Martin Schmelz Department of Anaesthesiology University of Mannheim Biography Publications Institution JoVE Articles Martin Schmelz has not added a biography. If you are Martin Schmelz and would like to personalize this page please email our Author Liaison for assistance. Publications Double Spikes to Single Electrical Stimulation Correlates to Spontaneous Activity of Nociceptors in Painful Neuropathy Patients Pain. Feb, 2012 | Pubmed ID: 22154219 Does Spontaneous Activity in C-nociceptors Provide a Readout to Quantify Neuropathic Pain? Pain. Jan, 2012 | Pubmed ID: 22014531 A Study of Serum Concentrations and Dermal Levels of NGF in Atopic Dermatitis and Healthy Subjects Neuropeptides. Dec, 2011 | Pubmed ID: 21893340 Nerve Growth Factor Selectively Decreases Activity-dependent Conduction Slowing in Mechano-insensitive C-nociceptors Pain. Sep, 2011 | Pubmed ID: 21763072 Structural and Functional Differences Between Neuropathy with and Without Pain? Experimental Neurology. Oct, 2011 | Pubmed ID: 21683699 Neuronal Sensitivity of the Skin European Journal of Dermatology : EJD. May, 2011 | Pubmed ID: 21628129 NGF Enhances Electrically Induced Pain, but Not Axon Reflex Sweating Pain. Aug, 2011 | Pubmed ID: 21546161 Time Course of Acetylcholine-induced Activation of Sympathetic Efferents Matches Axon Reflex Sweating in Humans Journal of the Peripheral Nervous System : JPNS. Mar, 2011 | Pubmed ID: 21504500 Effects of COX Inhibition on Experimental Pain and Hyperalgesia During and After Remifentanil Infusion in Humans Pain. Jun, 2011 | Pubmed ID: 21396775 Chimpanzees Know That Others Make Inferences Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21282649 Differential Central Pain Processing Following Repetitive Intramuscular Proton/prostaglandin E₂ Injections in Female Fibromyalgia Patients and Healthy Controls European Journal of Pain (London, England). Aug, 2011 | Pubmed ID: 21277243 Pathogenesis of Pruritus Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. Jun, 2011 | Pubmed ID: 21208378 Electrically Induced Quantitative Sudomotor Axon Reflex Test in Human Volunteers Autonomic Neuroscience : Basic & Clinical. Jan, 2011 | Pubmed ID: 20923721 Experimental Thermal Lesions Induce Beta-thromboglobulin Release from Activated Platelets European Journal of Pain (London, England). Jan, 2011 | Pubmed ID: 20510637 Pituitary Adenylate Cyclase Activating Polypeptide: an Important Vascular Regulator in Human Skin in Vivo The American Journal of Pathology. Nov, 2010 | Pubmed ID: 20889562 Thoracoscopic Sympathectomy at the T2 or T3 Level Facilitates Bradykinin-induced Protein Extravasation in Human Forearm Skin Pain Medicine (Malden, Mass.). May, 2010 | Pubmed ID: 20202140 Nerve Growth Factor-evoked Nociceptor Sensitization in Pig Skin in Vivo Journal of Neuroscience Research. Jul, 2010 | Pubmed ID: 20143422 NGF Induces Non-inflammatory Localized and Lasting Mechanical and Thermal Hypersensitivity in Human Skin Pain. Mar, 2010 | Pubmed ID: 20022698 Patterns of Activity-dependent Conduction Velocity Changes Differentiate Classes of Unmyelinated Mechano-insensitive Afferents Including Cold Nociceptors, in Pig and in Human Pain. Jan, 2010 | Pubmed ID: 19913997 Single-fiber Recordings of Unmyelinated Afferents in Pig Neuroscience Letters. Feb, 2010 | Pubmed ID: 19818831 Itch and Pain Neuroscience and Biobehavioral Reviews. Feb, 2010 | Pubmed ID: 19146873 Pain: Itch Without Pain-a Labeled Line for Itch Sensation? Nature Reviews. Neurology. Dec, 2009 | Pubmed ID: 19953111 Neurotrophins in the Cerebrospinal Fluid of Patient Cohorts with Neuropathic Pain, Nociceptive Pain, or Normal Pressure Hydrocephalus The Clinical Journal of Pain. Oct, 2009 | Pubmed ID: 19920725 Acute Hyperinsulinemia Differentially Regulates Interstitial and Circulating Adiponectin Oligomeric Pattern in Lean and Insulin-resistant, Obese Individuals The Journal of Clinical Endocrinology and Metabolism. Nov, 2009 | Pubmed ID: 19820029 Long-acting Local Anesthetics Attenuate FMLP-induced Acute Lung Injury in Rats Anesthesia and Analgesia. Sep, 2009 | Pubmed ID: 19690261 Hematopoietic Colony-stimulating Factors Mediate Tumor-nerve Interactions and Bone Cancer Pain Nature Medicine. Jul, 2009 | Pubmed ID: 19525966 Predominant CB2 Receptor Expression in Endothelial Cells of Glioblastoma in Humans Brain Research Bulletin. Jun, 2009 | Pubmed ID: 19480992 How Pain Becomes Itch Pain. Jul, 2009 | Pubmed ID: 19467787 Post-junctional Facilitation of Substance P Signaling in a Tibia Fracture Rat Model of Complex Regional Pain Syndrome Type I Pain. Aug, 2009 | Pubmed ID: 19464118 Translating Nociceptive Processing into Human Pain Models Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale. Jun, 2009 | Pubmed ID: 19404625 Neural Fractalkine Expression is Closely Linked to Pain and Pancreatic Neuritis in Human Chronic Pancreatitis Laboratory Investigation; a Journal of Technical Methods and Pathology. Mar, 2009 | Pubmed ID: 19153557 Differential Endogenous Pain Modulation in Complex-regional Pain Syndrome Brain : a Journal of Neurology. Mar, 2009 | Pubmed ID: 19153154 Facilitated Neurotrophin Release in Sensitized Human Skin European Journal of Pain (London, England). Apr, 2009 | Pubmed ID: 18571954 Painful and Nonpainful Phantom and Stump Sensations in Acute Traumatic Amputees The Journal of Trauma. Oct, 2008 | Pubmed ID: 18849803 In Situ Profiling of Adipokines in Subcutaneous Microdialysates from Lean and Obese Individuals American Journal of Physiology. Endocrinology and Metabolism. Nov, 2008 | Pubmed ID: 18780773 Separate Peripheral Pathways for Pruritus in Man Journal of Neurophysiology. Oct, 2008 | Pubmed ID: 18562548 Role of TRPM8 and TRPA1 for Cold Allodynia in Patients with Cold Injury Pain. Sep, 2008 | Pubmed ID: 18440147 Neuropeptides, Neurogenic Inflammation and Complex Regional Pain Syndrome (CRPS) Neuroscience Letters. Jun, 2008 | Pubmed ID: 18423863 A Subpopulation of Capsaicin-sensitive Porcine Dorsal Root Ganglion Neurons is Lacking Hyperpolarization-activated Cyclic Nucleotide-gated Channels European Journal of Pain (London, England). Aug, 2008 | Pubmed ID: 18218331 Representation of UV-B-induced Thermal and Mechanical Hyperalgesia in the Human Brain: a Functional MRI Study Human Brain Mapping. Dec, 2008 | Pubmed ID: 17948883 Endothelin 1 Activates and Sensitizes Human C-nociceptors Pain. Jul, 2008 | Pubmed ID: 17884295 Nociceptor Sensitization to Mechanical and Thermal Stimuli in Pig Skin in Vivo European Journal of Pain (London, England). Feb, 2008 | Pubmed ID: 17611131 Clinical Classification of Itch: a Position Paper of the International Forum for the Study of Itch Acta Dermato-venereologica. 2007 | Pubmed ID: 17598029 Rapid Flare Development Evoked by Current Frequency-dependent Stimulation Analyzed by Full-field Laser Perfusion Imaging Neuroreport. Jul, 2007 | Pubmed ID: 17589307 Differential Sensitivity of Thick and Thin Fibers to HIV and Therapy-induced Neuropathy Autonomic Neuroscience : Basic & Clinical. Oct, 2007 | Pubmed ID: 17561445 Opioids and the Skin: "itchy" Perspectives Beyond Analgesia and Abuse The Journal of Investigative Dermatology. Jun, 2007 | Pubmed ID: 17502859 The Impact of Opioid-induced Hyperalgesia for Postoperative Pain Best Practice & Research. Clinical Anaesthesiology. Mar, 2007 | Pubmed ID: 17489220 Monocyte Chemoattractant Protein-1 in Subcutaneous Abdominal Adipose Tissue: Characterization of Interstitial Concentration and Regulation of Gene Expression by Insulin The Journal of Clinical Endocrinology and Metabolism. Jul, 2007 | Pubmed ID: 17456576 Potentiation of Nociceptive Responses to Low PH Injections in Humans by Prostaglandin E2 The Journal of Pain : Official Journal of the American Pain Society. May, 2007 | Pubmed ID: 17337250 Catecholamine-induced Excitation of Nociceptors in Sympathetically Maintained Pain Pain. Feb, 2007 | Pubmed ID: 16997471 Chapter 29 Microneurography in the Assessment of Neuropathic Pain Handbook of Clinical Neurology / Edited by P.J. Vinken and G.W. Bruyn. 2006 | Pubmed ID: 18808851 Chapter 18 Itch and Cold Allodynia Handbook of Clinical Neurology / Edited by P.J. Vinken and G.W. Bruyn. 2006 | Pubmed ID: 18808840 Abnormal Function of C-fibers in Patients with Diabetic Neuropathy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006 | Pubmed ID: 17079656 Modulation of Remifentanil-induced Analgesia and Postinfusion Hyperalgesia by Parecoxib in Humans Anesthesiology. Nov, 2006 | Pubmed ID: 17065897 Neurophysiological, Neuroimmunological, and Neuroendocrine Basis of Pruritus The Journal of Investigative Dermatology. Aug, 2006 | Pubmed ID: 16845410 Bradykinin is a Potent Pruritogen in Atopic Dermatitis: a Switch from Pain to Itch Pain. Dec, 2006 | Pubmed ID: 16842920 Delta-9-THC Based Monotherapy in Fibromyalgia Patients on Experimentally Induced Pain, Axon Reflex Flare, and Pain Relief Current Medical Research and Opinion. Jul, 2006 | Pubmed ID: 16834825 The Neurobiology of Itch Nature Reviews. Neuroscience. Jul, 2006 | Pubmed ID: 16791143 Reduction of Pulmonary Edema by Short-acting Local Anesthetics Regional Anesthesia and Pain Medicine. May-Jun, 2006 | Pubmed ID: 16701192 Chronic Itch and Pain--similarities and Differences European Journal of Pain (London, England). Jul, 2006 | Pubmed ID: 16678456 Frontiers in Pruritus Research: Scratching the Brain for More Effective Itch Therapy The Journal of Clinical Investigation. May, 2006 | Pubmed ID: 16670758 Pathophysiology and Treatment of Pain in Joint Disease Advanced Drug Delivery Reviews. May, 2006 | Pubmed ID: 16626837 Duration of Effects of Aspirin on Platelet Function in Healthy Volunteers: an Analysis Using the PFA-100 Journal of Clinical Anesthesia. Feb, 2006 | Pubmed ID: 16517326 Angiotensin Converting Enzyme Has an Inhibitory Role in CGRP Metabolism in Human Skin Peptides. Apr, 2006 | Pubmed ID: 16406141 Neurogenic Components of Trypsin- and Thrombin-induced Inflammation in Rat Skin, in Vivo Experimental Dermatology. Jan, 2006 | Pubmed ID: 16364032 Itch and Pain Dermatologic Therapy. Jul-Aug, 2005 | Pubmed ID: 16297001 Activation of Naloxone-sensitive and -insensitive Inhibitory Systems in a Human Pain Model The Journal of Pain : Official Journal of the American Pain Society. Nov, 2005 | Pubmed ID: 16275600 Different Profiles of Buprenorphine-induced Analgesia and Antihyperalgesia in a Human Pain Model Pain. Nov, 2005 | Pubmed ID: 16154698 Distribution of Cannabinoid Receptor 1 (CB1) and 2 (CB2) on Sensory Nerve Fibers and Adnexal Structures in Human Skin Journal of Dermatological Science. Jun, 2005 | Pubmed ID: 15927811 Altered Central Excitability and Analgesic Treatment in Patients with Restless Legs Syndrome Brain : a Journal of Neurology. Jun, 2005 | Pubmed ID: 15900027 Transcutaneous Penetration of Toluene in Rat Skin a Microdialysis Study Experimental Dermatology. Feb, 2005 | Pubmed ID: 15679579 Electrically Evoked Itch in Humans Pain. Jan, 2005 | Pubmed ID: 15621375 The Effect of Intravenous Infusion of Adenosine on Electrically Evoked Hyperalgesia in a Healthy Volunteer Model of Central Sensitization Anesthesia and Analgesia. Sep, 2004 | Pubmed ID: 15333416 Chemically and Electrically Induced Sweating and Flare Reaction Autonomic Neuroscience : Basic & Clinical. Jul, 2004 | Pubmed ID: 15331047 Sensitization to Bradykinin B1 and B2 Receptor Activation in UV-B Irradiated Human Skin Pain. Jul, 2004 | Pubmed ID: 15275768 Neural Activation During Experimental Allodynia: a Functional Magnetic Resonance Imaging Study The European Journal of Neuroscience. Jun, 2004 | Pubmed ID: 15217377 Catecholamine Release in Human Skin--a Microdialysis Study Experimental Neurology. Jul, 2004 | Pubmed ID: 15191805 Mechanically Induced Axon Reflex and Hyperalgesia in Human UV-B Burn Are Reduced by Systemic Lidocaine European Journal of Pain (London, England). Jun, 2004 | Pubmed ID: 15109974 The Cyclooxygenase Isozyme Inhibitors Parecoxib and Paracetamol Reduce Central Hyperalgesia in Humans Pain. Mar, 2004 | Pubmed ID: 15109518 Facilitated Neurogenic Inflammation in Unaffected Limbs of Patients with Complex Regional Pain Syndrome Neuroscience Letters. Apr, 2004 | Pubmed ID: 15050689 High Local Concentrations and Effects on Differentiation Implicate Interleukin-6 As a Paracrine Regulator Obesity Research. Mar, 2004 | Pubmed ID: 15044662 Perioperative Intravenous Lidocaine Has Preventive Effects on Postoperative Pain and Morphine Consumption After Major Abdominal Surgery Anesthesia and Analgesia. Apr, 2004 | Pubmed ID: 15041597 Electrically Stimulated Axon Reflexes Are Diminished in Diabetic Small Fiber Neuropathies Diabetes. Mar, 2004 | Pubmed ID: 14988263 Opioid-induced Mast Cell Activation and Vascular Responses is Not Mediated by Mu-opioid Receptors: an in Vivo Microdialysis Study in Human Skin Anesthesia and Analgesia. Feb, 2004 | Pubmed ID: 14742371 No Alpha-adrenoreceptor-induced C-fiber Activation in Healthy Human Skin Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2004 | Pubmed ID: 14672966 Differential Effects of Surgical Sympathetic Block at the T2 and T4 Level on Vasoconstrictor Function Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society. Dec, 2003 | Pubmed ID: 14673681 Effects of Gender and Level of Surgical Sympathetic Block on Vasoconstrictor Function Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society. Dec, 2003 | Pubmed ID: 14673680 Modern Aspects of Cutaneous Neurogenic Inflammation Archives of Dermatology. Nov, 2003 | Pubmed ID: 14623709 Neurophysiology of Pruritus: Interaction of Itch and Pain Archives of Dermatology. Nov, 2003 | Pubmed ID: 14623707 Neurophysiology of Pruritus: Cutaneous Elicitation of Itch Archives of Dermatology. Nov, 2003 | Pubmed ID: 14623706 Neuronal Sensitization for Histamine-induced Itch in Lesional Skin of Patients with Atopic Dermatitis Archives of Dermatology. Nov, 2003 | Pubmed ID: 14623705 Naloxone Provokes Similar Pain Facilitation As Observed After Short-term Infusion of Remifentanil in Humans Pain. Nov, 2003 | Pubmed ID: 14581115 Short-term Infusion of the Mu-opioid Agonist Remifentanil in Humans Causes Hyperalgesia During Withdrawal Pain. Nov, 2003 | Pubmed ID: 14581110 Proinflammatory Role of Proteinase-activated Receptor-2 in Humans and Mice During Cutaneous Inflammation in Vivo FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2003 | Pubmed ID: 14519665 Substance-P-induced Protein Extravasation is Bilaterally Increased in Complex Regional Pain Syndrome Experimental Neurology. Sep, 2003 | Pubmed ID: 12957502 Proteinase-activated Receptor-2 Mediates Itch: a Novel Pathway for Pruritus in Human Skin The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2003 | Pubmed ID: 12867500 Central Origin of Secondary Mechanical Hyperalgesia Journal of Neurophysiology. Jul, 2003 | Pubmed ID: 12843313 Differential Modulation of Remifentanil-induced Analgesia and Postinfusion Hyperalgesia by S-ketamine and Clonidine in Humans Anesthesiology. Jul, 2003 | Pubmed ID: 12826855 The Effect of the Nitric Oxide Synthase Inhibitor N-nitro-L-arginine-methyl Ester on Neuropeptide-induced Vasodilation and Protein Extravasation in Human Skin Journal of Vascular Research. Mar-Apr, 2003 | Pubmed ID: 12808346 Itch Lancet. Feb, 2003 | Pubmed ID: 12606187 Pathological C-fibres in Patients with a Chronic Painful Condition Brain : a Journal of Neurology. Mar, 2003 | Pubmed ID: 12566278 Neural Signal Processing: the Underestimated Contribution of Peripheral Human C-fibers The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2002 | Pubmed ID: 12151549 Sensitivity of Human Scalp Skin to Pruritic Stimuli Investigated by Intradermal Microdialysis in Vivo Journal of the American Academy of Dermatology. Aug, 2002 | Pubmed ID: 12140471 ATP Responses in Human C Nociceptors Pain. Jul, 2002 | Pubmed ID: 12098617 Prostaglandin E2 Induces Vasodilation and Pruritus, but No Protein Extravasation in Atopic Dermatitis and Controls Journal of the American Academy of Dermatology. Jul, 2002 | Pubmed ID: 12077577 Interleukin-6 in Combination with Its Soluble IL-6 Receptor Sensitises Rat Skin Nociceptors to Heat, in Vivo Pain. Mar, 2002 | Pubmed ID: 11932061 Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators Martin S Angst1, Martha Tingle1, Martin Schmelz2,3, Brendan Carvalho1, David C Yeomans1 1Department of Anesthesia, Stanford University School of Medicine, 2Department of Anaesthesiology, University of Mannheim, 3Department of Anaesthesiology, University of Heidelberg JoVE 1074 Biology
Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators Martin S Angst1, Martha Tingle1, Martin Schmelz2,3, Brendan Carvalho1, David C Yeomans1 1Department of Anesthesia, Stanford University School of Medicine, 2Department of Anaesthesiology, University of Mannheim, 3Department of Anaesthesiology, University of Heidelberg JoVE 1074 Biology
