Michael T. Lewis

Publications

• Landscape Analysis of Adjacent Gene Rearrangements Reveals BCL2L14-ETV6 Gene Fusions in More Aggressive Triple-negative Breast Cancer
  Proceedings of the National Academy of Sciences of the United States of America. May, 2020  |   Pubmed ID: 32321829
• A CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer
  Journal of Clinical Medicine. 10, 2019  |   Pubmed ID: 31652963
• The Altered Transcriptome and DNA Methylation Profiles of Docetaxel Resistance in Breast Cancer PDX Models
  Molecular Cancer Research : MCR. 10, 2019  |   Pubmed ID: 31320385
• S100a4-Cre-mediated Deletion of Patched1 Causes Hypogonadotropic Hypogonadism: Role of Pituitary Hematopoietic Cells in Endocrine Regulation
  JCI Insight. Jul, 2019  |   Pubmed ID: 31265437
• Chromosome 12p Amplification in Triple-Negative/Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity
  Cancer Research. 08, 2019  |   Pubmed ID: 31213465
• Circulating Tumor Cell Investigation in Breast Cancer Patient-derived Xenograft Models by Automated Immunofluorescence Staining, Image Acquisition, and Single Cell Retrieval and Analysis
  BMC Cancer. Mar, 2019  |   Pubmed ID: 30871481
• Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes
  Cancer Research. 01, 2019  |   Pubmed ID: 30401712
• C/EBPδ Links IL-6 and HIF-1 Signaling to Promote Breast Cancer Stem Cell-associated Phenotypes
  Oncogene. 05, 2019  |   Pubmed ID: 30262865
• Publisher Correction: EMT Cells Increase Breast Cancer Metastasis Via Paracrine GLI Activation in Neighbouring Tumour Cells
  Nature Communications. 11, 2018  |   Pubmed ID: 30420638
• Differentiation-state Plasticity is a Targetable Resistance Mechanism in Basal-like Breast Cancer
  Nature Communications. 09, 2018  |   Pubmed ID: 30232459
• The Chick Chorioallantoic Membrane (CAM) As a Versatile Patient-derived Xenograft (PDX) Platform for Precision Medicine and Preclinical Research
  American Journal of Cancer Research. 2018  |   Pubmed ID: 30210932
• GpGrouper: A Peptide Grouping Algorithm for Gene-Centric Inference and Quantitation of Bottom-Up Proteomics Data
  Molecular & Cellular Proteomics : MCP. 11, 2018  |   Pubmed ID: 30093420
• Combinatorial Inhibition of PTPN12-regulated Receptors Leads to a Broadly Effective Therapeutic Strategy in Triple-negative Breast Cancer
  Nature Medicine. 05, 2018  |   Pubmed ID: 29578538
• Pharmacological Targeting of MYC-regulated IRE1/XBP1 Pathway Suppresses MYC-driven Breast Cancer
  The Journal of Clinical Investigation. 04, 2018  |   Pubmed ID: 29480818
• TEM8/ANTXR1-Specific CAR T Cells As a Targeted Therapy for Triple-Negative Breast Cancer
  Cancer Research. 01, 2018  |   Pubmed ID: 29183891
• PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
  Cancer Research. 11, 2017  |   Pubmed ID: 29092942
• New Paradigms for the Hedgehog Signaling Network in Mammary Gland Development and Breast Cancer
  Biochimica Et Biophysica Acta. Reviews on Cancer. Aug, 2017  |   Pubmed ID: 28624497
• EMT Cells Increase Breast Cancer Metastasis Via Paracrine GLI Activation in Neighbouring Tumour Cells
  Nature Communications. 06, 2017  |   Pubmed ID: 28604738
• Carbon Nanotube Capsules Enhance the in Vivo Efficacy of Cisplatin
  Acta Biomaterialia. 08, 2017  |   Pubmed ID: 28465075
• Mutual Regulation of Tumour Vessel Normalization and Immunostimulatory Reprogramming
  Nature. 04, 2017  |   Pubmed ID: 28371798
• Epithelial and Non-epithelial Play Opposing Roles to Regulate Proliferation and Morphogenesis of the Mouse Mammary Gland
  Development (Cambridge, England). 04, 2017  |   Pubmed ID: 28275010
• The Terminal End Bud: the Little Engine That Could
  Journal of Mammary Gland Biology and Neoplasia. 06, 2017  |   Pubmed ID: 28168376
• Patient-derived Xenograft (PDX) Models in Basic and Translational Breast Cancer Research
  Cancer Metastasis Reviews. 12, 2016  |   Pubmed ID: 28025748
• The Pursuit of Truth in the Company of Friends : In Memorium: Charles W. Daniel
  Journal of Mammary Gland Biology and Neoplasia. 12, 2016  |   Pubmed ID: 27889858
• Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 Through Poly-ubiquitination
  PLoS Genetics. 05, 2016  |   Pubmed ID: 27195754
• Oncogenic MTOR Signalling Recruits Myeloid-derived Suppressor Cells to Promote Tumour Initiation
  Nature Cell Biology. Jun, 2016  |   Pubmed ID: 27183469
• A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics Within the Terminal End Bud
  PLoS Computational Biology. Apr, 2016  |   Pubmed ID: 27115287
• Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer
  Cell Reports. Mar, 2016  |   Pubmed ID: 26923594
• An Essential Role for Gα(i2) in Smoothened-stimulated Epithelial Cell Proliferation in the Mammary Gland
  Science Signaling. Sep, 2015  |   Pubmed ID: 26373672
• Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion Via JAK2 Activation
  Cell Reports. Jul, 2015  |   Pubmed ID: 26166574
• Identifying and Targeting Tumor-initiating Cells in the Treatment of Breast Cancer
  Endocrine-related Cancer. Jun, 2015  |   Pubmed ID: 25876646
• Patient-derived Xenograft Models of Breast Cancer and Their Predictive Power
  Breast Cancer Research : BCR. Feb, 2015  |   Pubmed ID: 25849559
• Circulating and Disseminated Tumor Cells from Breast Cancer Patient-derived Xenograft-bearing Mice As a Novel Model to Study Metastasis
  Breast Cancer Research : BCR. 2015  |   Pubmed ID: 25572662
• Drug-repositioning Screening Identified Piperlongumine As a Direct STAT3 Inhibitor with Potent Activity Against Breast Cancer
  Oncogene. Mar, 2015  |   Pubmed ID: 24681959
• STAT3 Signaling is Activated Preferentially in Tumor-initiating Cells in Claudin-low Models of Human Breast Cancer
  Stem Cells (Dayton, Ohio). Oct, 2014  |   Pubmed ID: 24891218
• Wnt-responsive Cancer Stem Cells Are Located Close to Distorted Blood Vessels and Not in Hypoxic Regions in a P53-null Mouse Model of Human Breast Cancer
  Stem Cells Translational Medicine. Jul, 2014  |   Pubmed ID: 24797826
• Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy
  Journal of Biomolecular Screening. Jul, 2014  |   Pubmed ID: 24525869
• A Dosage-dependent Pleiotropic Role of Dicer in Prostate Cancer Growth and Metastasis
  Oncogene. Jun, 2014  |   Pubmed ID: 23851498
• Establishment of Patient-Derived Xenograft (PDX) Models of Human Breast Cancer
  Current Protocols in Mouse Biology. Mar, 2013  |   Pubmed ID: 26069021
• Three-dimensional Vasculature Reconstruction of Tumour Microenvironment Via Local Clustering and Classification
  Interface Focus. Aug, 2013  |   Pubmed ID: 24511379
• Cancer Stem Cell Markers Are Enriched in Normal Tissue Adjacent to Triple Negative Breast Cancer and Inversely Correlated with DNA Repair Deficiency
  Breast Cancer Research : BCR. 2013  |   Pubmed ID: 24008095
• A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-derived Human Breast Cancer Xenograft Models
  Cancer Research. Aug, 2013  |   Pubmed ID: 23737486
• Paracrine Wnt Signaling Both Promotes and Inhibits Human Breast Tumor Growth
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013  |   Pubmed ID: 23559372
• Separation by Cell Size Enriches for Mammary Stem Cell Repopulation Activity
  Stem Cells Translational Medicine. Mar, 2013  |   Pubmed ID: 23408103
• Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-initiating Cells and Improves Recurrence Free Survival in a Human-xenograft Model
  PloS One. 2012  |   Pubmed ID: 22879872
• A Mystery Wrapped in an Enigma: Matrigel Enhancement of Mammary Cell Growth and Morphogenesis
  Journal of Mammary Gland Biology and Neoplasia. Jun, 2012  |   Pubmed ID: 22581302
• Cisplatin@US-tube Carbon Nanocapsules for Enhanced Chemotherapeutic Delivery
  Biomaterials. Feb, 2012  |   Pubmed ID: 22078812
• Integrative Physical Oncology
  Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Jan-Feb, 2012  |   Pubmed ID: 21853537
• ID4 Regulates Mammary Gland Development by Suppressing P38MAPK Activity
  Development (Cambridge, England). Dec, 2011  |   Pubmed ID: 22069192
• Dicer-mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2011  |   Pubmed ID: 21878538
• Altered Differentiation and Paracrine Stimulation of Mammary Epithelial Cell Proliferation by Conditionally Activated Smoothened
  Developmental Biology. Apr, 2011  |   Pubmed ID: 21276786
• High IGF-IR Activity in Triple-negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2011  |   Pubmed ID: 21177763
• Cancer Stem Cell, Niche and EGFR Decide Tumor Development and Treatment Response: A Bio-computational Simulation Study
  Journal of Theoretical Biology. Jan, 2011  |   Pubmed ID: 20969880
• Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-cadherin in Normal and Malignant Breast Cells
  PloS One. 2010  |   Pubmed ID: 20808935
• Characterizing Cancer Cells with Cancer Stem Cell-like Features in 293T Human Embryonic Kidney Cells
  Molecular Cancer. Jul, 2010  |   Pubmed ID: 20615238
• Hedgehog Signaling in the Normal and Neoplastic Mammary Gland
  Current Drug Targets. Sep, 2010  |   Pubmed ID: 20545610
• Activation of Erk by Sonic Hedgehog Independent of Canonical Hedgehog Signalling
  The International Journal of Biochemistry & Cell Biology. Sep, 2010  |   Pubmed ID: 20451654
• Constitutive Activation of Smoothened Leads to Female Infertility and Altered Uterine Differentiation in the Mouse
  Biology of Reproduction. May, 2010  |   Pubmed ID: 20130264
• Androgen Receptor Overexpression Induces Tamoxifen Resistance in Human Breast Cancer Cells
  Breast Cancer Research and Treatment. May, 2010  |   Pubmed ID: 19533338
• Decreased TGFbeta Signaling and Increased COX2 Expression in High Risk Women with Increased Mammographic Breast Density
  Breast Cancer Research and Treatment. Jan, 2010  |   Pubmed ID: 19241157
• Methods in Mammary Gland Biology and Breast Cancer Research: an Update
  Journal of Mammary Gland Biology and Neoplasia. Dec, 2009  |   Pubmed ID: 19949842
• Methods for Preparing Fluorescent and Neutral Red-stained Whole Mounts of Mouse Mammary Glands
  Journal of Mammary Gland Biology and Neoplasia. Dec, 2009  |   Pubmed ID: 19936989
• Residual Breast Cancers After Conventional Therapy Display Mesenchymal As Well As Tumor-initiating Features
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009  |   Pubmed ID: 19666588
• Pygo2 Expands Mammary Progenitor Cells by Facilitating Histone H3 K4 Methylation
  The Journal of Cell Biology. Jun, 2009  |   Pubmed ID: 19487454
• Ptch1 is Required Locally for Mammary Gland Morphogenesis and Systemically for Ductal Elongation
  Development (Cambridge, England). May, 2009  |   Pubmed ID: 19297414
• Scaffold Attachment Factor B1 (SAFB1) Heterozygosity Does Not Influence Wnt-1 or DMBA-induced Tumorigenesis
  Molecular Cancer. Mar, 2009  |   Pubmed ID: 19267898
• Cyclopamine Inhibition of Human Breast Cancer Cell Growth Independent of Smoothened (Smo)
  Breast Cancer Research and Treatment. Jun, 2009  |   Pubmed ID: 18563554
• Faith, Heresy and the Cancer Stem Cell Hypothesis
  Future Oncology (London, England). Oct, 2008  |   Pubmed ID: 18922113
• Evidence That an Early Pregnancy Causes a Persistent Decrease in the Number of Functional Mammary Epithelial Stem Cells--implications for Pregnancy-induced Protection Against Breast Cancer
  Stem Cells (Dayton, Ohio). Dec, 2008  |   Pubmed ID: 18787212
• Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
  Journal of the National Cancer Institute. May, 2008  |   Pubmed ID: 18445819
• Constitutively Active Type I Insulin-like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and is Accompanied by an Epithelial-to-mesenchymal Transition Mediated by NF-kappaB and Snail
  Molecular and Cellular Biology. Apr, 2007  |   Pubmed ID: 17296734
• Constitutive Activation of Smoothened (SMO) in Mammary Glands of Transgenic Mice Leads to Increased Proliferation, Altered Differentiation and Ductal Dysplasia
  Development (Cambridge, England). Mar, 2007  |   Pubmed ID: 17287253
• The Hedgehog Signaling Network, Mammary Stem Cells, and Breast Cancer: Connections and Controversies
  Ernst Schering Foundation Symposium Proceedings. 2006  |   Pubmed ID: 17939302
• Introduction of Oncogenes into Mammary Glands in Vivo with an Avian Retroviral Vector Initiates and Promotes Carcinogenesis in Mouse Models
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006  |   Pubmed ID: 17090666
• Patterns of Resistance and Incomplete Response to Docetaxel by Gene Expression Profiling in Breast Cancer Patients
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2005  |   Pubmed ID: 15718313
• Next Stop, the Twilight Zone: Hedgehog Network Regulation of Mammary Gland Development
  Journal of Mammary Gland Biology and Neoplasia. Apr, 2004  |   Pubmed ID: 15300011