Michael R. Sierks

Publications

• Isolation and Characterization of Antibody Fragments Selective for Toxic Oligomeric Tau
  Neurobiology of Aging. Dec, 2014  |   Pubmed ID: 25616912
• A Sensitive Phage-based Capture ELISA for Sub-femtomolar Detection of Protein Variants Directly from Biological Samples
  Biotechnology Progress. Sep, 2014  |   Pubmed ID: 25203940
• Human α4β2 Nicotinic Acetylcholine Receptor As a Novel Target of Oligomeric α-synuclein
  PloS One. 2013  |   Pubmed ID: 23437071
• Isolation and Characterization of Antibody Fragments Selective for Specific Protein Morphologies from Nanogram Antigen Samples
  Biotechnology Progress. Mar-Apr, 2013  |   Pubmed ID: 23359572
• Bispecific Tandem Single Chain Antibody Simultaneously Inhibits β-secretase and Promotes α-secretase Processing of AβPP
  Journal of Alzheimer's Disease : JAD. 2012  |   Pubmed ID: 22156046
• Nanobody Specific for Oligomeric β-amyloid Stabilizes Nontoxic Form
  Neurobiology of Aging. Jul, 2012  |   Pubmed ID: 21067847
• CSF Levels of Oligomeric Alpha-synuclein and Beta-amyloid As Biomarkers for Neurodegenerative Disease
  Integrative Biology : Quantitative Biosciences from Nano to Macro. Dec, 2011  |   Pubmed ID: 22076255
• Inhibiting β-secretase Activity in Alzheimer's Disease Cell Models with Single-chain Antibodies Specifically Targeting APP
  Journal of Molecular Biology. Jan, 2011  |   Pubmed ID: 21073877
• Curcumin Reduces Alpha-synuclein Induced Cytotoxicity in Parkinson's Disease Cell Model
  BMC Neuroscience. 2010  |   Pubmed ID: 20433710
• Engineered Proteolytic Nanobodies Reduce Abeta Burden and Ameliorate Abeta-induced Cytotoxicity
  Biochemistry. Jun, 2010  |   Pubmed ID: 20429609
• Physico-chemical Determinants of Soluble Intrabody Expression in Mammalian Cell Cytoplasm
  Protein Engineering, Design & Selection : PEDS. Jun, 2010  |   Pubmed ID: 20378699
• Antifibrillizing Agents Catalyze the Formation of Unstable Intermediate Aggregates of Beta-amyloid
  Biotechnology Progress. Jul-Aug, 2010  |   Pubmed ID: 20306540
• Cyclodextrins Promote Protein Aggregation Posing Risks for Therapeutic Applications
  Biochemical and Biophysical Research Communications. Aug, 2009  |   Pubmed ID: 19540204
• Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity
  PloS One. 2009  |   Pubmed ID: 19492089
• Intracellular Targeting and Clearance of Oligomeric Alpha-synuclein Alleviates Toxicity in Mammalian Cells
  Neuroscience Letters. Jul, 2009  |   Pubmed ID: 19394405
• Detecting Morphologically Distinct Oligomeric Forms of Alpha-synuclein
  The Journal of Biological Chemistry. Apr, 2009  |   Pubmed ID: 19141614
• Characterizing Antibody Specificity to Different Protein Morphologies by AFM
  Langmuir : the ACS Journal of Surfaces and Colloids. Jan, 2009  |   Pubmed ID: 19090748
• Anti-oligomeric Abeta Single-chain Variable Domain Antibody Blocks Abeta-induced Toxicity Against Human Neuroblastoma Cells
  Journal of Molecular Biology. Dec, 2008  |   Pubmed ID: 18929576
• Anti-oligomeric Single Chain Variable Domain Antibody Differentially Affects Huntingtin and Alpha-synuclein Aggregates
  FEBS Letters. Feb, 2008  |   Pubmed ID: 18230361
• Characterization of an Antibody ScFv That Recognizes Fibrillar Insulin and Beta-amyloid Using Atomic Force Microscopy
  Nanomedicine : Nanotechnology, Biology, and Medicine. Mar, 2008  |   Pubmed ID: 18201941
• Single-molecule Selection and Recovery of Structure-specific Antibodies Using Atomic Force Microscopy
  Nanomedicine : Nanotechnology, Biology, and Medicine. Sep, 2007  |   Pubmed ID: 17662669
• Isolation of a Human Single Chain Antibody Fragment Against Oligomeric Alpha-synuclein That Inhibits Aggregation and Prevents Alpha-synuclein-induced Toxicity
  Journal of Molecular Biology. May, 2007  |   Pubmed ID: 17391701
• Insights into the Mechanisms of Action of Anti-Abeta Antibodies in Alzheimer's Disease Mouse Models
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2006  |   Pubmed ID: 17068112
• Isolating Recombinant Antibodies Against Specific Protein Morphologies Using Atomic Force Microscopy and Phage Display Technologies
  Protein Engineering, Design & Selection : PEDS. Nov, 2006  |   Pubmed ID: 16984950
• Single Chain Fv Antibodies Against the 25-35 Abeta Fragment Inhibit Aggregation and Toxicity of Abeta42
  Biochemistry. Sep, 2006  |   Pubmed ID: 16981713
• Identification and Repair of Positive Binding Antibodies Containing Randomly Generated Amber Codons from Synthetic Phage Display Libraries
  Biotechnology Progress. May-Jun, 2006  |   Pubmed ID: 16739981
• Quantification of Cytokines Involved in Wound Healing Using Surface Plasmon Resonance
  Analytical Chemistry. Nov, 2005  |   Pubmed ID: 16255604
• Trehalose Differentially Inhibits Aggregation and Neurotoxicity of Beta-amyloid 40 and 42
  Neurobiology of Disease. Oct, 2005  |   Pubmed ID: 16137568
• A Human Single-chain Fv Intrabody Blocks Aberrant Cellular Effects of Overexpressed Alpha-synuclein
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2004  |   Pubmed ID: 15564134
• Proteolytic Antibody Light Chains Alter Beta-amyloid Aggregation and Prevent Cytotoxicity
  Biochemistry. Aug, 2004  |   Pubmed ID: 15287727
• Single Chain Variable Fragments Against Beta-amyloid (Abeta) Can Inhibit Abeta Aggregation and Prevent Abeta-induced Neurotoxicity
  Biochemistry. Jun, 2004  |   Pubmed ID: 15170333
• Inhibiting Aggregation of Alpha-synuclein with Human Single Chain Antibody Fragments
  Biochemistry. Mar, 2004  |   Pubmed ID: 15005622
• Residues 17-20 and 30-35 of Beta-amyloid Play Critical Roles in Aggregation
  Journal of Neuroscience Research. Jan, 2004  |   Pubmed ID: 14705137
• Degradation of Beta-amyloid by Proteolytic Antibody Light Chains
  Biochemistry. Dec, 2003  |   Pubmed ID: 14640701