Massimo Negrini Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) University of Ferrara Biography Publications Institution JoVE Articles Massimo Negrini has not added a biography. If you are Massimo Negrini and would like to personalize this page please email our Author Liaison for assistance. Publications Dissecting Chronic Lymphocytic Leukemia with 13q- Using MicroRNA Expression Profile: Editorial for the Paper "MiRNA Expression Profile of Chronic Lymphocytic Leukemia Patients with 13q Deletion" Leukemia Research. May, 2016 | Pubmed ID: 27304710 Over-expression of the MiR-483-3p Overcomes the MiR-145/TP53 Pro-apoptotic Loop in Hepatocellular Carcinoma Oncotarget. Apr, 2016 | Pubmed ID: 27120784 MiRNA Array Screening Reveals Cooperative MGMT-regulation Between MiR-181d-5p and MiR-409-3p in Glioblastoma Oncotarget. Apr, 2016 | Pubmed ID: 27057640 MicroRNA Profiling of Primary Pulmonary Enteric Adenocarcinoma in Members from the Same Family Reveals Some Similarities to Pancreatic Adenocarcinoma-a Step Towards Personalized Therapy Clinical Epigenetics. 2015 | Pubmed ID: 26677401 Circulating MicroRNAs, MiR-939, MiR-595, MiR-519d and MiR-494, Identify Cirrhotic Patients with HCC PloS One. 2015 | Pubmed ID: 26509672 Prediction of Response to Anti-EGFR Antibody-based Therapies by Multigene Sequencing in Colorectal Cancer Patients BMC Cancer. 2015 | Pubmed ID: 26508446 MicroRNA Expression Profiling Identifies MiR-31-5p/3p As Associated with Time to Progression in Wild-type RAS Metastatic Colorectal Cancer Treated with Cetuximab Oncotarget. Nov, 2015 | Pubmed ID: 26497852 Interspecies Gene Name Extrapolation--A New Approach PloS One. 2015 | Pubmed ID: 26407293 Chromosome Aberrations Detected by Conventional Karyotyping Using Novel Mitogens in Chronic Lymphocytic Leukemia: Clinical and Biologic Correlations Genes, Chromosomes & Cancer. Dec, 2015 | Pubmed ID: 26355802 Micromarkers 2.0: an Update on the Role of MicroRNAs in Cancer Diagnosis and Prognosis Expert Review of Molecular Diagnostics. 2015 | Pubmed ID: 26338209 Epstein-Barr Virus MicroRNAs Are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival EBioMedicine. Jun, 2015 | Pubmed ID: 26288818 Diagnostic and Prognostic MicroRNAs in the Serum of Breast Cancer Patients Measured by Droplet Digital PCR Biomarker Research. 2015 | Pubmed ID: 26120471 MiR-181b As a Therapeutic Agent for Chronic Lymphocytic Leukemia in the Eµ-TCL1 Mouse Model Oncotarget. Aug, 2015 | Pubmed ID: 26090867 Absolute Quantification of Cell-free MicroRNAs in Cancer Patients Oncotarget. Jun, 2015 | Pubmed ID: 26036630 Association Between Gene and MiRNA Expression Profiles and Stereotyped Subset #4 B-cell Receptor in Chronic Lymphocytic Leukemia Leukemia & Lymphoma. 2015 | Pubmed ID: 25860243 Increase of MicroRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins Following Mithramycin Treatment of Human Erythroid Cells PloS One. 2015 | Pubmed ID: 25849663 Mesenchymal Progenitors Aging Highlights a MiR-196 Switch Targeting HOXB7 As Master Regulator of Proliferation and Osteogenesis Stem Cells (Dayton, Ohio). Mar, 2015 | Pubmed ID: 25428821 Gene Expression Changes in Progression of Cervical Neoplasia Revealed by Microarray Analysis of Cervical Neoplastic Keratinocytes Journal of Cellular Physiology. Apr, 2015 | Pubmed ID: 25205602 Quantification of Circulating MiRNAs by Droplet Digital PCR: Comparison of EvaGreen- and TaqMan-based Chemistries Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Dec, 2014 | Pubmed ID: 25472671 Inhibiting the Oncogenic Mir-221 by MicroRNA Sponge: Toward MicroRNA-based Therapeutics for Hepatocellular Carcinoma Gastroenterology and Hepatology from Bed to Bench. 2014 | Pubmed ID: 25436097 Pluripotent Stem Cell MiRNAs and Metastasis in Invasive Breast Cancer Journal of the National Cancer Institute. Dec, 2014 | Pubmed ID: 25306216 OncomiR Detection in Circulating Body Fluids: a PDMS Microdevice Perspective Lab on a Chip. Oct, 2014 | Pubmed ID: 25178053 MicroRNAome Expression in Chronic Lymphocytic Leukemia: Comparison with Normal B-cell Subsets and Correlations with Prognostic and Clinical Parameters Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2014 | Pubmed ID: 24916701 Modern Treatment in Chronic Lymphocytic Leukemia: Impact on Survival and Efficacy in High-risk Subgroups Cancer Medicine. Jun, 2014 | Pubmed ID: 24648042 Genetic Subclonal Complexity and MiR125a-5p Down-regulation Identify a Subset of Patients with Inferior Outcome in Low-risk CLL Patients Oncotarget. Jan, 2014 | Pubmed ID: 24334759 P53/mdm2 Feedback Loop Sustains MiR-221 Expression and Dictates the Response to Anticancer Treatments in Hepatocellular Carcinoma Molecular Cancer Research : MCR. Feb, 2014 | Pubmed ID: 24324033 STAT3-mediated Activation of MicroRNA Cluster 17~92 Promotes Proliferation and Survival of ALK-positive Anaplastic Large Cell Lymphoma Haematologica. Jan, 2014 | Pubmed ID: 23975180 MiR-125b Targets Erythropoietin and Its Receptor and Their Expression Correlates with Metastatic Potential and ERBB2/HER2 Expression Molecular Cancer. 2013 | Pubmed ID: 24165569 Anti-tumor Activity of a MiR-199-dependent Oncolytic Adenovirus PloS One. 2013 | Pubmed ID: 24069256 First Report of Circulating MicroRNAs in Tumour Necrosis Factor Receptor-associated Periodic Syndrome (TRAPS) PloS One. 2013 | Pubmed ID: 24066048 Role of MicroRNAs in Hepatocellular Carcinoma: a Clinical Perspective OncoTargets and Therapy. 2013 | Pubmed ID: 24039437 Clinical Monoclonal B Lymphocytosis Versus Rai 0 Chronic Lymphocytic Leukemia: A Comparison of Cellular, Cytogenetic, Molecular, and Clinical Features Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013 | Pubmed ID: 24036852 Small Nucleolar RNAs As New Biomarkers in Chronic Lymphocytic Leukemia BMC Medical Genomics. 2013 | Pubmed ID: 24004562 CCAT2, a Novel Non-coding RNA Mapping to 8q24, Underlies Metastatic Progression and Chromosomal Instability in Colon Cancer Genome Research. Jun, 2013 | Pubmed ID: 23796952 MiR-221 Affects Multiple Cancer Pathways by Modulating the Level of Hundreds Messenger RNAs Frontiers in Genetics. 2013 | Pubmed ID: 23630541 MiR-126&126* Restored Expressions Play a Tumor Suppressor Role by Directly Regulating ADAM9 and MMP7 in Melanoma PloS One. 2013 | Pubmed ID: 23437250 BCR/ABL1-positive Acute Lymphoblastic Leukemia Relapsing As BCR/ABL1-negative Acute Lymphoblastic Leukemia Leukemia & Lymphoma. Sep, 2013 | Pubmed ID: 23323950 Downregulation of the Mitochondrial Calcium Uniporter by Cancer-related MiR-25 Current Biology : CB. Jan, 2013 | Pubmed ID: 23246404 DNA-demethylating and Anti-tumor Activity of Synthetic MiR-29b Mimics in Multiple Myeloma Oncotarget. Oct, 2012 | Pubmed ID: 23100393 Synthetic MiR-34a Mimics As a Novel Therapeutic Agent for Multiple Myeloma: in Vitro and in Vivo Evidence Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2012 | Pubmed ID: 23035210 Liver Tumorigenicity Promoted by MicroRNA-221 in a Mouse Transgenic Model Hepatology (Baltimore, Md.). Sep, 2012 | Pubmed ID: 22473819 In Hepatocellular Carcinoma MiR-519d is Up-regulated by P53 and DNA Hypomethylation and Targets CDKN1A/p21, PTEN, AKT3 and TIMP2 The Journal of Pathology. Jul, 2012 | Pubmed ID: 22262409 Chromosome Aberrations Detected by Conventional Karyotyping Using Novel Mitogens in Chronic Lymphocytic Leukemia with "normal" FISH: Correlations with Clinicobiologic Parameters Blood. Mar, 2012 | Pubmed ID: 22246039 MINT31 Methylation in Gastric Noninvasive Neoplasia: Potential Role in the Secondary Prevention of Gastric Cancer European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP). Sep, 2012 | Pubmed ID: 22179688 MiR-34a Predicts Survival of Ewing's Sarcoma Patients and Directly Influences Cell Chemo-sensitivity and Malignancy The Journal of Pathology. Apr, 2012 | Pubmed ID: 21960059 MicroRNAs: Toward the Clinic for Breast Cancer Patients Seminars in Oncology. Dec, 2011 | Pubmed ID: 22082762 MicroRNA Profiling for the Identification of Cancers with Unknown Primary Tissue-of-origin The Journal of Pathology. Sep, 2011 | Pubmed ID: 21630269 MicroRNA Involvement in Hepatocellular Carcinoma Anti-cancer Agents in Medicinal Chemistry. Jul, 2011 | Pubmed ID: 21554203 MicroRNA Response to Environmental Mutagens in Liver Mutation Research. Dec, 2011 | Pubmed ID: 21514310 Mutated Beta-catenin Evades a MicroRNA-dependent Regulatory Loop Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21383185 MicroRNAs Dysregulation in Human Malignant Pleural Mesothelioma Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. May, 2011 | Pubmed ID: 21358347 Association of a MicroRNA/TP53 Feedback Circuitry with Pathogenesis and Outcome of B-cell Chronic Lymphocytic Leukemia JAMA. Jan, 2011 | Pubmed ID: 21205967 MicroRNA-mediated Regulation of Pancreatic Cancer Cell Proliferation Oncology Letters. May, 2010 | Pubmed ID: 22966344 Altered MiRNA Expression in T Regulatory Cells in Course of Multiple Sclerosis Journal of Neuroimmunology. Sep, 2010 | Pubmed ID: 20637509 MicroRNAs Involvement in Fludarabine Refractory Chronic Lymphocytic Leukemia Molecular Cancer. 2010 | Pubmed ID: 20504344 MiR-199a-3p Regulates MTOR and C-Met to Influence the Doxorubicin Sensitivity of Human Hepatocarcinoma Cells Cancer Research. Jun, 2010 | Pubmed ID: 20501828 Reprogramming of MiRNA Networks in Cancer and Leukemia Genome Research. May, 2010 | Pubmed ID: 20439436 MicroRNA Fingerprinting of CLL Patients with Chromosome 17p Deletion Identify a MiR-21 Score That Stratifies Early Survival Blood. Aug, 2010 | Pubmed ID: 20393129 Oncogenic Role of MiR-483-3p at the IGF2/483 Locus Cancer Research. Apr, 2010 | Pubmed ID: 20388800 Micromarkers: MiRNAs in Cancer Diagnosis and Prognosis Expert Review of Molecular Diagnostics. Apr, 2010 | Pubmed ID: 20370587 Modulation of Mismatch Repair and Genomic Stability by MiR-155 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20351277 Differential Cytogenomics and MiRNA Signature of the Acute Myeloid Leukaemia Kasumi-1 Cell Line CD34+38- Compartment Leukemia Research. Oct, 2010 | Pubmed ID: 20227111 Non-coding RNAs Change Their Expression Profile After Retinoid Induced Differentiation of the Promyelocytic Cell Line NB4 BMC Research Notes. 2010 | Pubmed ID: 20181027 Clinicobiologic Importance of Cytogenetic Lesions in Chronic Lymphocytic Leukemia Expert Review of Hematology. Jun, 2009 | Pubmed ID: 21082972 MicroRNA Fingerprints Identify MiR-150 As a Plasma Prognostic Marker in Patients with Sepsis PloS One. 2009 | Pubmed ID: 19823581 Karyotype-specific MicroRNA Signature in Chronic Lymphocytic Leukemia Blood. Oct, 2009 | Pubmed ID: 19717645 MicroRNA-221 Targets Bmf in Hepatocellular Carcinoma and Correlates with Tumor Multifocality Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2009 | Pubmed ID: 19671867 MiR-122/cyclin G1 Interaction Modulates P53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells Cancer Research. Jul, 2009 | Pubmed ID: 19584283 MicroRNAs and Cancer--new Paradigms in Molecular Oncology Current Opinion in Cell Biology. Jun, 2009 | Pubmed ID: 19411171 MicroRNA Expression Changes During Human Leukemic HL-60 Cell Differentiation Induced by 4-hydroxynonenal, a Product of Lipid Peroxidation Free Radical Biology & Medicine. Jan, 2009 | Pubmed ID: 19022373 MicroRNA Involvement in Hepatocellular Carcinoma Journal of Cellular and Molecular Medicine. Dec, 2008 | Pubmed ID: 19120703 Genome Wide Identification of Recessive Cancer Genes by Combinatorial Mutation Analysis PloS One. 2008 | Pubmed ID: 18846217 Isolation and Characterization of CD146+ Multipotent Mesenchymal Stromal Cells Experimental Hematology. Aug, 2008 | Pubmed ID: 18504067 Breast Cancer Metastasis: a MicroRNA Story Breast Cancer Research : BCR. 2008 | Pubmed ID: 18373886 MiR-15a and MiR-16-1 Cluster Functions in Human Leukemia Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18362358 E2F1-regulated MicroRNAs Impair TGFbeta-dependent Cell-cycle Arrest and Apoptosis in Gastric Cancer Cancer Cell. Mar, 2008 | Pubmed ID: 18328430 Micro-RNA Profiling in Kidney and Bladder Cancers Urologic Oncology. Sep-Oct, 2007 | Pubmed ID: 17826655 Ultraconserved Regions Encoding NcRNAs Are Altered in Human Leukemias and Carcinomas Cancer Cell. Sep, 2007 | Pubmed ID: 17785203 MRNA/microRNA Gene Expression Profile in Microsatellite Unstable Colorectal Cancer Molecular Cancer. 2007 | Pubmed ID: 17716371 Tumor Suppressor Functions of ARLTS1 in Lung Cancers Cancer Research. Aug, 2007 | Pubmed ID: 17699778 Regulatory Mechanisms of MicroRNAs Involvement in Cancer Expert Opinion on Biological Therapy. Jul, 2007 | Pubmed ID: 17665990 Cyclin G1 is a Target of MiR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma Cancer Research. Jul, 2007 | Pubmed ID: 17616664 Regulation of MicroRNA Expression: the Hypoxic Component Cell Cycle (Georgetown, Tex.). Jun, 2007 | Pubmed ID: 17582223 MicroRNAs in Human Cancer: from Research to Therapy Journal of Cell Science. Jun, 2007 | Pubmed ID: 17515481 Nidogen 1 and 2 Gene Promoters Are Aberrantly Methylated in Human Gastrointestinal Cancer Molecular Cancer. 2007 | Pubmed ID: 17328794 A MicroRNA Signature of Hypoxia Molecular and Cellular Biology. Mar, 2007 | Pubmed ID: 17194750 Mechanisms Causing Imprinting Defects in Familial Beckwith-Wiedemann Syndrome with Wilms' Tumour Human Molecular Genetics. Feb, 2007 | Pubmed ID: 17158821 Identification of Differentially Expressed MicroRNAs by Microarray: a Possible Role for MicroRNA Genes in Pituitary Adenomas Journal of Cellular Physiology. Feb, 2007 | Pubmed ID: 17111382 Alterations of the Tumor Suppressor Gene ARLTS1 in Ovarian Cancer Cancer Research. Nov, 2006 | Pubmed ID: 17079447 BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors Advances in Experimental Medicine and Biology. 2006 | Pubmed ID: 16626046 A MicroRNA Expression Signature of Human Solid Tumors Defines Cancer Gene Targets Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16461460 Identification of NUP98 Abnormalities in Acute Leukemia: JARID1A (12p13) As a New Partner Gene Genes, Chromosomes & Cancer. May, 2006 | Pubmed ID: 16419055 Neoplastic Circulating Endothelial Cells in Multiple Myeloma with 13q14 Deletion Blood. Mar, 2006 | Pubmed ID: 16317105 A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia The New England Journal of Medicine. Oct, 2005 | Pubmed ID: 16251535 MiR-15 and MiR-16 Induce Apoptosis by Targeting BCL2 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16166262 MicroRNA Gene Expression Deregulation in Human Breast Cancer Cancer Research. Aug, 2005 | Pubmed ID: 16103053 Familial Cancer Associated with a Polymorphism in ARLTS1 The New England Journal of Medicine. Apr, 2005 | Pubmed ID: 15843669 Adenoviral Transduction of TESTIN Gene into Breast and Uterine Cancer Cell Lines Promotes Apoptosis and Tumor Reduction in Vivo Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2005 | Pubmed ID: 15701871 Frequent Aberrant Methylation of the CDH4 Gene Promoter in Human Colorectal and Gastric Cancer Cancer Research. Nov, 2004 | Pubmed ID: 15548679 Cryptic Insertion Producing Two NUP98/NSD1 Chimeric Transcripts in Adult Refractory Anemia with an Excess of Blasts Genes, Chromosomes & Cancer. Dec, 2004 | Pubmed ID: 15382262 MicroRNA Profiling Reveals Distinct Signatures in B Cell Chronic Lymphocytic Leukemias Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15284443 An Oligonucleotide Microchip for Genome-wide MicroRNA Profiling in Human and Mouse Tissues Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15210942 Simian Virus 40 Infection in Humans and Association with Human Diseases: Results and Hypotheses Virology. Jan, 2004 | Pubmed ID: 15015494 Human MicroRNA Genes Are Frequently Located at Fragile Sites and Genomic Regions Involved in Cancers Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14973191 Multigene Methylation Analysis of Gastrointestinal Tumors: TPEF Emerges As a Frequent Tumor-specific Aberrantly Methylated Marker That Can Be Detected in Peripheral Blood Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology. 2003 | Pubmed ID: 15068392 The BCSC-1 Locus at Chromosome 11q23-q24 is a Candidate Tumor Suppressor Gene Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 14504409 Oncogenic Transformation by BK Virus and Association with Human Tumors Oncogene. Aug, 2003 | Pubmed ID: 12910256 Human Homeobox Gene HOXC13 is the Partner of NUP98 in Adult Acute Myeloid Leukemia with T(11;12)(p15;q13) Genes, Chromosomes & Cancer. Apr, 2003 | Pubmed ID: 12619167 Genetic Chaos and Antichaos in Human Cancers Medical Hypotheses. Feb, 2003 | Pubmed ID: 12606244 Frequent Deletions and Down-regulation of Micro- RNA Genes MiR15 and MiR16 at 13q14 in Chronic Lymphocytic Leukemia Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12434020 Cloning and Characterization of the Common Fragile Site FRA6F Harboring a Replicative Senescence Gene and Frequently Deleted in Human Tumors Oncogene. Oct, 2002 | Pubmed ID: 12370818 NUP98 is Fused to the NSD3 Gene in Acute Myeloid Leukemia Associated with T(8;11)(p11.2;p15) Blood. May, 2002 | Pubmed ID: 11986249 Loss of Methylation at Chromosome 11p15.5 is Common in Human Adult Tumors Oncogene. Apr, 2002 | Pubmed ID: 11971191 Late Appearance of the 11q22.3-23.1 Deletion Involving the ATM Locus in B-cell Chronic Lymphocytic Leukemia and Related Disorders. Clinico-biological Significance Haematologica. Jan, 2002 | Pubmed ID: 11801464 تعميم الرنا الميكروي الكمي باستخدام الحمض النووي ملزم صبغ الكيمياء والقطرة PCR الرقمية Manuela Ferracin1, Irene Salamon2, Laura Lupini2, Elena Miotto2, Silvia Sabbioni3, Massimo Negrini4 1Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, 2Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 3Department of Life Sciences and Biotechnology, University of Ferrara, 4Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara Bioengineering
تعميم الرنا الميكروي الكمي باستخدام الحمض النووي ملزم صبغ الكيمياء والقطرة PCR الرقمية Manuela Ferracin1, Irene Salamon2, Laura Lupini2, Elena Miotto2, Silvia Sabbioni3, Massimo Negrini4 1Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, 2Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 3Department of Life Sciences and Biotechnology, University of Ferrara, 4Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara Bioengineering
