Masato Koike Department of Cell Biology and Neuroscience Juntendo University Graduate School of Medicine Biography Publications Institution JoVE Articles Masato Koike has not added a biography. If you are Masato Koike and would like to personalize this page please email our Author Liaison for assistance. Publications An Optimized Protocol for Immuno-electron Microscopy of Endogenous LC3 Autophagy. Apr, 2022 | Pubmed ID: 35387562 Multi-scale Light Microscopy/electron Microscopy Neuronal Imaging from Brain to Synapse with a Tissue Clearing Method, ScaeSF IScience. Jan, 2022 | Pubmed ID: 35106459 Phase-separated Protein Droplets of Amyotrophic Lateral Sclerosis-associated P62/SQSTM1 Mutants Show Reduced Inner Fluidity The Journal of Biological Chemistry. 12, 2021 | Pubmed ID: 34774801 Susceptibility of Subregions of Prefrontal Cortex and Corpus Callosum to Damage by High-dose Oxytocin-induced Labor in Male Neonatal Mice PloS One. 2021 | Pubmed ID: 34437622 Melanocyte Progenitor Cells Reside in Human Subcutaneous Adipose Tissue PloS One. 2021 | Pubmed ID: 34432824 Three-Dimensional Structure of Dendritic Spines Revealed by Volume Electron Microscopy Techniques Frontiers in Neuroanatomy. 2021 | Pubmed ID: 34135737 CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue Antioxidants (Basel, Switzerland). Mar, 2021 | Pubmed ID: 33804126 Establishment of an in Vitro Model for Analyzing Mitochondrial Ultrastructure in PRKN-mutated Patient IPSC-derived Dopaminergic Neurons Molecular Brain. 03, 2021 | Pubmed ID: 33757554 Cells Recognize Osmotic Stress Through Liquid-liquid Phase Separation Lubricated with Poly(ADP-ribose) Nature Communications. 03, 2021 | Pubmed ID: 33649309 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition) Autophagy. Feb, 2021 | Pubmed ID: 33634751 Exclusive Labeling of Direct and Indirect Pathway Neurons in the Mouse Neostriatum by an Adeno-associated Virus Vector with Cre/lox System STAR Protocols. 03, 2021 | Pubmed ID: 33364620 Alternative Mitochondrial Quality Control Mediated by Extracellular Release Autophagy. 10, 2021 | Pubmed ID: 33218272 Geometry and the Organizational Principle of Spine Synapses Along a Dendrite ENeuro. Nov-Dec, 2020 | Pubmed ID: 33109633 Overlapping Projections of Neighboring Direct and Indirect Pathway Neostriatal Neurons to Globus Pallidus External Segment IScience. Aug, 2020 | Pubmed ID: 32877648 Unique Synaptic Topography of Crest-type Synapses in the Interpeduncular Nucleus Biochemical and Biophysical Research Communications. 09, 2020 | Pubmed ID: 32828274 Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson's Disease ENeuro. Jul/Aug, 2020 | Pubmed ID: 32817196 Insulin2 (Kuma) Mutant Mice Develop Diabetes with Dominant Inheritance Scientific Reports. 07, 2020 | Pubmed ID: 32699230 NBR1-mediated P62-liquid Droplets Enhance the Keap1-Nrf2 System EMBO Reports. 03, 2020 | Pubmed ID: 31916398 Loss of Autophagy Impairs Physiological Steatosis by Accumulation of NCoR1 Life Science Alliance. 01, 2020 | Pubmed ID: 31879337 α-Synuclein BAC Transgenic Mice Exhibit RBD-like Behaviour and Hyposmia: a Prodromal Parkinson's Disease Model Brain : a Journal of Neurology. 01, 2020 | Pubmed ID: 31816026 Oxytocin Induced Labor Causes Region and Sex-specific Transient Oligodendrocyte Cell Death in Neonatal Mouse Brain The Journal of Obstetrics and Gynaecology Research. Jan, 2020 | Pubmed ID: 31746074 Structurally Distinct α-synuclein Fibrils Induce Robust Parkinsonian Pathology Movement Disorders : Official Journal of the Movement Disorder Society. 02, 2020 | Pubmed ID: 31643109 Mutant Calreticulin Interacts with MPL in the Secretion Pathway for Activation on the Cell Surface Leukemia. 02, 2020 | Pubmed ID: 31462733 Cellular Autophagy in Cells Plays a Role in the Maintenance of Islet Architecture Journal of the Endocrine Society. Nov, 2019 | Pubmed ID: 31620668 Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis IScience. May, 2019 | Pubmed ID: 31132747 Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi PH Regulator-Deficient Mice ENeuro. May/Jun, 2019 | Pubmed ID: 31118204 GBA Haploinsufficiency Accelerates Alpha-synuclein Pathology with Altered Lipid Metabolism in a Prodromal Model of Parkinson's Disease Human Molecular Genetics. 06, 2019 | Pubmed ID: 30689867 Blockade of TNF Receptor Superfamily 1 (TNFR1)-dependent and TNFR1-independent Cell Death is Crucial for Normal Epidermal Differentiation The Journal of Allergy and Clinical Immunology. 01, 2019 | Pubmed ID: 29596938 Superoxide Dismutase Activity is Significantly Lower in End-stage Osteoarthritic Cartilage Than Non-osteoarthritic Cartilage PloS One. 2018 | Pubmed ID: 30222787 LRRK2 and Its Substrate Rab GTPases Are Sequentially Targeted Onto Stressed Lysosomes and Maintain Their Homeostasis Proceedings of the National Academy of Sciences of the United States of America. 09, 2018 | Pubmed ID: 30209220 Defective Autophagy in Vascular Smooth Muscle Cells Enhances Cell Death and Atherosclerosis Autophagy. 2018 | Pubmed ID: 30025494 Phosphorylated Recombinant HSP27 Protects the Brain and Attenuates Blood-brain Barrier Disruption Following Stroke in Mice Receiving Intravenous Tissue-plasminogen Activator PloS One. 2018 | Pubmed ID: 29795667 Apple Procyanidins Promote Mitochondrial Biogenesis and Proteoglycan Biosynthesis in Chondrocytes Scientific Reports. 05, 2018 | Pubmed ID: 29739985 Innate Immune Adaptor TRIF Deficiency Accelerates Disease Progression of ALS Mice with Accumulation of Aberrantly Activated Astrocytes Cell Death and Differentiation. 12, 2018 | Pubmed ID: 29568058 TDP-43 Accelerates Age-dependent Degeneration of Interneurons Scientific Reports. 11, 2017 | Pubmed ID: 29097807 Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7 The American Journal of Pathology. Jul, 2017 | Pubmed ID: 28502476 Vps35 in Cooperation with LRRK2 Regulates Synaptic Vesicle Endocytosis Through the Endosomal Pathway in Drosophila Human Molecular Genetics. 08, 2017 | Pubmed ID: 28482024 Mice Lacking BCAS1, a Novel Myelin-associated Protein, Display Hypomyelination, Schizophrenia-like Abnormal Behaviors, and Upregulation of Inflammatory Genes in the Brain Glia. 05, 2017 | Pubmed ID: 28230289 Morphological Process of Podocyte Development Revealed by Block-face Scanning Electron Microscopy Journal of Cell Science. 01, 2017 | Pubmed ID: 27358478 The ATG Conjugation Systems Are Important for Degradation of the Inner Autophagosomal Membrane Science (New York, N.Y.). 11, 2016 | Pubmed ID: 27885029 Lysosomal Storage of Subunit C of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice The American Journal of Pathology. 12, 2016 | Pubmed ID: 27770614 Differential Roles of NF-Y Transcription Factor in ER Chaperone Expression and Neuronal Maintenance in the CNS Scientific Reports. Sep, 2016 | Pubmed ID: 27687130 Functional Links Between SQSTM1 and ALS2 in the Pathogenesis of ALS: Cumulative Impact on the Protection Against Mutant SOD1-mediated Motor Dysfunction in Mice Human Molecular Genetics. 08, 2016 | Pubmed ID: 27439389 Suppression of Ischemia-Induced Hippocampal Pyramidal Neuron Death by Hyaluronan Tetrasaccharide Through Inhibition of Toll-Like Receptor 2 Signaling Pathway The American Journal of Pathology. 08, 2016 | Pubmed ID: 27301359 Differential Remodelling of Peroxisome Function Underpins the Environmental and Metabolic Adaptability of Diplonemids and Kinetoplastids Proceedings. Biological Sciences. 05, 2016 | Pubmed ID: 27170716 The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress EBioMedicine. Mar, 2016 | Pubmed ID: 27077115 Ethambutol Neutralizes Lysosomes and Causes Lysosomal Zinc Accumulation Biochemical and Biophysical Research Communications. Feb, 2016 | Pubmed ID: 26851368 Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD Journal of the American Society of Nephrology : JASN. 09, 2016 | Pubmed ID: 26823550 Human Herpesvirus 6A U14 Is Important for Virus Maturation Journal of Virology. 02, 2016 | Pubmed ID: 26559847 Mechanical Overloading Causes Mitochondrial Superoxide and SOD2 Imbalance in Chondrocytes Resulting in Cartilage Degeneration Scientific Reports. 2015 | Pubmed ID: 26108578 VPS29-VPS35 Intermediate of Retromer is Stable and May Be Involved in the Retromer Complex Assembly Process FEBS Letters. Jun, 2015 | Pubmed ID: 25937119 Cellular Localization and Tissue Distribution of Endogenous DFCP1 Protein Biomedical Research (Tokyo, Japan). 2015 | Pubmed ID: 25876663 Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias Latipes) Displays Axonal Accumulation of Alpha-synuclein PLoS Genetics. Apr, 2015 | Pubmed ID: 25835295 Mitochondrial Superoxide in Osteocytes Perturbs Canalicular Networks in the Setting of Age-related Osteoporosis Scientific Reports. 2015 | Pubmed ID: 25779629 Three-dimensional Architecture of Podocytes Revealed by Block-face Scanning Electron Microscopy Scientific Reports. Mar, 2015 | Pubmed ID: 25759085 Long-term Safety Issues of IPSC-based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-mesenchymal Transition Stem Cell Reports. Mar, 2015 | Pubmed ID: 25684226 L-carnitine Enhances Axonal Plasticity and Improves White-matter Lesions After Chronic Hypoperfusion in Rat Brain Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2015 | Pubmed ID: 25465043 Human IAPP-induced Pancreatic β Cell Toxicity and Its Regulation by Autophagy The Journal of Clinical Investigation. Aug, 2014 | Pubmed ID: 25036706 Increased Immunoreactivity of Cathepsins in the Rat Esophagus Under Chronic Acid Reflux Esophagitis The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Sep, 2014 | Pubmed ID: 24943348 Pancreatic β-cell Failure Mediated by MTORC1 Hyperactivity and Autophagic Impairment Diabetes. Sep, 2014 | Pubmed ID: 24740570 NF-Y Inactivation Causes Atypical Neurodegeneration Characterized by Ubiquitin and P62 Accumulation and Endoplasmic Reticulum Disorganization Nature Communications. Feb, 2014 | Pubmed ID: 24566496 Deregulation of Pancreas-specific Oxidoreductin ERO1β in the Pathogenesis of Diabetes Mellitus Molecular and Cellular Biology. Apr, 2014 | Pubmed ID: 24469402 Local Apoptosis Modulates Early Mammalian Brain Development Through the Elimination of Morphogen-producing Cells Developmental Cell. Dec, 2013 | Pubmed ID: 24369835 Exendin-4 Improves β-cell Function in Autophagy-deficient β-cells Endocrinology. Dec, 2013 | Pubmed ID: 24105478 Cytoplasmic Reactive Oxygen Species and SOD1 Regulate Bone Mass During Mechanical Unloading Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Nov, 2013 | Pubmed ID: 23674366 Differences in Expression Patterns of Cathepsin C/dipeptidyl Peptidase I in Normal, Pathological and Aged Mouse Central Nervous System The European Journal of Neuroscience. Mar, 2013 | Pubmed ID: 23279039 C-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis Science Signaling. Dec, 2012 | Pubmed ID: 23250397 Motor Neuron-specific Disruption of Proteasomes, but Not Autophagy, Replicates Amyotrophic Lateral Sclerosis The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23095749 Development of Purkinje Cell Degeneration in a Knockin Mouse Model Reveals Lysosomal Involvement in the Pathogenesis of SCA6 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23054835 Mitochondrial Dysfunction Associated with Increased Oxidative Stress and α-synuclein Accumulation in PARK2 IPSC-derived Neurons and Postmortem Brain Tissue Molecular Brain. Oct, 2012 | Pubmed ID: 23039195 Rhomboid Protease PARL Mediates the Mitochondrial Membrane Potential Loss-induced Cleavage of PGAM5 The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22915595 Grafted Human-induced Pluripotent Stem-cell-derived Neurospheres Promote Motor Functional Recovery After Spinal Cord Injury in Mice Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21949375 Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria Through Activation of MTORC1 PloS One. 2011 | Pubmed ID: 21886784 Free Fatty Acids Stimulate Autophagy in Pancreatic β-cells Via JNK Pathway Biochemical and Biophysical Research Communications. Oct, 2010 | Pubmed ID: 20888798 New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain Neuron. Jul, 2010 | Pubmed ID: 20670830 Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1-expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking PloS One. Mar, 2010 | Pubmed ID: 20339559 Atg9A Protein, an Autophagy-related Membrane Protein, is Localized in the Neurons of Mouse Brains The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. May, 2010 | Pubmed ID: 20124090 Autophagic Neuron Death Methods in Enzymology. 2009 | Pubmed ID: 19216901 A Tissue Clearing Method for Neuronal Imaging from Mesoscopic to Microscopic Scales Kenta Yamauchi1,2, Shinichiro Okamoto1,2,3, Megumu Takahashi1,2,4,5, Masato Koike2,3, Takahiro Furuta6, Hiroyuki Hioki1,2,7 1Department of Neuroanatomy, Juntendo University Graduate School of Medicine, 2Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 3Advanced Research Institute for Health Sciences, Juntendo University, 4Department of Neuroscience, Graduate School of Medicine, Kyoto University, 5Japan Society for the Promotion of Science, 6Department of Oral Anatomy and Neurobiology, Graduate School of Dentistry, Osaka University, 7Department of Multi-Scale Brain Structure Imaging, Juntendo University Graduate School of Medicine JoVE 63941 Neuroscience
A Tissue Clearing Method for Neuronal Imaging from Mesoscopic to Microscopic Scales Kenta Yamauchi1,2, Shinichiro Okamoto1,2,3, Megumu Takahashi1,2,4,5, Masato Koike2,3, Takahiro Furuta6, Hiroyuki Hioki1,2,7 1Department of Neuroanatomy, Juntendo University Graduate School of Medicine, 2Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 3Advanced Research Institute for Health Sciences, Juntendo University, 4Department of Neuroscience, Graduate School of Medicine, Kyoto University, 5Japan Society for the Promotion of Science, 6Department of Oral Anatomy and Neurobiology, Graduate School of Dentistry, Osaka University, 7Department of Multi-Scale Brain Structure Imaging, Juntendo University Graduate School of Medicine JoVE 63941 Neuroscience
