Michael X. Zhu Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston Biography Publications Institution JoVE Articles Michael X. Zhu has not added a biography. If you are Michael X. Zhu and would like to personalize this page please email our Author Liaison for assistance. Publications Heteromeric Heat-sensitive TRP Channels Exhibit Distinct Temperature and Chemical Response The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 22184123 Hysteresis of Gating Underlines Sensitization of TRPV3 Channels The Journal of General Physiology. Nov, 2011 | Pubmed ID: 22006988 TRPM8 Acute Desensitization is Mediated by Calmodulin and Requires PIP(2): Distinction from Tachyphylaxis Journal of Neurophysiology. Dec, 2011 | Pubmed ID: 21900509 Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21795696 Ca2+: a Versatile Master Key for Intracellular Signaling Cascades Science China. Life Sciences. Aug, 2011 | Pubmed ID: 21786190 Rapid and Efficient Generation of Functional Motor Neurons from Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor Codes Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011 | Pubmed ID: 21772256 Extracellular Spermine Exacerbates Ischemic Neuronal Injury Through Sensitization of ASIC1a Channels to Extracellular Acidosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011 | Pubmed ID: 21307247 Cyclic Adenosine Diphosphate Ribose Activates Ryanodine Receptors, Whereas NAADP Activates Two-pore Domain Channels The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21216967 An Emerging Role for NAADP-mediated Ca2+ Signaling in the Pancreatic β-cell Islets. Sep-Oct, 2010 | Pubmed ID: 21099331 Agonist-activated Ca2+ Influx Occurs at Stable Plasma Membrane and Endoplasmic Reticulum Junctions Journal of Cell Science. Dec, 2010 | Pubmed ID: 21062895 TPC2 is a Novel NAADP-sensitive Ca2+ Release Channel, Operating As a Dual Sensor of Luminal PH and Ca2+ The Journal of Biological Chemistry. Nov, 2010 | Pubmed ID: 20720007 Negative Allosteric Modulators That Target Human Alpha4beta2 Neuronal Nicotinic Receptors The Journal of Pharmacology and Experimental Therapeutics. Sep, 2010 | Pubmed ID: 20551292 Two-pore Channels for Integrative Ca Signaling Communicative & Integrative Biology. Jan, 2010 | Pubmed ID: 20539775 The Roles of ATF3, an Adaptive-response Gene, in High-fat-diet-induced Diabetes and Pancreatic Beta-cell Dysfunction Molecular Endocrinology (Baltimore, Md.). Jul, 2010 | Pubmed ID: 20519332 Identification of Translational Activators of Glial Glutamate Transporter EAAT2 Through Cell-based High-throughput Screening: an Approach to Prevent Excitotoxicity Journal of Biomolecular Screening. Jul, 2010 | Pubmed ID: 20508255 Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca(2+) Signaling and Endolysosomal Trafficking Current Biology : CB. Apr, 2010 | Pubmed ID: 20346675 TPCs: Endolysosomal Channels for Ca2+ Mobilization from Acidic Organelles Triggered by NAADP FEBS Letters. May, 2010 | Pubmed ID: 20159015 Calcium Signaling Via Two-pore Channels: Local or Global, That is the Question American Journal of Physiology. Cell Physiology. Mar, 2010 | Pubmed ID: 20018950 Activation of TRPA1 Channels by Fenamate Nonsteroidal Anti-inflammatory Drugs Pflügers Archiv : European Journal of Physiology. Mar, 2010 | Pubmed ID: 19888597 Potencies of Cocaine Methiodide on Major Cocaine Targets in Mice PloS One. 2009 | Pubmed ID: 19855831 Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility in Vivo Gastroenterology. Oct, 2009 | Pubmed ID: 19549525 The Acid Test: the Discovery of Two-pore Channels (TPCs) As NAADP-gated Endolysosomal Ca(2+) Release Channels Pflügers Archiv : European Journal of Physiology. Sep, 2009 | Pubmed ID: 19475418 NAADP Mobilizes Calcium from Acidic Organelles Through Two-pore Channels Nature. May, 2009 | Pubmed ID: 19387438 Zinc Activates Damage-sensing TRPA1 Ion Channels Nature Chemical Biology. Mar, 2009 | Pubmed ID: 19202543 Dopamine Modulates an MGluR5-mediated Depolarization Underlying Prefrontal Persistent Activity Nature Neuroscience. Feb, 2009 | Pubmed ID: 19169252 Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery The Journal of Pharmacology and Experimental Therapeutics. Feb, 2009 | Pubmed ID: 18984653 Sensorimotor Enhancement in Mouse Mutants Lacking the Purkinje Cell-specific Gi/o Modulator, Pcp2(L7) Molecular and Cellular Neurosciences. Jan, 2009 | Pubmed ID: 18930827 Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-bisphosphate The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18230622 Calcium Plays a Central Role in the Sensitization of TRPV3 Channel to Repetitive Stimulations The Journal of Biological Chemistry. Mar, 2008 | Pubmed ID: 18178557 The TRPV3 Mutation Associated with the Hairless Phenotype in Rodents is Constitutively Active Cell Calcium. Apr, 2008 | Pubmed ID: 17706768 The Axon-dendrite Targeting of Kv3 (Shaw) Channels is Determined by a Targeting Motif That Associates with the T1 Domain and Ankyrin G The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2007 | Pubmed ID: 18094255 Understanding the Role of Voltage Gating of Polymodal TRP Channels The Journal of Physiology. Dec, 2007 | Pubmed ID: 18056113 Beta-nicotinamide Adenine Dinucleotide is an Inhibitory Neurotransmitter in Visceral Smooth Muscle Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17913880 Analogs of Methyllycaconitine As Novel Noncompetitive Inhibitors of Nicotinic Receptors: Pharmacological Characterization, Computational Modeling, and Pharmacophore Development Molecular Pharmacology. May, 2007 | Pubmed ID: 17308033 Potentiation of TRPV3 Channel Function by Unsaturated Fatty Acids Journal of Cellular Physiology. Jul, 2006 | Pubmed ID: 16557504 TRPC3 and TRPC4 Associate to Form a Redox-sensitive Cation Channel. Evidence for Expression of Native TRPC3-TRPC4 Heteromeric Channels in Endothelial Cells The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16537542 Thermal Sensitivity of Isolated Vagal Pulmonary Sensory Neurons: Role of Transient Receptor Potential Vanilloid Receptors American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2006 | Pubmed ID: 16513770 Cellular Cholesterol Controls TRPC3 Function: Evidence from a Novel Dominant-negative Knockdown Strategy The Biochemical Journal. May, 2006 | Pubmed ID: 16448384 Activation of the Endothelial Store-operated ISOC Ca2+ Channel Requires Interaction of Protein 4.1 with TRPC4 Circulation Research. Nov, 2005 | Pubmed ID: 16254212 Calmodulin and Calcium Interplay in the Modulation of TRPC5 Channel Activity. Identification of a Novel C-terminal Domain for Calcium/calmodulin-mediated Facilitation The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 15987684 Inhibition of TRPC5 Channels by Ca2+-binding Protein 1 in Xenopus Oocytes Pflügers Archiv : European Journal of Physiology. Aug, 2005 | Pubmed ID: 15895247 The Selectivity Filter of the Cation Channel TRPM4 The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15845551 2-aminoethoxydiphenyl Borate Stimulates Pulmonary C Neurons Via the Activation of TRPV Channels American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2005 | Pubmed ID: 15653710 Regulation of the Ca2+ Sensitivity of the Nonselective Cation Channel TRPM4 The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15590641 Junctate is a Key Element in Calcium Entry Induced by Activation of InsP3 Receptors And/or Calcium Store Depletion The Journal of Cell Biology. Aug, 2004 | Pubmed ID: 15302852 An Alternative Splicing Product of the Murine Trpv1 Gene Dominant Negatively Modulates the Activity of TRPV1 Channels The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15234965 2-aminoethoxydiphenyl Borate is a Common Activator of TRPV1, TRPV2, and TRPV3 The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15194687 TRPC Channel Interactions with Calmodulin and IP3 Receptors Novartis Foundation Symposium. 2004 | Pubmed ID: 15104175 Ca(2+) Signaling by TRPC3 Involves Na(+) Entry and Local Coupling to the Na(+)/Ca(2+) Exchanger The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14736881 Characterization of a Human Peptide Deformylase: Implications for Antibacterial Drug Design Biochemistry. Aug, 2003 | Pubmed ID: 12924944 Epidermal Growth Factor-induced Depletion of the Intracellular Ca2+ Store Fails to Activate Capacitative Ca2+ Entry in a Human Salivary Cell Line The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12368284 Expression and Role of TRPC Proteins in Human Platelets: Evidence That TRPC6 Forms the Store-independent Calcium Entry Channel Blood. Oct, 2002 | Pubmed ID: 12351388 Calmodulin Regulates Ca(2+)-dependent Feedback Inhibition of Store-operated Ca(2+) Influx by Interaction with a Site in the C Terminus of TrpC1 Molecular Cell. Apr, 2002 | Pubmed ID: 11983166 A Unified Nomenclature for the Superfamily of TRP Cation Channels Molecular Cell. Feb, 2002 | Pubmed ID: 11864597 Rapid Activation of Protein Tyrosine Kinase and Phospholipase C-gamma2 and Increase in Cytosolic Free Calcium Are Required by Ehrlichia Chaffeensis for Internalization and Growth in THP-1 Cells Infection and Immunity. Feb, 2002 | Pubmed ID: 11796624 الخلية المستندة إلى الفحص الكالسيوم لمتوسطة إلى فحص وظائف إنتاجية عالية باستخدام قناة الحزب FlexStation 3 Jialie Luo1, Yingmin Zhu1, Michael X. Zhu1, Hongzhen Hu1 1Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston JoVE 3149 Bioengineering
الخلية المستندة إلى الفحص الكالسيوم لمتوسطة إلى فحص وظائف إنتاجية عالية باستخدام قناة الحزب FlexStation 3 Jialie Luo1, Yingmin Zhu1, Michael X. Zhu1, Hongzhen Hu1 1Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston JoVE 3149 Bioengineering