In JoVE (4)
- Regular Care and Maintenance of a Zebrafish (Danio rerio) Laboratory: An Introduction
- Ultrasonic Assessment of Myocardial Microstructure
- Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
- Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Other Publications (1)
Articles by Michael Chen in JoVE
Regular Care and Maintenance of a Zebrafish (Danio rerio) Laboratory: An Introduction Avdesh Avdesh*1,2, Mengqi Chen*1,3, Mathew T. Martin-Iverson1,2,4, Alinda Mondal1,3, Daniel Ong1, Stephanie Rainey-Smith1,3, Kevin Taddei1,3, Michael Lardelli5, David M. Groth6, Giuseppe Verdile1,3, Ralph N. Martins1,2,3,7 1Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical sciences, Edith Cowan University, 2Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, University of Western Australia, 3McCusker Alzheimer's Research foundation, 4School of Medicine and Pharmacology, University of Western Australia, 5Department of Molecular and Biomedical Sciences, University of Adelaide, 6School of Biomedical Sciences, Curtin University of Technology, 7School of Psychiatry and Clinical Neurosciences, University of Western Australia This protocol outlines regular maintenance and care to maintain optimal conditions for zebrafish husbandry. The video illustrates the protocol for system maintenance, regular housing, feeding, breeding, and raising of zebrafish larvae.
Ultrasonic Assessment of Myocardial Microstructure Pranoti Hiremath1, Michael Bauer2, Hui-Wen Cheng2, Kazumasa Unno2, Ronglih Liao2, Susan Cheng2 1Harvard Medical School, 2Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School Echocardiography is commonly used to noninvasively characterize and quantify changes in cardiac structure and function. We describe an ultrasound-based imaging algorithm that offers an enhanced surrogate measure of myocardial microstructure and can be performed using open-access image analysis software.
Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography Hui-Wen Cheng*1,2, Sudeshna Fisch*1, Susan Cheng1, Michael Bauer1, Soeun Ngoy1, Yiling Qiu1, Jian Guan1, Shikha Mishra1, Christopher Mbah1, Ronglih Liao1 1Cardiac Muscle Research Labratory, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, 2Cardiovascular Department, Chang Gung Memorial Hospital Right ventricle (RV) dysfunction is critical to the pathogenesis of cardiovascular disease, yet limited methodologies are available for its evaluation. Recent advances in ultrasound imaging provide a noninvasive and accurate option for longitudinal RV study. Herein, we detail a step-by-step echocardiographic method using a murine model of RV pressure overload.
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice Wei-Ting Chang*1,2, Sudeshna Fisch*1, Michael Chen1, Yiling Qiu1, Susan Cheng1, Ronglih Liao1 1Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 2Division of Cardiovascular Medicine, Chi-Mei Medical Center, Tainan Coronary flow reserve (CFR) is useful for assessment of myocardial oxygen demand and evaluation of cardiovascular risk. This study establishes a step-by-step transthoracic Doppler echocardiographic (TTDE) method for longitudinal monitoring of the changes in CFR, as measured from coronary artery in mice, under the experimental pressure overload of aortic banding.
Other articles by Michael Chen on PubMed
Patent Review of Novel Nanostructrued Devices, Nanofabrication Methods and Applications in Nanofluidics and Nanomedicine Recent Patents on Nanotechnology. Jun, 2012 | Pubmed ID: 22181669 Over the past two decades, scientists and researchers have successfully developed MEMS (Micro-Electro- Mechanical Systems) technology and its applications that provide a stepping stone for nanotechnology and nanostructure fabrication. Nanostructured devices, which have higher efficiency, less weight and lower power consumption, have been applied in the fields of electronics, chemistry, energy, environmental science and medicine. This patent review focuses on novel nanostructure fabrication methods and nanostructure devices applied in nanofluidics and nanomedicine. We can reasonably expect that the number of nanostructure patents will continue to grow, especially in the fields of biomedical science and energy.