Martin Holcik Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute and Department of Pediatrics University of Ottawa Biography Publications Institution JoVE Articles Martin Holcik has not added a biography. If you are Martin Holcik and would like to personalize this page please email our Author Liaison for assistance. Publications HnRNPA1 Couples Nuclear Export and Translation of Specific MRNAs Downstream of FGF-2/S6K2 Signalling Nucleic Acids Research. Oct, 2014 | Pubmed ID: 25324306 The Role of IRES Trans-acting Factors in Carcinogenesis Biochimica Et Biophysica Acta. Sep, 2014 | Pubmed ID: 25257759 Mutations in TRNT1, Encoding the CCA-adding Enzyme, Cause Congenital Sideroblastic Anemia with B Cell Immunodeficiency, Periodic Fevers and Developmental Delay (SIFD) Blood. Sep, 2014 | Pubmed ID: 25193871 VPAC2 Receptor Agonist BAY 55-9837 Increases SMN Protein Levels and Moderates Disease Phenotype in Severe Spinal Muscular Atrophy Mouse Models Orphanet Journal of Rare Diseases. 2014 | Pubmed ID: 24405637 HuR Controls Mitochondrial Morphology Through the Regulation of BclxL Translation Translation (Austin, Tex.). Apr, 2013 | Pubmed ID: 25328858 Loss of Cellular Inhibitor of Apoptosis Protein 2 Reduces Atherosclerosis in Atherogenic ApoE-/- C57BL/6 Mice on High-fat Diet Journal of the American Heart Association. Oct, 2013 | Pubmed ID: 24072531 Involvement of Yeast HSP90 Isoforms in Response to Stress and Cell Death Induced by Acetic Acid PloS One. 2013 | Pubmed ID: 23967187 Loss of PDCD4 Contributes to Enhanced Chemoresistance in Glioblastoma Multiforme Through De-repression of Bcl-xL Translation Oncotarget. Sep, 2013 | Pubmed ID: 23965755 Celecoxib Increases SMN and Survival in a Severe Spinal Muscular Atrophy Mouse Model Via P38 Pathway Activation Human Molecular Genetics. Sep, 2013 | Pubmed ID: 23656793 A Novel Cis-acting Element from the 3'UTR of DNA Damage-binding Protein 2 MRNA Links Transcriptional and Post-transcriptional Regulation of Gene Expression Nucleic Acids Research. Jun, 2013 | Pubmed ID: 23605047 Nucleotide Composition of Cellular Internal Ribosome Entry Sites Defines Dependence on NF45 and Predicts a Posttranscriptional Mitotic Regulon Molecular and Cellular Biology. Jan, 2013 | Pubmed ID: 23129811 An Oxygen-regulated Switch in the Protein Synthesis Machinery Nature. Jun, 2012 | Pubmed ID: 22678294 Tumor Suppressor PDCD4 Represses Internal Ribosome Entry Site-mediated Translation of Antiapoptotic Proteins and is Regulated by S6 Kinase 2 Molecular and Cellular Biology. May, 2012 | Pubmed ID: 22431522 IRES-mediated Translation of Cellular Messenger RNA Operates in EIF2α- Independent Manner During Stress Nucleic Acids Research. Jan, 2012 | Pubmed ID: 21917851 Prolactin Increases SMN Expression and Survival in a Mouse Model of Severe Spinal Muscular Atrophy Via the STAT5 Pathway The Journal of Clinical Investigation. Aug, 2011 | Pubmed ID: 21785216 Phosphorylation of EIF2α at Serine 51 is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency Molecular Biology of the Cell. Sep, 2010 | Pubmed ID: 20660158 Distinct 5' UTRs Regulate XIAP Expression Under Normal Growth Conditions and During Cellular Stress Nucleic Acids Research. Aug, 2010 | Pubmed ID: 20385593 EIF2alpha Phosphorylation Tips the Balance to Apoptosis During Osmotic Stress The Journal of Biological Chemistry. May, 2010 | Pubmed ID: 20338999 An Internal Ribosomal Entry Site Mediates Redox-sensitive Translation of Nrf2 Nucleic Acids Research. Jan, 2010 | Pubmed ID: 19934254 P38 Mitogen-activated Protein Kinase Stabilizes SMN MRNA Through RNA Binding Protein HuR Human Molecular Genetics. Nov, 2009 | Pubmed ID: 19648294 RNA Structure: New Messages in Translation, Replication and Disease. Workshop on the Role of RNA Structures in the Translation of Viral and Cellular RNAs EMBO Reports. May, 2009 | Pubmed ID: 19343048 Strong Eukaryotic IRESs Have Weak Secondary Structure PloS One. 2009 | Pubmed ID: 19125192 Post-transcriptional Control of Gene Expression Through Subcellular Relocalization of MRNA Binding Proteins Biochemical Pharmacology. Dec, 2008 | Pubmed ID: 18582437 IRES-mediated Translation of Utrophin A is Enhanced by Glucocorticoid Treatment in Skeletal Muscle Cells PloS One. 2008 | Pubmed ID: 18545658 The EIF4G Homolog DAP5/p97 Supports the Translation of Select MRNAs During Endoplasmic Reticulum Stress Nucleic Acids Research. Jan, 2008 | Pubmed ID: 18003655 RNA-binding Proteins HuR and PTB Promote the Translation of Hypoxia-inducible Factor 1alpha Molecular and Cellular Biology. Jan, 2008 | Pubmed ID: 17967866 Cap-independent Regulation of Gene Expression in Apoptosis Molecular BioSystems. Dec, 2007 | Pubmed ID: 18000559 Cytoplasmic Relocalization of Heterogeneous Nuclear Ribonucleoprotein A1 Controls Translation Initiation of Specific MRNAs Molecular Biology of the Cell. Dec, 2007 | Pubmed ID: 17898077 A Search for Structurally Similar Cellular Internal Ribosome Entry Sites Nucleic Acids Research. 2007 | Pubmed ID: 17591613 Translation Mechanism and Regulation: Old Players, New Concepts. Meeting on Translational Control and Non-coding RNA EMBO Reports. Jul, 2007 | Pubmed ID: 17571077 Subcellular Relocalization of a Trans-acting Factor Regulates XIAP IRES-dependent Translation Molecular Biology of the Cell. Apr, 2007 | Pubmed ID: 17287399 Perk-dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress Molecular and Cellular Biology. Dec, 2006 | Pubmed ID: 17030613 Searching for IRES RNA (New York, N.Y.). Oct, 2006 | Pubmed ID: 16957278 Distinct Patterns of Expression of the Inhibitor of Apoptosis Protein CIAP2 During Murine Embryogenesis Apoptosis : an International Journal on Programmed Cell Death. Jul, 2006 | Pubmed ID: 16699955 Internal Ribosome Entry Site-mediated Translation of Apaf-1, but Not XIAP, is Regulated During UV-induced Cell Death The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16595687 Inhibitor of Apoptosis Protein CIAP2 is Essential for Lipopolysaccharide-induced Macrophage Survival Molecular and Cellular Biology. Jan, 2006 | Pubmed ID: 16382159 Spurious Splicing Within the XIAP 5' UTR Occurs in the Rluc/Fluc but Not the Betagal/CAT Bicistronic Reporter System RNA (New York, N.Y.). Nov, 2005 | Pubmed ID: 16177136 The Utrophin A 5'-untranslated Region Confers Internal Ribosome Entry Site-mediated Translational Control During Regeneration of Skeletal Muscle Fibers The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 16061482 Translational Control in Stress and Apoptosis Nature Reviews. Molecular Cell Biology. Apr, 2005 | Pubmed ID: 15803138 Targeting Endogenous Inhibitors of Apoptosis for Treatment of Cancer, Stroke and Multiple Sclerosis Expert Opinion on Therapeutic Targets. Jun, 2004 | Pubmed ID: 15161430 Targeting Translation for Treatment of Cancer--a Novel Role for IRES? Current Cancer Drug Targets. May, 2004 | Pubmed ID: 15134536 Translational Regulation of X-linked Inhibitor of Apoptosis Protein by Interleukin-6: a Novel Mechanism of Tumor Cell Survival Cancer Research. Feb, 2004 | Pubmed ID: 14973058 Translational Induction of the Inhibitor of Apoptosis Protein HIAP2 During Endoplasmic Reticulum Stress Attenuates Cell Death and is Mediated Via an Inducible Internal Ribosome Entry Site Element The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14960583 Translational Upregulation of the X-linked Inhibitor of Apoptosis Annals of the New York Academy of Sciences. Dec, 2003 | Pubmed ID: 15033729 The Internal Ribosome Entry Site-mediated Translation of Antiapoptotic Protein XIAP is Modulated by the Heterogeneous Nuclear Ribonucleoproteins C1 and C2 Molecular and Cellular Biology. Jan, 2003 | Pubmed ID: 12482981 Distinct Regulation of Internal Ribosome Entry Site-mediated Translation Following Cellular Stress is Mediated by Apoptotic Fragments of EIF4G Translation Initiation Factor Family Members EIF4GI and P97/DAP5/NAT1 The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12458215 The IAP Proteins Trends in Genetics : TIG. Oct, 2002 | Pubmed ID: 12350344 Drosophila Veto Puts a Stop to Cell Survival Trends in Cell Biology. May, 2002 | Pubmed ID: 12062163 Distinct Expression of Neuronal Apoptosis Inhibitory Protein (NAIP) During Murine Development Neuroreport. Mar, 2002 | Pubmed ID: 11930148 Cloning and Characterization of the Rat Homologues of the Inhibitor of Apoptosis Protein 1, 2, and 3 Genes BMC Genomics. 2002 | Pubmed ID: 11860601 Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling Mame Daro Faye1, Tyson E Graber2, Martin Holcik3 1Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 2Montreal Neurological Institute, 3Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute and Department of Pediatrics, University of Ottawa JoVE 52295 Biology
Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling Mame Daro Faye1, Tyson E Graber2, Martin Holcik3 1Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 2Montreal Neurological Institute, 3Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute and Department of Pediatrics, University of Ottawa JoVE 52295 Biology
