Michael F. Olson The Beatson Institute for Cancer Research Biography Publications Institution JoVE Articles Michael F. Olson has not added a biography. If you are Michael F. Olson and would like to personalize this page please email our Author Liaison for assistance. Publications Targeting Rho GTPase Signaling for Cancer Therapy Future Oncology (London, England). Feb, 2012 | Pubmed ID: 22335581 The Development of a Rat in Vitro Model of Spinal Cord Injury Demonstrating the Additive Effects of Rho and ROCK Inhibitors on Neurite Outgrowth and Myelination Glia. Mar, 2012 | Pubmed ID: 22139636 Transcriptional Regulation of Rho GTPase Signaling Transcription. Sep-Oct, 2011 | Pubmed ID: 22231116 Development of a High-Throughput Screening Method for LIM Kinase 1 Using a Luciferase-Based Assay of ATP Consumption Journal of Biomolecular Screening. Dec, 2011 | Pubmed ID: 22156225 Actomyosin Contractililty: Force Power Drives Tumor Growth Cell Cycle (Georgetown, Tex.). Oct, 2011 | Pubmed ID: 22067650 Co-crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion PloS One. 2011 | Pubmed ID: 21949762 Trailblazing LIM Kinases Take the Lead in Collective Tumor Cell Invasion Bioarchitecture. 1, 2011 | Pubmed ID: 21866254 Actomyosin-mediated Cellular Tension Drives Increased Tissue Stiffness and β-catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth Cancer Cell. Jun, 2011 | Pubmed ID: 21665151 K-Ras Mediated Murine Epidermal Tumorigenesis is Dependent Upon and Associated with Elevated Rac1 Activity PloS One. 2011 | Pubmed ID: 21358804 Spatial Regulation of RhoA Activity During Pancreatic Cancer Cell Invasion Driven by Mutant P53 Cancer Research. Feb, 2011 | Pubmed ID: 21266354 P53-mediated Transcriptional Regulation and Activation of the Actin Cytoskeleton Regulatory RhoC to LIMK2 Signaling Pathway Promotes Cell Survival Cell Research. Apr, 2011 | Pubmed ID: 21079653 Differing Contributions of LIMK and ROCK to TGFβ-induced Transcription, Motility and Invasion European Journal of Cell Biology. Jan, 2011 | Pubmed ID: 21074289 Follow the Leader: LIM Kinases Pave the Way for Collective Tumor Cell Invasion Cell Cycle (Georgetown, Tex.). Nov, 2010 | Pubmed ID: 21088476 LIM Kinases Are Required for Invasive Path Generation by Tumor and Tumor-associated Stromal Cells The Journal of Cell Biology. Oct, 2010 | Pubmed ID: 20876278 Dying Alone: a Tale of Rho Cell Stem Cell. Aug, 2010 | Pubmed ID: 20682437 MST Kinases Monitor Actin Cytoskeletal Integrity and Signal Via C-Jun N-terminal Kinase Stress-activated Kinase to Regulate P21Waf1/Cip1 Stability Molecular and Cellular Biology. Dec, 2009 | Pubmed ID: 19822666 Sprouty2 Association with B-Raf is Regulated by Phosphorylation and Kinase Conformation Cancer Research. Sep, 2009 | Pubmed ID: 19690147 Constitutively Active RhoA Inhibits Proliferation by Retarding G(1) to S Phase Cell Cycle Progression and Impairing Cytokinesis European Journal of Cell Biology. Sep, 2009 | Pubmed ID: 19515453 Tissue Selective Expression of Conditionally-regulated ROCK by Gene Targeting to a Defined Locus Genesis (New York, N.Y. : 2000). Jul, 2009 | Pubmed ID: 19391117 The Actin Cytoskeleton in Cancer Cell Motility Clinical & Experimental Metastasis. 2009 | Pubmed ID: 18498004 Regulating the Conversion Between Rounded and Elongated Modes of Cancer Cell Movement Cancer Cell. Nov, 2008 | Pubmed ID: 18977323 Applications for ROCK Kinase Inhibition Current Opinion in Cell Biology. Apr, 2008 | Pubmed ID: 18282695 Alpha(E)-Catenin Induces SRF-dependent Transcriptional Activity Through Its C-terminal Region and is Partly RhoA/ROCK-dependent Biochemical and Biophysical Research Communications. Feb, 2008 | Pubmed ID: 18078809 The Ras Signalling Pathway As a Target in Cancer Therapy Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer. 2007 | Pubmed ID: 17607939 Mechanisms of Tumour Cell Invasion and Metastasis Journal of Molecular Medicine (Berlin, Germany). Jun, 2007 | Pubmed ID: 17404698 LIM Kinases: Function, Regulation and Association with Human Disease Journal of Molecular Medicine (Berlin, Germany). Jun, 2007 | Pubmed ID: 17294230 The Rho GTPase Effector ROCK Regulates Cyclin A, Cyclin D1, and P27Kip1 Levels by Distinct Mechanisms Molecular and Cellular Biology. Jun, 2006 | Pubmed ID: 16738326 Conditional Regulation of a ROCK-estrogen Receptor Fusion Protein Methods in Enzymology. 2006 | Pubmed ID: 16472686 Purification of TAT-C3 Exoenzyme Methods in Enzymology. 2006 | Pubmed ID: 16472655 AP-1 Differentially Expressed Proteins Krp1 and Fibronectin Cooperatively Enhance Rho-ROCK-independent Mesenchymal Invasion by Altering the Function, Localization, and Activity of Nondifferentially Expressed Proteins Molecular and Cellular Biology. Feb, 2006 | Pubmed ID: 16449658 Modeling Human Cancer: Report on the Eighth Beatson International Cancer Conference Cancer Research. Dec, 2005 | Pubmed ID: 16357126 Targeting Ras and Rho GTPases As Opportunities for Cancer Therapeutics Current Opinion in Genetics & Development. Feb, 2005 | Pubmed ID: 15661535 Actin-myosin-based Contraction is Responsible for Apoptotic Nuclear Disintegration The Journal of Cell Biology. Jan, 2005 | Pubmed ID: 15657395 Conditional ROCK Activation in Vivo Induces Tumor Cell Dissemination and Angiogenesis Cancer Research. Dec, 2004 | Pubmed ID: 15604264 SPRY2 is an Inhibitor of the Ras/extracellular Signal-regulated Kinase Pathway in Melanocytes and Melanoma Cells with Wild-type BRAF but Not with the V599E Mutant Cancer Research. Aug, 2004 | Pubmed ID: 15313890 RAS and RHO GTPases in G1-phase Cell-cycle Regulation Nature Reviews. Molecular Cell Biology. May, 2004 | Pubmed ID: 15122349 Contraction Reaction: Mechanical Regulation of Rho GTPase Trends in Cell Biology. Mar, 2004 | Pubmed ID: 15055199 Rac Transformation: the Actin Connection Cancer Biology & Therapy. Jan, 2004 | Pubmed ID: 14726705 Keratinocyte Differentiation is Regulated by the Rho and ROCK Signaling Pathway Current Biology : CB. Dec, 2003 | Pubmed ID: 14680635 Extracellular ATP Causes ROCK I-dependent Bleb Formation in P2X7-transfected HEK293 Cells Molecular Biology of the Cell. Jul, 2003 | Pubmed ID: 12857854 Ras Promotes P21(Waf1/Cip1) Protein Stability Via a Cyclin D1-imposed Block in Proteasome-mediated Degradation The EMBO Journal. May, 2003 | Pubmed ID: 12727871 Dispatch. GTPase Signalling: New Functions for Diaphanous-related Formins Current Biology : CB. Apr, 2003 | Pubmed ID: 12725753 Gem GTPase: Between a ROCK and a Hard Place Current Biology : CB. Jul, 2002 | Pubmed ID: 12176351 Modellering og Imaging 3-Dimensional Collective Cell Invasion Rebecca W. Scott1, Diane Crighton2, Michael F. Olson2 1Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, 2The Beatson Institute for Cancer Research JoVE 3525 Medicine
Modellering og Imaging 3-Dimensional Collective Cell Invasion Rebecca W. Scott1, Diane Crighton2, Michael F. Olson2 1Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, 2The Beatson Institute for Cancer Research JoVE 3525 Medicine