. Aug, 2003 | Pubmed ID: 12959012 A Temporal Threshold for Induction of Persistent Alcohol Preference: Behavioral Evidence in a Rat Model of Intermittent Intoxication Journal of Studies on Alcohol. Jul, 2003 | Pubmed ID: 12921185 Behavioural Analysis of Melanin-concentrating Hormone in Rats: Evidence for Orexigenic and Anxiolytic Properties Regulatory Peptides. Jul, 2003 | Pubmed ID: 12832098 [Ecstasy is a Dangerous Drug the Society Chooses to Ignore] Lakartidningen. Feb, 2003 | Pubmed ID: 12674555 Persistent Behavioral and Autonomic Supersensitivity to Stress Following Prenatal Stress Exposure in Rats Behavioural Brain Research. Mar, 2003 | Pubmed ID: 12644280 [Researchers and Psychiatrists Defending Gillberg's Research on ADDH: Karfve's Campaign is a Form of Personal Persecution and Scientific Basis is Missing] Lakartidningen. Feb, 2003 | Pubmed ID: 12640980 1-year Retention and Social Function After Buprenorphine-assisted Relapse Prevention Treatment for Heroin Dependence in Sweden: a Randomised, Placebo-controlled Trial Lancet (London, England). Feb, 2003 | Pubmed ID: 12606177 Neuropeptide Y and Alcoholism: Genetic, Molecular, and Pharmacological Evidence Alcoholism, Clinical and Experimental Research. Feb, 2003 | Pubmed ID: 12605064 NPY Leu7Pro and Alcohol Dependence in Finnish and Swedish Populations Alcoholism, Clinical and Experimental Research. Jan, 2003 | Pubmed ID: 12544000 The Dual-diagnosis Concept Used by Swedish Social Workers: Limited Validity Upon Examination Using a Structured Diagnostic Approach European Psychiatry : the Journal of the Association of European Psychiatrists. Oct, 2002 | Pubmed ID: 12457747 [The Brain Behind Stress and Fatigue Depression] Lakartidningen. May, 2002 | Pubmed ID: 12092052 Brain Neuropeptide Y (NPY) in Stress and Alcohol Dependence Reviews in the Neurosciences. 2002 | Pubmed ID: 12013027 [Documented Effect of Methadone, but Not Naltrexone] Lakartidningen. Feb, 2002 | Pubmed ID: 11881232 Anxiogenic-like Action of Centrally Administered Glucagon-like Peptide-1 in a Punished Drinking Test Progress in Neuro-psychopharmacology & Biological Psychiatry. Jan, 2002 | Pubmed ID: 11853101 [Surprising Conclusion by the SBU Concerning the Benefits of Naltrexone in the Treatment of Heroin Dependence] Lakartidningen. Jan, 2002 | Pubmed ID: 11838078 Long-lasting Increase in Voluntary Ethanol Consumption and Transcriptional Regulation in the Rat Brain After Intermittent Exposure to Alcohol FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2002 | Pubmed ID: 11772933 Использование лица электромиография для оценки реакции лицевые мышцы для опытных и наблюдаемых аффективных Touch в организме человека Anbjørn Ree1, India Morrison2, Håkan Olausson2, Uta Sailer1, Markus Heilig2, Leah M. Mayo2 1Department of Behavioral Sciences in Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 2Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine, Linköping University JoVE 59228 Behavior Способ оценки подкрепляющих свойств этанола в Крысы без воды депривации, сахарин выцветания или дополнительного обучения доступа Eric Augier1, Russell S. Dulman2, Erick Singley2, Markus Heilig1 1Center for Social and Affective Neuroscience, IKE, Linköping University, 2Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health JoVE 53305 Behavior
Использование лица электромиография для оценки реакции лицевые мышцы для опытных и наблюдаемых аффективных Touch в организме человека Anbjørn Ree1, India Morrison2, Håkan Olausson2, Uta Sailer1, Markus Heilig2, Leah M. Mayo2 1Department of Behavioral Sciences in Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 2Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine, Linköping University JoVE 59228 Behavior
Способ оценки подкрепляющих свойств этанола в Крысы без воды депривации, сахарин выцветания или дополнительного обучения доступа Eric Augier1, Russell S. Dulman2, Erick Singley2, Markus Heilig1 1Center for Social and Affective Neuroscience, IKE, Linköping University, 2Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health JoVE 53305 Behavior
