Megumu K. Saito Department of Clinical Application, Center for iPS Cell Research and Application (CiRA) Kyoto University Biography Publications Institution JoVE Articles Megumu K. Saito has not added a biography. If you are Megumu K. Saito and would like to personalize this page please email our Author Liaison for assistance. Publications IPSCs Established from a Female Patient with Xq22 Deletion Confirm That BEX2 Escapes from X-chromosome Inactivation Congenital Anomalies. Nov, 2020 | Pubmed ID: 33244819 Pluripotent Stem Cell Model of Shwachman-Diamond Syndrome Reveals Apoptotic Predisposition of Hemoangiogenic Progenitors Scientific Reports. 09, 2020 | Pubmed ID: 32908229 Induced Pluripotent Stem Cell-derived Monocytic Cell Lines from a NOMID Patient Serve As a Screening Platform for Modulating NLRP3 Inflammasome Activity PloS One. 2020 | Pubmed ID: 32810141 Clinical Characteristics and Treatment of 50 Cases of Blau Syndrome in Japan Confirmed by Genetic Analysis of the Mutation Annals of the Rheumatic Diseases. 11, 2020 | Pubmed ID: 32647028 Blau Syndrome: NOD2-related Systemic Autoinflammatory Granulomatosis Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia. Jul, 2020 | Pubmed ID: 32618442 Biomimetic Aorta-gonad-Mesonephros-on-a-Chip to Study Human Developmental Hematopoiesis Biomedical Microdevices. 05, 2020 | Pubmed ID: 32377802 Down Syndrome-related Transient Abnormal Myelopoiesis is Attributed to a Specific Erythro-megakaryocytic Subpopulation with GATA1 Mutation Haematologica. Apr, 2020 | Pubmed ID: 32354872 Recapitulating the Human Segmentation Clock with Pluripotent Stem Cells Nature. 04, 2020 | Pubmed ID: 32238941 Genome-wide Microhomologies Enable Precise Template-free Editing of Biologically Relevant Deletion Mutations Nature Communications. 10, 2019 | Pubmed ID: 31649251 Functional Evaluation of the Pathological Significance of MEFV Variants Using Induced Pluripotent Stem Cell-derived Macrophages The Journal of Allergy and Clinical Immunology. 11, 2019 | Pubmed ID: 31542286 IPSC-derived Functional Human Neuromuscular Junctions Model the Pathophysiology of Neuromuscular Diseases JCI Insight. 09, 2019 | Pubmed ID: 31534050 Induced Pluripotent Stem Cells Representing Nakajo-Nishimura Syndrome Inflammation and Regeneration. 2019 | Pubmed ID: 31143302 Beneficial Effect of Methotrexate on a Child Case of Nakajo-Nishimura Syndrome The Journal of Dermatology. 10, 2019 | Pubmed ID: 31058345 Induction of Human Pluripotent Stem Cell-derived Natural Killer Cells for Immunotherapy Under Chemically Defined Conditions Biochemical and Biophysical Research Communications. Jul, 2019 | Pubmed ID: 30948156 Generation of a Human Induced Pluripotent Stem Cell Line, BRCi001-A, Derived from a Patient with Mucopolysaccharidosis Type I Stem Cell Research. 04, 2019 | Pubmed ID: 30849633 Verification and Rectification of Cell Type-specific Splicing of a Seckel Syndrome-associated ATR Mutation Using IPS Cell Model Journal of Human Genetics. May, 2019 | Pubmed ID: 30846821 Application of Induced Pluripotent Stem Cells to Primary Immunodeficiency Diseases Experimental Hematology. 03, 2019 | Pubmed ID: 30664903 Rescue of Recurrent Deep Intronic Mutation Underlying Cell Type-dependent Quantitative NEMO Deficiency The Journal of Clinical Investigation. 02, 2019 | Pubmed ID: 30422821 Disease Modeling of Immunological Disorders Using Induced Pluripotent Stem Cells Immunological Medicine. Jun, 2018 | Pubmed ID: 30618339 Efficient Derivation of Sympathetic Neurons from Human Pluripotent Stem Cells with a Defined Condition Scientific Reports. Aug, 2018 | Pubmed ID: 30150715 Lysosomal Membrane Permeabilization Causes Secretion of IL-1β in Human Vascular Smooth Muscle Cells Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. Oct, 2018 | Pubmed ID: 30136196 Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress Stem Cell Reports. 06, 2018 | Pubmed ID: 29731430 Human AK2 Links Intracellular Bioenergetic Redistribution to the Fate of Hematopoietic Progenitors Biochemical and Biophysical Research Communications. 03, 2018 | Pubmed ID: 29462620 Pluripotent Stem Cell Models of Blau Syndrome Reveal an IFN-γ-dependent Inflammatory Response in Macrophages The Journal of Allergy and Clinical Immunology. 01, 2018 | Pubmed ID: 28587749 Human Pluripotent Stem Cell-derived Erythropoietin-producing Cells Ameliorate Renal Anemia in Mice Science Translational Medicine. Sep, 2017 | Pubmed ID: 28954928 Microarray Analyses of Otospheres Derived from the Cochlea in the Inner Ear Identify Putative Transcription Factors That Regulate the Characteristics of Otospheres PloS One. 2017 | Pubmed ID: 28662075 Hypoxic Adaptation of Leukemic Cells Infiltrating the CNS Affords a Therapeutic Strategy Targeting VEGFA Blood. 06, 2017 | Pubmed ID: 28424164 Identification of a High-Frequency Somatic NLRC4 Mutation As a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection Arthritis & Rheumatology (Hoboken, N.J.). 02, 2017 | Pubmed ID: 27788288 Laminin-guided Highly Efficient Endothelial Commitment from Human Pluripotent Stem Cells Scientific Reports. 11, 2016 | Pubmed ID: 27804979 A Portable Platform for Stepwise Hematopoiesis from Human Pluripotent Stem Cells Within PET-reinforced Collagen Sponges International Journal of Hematology. Dec, 2016 | Pubmed ID: 27599982 Mislocalization of Syntaxin-1 and Impaired Neurite Growth Observed in a Human IPSC Model for STXBP1-related Epileptic Encephalopathy Epilepsia. Apr, 2016 | Pubmed ID: 26918652 Establishment of Isogenic IPSCs from an Individual with SCN1A Mutation Mosaicism As a Model for Investigating Neurocognitive Impairment in Dravet Syndrome Journal of Human Genetics. Jun, 2016 | Pubmed ID: 26841829 GSK3β Inhibition Activates the CDX/HOX Pathway and Promotes Hemogenic Endothelial Progenitor Differentiation from Human Pluripotent Stem Cells Experimental Hematology. Jan, 2016 | Pubmed ID: 26477526 Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-derived IPSCs Stem Cell Reports. Apr, 2015 | Pubmed ID: 25801509 Pluripotent Cell Models of Fanconi Anemia Identify the Early Pathological Defect in Human Hemoangiogenic Progenitors Stem Cells Translational Medicine. Apr, 2015 | Pubmed ID: 25762002 Enhanced Chondrogenesis of Induced Pluripotent Stem Cells from Patients with Neonatal-onset Multisystem Inflammatory Disease Occurs Via the Caspase 1-independent CAMP/protein Kinase A/CREB Pathway Arthritis & Rheumatology (Hoboken, N.J.). Jan, 2015 | Pubmed ID: 25302486 Somatic NLRP3 Mosaicism in Muckle-Wells Syndrome. A Genetic Mechanism Shared by Different Phenotypes of Cryopyrin-associated Periodic Syndromes Annals of the Rheumatic Diseases. Mar, 2015 | Pubmed ID: 24326009 Genetic Correction of HAX1 in Induced Pluripotent Stem Cells from a Patient with Severe Congenital Neutropenia Improves Defective Granulopoiesis Haematologica. Jan, 2014 | Pubmed ID: 23975175 Robust and Highly-efficient Differentiation of Functional Monocytic Cells from Human Pluripotent Stem Cells Under Serum- and Feeder Cell-free Conditions PloS One. 2013 | Pubmed ID: 23573196 Induced Pluripotent Stem Cells from CINCA Syndrome Patients As a Model for Dissecting Somatic Mosaicism and Drug Discovery Blood. Aug, 2012 | Pubmed ID: 22723549 Detection of Base Substitution-Type Somatic Mosaicism of the NLRP3 Gene with >99.9% Statistical Confidence by Massively Parallel Sequencing DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes. Jan, 2012 | Pubmed ID: 22279087 Identification of Hepatic Niche Harboring Human Acute Lymphoblastic Leukemic Cells Via the SDF-1/CXCR4 Axis PloS One. 2011 | Pubmed ID: 22069486 [CAPS: Cryopyrin-associated Periodic Syndrome] Nihon Rinsho Men'eki Gakkai Kaishi = Japanese Journal of Clinical Immunology. 2011 | Pubmed ID: 22041424 A Novel Serum-free Monolayer Culture for Orderly Hematopoietic Differentiation of Human Pluripotent Cells Via Mesodermal Progenitors PloS One. 2011 | Pubmed ID: 21818303 High Incidence of NLRP3 Somatic Mosaicism in Patients with Chronic Infantile Neurologic, Cutaneous, Articular Syndrome: Results of an International Multicenter Collaborative Study Arthritis and Rheumatism. Nov, 2011 | Pubmed ID: 21702021 [Inflammasomes and Related Diseases] Nihon Rinsho Men'eki Gakkai Kaishi = Japanese Journal of Clinical Immunology. 2011 | Pubmed ID: 21372510 In vitro Neuromuscular Junction Induced from Human Induced Pluripotent Stem Cells Chuang-Yu Lin1, Michiko Yoshida1,2, Li-Tzu Li3, Megumu K. Saito1 1Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, 2Department of Pediatrics, Kyoto Prefectural University of Medicine, 3Graduate Institute of Clinical Medicine, Taipei Medical University JoVE 61396 Developmental Biology Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition Ryo Ohta*1, Ryohichi Sugimura*1, Akira Niwa1, Megumu K. Saito1 1Center for iPS cell research and application (CiRA) JoVE 59823 Developmental Biology
In vitro Neuromuscular Junction Induced from Human Induced Pluripotent Stem Cells Chuang-Yu Lin1, Michiko Yoshida1,2, Li-Tzu Li3, Megumu K. Saito1 1Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, 2Department of Pediatrics, Kyoto Prefectural University of Medicine, 3Graduate Institute of Clinical Medicine, Taipei Medical University JoVE 61396 Developmental Biology
Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition Ryo Ohta*1, Ryohichi Sugimura*1, Akira Niwa1, Megumu K. Saito1 1Center for iPS cell research and application (CiRA) JoVE 59823 Developmental Biology
