Martin Tolstrup Department of Clinical Medicine Aarhus University Biography Publications Institution JoVE Articles Martin Tolstrup has not added a biography. If you are Martin Tolstrup and would like to personalize this page please email our Author Liaison for assistance. Publications Fimepinostat, a Novel Dual Inhibitor of HDAC and PI3K, Effectively Reverses HIV-1 Latency Without T Cell Activation Journal of Virus Eradication. Sep, 2019 | Pubmed ID: 31700656 Fimepinostat, a Novel Dual Inhibitor of HDAC and PI3K, Effectively Reverses HIV-1 Latency Without T Cell Activation Journal of Virus Eradication. Sep, 2019 | Pubmed ID: 31700655 Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues Frontiers in Microbiology. 2019 | Pubmed ID: 31497010 IL-1R3 Blockade Broadly Attenuates the Functions of Six Members of the IL-1 Family, Revealing Their Contribution to Models of Disease Nature Immunology. 09, 2019 | Pubmed ID: 31427775 TLR9 Agonist MGN1703 Enhances B Cell Differentiation and Function in Lymph Nodes EBioMedicine. Jul, 2019 | Pubmed ID: 31300344 Nucleic Acids As a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Mar, 2019 | Pubmed ID: 30937274 Effects of 24-week Toll-like Receptor 9 Agonist Treatment in HIV Type 1+ Individuals AIDS (London, England). 07, 2019 | Pubmed ID: 30932955 CAIMP Administration in Humanized Mice Induces a Chimerization-level-dependent STING Response Immunology. 06, 2019 | Pubmed ID: 30919991 In-vivo Administration of Histone Deacetylase Inhibitors Does Not Impair Natural Killer Cell Function in HIV+ Individuals AIDS (London, England). 03, 2019 | Pubmed ID: 30830886 Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption Journal of Virology. 04, 2019 | Pubmed ID: 30700598 Non-covalent Hitchhiking on Endogenous Carriers As a Protraction Mechanism for Antiviral Macromolecular Prodrugs Journal of Controlled Release : Official Journal of the Controlled Release Society. 01, 2019 | Pubmed ID: 30552954 Characterization of the HIV-1 Transcription Profile After Romidepsin Administration in ART-suppressed Individuals AIDS (London, England). 03, 2019 | Pubmed ID: 30531314 Whole Exome Sequencing of HIV-1 Long-term Non-progressors Identifies Rare Variants in Genes Encoding Innate Immune Sensors and Signaling Molecules Scientific Reports. 10, 2018 | Pubmed ID: 30323326 Differences in Antiretroviral Regimens Do Not Impact Safety or Level of Latency Reversal in Persons Receiving Romidepsin AIDS (London, England). 07, 2018 | Pubmed ID: 30001247 Genetic Characterization of the HIV-1 Reservoir After Vacc-4x and Romidepsin Therapy in HIV-1-infected Individuals AIDS (London, England). 08, 2018 | Pubmed ID: 29762162 Multiple Homozygous Variants in the STING-Encoding Gene in HIV Long-Term Nonprogressors Journal of Immunology (Baltimore, Md. : 1950). 05, 2018 | Pubmed ID: 29632140 Levels of Regulatory B Cells Do Not Predict Serological Responses to Hepatitis B Vaccine Human Vaccines & Immunotherapeutics. 06, 2018 | Pubmed ID: 29474139 Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Lipopolysaccharide-Induced Inflammatory Responses MSphere. Jan-Feb, 2018 | Pubmed ID: 29468194 Macromolecular Prodrugs of Ribavirin: Polymer Backbone Defines Blood Safety, Drug Release, and Efficacy of Anti-inflammatory Effects Journal of Controlled Release : Official Journal of the Controlled Release Society. 04, 2018 | Pubmed ID: 29432822 Cellular Immunogenicity of Human Papillomavirus Vaccines Cervarix and Gardasil in Adults with HIV Infection Human Vaccines & Immunotherapeutics. 04, 2018 | Pubmed ID: 29172992 Estimating Initial Viral Levels During Simian Immunodeficiency Virus/Human Immunodeficiency Virus Reactivation from Latency Journal of Virology. 01, 2018 | Pubmed ID: 29118123 The TLR9 Agonist MGN1703 Triggers a Potent Type I Interferon Response in the Sigmoid Colon Mucosal Immunology. Mar, 2018 | Pubmed ID: 28766555 Macromolecular Antiviral Agents Against Zika, Ebola, SARS, and Other Pathogenic Viruses Advanced Healthcare Materials. Dec, 2017 | Pubmed ID: 28945945 HDAC Inhibition Induces HIV-1 Protein and Enables Immune-based Clearance Following Latency Reversal JCI Insight. Aug, 2017 | Pubmed ID: 28814661 Anti-HIV-1 ADCC Antibodies Following Latency Reversal and Treatment Interruption Journal of Virology. 08, 2017 | Pubmed ID: 28539449 Beyond Antiretroviral Therapy: Early Interventions to Control HIV-1 Infection AIDS (London, England). 07, 2017 | Pubmed ID: 28463884 Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jun, 2017 | Pubmed ID: 28329286 Romidepsin-induced HIV-1 Viremia During Effective Antiretroviral Therapy Contains Identical Viral Sequences with Few Deleterious Mutations AIDS (London, England). 03, 2017 | Pubmed ID: 28272134 Macromolecular Prodrugs of Ribavirin: Structure-Function Correlation As Inhibitors of Influenza Infectivity Molecular Pharmaceutics. 01, 2017 | Pubmed ID: 28043136 HIV Anti-latency Treatment Mediated by Macromolecular Prodrugs of Histone Deacetylase Inhibitor, Panobinostat Chemical Science. Mar, 2016 | Pubmed ID: 29997778 Combined Effect of Vacc-4x, Recombinant Human Granulocyte Macrophage Colony-stimulating Factor Vaccination, and Romidepsin on the HIV-1 Reservoir (REDUC): a Single-arm, Phase 1B/2A Trial The Lancet. HIV. 10, 2016 | Pubmed ID: 27658863 Broad Activation of Latent HIV-1 in Vivo Nature Communications. 09, 2016 | Pubmed ID: 27605062 Modeling of Experimental Data Supports HIV Reactivation from Latency After Treatment Interruption on Average Once Every 5-8 Days PLoS Pathogens. 08, 2016 | Pubmed ID: 27560972 Immune Checkpoints and the HIV-1 Reservoir: Proceed with Caution Journal of Virus Eradication. Jul, 2016 | Pubmed ID: 27482460 International AIDS Society Global Scientific Strategy: Towards an HIV Cure 2016 Nature Medicine. 08, 2016 | Pubmed ID: 27400264 Triple Activity of Lamivudine Releasing Sulfonated Polymers Against HIV-1 Molecular Pharmaceutics. 07, 2016 | Pubmed ID: 27244595 New Insights on the Phenotype of HIV Reservoirs AIDS (London, England). 06, 2016 | Pubmed ID: 27243776 The Potential Role for Romidepsin As a Component in Early HIV-1 Curative Efforts Expert Review of Anti-infective Therapy. 2016 | Pubmed ID: 26953620 Human Papillomavirus Neutralizing and Cross-reactive Antibodies Induced in HIV-positive Subjects After Vaccination with Quadrivalent and Bivalent HPV Vaccines Vaccine. Mar, 2016 | Pubmed ID: 26896686 A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+ T Cells Journal of Virology. May, 2016 | Pubmed ID: 26889036 Using Animal Models to Overcome Temporal, Spatial and Combinatorial Challenges in HIV Persistence Research Journal of Translational Medicine. Feb, 2016 | Pubmed ID: 26861779 ART Influences HIV Persistence in the Female Reproductive Tract and Cervicovaginal Secretions The Journal of Clinical Investigation. Mar, 2016 | Pubmed ID: 26854925 Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity Advanced Healthcare Materials. Mar, 2016 | Pubmed ID: 26789641 Reversal of Latency As Part of a Cure for HIV-1 Trends in Microbiology. Feb, 2016 | Pubmed ID: 26690612 HIV-1 Transcriptional Activity During Frequent Longitudinal Sampling in Aviremic Patients on Antiretroviral Therapy AIDS (London, England). Mar, 2016 | Pubmed ID: 26595541 Macromolecular Prodrugs of Ribavirin: Towards a Treatment for Co-infection with HIV and HCV Chemical Science. Jan, 2015 | Pubmed ID: 28580095 Administration of Panobinostat Is Associated with Increased IL-17A MRNA in the Intestinal Epithelium of HIV-1 Patients Mediators of Inflammation. 2015 | Pubmed ID: 26696749 The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo PLoS Pathogens. Sep, 2015 | Pubmed ID: 26379282 Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline During Latency-Reversing Treatment with Panobinostat Journal of Virology. Oct, 2015 | Pubmed ID: 26223643 HIV Reactivation from Latency After Treatment Interruption Occurs on Average Every 5-8 Days--Implications for HIV Remission PLoS Pathogens. Jul, 2015 | Pubmed ID: 26133551 Activation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: a Pilot Study to Assess Effects on the Central Nervous System Open Forum Infectious Diseases. Jan, 2015 | Pubmed ID: 26034779 Histone Deacetylase Inhibitor Romidepsin Inhibits De Novo HIV-1 Infections Antimicrobial Agents and Chemotherapy. Jul, 2015 | Pubmed ID: 25896701 High Level of HIV-1 Drug Resistance Among Patients with HIV-1 and HIV-1/2 Dual Infections in Guinea-Bissau Virology Journal. Mar, 2015 | Pubmed ID: 25889017 Interleukin-37 Expression Is Increased in Chronic HIV-1-Infected Individuals and Is Associated with Inflammation and the Size of the Total Viral Reservoir Molecular Medicine (Cambridge, Mass.). Apr, 2015 | Pubmed ID: 25879630 The Histone Deacetylase Inhibitor Panobinostat Lowers Biomarkers of Cardiovascular Risk and Inflammation in HIV Patients AIDS (London, England). Jun, 2015 | Pubmed ID: 25870990 Highly Active Macromolecular Prodrugs Inhibit Expression of the Hepatitis C Virus Genome in the Host Cells Advanced Healthcare Materials. Jan, 2015 | Pubmed ID: 25132665 Polymers Fight HIV: Potent (pro)drugs Identified Through Parallel Automated Synthesis Advanced Healthcare Materials. Jan, 2015 | Pubmed ID: 24811313 Panobinostat, a Histone Deacetylase Inhibitor, for Latent-virus Reactivation in HIV-infected Patients on Suppressive Antiretroviral Therapy: a Phase 1/2, Single Group, Clinical Trial The Lancet. HIV. Oct, 2014 | Pubmed ID: 26423811 Disulfide Reshuffling Triggers the Release of a Thiol-free Anti-HIV Agent to Make Up Fast-acting, Potent Macromolecular Prodrugs Chemical Communications (Cambridge, England). Dec, 2014 | Pubmed ID: 25285337 Vaccination Against Oncogenic Human Papillomavirus Infection in HIV-infected Populations: Review of Current Status and Future Perspectives Sexual Health. Dec, 2014 | Pubmed ID: 25218800 Comparison of the Immunogenicity of Cervarix® and Gardasil® Human Papillomavirus Vaccines for Oncogenic Non-vaccine Serotypes HPV-31, HPV-33, and HPV-45 in HIV-infected Adults Human Vaccines & Immunotherapeutics. 2014 | Pubmed ID: 24553190 T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication PloS One. 2014 | Pubmed ID: 24404168 Editorial Commentary: Reversing Latency in HIV-infected Patients Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Mar, 2014 | Pubmed ID: 24336824 Comparison of the Immunogenicity and Reactogenicity of Cervarix and Gardasil Human Papillomavirus Vaccines in HIV-infected Adults: a Randomized, Double-blind Clinical Trial The Journal of Infectious Diseases. Apr, 2014 | Pubmed ID: 24273179 Anti-inflammatory Effect of a Retrovirus-derived Immunosuppressive Peptide in Mouse Models BMC Immunology. Nov, 2013 | Pubmed ID: 24245569 Administration of a Toll-like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-infected Patients PloS One. 2013 | Pubmed ID: 23637967 Eliminating the Latent HIV Reservoir by Reactivation Strategies: Advancing to Clinical Trials Human Vaccines & Immunotherapeutics. Apr, 2013 | Pubmed ID: 23563519 Comparison of HDAC Inhibitors in Clinical Development: Effect on HIV Production in Latently Infected Cells and T-cell Activation Human Vaccines & Immunotherapeutics. May, 2013 | Pubmed ID: 23370291 Antiviral and Immunological Effects of Tenofovir Microbicide in Vaginal Herpes Simplex Virus 2 Infection AIDS Research and Human Retroviruses. Nov, 2012 | Pubmed ID: 22867119 The Impact of B-cell Perturbations on Pneumococcal Conjugate Vaccine Response in HIV-infected Adults PloS One. 2012 | Pubmed ID: 22860110 TLR9-adjuvanted Pneumococcal Conjugate Vaccine Induces Antibody-independent Memory Responses in HIV-infected Adults Human Vaccines & Immunotherapeutics. Aug, 2012 | Pubmed ID: 22854665 Construction of a Gammaretrovirus with a Novel Tropism and Wild-type Replication Kinetics Capable of Using Human APJ As Entry Receptor Journal of Virology. Oct, 2012 | Pubmed ID: 22811542 Comparison of Bone and Renal Effects in HIV-infected Adults Switching to Abacavir or Tenofovir Based Therapy in a Randomized Trial PloS One. 2012 | Pubmed ID: 22479327 Timing of Toll-like Receptor 9 Agonist Administration in Pneumococcal Vaccination Impacts Both Humoral and Cellular Immune Responses As Well As Nasopharyngeal Colonization in Mice Infection and Immunity. May, 2012 | Pubmed ID: 22371375 Evaluation of Cardiovascular Biomarkers in HIV-infected Patients Switching to Abacavir or Tenofovir Based Therapy BMC Infectious Diseases. Oct, 2011 | Pubmed ID: 21970555 Induction of Humoral and Cellular Immune Responses Against the HIV-1 Envelope Protein Using γ-retroviral Virus-like Particles Virology Journal. Aug, 2011 | Pubmed ID: 21806819 Endotoxemia is Associated with Altered Innate and Adaptive Immune Responses in Untreated HIV-1 Infected Individuals PloS One. 2011 | Pubmed ID: 21731690 Tenofovir Selectively Regulates Production of Inflammatory Cytokines and Shifts the IL-12/IL-10 Balance in Human Primary Cells Journal of Acquired Immune Deficiency Syndromes (1999). Aug, 2011 | Pubmed ID: 21471820 Transmission of HIV-1 Drug-resistant Variants: Prevalence and Effect on Treatment Outcome Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Feb, 2010 | Pubmed ID: 20085464 Population-based Study of Diagnostic Assays for Borrelia Infection: Comparison of Purified Flagella Antigen Assay (Ideia, Dako Cytomation) and Recombinant Antigen Assay (Liaison, DiaSorin) BMC Clinical Pathology. Apr, 2008 | Pubmed ID: 18423001 Entecavir Therapy Induces De Novo HIV Reverse-transcriptase M184V Mutation in an Antiretroviral Therapy-naive Patient Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. May, 2008 | Pubmed ID: 18419429 Full Fusion Competence Rescue of the Enfuvirtide Resistant HIV-1 Gp41 Genotype (43D) by a Prevalent Polymorphism (137K) AIDS (London, England). Feb, 2007 | Pubmed ID: 17301572 أنسوية NOG الفئران للتعرض لفيروس نقص المناعة البشرية داخل المهبل وعلاج عدوى فيروس نقص المناعة البشرية Anna H. F. Andersen1,2, Stine S. F. Nielsen1,2, Rikke Olesen1,2, Katharina Mack1, Frederik Dagnæs-Hansen3, Niels Uldbjerg1,4, Lars Østergaard1,2, Ole S. Søgaard1,2, Paul W. Denton1,2,5, Martin Tolstrup1,2 1Department of Clinical Medicine, Aarhus University, 2Department of Infectious Diseases, Aarhus University Hospital, 3Department of Biomedicine, Aarhus University, 4Department of Gynecology and Obstetrics, Aarhus University Hospital, 5Department of Biology, University of Nebraska at Omaha JoVE 60723 Immunology and Infection
أنسوية NOG الفئران للتعرض لفيروس نقص المناعة البشرية داخل المهبل وعلاج عدوى فيروس نقص المناعة البشرية Anna H. F. Andersen1,2, Stine S. F. Nielsen1,2, Rikke Olesen1,2, Katharina Mack1, Frederik Dagnæs-Hansen3, Niels Uldbjerg1,4, Lars Østergaard1,2, Ole S. Søgaard1,2, Paul W. Denton1,2,5, Martin Tolstrup1,2 1Department of Clinical Medicine, Aarhus University, 2Department of Infectious Diseases, Aarhus University Hospital, 3Department of Biomedicine, Aarhus University, 4Department of Gynecology and Obstetrics, Aarhus University Hospital, 5Department of Biology, University of Nebraska at Omaha JoVE 60723 Immunology and Infection
