Michael R. Holbrook Integrated Research Facility at Frederick, National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH) Biography Publications Institution JoVE Articles Michael R. Holbrook has not added a biography. If you are Michael R. Holbrook and would like to personalize this page please email our Author Liaison for assistance. Publications Characterization of Yellow Fever Virus Infection of Human and Non-human Primate Antigen Presenting Cells and Their Interaction with CD4+ T Cells PLoS Neglected Tropical Diseases. May, 2016 | Pubmed ID: 27191161 Human Polyclonal Immunoglobulin G from Transchromosomic Bovines Inhibits MERS-CoV in Vivo Science Translational Medicine. Feb, 2016 | Pubmed ID: 26888429 3B11-N, a Monoclonal Antibody Against MERS-CoV, Reduces Lung Pathology in Rhesus Monkeys Following Intratracheal Inoculation of MERS-CoV Jordan-n3/2012 Virology. Mar, 2016 | Pubmed ID: 26828465 Intratracheal Exposure of Common Marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 Isolates Does Not Result in Lethal Disease Virology. Nov, 2015 | Pubmed ID: 26342468 Inactivation and Safety Testing of Middle East Respiratory Syndrome Coronavirus Journal of Virological Methods. Oct, 2015 | Pubmed ID: 26190637 Possible Sexual Transmission of Ebola Virus - Liberia, 2015 MMWR. Morbidity and Mortality Weekly Report. May, 2015 | Pubmed ID: 25950255 Cytokine Response in Mouse Bone Marrow Derived Macrophages After Infection with Pathogenic and Non-pathogenic Rift Valley Fever Virus The Journal of General Virology. Jul, 2015 | Pubmed ID: 25759029 Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection As Identified by Temporal Kinome Analysis Antimicrobial Agents and Chemotherapy. Feb, 2015 | Pubmed ID: 25487801 Animal Models of Viral Hemorrhagic Fever Antiviral Research. Dec, 2014 | Pubmed ID: 25448088 Comparative Pathogenesis of Alkhumra Hemorrhagic Fever and Kyasanur Forest Disease Viruses in a Mouse Model PLoS Neglected Tropical Diseases. Jun, 2014 | Pubmed ID: 24922308 Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection Antimicrobial Agents and Chemotherapy. Aug, 2014 | Pubmed ID: 24841273 A Critical Determinant of Neurological Disease Associated with Highly Pathogenic Tick-borne Flavivirus in Mice Journal of Virology. May, 2014 | Pubmed ID: 24574402 Interferon-β and Mycophenolic Acid Are Potent Inhibitors of Middle East Respiratory Syndrome Coronavirus in Cell-based Assays The Journal of General Virology. Mar, 2014 | Pubmed ID: 24323636 Coagulation Factors, Fibrinogen and Plasminogen Activator Inhibitor-1, Are Differentially Regulated by Yellow Fever Virus Infection of Hepatocytes Virus Research. Aug, 2013 | Pubmed ID: 23639427 Release of Dengue Virus Genome Induced by a Peptide Inhibitor PloS One. 2012 | Pubmed ID: 23226444 Kyasanur Forest Disease Antiviral Research. Dec, 2012 | Pubmed ID: 23110991 An Assembly Model of Rift Valley Fever Virus Frontiers in Microbiology. 2012 | Pubmed ID: 22837754 肝脏和大脑中的趋化和炎症反应是鼠标裂谷热病毒感染的发病机制与相关联。 PLoS Neglected Tropical Diseases. 2012 | Pubmed ID: 22389738 Tick-borne Encephalitis Vaccines Journal of Bioterrorism & Biodefense. 2011 | Pubmed ID: 23997980 Japanese Encephalitis Vaccines Journal of Bioterrorism & Biodefense. Sep, 2011 | Pubmed ID: 23125946 Recombinant Rift Valley Fever Vaccines Induce Protective Levels of Antibody in Baboons and Resistance to Lethal Challenge in Mice Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21873194 Inactivated or Live-attenuated Bivalent Vaccines That Confer Protection Against Rabies and Ebola Viruses Journal of Virology. Oct, 2011 | Pubmed ID: 21849459 Infection of Hepatocytes with 17-D Vaccine-strain Yellow Fever Virus Induces a Strong Pro-inflammatory Host Response The Journal of General Virology. Oct, 2011 | Pubmed ID: 21697351 Differential Cytokine Responses from Primary Human Kupffer Cells Following Infection with Wild-type or Vaccine Strain Yellow Fever Virus Virology. Mar, 2011 | Pubmed ID: 21277609 T-705 (favipiravir) Inhibition of Arenavirus Replication in Cell Culture Antimicrobial Agents and Chemotherapy. Feb, 2011 | Pubmed ID: 21115797 Antiviral Activities of ISG20 in Positive-strand RNA Virus Infections Virology. Jan, 2011 | Pubmed ID: 21036379 Construction of an Infectious CDNA Clone for Omsk Hemorrhagic Fever Virus, and Characterization of Mutations in NS2A and NS5 Virus Research. Jan, 2011 | Pubmed ID: 20817056 Ubiquitin-regulated Nuclear-cytoplasmic Trafficking of the Nipah Virus Matrix Protein is Important for Viral Budding PLoS Pathogens. 2010 | Pubmed ID: 21085610 A Proposal to Change Existing Virus Species Names to Non-Latinized Binomials Archives of Virology. Nov, 2010 | Pubmed ID: 20953644 Comparative Analysis of Immune Responses to Russian Spring-summer Encephalitis and Omsk Hemorrhagic Fever Viruses in Mouse Models Virology. Dec, 2010 | Pubmed ID: 20875909 Novel Suspension Cell-based Vaccine Production Systems for Rift Valley Fever Virus-like Particles Journal of Virological Methods. Nov, 2010 | Pubmed ID: 20655330 VIPR: A Probabilistic Algorithm for Analysis of Microbial Detection Microarrays BMC Bioinformatics. 2010 | Pubmed ID: 20646301 Gammadelta T Cells Promote the Maturation of Dendritic Cells During West Nile Virus Infection FEMS Immunology and Medical Microbiology. Jun, 2010 | Pubmed ID: 20337718 针对入境的包膜病毒的广谱抗病毒。 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133606 The NS5 Protein of the Virulent West Nile Virus NY99 Strain is a Potent Antagonist of Type I Interferon-mediated JAK-STAT Signaling Journal of Virology. Apr, 2010 | Pubmed ID: 20106931 A Replication-incompetent Rift Valley Fever Vaccine: Chimeric Virus-like Particles Protect Mice and Rats Against Lethal Challenge Virology. Feb, 2010 | Pubmed ID: 19932911 Combined Chloroquine and Ribavirin Treatment Does Not Prevent Death in a Hamster Model of Nipah and Hendra Virus Infection The Journal of General Virology. Mar, 2010 | Pubmed ID: 19889926 Identification of Novel Cellular Targets for Therapeutic Intervention Against Ebola Virus Infection by SiRNA Screening Drug Development Research. Jun, 2009 | Pubmed ID: 20930947 A Complex Adenovirus-vectored Vaccine Against Rift Valley Fever Virus Protects Mice Against Lethal Infection in the Presence of Preexisting Vector Immunity Clinical and Vaccine Immunology : CVI. Nov, 2009 | Pubmed ID: 19776190 A Catalytically and Genetically Optimized Beta-lactamase-matrix Based Assay for Sensitive, Specific, and Higher Throughput Analysis of Native Henipavirus Entry Characteristics Virology Journal. 2009 | Pubmed ID: 19646266 Potential Impact of a 2-person Security Rule on BioSafety Level 4 Laboratory Workers Emerging Infectious Diseases. Jul, 2009 | Pubmed ID: 19624910 Clinical Evaluation of Highly Pathogenic Tick-borne Flavivirus Infection in the Mouse Model Journal of Medical Virology. Jul, 2009 | Pubmed ID: 19475605 Single-particle Cryo-electron Microscopy of Rift Valley Fever Virus Virology. Apr, 2009 | Pubmed ID: 19304307 Sub-genomic Replicon and Virus-like Particles of Omsk Hemorrhagic Fever Virus Archives of Virology. 2009 | Pubmed ID: 19277843 Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus PLoS Pathogens. 2008 | Pubmed ID: 18769720 Three-dimensional Organization of Rift Valley Fever Virus Revealed by Cryoelectron Tomography Journal of Virology. Nov, 2008 | Pubmed ID: 18715915 可注射 Peramivir 减轻疾病和促进在雪貂和高致病流感病毒，A/越南/1203年/04 （H5N1） 感染小鼠的生存。 Virology. Apr, 2008 | Pubmed ID: 18234269 Animal Models of Highly Pathogenic RNA Viral Infections: Hemorrhagic Fever Viruses Antiviral Research. Apr, 2008 | Pubmed ID: 18036672 Animal Models of Highly Pathogenic RNA Viral Infections: Encephalitis Viruses Antiviral Research. Apr, 2008 | Pubmed ID: 18031836 Structure of the Envelope Protein Domain III of Omsk Hemorrhagic Fever Virus Virology. Jul, 2006 | Pubmed ID: 16647096 Yellow Fever Virus Strains Asibi and 17D-204 Infect Human Umbilical Cord Endothelial Cells and Induce Novel Changes in Gene Expression Virology. Nov, 2005 | Pubmed ID: 16150475 An Animal Model for the Tickborne Flavivirus--Omsk Hemorrhagic Fever Virus The Journal of Infectious Diseases. Jan, 2005 | Pubmed ID: 15593010 Use of Recombinant E Protein Domain III-based Enzyme-linked Immunosorbent Assays for Differentiation of Tick-borne Encephalitis Serocomplex Flaviviruses from Mosquito-borne Flaviviruses Journal of Clinical Microbiology. Sep, 2004 | Pubmed ID: 15364996 Solution Structure and Structural Dynamics of Envelope Protein Domain III of Mosquito- and Tick-borne Flaviviruses Biochemistry. Jul, 2004 | Pubmed ID: 15248774 1H, 13C and 15N Resonance Assignments for Domain III of the West Nile Virus Envelope Protein Journal of Biomolecular NMR. Jul, 2004 | Pubmed ID: 15213461 Solution Structure and Antibody Binding Studies of the Envelope Protein Domain III from the New York Strain of West Nile Virus The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15190071 Use of a Recombinant Envelope Protein Subunit Antigen for Specific Serological Diagnosis of West Nile Virus Infection Journal of Clinical Microbiology. Jun, 2004 | Pubmed ID: 15184463 Molecular Determinants of Antigenicity of Two Subtypes of the Tick-borne Flavivirus Omsk Haemorrhagic Fever Virus The Journal of General Virology. Jun, 2004 | Pubmed ID: 15166446 Analysis of the Complete Genome of the Tick-borne Flavivirus Omsk Hemorrhagic Fever Virus Virology. Aug, 2003 | Pubmed ID: 12951023 Crystallization and Preliminary X-ray Diffraction Analysis of Langat Virus Envelope Protein Domain III Acta Crystallographica. Section D, Biological Crystallography. Jun, 2003 | Pubmed ID: 12777770 安全注意事项和操作步骤在（A）BSL-4实验室：2.常规做法 Steven Mazur1, Michael R. Holbrook1, Tracey Burdette1, Nicole Josleyn1, Jason Barr1, Daniela Pusl1, Laura Bollinger1, Linda Coe1, Peter B. Jahrling1, Matthew G. Lackemeyer1, Jiro Wada1, Jens H. Kuhn1, Krisztina Janosko1 1Integrated Research Facility at Frederick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Immunology and Infection 安全注意事项和操作步骤在（A）BSL-4实验室：1.生物安全4级实验室西服套房出入境手续 Krisztina Janosko1, Michael R. Holbrook1, Ricky Adams1, Jason Barr1, Laura Bollinger1, Je T'aime Newton2, Corrie Ntiforo2, Linda Coe1, Jiro Wada1, Daniela Pusl1, Peter B. Jahrling1, Jens H. Kuhn1, Matthew G. Lackemeyer1 1Integrated Research Facility at Frederick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 2Environmental Health and Safety, Biological and Chemical Safety Program, University of Texas Medical Branch Immunology and Infection 安全注意事项和操作步骤在（A）BSL-4实验室：4.医疗成像过程 Russell Byrum1, Lauren Keith1, Christopher Bartos1, Marisa St. Claire1, Matthew G. Lackemeyer1, Michael R. Holbrook1, Krisztina Janosko1, Jason Barr1, Daniela Pusl1, Laura Bollinger1, Jiro Wada1, Linda Coe1, Lisa E. Hensley1, Peter B. Jahrling1, Jens H. Kuhn1, Margaret R. Lentz1 1Integrated Research Facility at Frederick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Immunology and Infection 安全注意事项和操作步骤在（A）BSL-4实验室：3，大气生物学 J. Kyle Bohannon1, Krisztina Janosko1, Michael R. Holbrook1, Jason Barr1, Daniela Pusl1, Laura Bollinger1, Linda Coe1, Lisa E. Hensley1, Peter B. Jahrling1, Jiro Wada1, Jens H. Kuhn1, Matthew G. Lackemeyer1 1Integrated Research Facility at Frederick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Immunology and Infection
安全注意事项和操作步骤在（A）BSL-4实验室：2.常规做法 Steven Mazur1, Michael R. Holbrook1, Tracey Burdette1, Nicole Josleyn1, Jason Barr1, Daniela Pusl1, Laura Bollinger1, Linda Coe1, Peter B. Jahrling1, Matthew G. Lackemeyer1, Jiro Wada1, Jens H. Kuhn1, Krisztina Janosko1 1Integrated Research Facility at Frederick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Immunology and Infection
安全注意事项和操作步骤在（A）BSL-4实验室：1.生物安全4级实验室西服套房出入境手续 Krisztina Janosko1, Michael R. Holbrook1, Ricky Adams1, Jason Barr1, Laura Bollinger1, Je T'aime Newton2, Corrie Ntiforo2, Linda Coe1, Jiro Wada1, Daniela Pusl1, Peter B. Jahrling1, Jens H. Kuhn1, Matthew G. Lackemeyer1 1Integrated Research Facility at Frederick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 2Environmental Health and Safety, Biological and Chemical Safety Program, University of Texas Medical Branch Immunology and Infection
安全注意事项和操作步骤在（A）BSL-4实验室：4.医疗成像过程 Russell Byrum1, Lauren Keith1, Christopher Bartos1, Marisa St. Claire1, Matthew G. Lackemeyer1, Michael R. Holbrook1, Krisztina Janosko1, Jason Barr1, Daniela Pusl1, Laura Bollinger1, Jiro Wada1, Linda Coe1, Lisa E. Hensley1, Peter B. Jahrling1, Jens H. Kuhn1, Margaret R. Lentz1 1Integrated Research Facility at Frederick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Immunology and Infection
安全注意事项和操作步骤在（A）BSL-4实验室：3，大气生物学 J. Kyle Bohannon1, Krisztina Janosko1, Michael R. Holbrook1, Jason Barr1, Daniela Pusl1, Laura Bollinger1, Linda Coe1, Lisa E. Hensley1, Peter B. Jahrling1, Jiro Wada1, Jens H. Kuhn1, Matthew G. Lackemeyer1 1Integrated Research Facility at Frederick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Immunology and Infection
