Michael K. Lee Department of Neuroscience University of Minnesota Biography Publications Institution JoVE Articles Michael K. Lee has not added a biography. If you are Michael K. Lee and would like to personalize this page please email our Author Liaison for assistance. Publications Small-molecule RA-9 Inhibits Proteasome-associated DUBs and Ovarian Cancer in Vitro and in Vivo Via Exacerbating Unfolded Protein Responses Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2014 | Pubmed ID: 24727327 Endoplasmic Reticulum Stress is Important for the Manifestations of α-synucleinopathy in Vivo The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2012 | Pubmed ID: 22399753 Accumulation of Toxic α-synuclein Oligomer Within Endoplasmic Reticulum Occurs in α-synucleinopathy in Vivo The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2012 | Pubmed ID: 22399752 Neurodegenerative Phenotypes in an A53T α-synuclein Transgenic Mouse Model Are Independent of LRRK2 Human Molecular Genetics. Jun, 2012 | Pubmed ID: 22357653 Magnetization Transfer and Adiabatic R 1ρ MRI in the Brainstem of Parkinson's Disease Parkinsonism & Related Disorders. Jun, 2012 | Pubmed ID: 22265140 Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2 PloS One. 2011 | Pubmed ID: 21494637 Resistance to MPTP-neurotoxicity in α-synuclein Knockout Mice is Complemented by Human α-synuclein and Associated with Increased β-synuclein and Akt Activation PloS One. 2011 | Pubmed ID: 21304957 Passive (amyloid-β) Immunotherapy Attenuates Monoaminergic Axonal Degeneration in the AβPPswe/PS1dE9 Mice Journal of Alzheimer's Disease : JAD. 2011 | Pubmed ID: 20966549 Synphilin-1 Attenuates Neuronal Degeneration in the A53T Alpha-synuclein Transgenic Mouse Model Human Molecular Genetics. Jun, 2010 | Pubmed ID: 20185556 Increased Expression of Alpha-synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering After Endocytosis Neuron. Jan, 2010 | Pubmed ID: 20152114 Amyloid Pathology is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008 | Pubmed ID: 19091971 Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2008 | Pubmed ID: 19010849 Lysine 63-linked Ubiquitination Promotes the Formation and Autophagic Clearance of Protein Inclusions Associated with Neurodegenerative Diseases Human Molecular Genetics. Feb, 2008 | Pubmed ID: 17981811 Differential Regulation of Small Heat Shock Proteins in Transgenic Mouse Models of Neurodegenerative Diseases Neurobiology of Aging. Apr, 2008 | Pubmed ID: 17316906 Myosin II Co-chaperone General Cell UNC-45 Overexpression is Associated with Ovarian Cancer, Rapid Proliferation, and Motility The American Journal of Pathology. Nov, 2007 | Pubmed ID: 17872978 Wild-type and Mutant Alpha-synuclein Induce a Multi-component Gene Expression Profile Consistent with Shared Pathophysiology in Different Transgenic Mouse Models of PD Experimental Neurology. Mar, 2007 | Pubmed ID: 17254569 Inclusion Body Formation and Neurodegeneration Are Parkin Independent in a Mouse Model of Alpha-synucleinopathy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2006 | Pubmed ID: 16597723 Ubiquitin-proteasome System Stress Sensitizes Ovarian Cancer to Proteasome Inhibitor-induced Apoptosis Cancer Research. Apr, 2006 | Pubmed ID: 16585202 Parkinson's Disease Alpha-synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2006 | Pubmed ID: 16399671 Ruptured Left Gastric Artery Aneurysm: Unique Presentation with Hemothorax and Hemomediastinum Cardiovascular and Interventional Radiology. May-Jun, 2006 | Pubmed ID: 16283575 Locomotor Hyperactivity and Alterations in Dopamine Neurotransmission Are Associated with Overexpression of A53T Mutant Human Alpha-synuclein in Mice Neurobiology of Disease. Feb, 2006 | Pubmed ID: 16230020 Alpha-synuclein Phosphorylation Enhances Eosinophilic Cytoplasmic Inclusion Formation in SH-SY5Y Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2005 | Pubmed ID: 15944382 Antiapoptotic Property of Human Alpha-synuclein in Neuronal Cell Lines is Associated with the Inhibition of Caspase-3 but Not Caspase-9 Activity Journal of Neurochemistry. Jun, 2005 | Pubmed ID: 15935070 Abeta Deposition is Associated with Enhanced Cortical Alpha-synuclein Lesions in Lewy Body Diseases Neurobiology of Aging. Aug-Sep, 2005 | Pubmed ID: 15917102 Aggregation Promoting C-terminal Truncation of Alpha-synuclein is a Normal Cellular Process and is Enhanced by the Familial Parkinson's Disease-linked Mutations Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15684072 Association of DJ-1 and Parkin Mediated by Pathogenic DJ-1 Mutations and Oxidative Stress Human Molecular Genetics. Jan, 2005 | Pubmed ID: 15525661 Stabilization of Alpha-synuclein Protein with Aging and Familial Parkinson's Disease-linked A53T Mutation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2004 | Pubmed ID: 15317865 Axonal Transport of Human Alpha-synuclein Slows with Aging but is Not Affected by Familial Parkinson's Disease-linked Mutations Journal of Neurochemistry. Jan, 2004 | Pubmed ID: 14690528 Mutant Presenilins Specifically Elevate the Levels of the 42 Residue Beta-amyloid Peptide in Vivo: Evidence for Augmentation of a 42-specific Gamma Secretase Human Molecular Genetics. Jan, 2004 | Pubmed ID: 14645205 No-reflow is an Independent Predictor of Death and Myocardial Infarction After Percutaneous Coronary Intervention American Heart Journal. Jan, 2003 | Pubmed ID: 12514653 Human Alpha-synuclein-harboring Familial Parkinson's Disease-linked Ala-53 --> Thr Mutation Causes Neurodegenerative Disease with Alpha-synuclein Aggregation in Transgenic Mice Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12084935 Accumulation of Proteolytic Fragments of Mutant Presenilin 1 and Accelerated Amyloid Deposition Are Co-regulated in Transgenic Mice Neurobiology of Aging. Mar-Apr, 2002 | Pubmed ID: 11804700 Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples Percy Griffin1,2, Ashley Sexton3, Lauren Macneill3, Yoshie Iizuka3,4, Michael K. Lee1,2, Martina Bazzaro3,4 1Department of Neuroscience, University of Minnesota, 2Institute for Translational Neuroscience, University of Minnesota, 3Department of Obstetrics, Gynecology, and Women’s Heath, University of Minnesota, 4Masonic Cancer Center, University of Minnesota JoVE 52784 Biology
Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples Percy Griffin1,2, Ashley Sexton3, Lauren Macneill3, Yoshie Iizuka3,4, Michael K. Lee1,2, Martina Bazzaro3,4 1Department of Neuroscience, University of Minnesota, 2Institute for Translational Neuroscience, University of Minnesota, 3Department of Obstetrics, Gynecology, and Women’s Heath, University of Minnesota, 4Masonic Cancer Center, University of Minnesota JoVE 52784 Biology
