Martin Friedlander Lowy Medical Research Institute Biography Publications Institution JoVE Articles Martin Friedlander has not added a biography. If you are Martin Friedlander and would like to personalize this page please email our Author Liaison for assistance. Publications Identification of Genetic Factors Influencing Metabolic Dysregulation and Retinal Support for MacTel, a Retinal Disorder Communications Biology. Mar, 2021 | Pubmed ID: 33654266 Hyper-reflectivity on Optical Coherence Tomography in Macular Telangiectasia Type 2 Retina (Philadelphia, Pa.). Jan, 2021 | Pubmed ID: 33438900 WITHDRAWN: Hyper-reflectivity on Optical Coherence Tomography in Macular Telangiectasia Type 2 Retina (Philadelphia, Pa.). 11, 2020 | Pubmed ID: 33230067 Deep Learning-based Classification and Segmentation of Retinal Cavitations on Optical Coherence Tomography Images of Macular Telangiectasia Type 2 The British Journal of Ophthalmology. Nov, 2020 | Pubmed ID: 33229343 An Allosteric Peptide Inhibitor of HIF-1α Regulates Hypoxia-induced Retinal Neovascularization Proceedings of the National Academy of Sciences of the United States of America. 11, 2020 | Pubmed ID: 33106407 CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10 Investigative Ophthalmology & Visual Science. 08, 2020 | Pubmed ID: 32780864 Systemic Lipid Dysregulation is a Risk Factor for Macular Neurodegenerative Disease Scientific Reports. 07, 2020 | Pubmed ID: 32699277 Optical Coherence Tomography-angiography for Monitoring Neovascularisations in Macular Telangiectasia Type 2 The British Journal of Ophthalmology. Jun, 2020 | Pubmed ID: 32513667 Retinal Microglia Are Critical for Subretinal Neovascular Formation JCI Insight. 06, 2020 | Pubmed ID: 32437334 Beyond Performance Metrics: Automatic Deep Learning Retinal OCT Analysis Reproduces Clinical Trial Outcome Ophthalmology. 06, 2020 | Pubmed ID: 32019699 Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy The New England Journal of Medicine. 10, 2019 | Pubmed ID: 31509666 Anti-VEGF Therapy: Higher Potency and Long-lasting Antagonism Are Not Necessarily Better The Journal of Clinical Investigation. 06, 2019 | Pubmed ID: 31232702 The Long Dystrophin Gene Product Dp427 Modulates Retinal Function and Vascular Morphology in Response to Age and Retinal Ischemia Neurochemistry International. 10, 2019 | Pubmed ID: 31199961 MiR-30a-5p Inhibition Promotes Interaction of Fas Endothelial Cells and FasL Microglia to Decrease Pathological Neovascularization and Promote Physiological Angiogenesis Glia. 02, 2019 | Pubmed ID: 30484883 Metabolomics in the Study of Retinal Health and Disease Progress in Retinal and Eye Research. 03, 2019 | Pubmed ID: 30423446 Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial Ophthalmology. 04, 2019 | Pubmed ID: 30292541 Global Connections to Study Idiopathic Macular Telangiectasia Type 2 Retina (Philadelphia, Pa.). 01, 2018 | Pubmed ID: 29190235 Fully Automated, Deep Learning Segmentation of Oxygen-induced Retinopathy Images JCI Insight. 12, 2017 | Pubmed ID: 29263301 Special Commentary: Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative Ophthalmology. 07, 2017 | Pubmed ID: 28365209 Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of β-Catenin Signaling Circulation. Jul, 2017 | Pubmed ID: 28356444 Genome-wide Analyses Identify Common Variants Associated with Macular Telangiectasia Type 2 Nature Genetics. Apr, 2017 | Pubmed ID: 28250457 CD44 Expression in Endothelial Colony-forming Cells Regulates Neurovascular Trophic Effect JCI Insight. 01, 2017 | Pubmed ID: 28138561 VEGF Regulates Local Inhibitory Complement Proteins in the Eye and Kidney The Journal of Clinical Investigation. 01, 2017 | Pubmed ID: 27918307 Quantitative Metabolomics of Photoreceptor Degeneration and the Effects of Stem Cell-derived Retinal Pigment Epithelium Transplantation Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences. Oct, 2016 | Pubmed ID: 27644974 CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy Investigative Ophthalmology & Visual Science. Aug, 2016 | Pubmed ID: 27494343 Corrigendum: Retinal Lipid and Glucose Metabolism Dictates Angiogenesis Through the Lipid Sensor Ffar1 Nature Medicine. Jun, 2016 | Pubmed ID: 27270778 Hypoxia-induced Metabolic Stress in Retinal Pigment Epithelial Cells is Sufficient to Induce Photoreceptor Degeneration ELife. 2016 | Pubmed ID: 26978795 Retinal Lipid and Glucose Metabolism Dictates Angiogenesis Through the Lipid Sensor Ffar1 Nature Medicine. Apr, 2016 | Pubmed ID: 26974308 IPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study Stem Cells International. 2016 | Pubmed ID: 26880994 Global Metabolomics Reveals Metabolic Dysregulation in Ischemic Retinopathy Metabolomics : Official Journal of the Metabolomic Society. 2016 | Pubmed ID: 26617478 Angiogenesis and Eye Disease Annual Review of Vision Science. Nov, 2015 | Pubmed ID: 28532369 A Challenging Form of Non-autoimmune Insulin-Dependent Diabetes in a Wolfram Syndrome Patient with a Novel Sequence Variant Journal of Diabetes & Metabolism. Jun, 2015 | Pubmed ID: 26819810 Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells Cell Stem Cell. Sep, 2015 | Pubmed ID: 26299572 Neurovascular Crosstalk Between Interneurons and Capillaries is Required for Vision The Journal of Clinical Investigation. Jun, 2015 | Pubmed ID: 25915585 Comprehensive Bioimaging with Fluorinated Nanoparticles Using Breathable Liquids Nature Communications. 2015 | Pubmed ID: 25601659 Local Acting Sticky-trap Inhibits Vascular Endothelial Growth Factor Dependent Pathological Angiogenesis in the Eye EMBO Molecular Medicine. May, 2014 | Pubmed ID: 24705878 Utilizing Stem Cell-derived RPE Cells As a Therapeutic Intervention for Age-related Macular Degeneration Advances in Experimental Medicine and Biology. 2014 | Pubmed ID: 24664714 Hypoxia-inducible Factor (HIF)/vascular Endothelial Growth Factor (VEGF) Signaling in the Retina Advances in Experimental Medicine and Biology. 2014 | Pubmed ID: 24664708 Ras Pathway Inhibition Prevents Neovascularization by Repressing Endothelial Cell Sprouting The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24084735 Targeted Deletion of Vegfa in Adult Mice Induces Vision Loss The Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 23093773 Using Flow Cytometry to Compare the Dynamics of Photoreceptor Outer Segment Phagocytosis in IPS-derived RPE Cells Investigative Ophthalmology & Visual Science. 2012 | Pubmed ID: 22871841 Advances in Treatment and Management: Immunologic and Cell-based Regenerative Therapies Investigative Ophthalmology & Visual Science. May, 2012 | Pubmed ID: 22562853 Generation of Retinal Pigment Epithelial Cells from Small Molecules and OCT4 Reprogrammed Human Induced Pluripotent Stem Cells Stem Cells Translational Medicine. Feb, 2012 | Pubmed ID: 22532929 Differential Macrophage Polarization Promotes Tissue Remodeling and Repair in a Model of Ischemic Retinopathy Scientific Reports. 2011 | Pubmed ID: 22355595 Astrocyte PVHL and HIF-α Isoforms Are Required for Embryonic-to-adult Vascular Transition in the Eye The Journal of Cell Biology. Nov, 2011 | Pubmed ID: 22084310 Analysis of Candidate Genes for Macular Telangiectasia Type 2 Molecular Vision. 2010 | Pubmed ID: 21179236 Stemming Vision Loss with Stem Cells The Journal of Clinical Investigation. Sep, 2010 | Pubmed ID: 20811157 Astrocyte Hypoxic Response is Essential for Pathological but Not Developmental Angiogenesis of the Retina Glia. Aug, 2010 | Pubmed ID: 20544853 Maintaining Retinal Astrocytes Normalizes Revascularization and Prevents Vascular Pathology Associated with Oxygen-induced Retinopathy Glia. Jan, 2010 | Pubmed ID: 19544395 Combination Angiostatic Therapies: Targeting Multiple Angiogenic Pathways Retina (Philadelphia, Pa.). Jun, 2009 | Pubmed ID: 19553794 Antioxidant or Neurotrophic Factor Treatment Preserves Function in a Mouse Model of Neovascularization-associated Oxidative Stress The Journal of Clinical Investigation. Mar, 2009 | Pubmed ID: 19188685 Chapter 6. Ocular Models of Angiogenesis Methods in Enzymology. 2008 | Pubmed ID: 19007663 Introducing Lois E. H. Smith, the 2008 Recipient of the Friedenwald Award Investigative Ophthalmology & Visual Science. Dec, 2008 | Pubmed ID: 18708612 Retinal Vascular Permeability Suppression by Topical Application of a Novel VEGFR2/Src Kinase Inhibitor in Mice and Rabbits The Journal of Clinical Investigation. Jun, 2008 | Pubmed ID: 18483622 Pathogenesis of Infantile Haemangioma: New Molecular and Cellular Insights Expert Reviews in Molecular Medicine. 2007 | Pubmed ID: 18045510 Hypertrophy and Heart Failure in Mice Overexpressing the Cardiac Sodium-calcium Exchanger Journal of Cardiac Failure. May, 2007 | Pubmed ID: 17517353 Progenitor Cells and Retinal Angiogenesis Angiogenesis. 2007 | Pubmed ID: 17372851 Role of Protease Activated Receptor 1 and 2 Signaling in Hypoxia-induced Angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2007 | Pubmed ID: 17363687 Fibrosis and Diseases of the Eye The Journal of Clinical Investigation. Mar, 2007 | Pubmed ID: 17332885 Ocular Neovascularization: Basic Mechanisms and Therapeutic Advances Survey of Ophthalmology. Jan, 2007 | Pubmed ID: 17240254 Combination Angiostatic Therapy Completely Inhibits Ocular and Tumor Angiogenesis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17210921 Myeloid Progenitors Differentiate into Microglia and Promote Vascular Repair in a Model of Ischemic Retinopathy The Journal of Clinical Investigation. Dec, 2006 | Pubmed ID: 17111048 Proceedings of the Third International Symposium on Retinopathy of Prematurity: an Update on ROP from the Lab to the Nursery (November 2003, Anaheim, California) Molecular Vision. 2006 | Pubmed ID: 16735995 T2-TrpRS Inhibits Preretinal Neovascularization and Enhances Physiological Vascular Regrowth in OIR As Assessed by a New Method of Quantification Investigative Ophthalmology & Visual Science. May, 2006 | Pubmed ID: 16639024 Mechanisms of Endothelial Cell Guidance and Vascular Patterning in the Developing Mouse Retina Progress in Retinal and Eye Research. May, 2006 | Pubmed ID: 16515881 A Homing Mechanism for Bone Marrow-derived Progenitor Cell Recruitment to the Neovasculature The Journal of Clinical Investigation. Mar, 2006 | Pubmed ID: 16498499 Myeloid Cells in Infantile Hemangioma The American Journal of Pathology. Feb, 2006 | Pubmed ID: 16436675 Recent Progress in Our Understanding of the Pathogenesis of Infantile Hemangiomas Lymphatic Research and Biology. 2005 | Pubmed ID: 16379591 Three-dimensional in Vivo Imaging of the Mouse Intraocular Vasculature During Development and Disease Investigative Ophthalmology & Visual Science. Sep, 2005 | Pubmed ID: 16123396 Retinal Vascular Regeneration Seminars in Ophthalmology. Jan-Mar, 2005 | Pubmed ID: 15804843 Rescue of Retinal Degeneration by Intravitreally Injected Adult Bone Marrow-derived Lineage-negative Hematopoietic Stem Cells The Journal of Clinical Investigation. Sep, 2004 | Pubmed ID: 15372100 Functional Adult Myocardium in the Absence of Na+-Ca2+ Exchange: Cardiac-specific Knockout of NCX1 Circulation Research. Sep, 2004 | Pubmed ID: 15308581 Regulation of Angiogenesis by Tissue Factor Cytoplasmic Domain Signaling Nature Medicine. May, 2004 | Pubmed ID: 15098027 Global Gene Expression Analysis of the Developing Postnatal Mouse Retina Investigative Ophthalmology & Visual Science. Mar, 2004 | Pubmed ID: 14985324 Adult Bone Marrow-derived Stem Cells Use R-cadherin to Target Sites of Neovascularization in the Developing Retina Blood. May, 2004 | Pubmed ID: 14726407 Identifying Potential Regulators of Infantile Hemangioma Progression Through Large-scale Expression Analysis: a Possible Role for the Immune System and Indoleamine 2,3 Dioxygenase (IDO) During Involution Lymphatic Research and Biology. 2003 | Pubmed ID: 15624557 Mouse Model of Subretinal Neovascularization with Choroidal Anastomosis Retina (Philadelphia, Pa.). Aug, 2003 | Pubmed ID: 12972764 Endothelial Proliferation in Diabetic Retinal Microaneurysms Archives of Ophthalmology. May, 2003 | Pubmed ID: 12742861 In Vivo Transduction of Photoreceptors or Ciliary Body by Intravitreal Injection of Pseudotyped Adenoviral Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2003 | Pubmed ID: 12573615 Co-translational Targeting and Translocation of the Amino Terminus of Opsin Across the Endoplasmic Membrane Requires GTP but Not ATP The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12486130 Retinal Vascular Development is Mediated by Endothelial Filopodia, a Preexisting Astrocytic Template and Specific R-cadherin Adhesion Investigative Ophthalmology & Visual Science. Nov, 2002 | Pubmed ID: 12407162 Bone Marrow-derived Stem Cells Target Retinal Astrocytes and Can Promote or Inhibit Retinal Angiogenesis Nature Medicine. Sep, 2002 | Pubmed ID: 12145646 The Amino Terminus of Opsin Translocates "posttranslationally" As Efficiently As Cotranslationally Biochemistry. Jun, 2002 | Pubmed ID: 12056902 Insulin-like Growth Factor 2 and Potential Regulators of Hemangioma Growth and Involution Identified by Large-scale Expression Analysis Proceedings of the National Academy of Sciences of the United States of America. May, 2002 | Pubmed ID: 12032304 Loss of P53 Compensates for Alpha V-integrin Function in Retinal Neovascularization The Journal of Biological Chemistry. Apr, 2002 | Pubmed ID: 11856728 A Human Aminoacyl-tRNA Synthetase As a Regulator of Angiogenesis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2002 | Pubmed ID: 11773626 A Fragment of Human TrpRS As a Potent Antagonist of Ocular Angiogenesis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2002 | Pubmed ID: 11773625 創薬のためのヒト網膜オルガノイドの毒性スクリーニング Kevin Eade1,2, Sarah Giles1,2, Sarah Harkins-Perry1,2, Martin Friedlander1,2 1Lowy Medical Research Institute, 2The Scripps Research Institute JoVE 62269 Bioengineering 網膜ミクログリアの貪食機能を評価します Salome Murinello1, Stacey K. Moreno1, Matthew S. Macauley2, Susumu Sakimoto1, Peter D. Westenskow1,3, Martin Friedlander1 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Department of Chemical Physiology, The Scripps Research Institute, 3The Lowy Medical Research Institute JoVE 54677 Immunology and Infection 幹細胞から網膜色素上皮細胞の効率的な導出 Peter Westenskow1,2, Zack Sedillo1,2, Ashley Barnett2, Martin Friedlander1,2 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Lowy Medical Research Institute Developmental Biology 懸濁液中の網膜色素上皮細胞を送達するげっ歯類における網膜下注射の実行 Peter D. Westenskow1,2, Toshihide Kurihara1, Stephen Bravo1, Daniel Feitelberg1, Zack A. Sedillo2, Edith Aguilar1, Martin Friedlander1,2 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Lowy Medical Research Institute Medicine
創薬のためのヒト網膜オルガノイドの毒性スクリーニング Kevin Eade1,2, Sarah Giles1,2, Sarah Harkins-Perry1,2, Martin Friedlander1,2 1Lowy Medical Research Institute, 2The Scripps Research Institute JoVE 62269 Bioengineering
網膜ミクログリアの貪食機能を評価します Salome Murinello1, Stacey K. Moreno1, Matthew S. Macauley2, Susumu Sakimoto1, Peter D. Westenskow1,3, Martin Friedlander1 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Department of Chemical Physiology, The Scripps Research Institute, 3The Lowy Medical Research Institute JoVE 54677 Immunology and Infection
幹細胞から網膜色素上皮細胞の効率的な導出 Peter Westenskow1,2, Zack Sedillo1,2, Ashley Barnett2, Martin Friedlander1,2 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Lowy Medical Research Institute Developmental Biology
懸濁液中の網膜色素上皮細胞を送達するげっ歯類における網膜下注射の実行 Peter D. Westenskow1,2, Toshihide Kurihara1, Stephen Bravo1, Daniel Feitelberg1, Zack A. Sedillo2, Edith Aguilar1, Martin Friedlander1,2 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Lowy Medical Research Institute Medicine
