Articles by Michael T. Shaw in JoVE
Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability Michael T. Shaw1, Margaret Kasschau2, Bryan Dobbs1, Natalie Pawlak1, William Pau1, Kathleen Sherman1, Marom Bikson3, Abhishek Datta4, Leigh E. Charvet1 1New York University, Langone Medical Center, 2Stony Brook Medicine, 3City College of New York, 4Soterix Medical This manuscript provides an updated remote supervision protocol that enables participation in transcranial direct current stimulation (tDCS) clinical trials while receiving treatment sessions from home. The protocol has been successfully piloted in both patients with multiple sclerosis and Parkinson's disease.
Other articles by Michael T. Shaw on PubMed
Cognitive Function in Multiple Sclerosis Improves with Telerehabilitation: Results from a Randomized Controlled Trial PloS One. 2017 | Pubmed ID: 28493924 Cognitive impairment affects more than half of all individuals living with multiple sclerosis (MS). We hypothesized that training at home with an adaptive online cognitive training program would have greater cognitive benefit than ordinary computer games in cognitively-impaired adults with MS. This was a double-blind, randomized, active-placebo-controlled trial. Participants with MS were recruited through Stony Brook Medicine and randomly assigned to either the adaptive cognitive remediation (ACR) program or active control of ordinary computer games for 60 hours over 12 weeks. Training was remotely-supervised and delivered through a study-provided laptop computer. A computer generated, blocked stratification table prepared by statistician provided the randomization schedule and condition was assigned by a study technician. The primary outcome, administered by study psychometrician, was measured by change in a neuropsychological composite measure from baseline to study end. An intent-to-treat analysis was employed and missing primary outcome values were imputed via Markov Chain Monte Carlo method. Participants in the ACR (n = 74) vs. active control (n = 61) training program had significantly greater improvement in the primary outcome of cognitive functioning (mean change in composite z score±SD: 0·25±0·45 vs. 0·09±0·37, p = 0·03, estimated difference = 0·16 with 95% CI: 0·02-0·30), despite greater training time in the active control condition (mean±SD:56·9 ± 34·6 vs. 37·7 ±23 ·8 hours played, p = 0·006). This study provides Class I evidence that adaptive, computer-based cognitive remediation accessed from home can improve cognitive functioning in MS. This telerehabilitation approach allowed for rapid recruitment and high compliance, and can be readily applied to other neurological conditions associated with cognitive dysfunction.
Adverse Childhood Experiences Are Linked to Age of Onset and Reading Recognition in Multiple Sclerosis Frontiers in Neurology. 2017 | Pubmed ID: 28626445 Adverse childhood experiences (ACEs) exert a psychological and physiological toll that increases risk of chronic conditions, poorer social functioning, and cognitive impairment in adulthood.
Remotely Supervised Transcranial Direct Current Stimulation for the Treatment of Fatigue in Multiple Sclerosis: Results from a Randomized, Sham-controlled Trial Multiple Sclerosis (Houndmills, Basingstoke, England). Sep, 2017 | Pubmed ID: 28937310 Fatigue is a common and debilitating feature of multiple sclerosis (MS) that remains without reliably effective treatment. Transcranial direct current stimulation (tDCS) is a promising option for fatigue reduction. We developed a telerehabilitation protocol that delivers tDCS to participants at home using specially designed equipment and real-time supervision (remotely supervised transcranial direct current stimulation (RS-tDCS)).