Michael D. Cahalan Biography Publications JoVE Articles Michael D. Cahalan has not added a biography. If you are Michael D. Cahalan and would like to personalize this page please email our Author Liaison for assistance. Publications CD95 Triggers Orai1-mediated Localized Ca2+ Entry, Regulates Recruitment of Protein Kinase C (PKC) β2, and Prevents Death-inducing Signaling Complex Formation Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22065776 Subunit Stoichiometry of Human Orai1 and Orai3 Channels in Closed and Open States Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21987805 Mutations in Orai1 Transmembrane Segment 1 Cause STIM1-independent Activation of Orai1 Channels at Glycine 98 and Channel Closure at Arginine 91 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21987804 Analysis of Transient Migration Behavior of Natural Killer Cells Imaged in Situ and in Vitro Integrative Biology : Quantitative Biosciences from Nano to Macro. Jul, 2011 | Pubmed ID: 21687858 Imaging Transplant Rejection: a New View Nature Medicine. Jun, 2011 | Pubmed ID: 21647143 Immunoimaging: Studying Immune System Dynamics Using Two-photon Microscopy Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285279 In Vivo Lymph Node Imaging Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285268 In Situ Lymph Node Imaging Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285267 Induction of an Immune Response for Imaging Antigen-presenting Cell/T-cell Interactions Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285266 General Approach to Adoptive Transfer and Cell Labeling for Immunoimaging Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285265 Protein Kinase D Orchestrates the Activation of DRAK2 in Response to TCR-induced Ca2+ Influx and Mitochondrial Reactive Oxygen Generation Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21148796 Mzb1 Protein Regulates Calcium Homeostasis, Antibody Secretion, and Integrin Activation in Innate-like B Cells Immunity. Nov, 2010 | Pubmed ID: 21093319 Cell Biology. How to STIMulate Calcium Channels Science (New York, N.Y.). Oct, 2010 | Pubmed ID: 20929798 Selective and Site-specific Mobilization of Dermal Dendritic Cells and Langerhans Cells by Th1- and Th2-polarizing Adjuvants Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20404167 The Immunological Synapse: a Dynamic Platform for Local Signaling Journal of Clinical Immunology. May, 2010 | Pubmed ID: 20390326 NK Cell Patrolling and Elimination of Donor-derived Dendritic Cells Favor Indirect Alloreactivity Journal of Immunology (Baltimore, Md. : 1950). Mar, 2010 | Pubmed ID: 20139277 The Functional Network of Ion Channels in T Lymphocytes Immunological Reviews. Sep, 2009 | Pubmed ID: 19754890 STIMulating Store-operated Ca(2+) Entry Nature Cell Biology. Jun, 2009 | Pubmed ID: 19488056 A Functional Single-nucleotide Polymorphism in the TRPC6 Gene Promoter Associated with Idiopathic Pulmonary Arterial Hypertension Circulation. May, 2009 | Pubmed ID: 19380626 Imaging of Effector Memory T Cells During a Delayed-type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block Immunity. Oct, 2008 | Pubmed ID: 18835197 Quantum Dots for Tracking Dendritic Cells and Priming an Immune Response in Vitro and in Vivo PloS One. 2008 | Pubmed ID: 18820727 The CRAC Channel Consists of a Tetramer Formed by Stim-induced Dimerization of Orai Dimers Nature. Nov, 2008 | Pubmed ID: 18820677 Store-dependent and -independent Modes Regulating Ca2+ Release-activated Ca2+ Channel Activity of Human Orai1 and Orai3 The Journal of Biological Chemistry. Jun, 2008 | Pubmed ID: 18420579 Orai1 and STIM1 Move to the Immunological Synapse and Are Up-regulated During T Cell Activation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18250319 Choreography of Cell Motility and Interaction Dynamics Imaged by Two-photon Microscopy in Lymphoid Organs Annual Review of Immunology. 2008 | Pubmed ID: 18173372 Class IA Phosphoinositide 3-kinase Modulates Basal Lymphocyte Motility in the Lymph Node Journal of Immunology (Baltimore, Md. : 1950). Aug, 2007 | Pubmed ID: 17675487 Ca2+ Signals in CD4+ T Cells During Early Contacts with Antigen-bearing Dendritic Cells in Lymph Node Journal of Immunology (Baltimore, Md. : 1950). Aug, 2007 | Pubmed ID: 17641025 Natural Killer Cells Actively Patrol Peripheral Lymph Nodes Forming Stable Conjugates to Eliminate MHC-mismatched Targets Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17609379 Molecular Basis of the CRAC Channel Cell Calcium. Aug, 2007 | Pubmed ID: 17482674 Molecular Identification of the CRAC Channel by Altered Ion Selectivity in a Mutant of Orai Nature. Sep, 2006 | Pubmed ID: 16921385 Enhancement of Capillary Leakage and Restoration of Lymphocyte Egress by a Chiral S1P1 Antagonist in Vivo Nature Chemical Biology. Aug, 2006 | Pubmed ID: 16829954 Imaging the Choreography of Lymphocyte Trafficking and the Immune Response Current Opinion in Immunology. Aug, 2006 | Pubmed ID: 16765574 Genome-wide RNAi Screen of Ca(2+) Influx Identifies Genes That Regulate Ca(2+) Release-activated Ca(2+) Channel Activity Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16751269 The Sense of Place in the Immune System Nature Immunology. Apr, 2006 | Pubmed ID: 16550194 Sphingosine 1-phosphate Type 1 Receptor Agonism Inhibits Transendothelial Migration of Medullary T Cells to Lymphatic Sinuses Nature Immunology. Dec, 2005 | Pubmed ID: 16273098 Close Encounters of the First and Second Kind: T-DC and T-B Interactions in the Lymph Node Seminars in Immunology. Dec, 2005 | Pubmed ID: 16263308 Charge Screening by Internal PH and Polyvalent Cations As a Mechanism for Activation, Inhibition, and Rundown of TRPM7/MIC Channels The Journal of General Physiology. Nov, 2005 | Pubmed ID: 16260839 STIM1 is a Ca2+ Sensor That Activates CRAC Channels and Migrates from the Ca2+ Store to the Plasma Membrane Nature. Oct, 2005 | Pubmed ID: 16208375 STIM1, an Essential and Conserved Component of Store-operated Ca2+ Channel Function The Journal of Cell Biology. May, 2005 | Pubmed ID: 15866891 Antigen-engaged B Cells Undergo Chemotaxis Toward the T Zone and Form Motile Conjugates with Helper T Cells PLoS Biology. Jun, 2005 | Pubmed ID: 15857154 Channel Function is Dissociated from the Intrinsic Kinase Activity and Autophosphorylation of TRPM7/ChaK1 The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15781465 STOP! In the Name of Positive Selection Nature Immunology. Feb, 2005 | Pubmed ID: 15662438 Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes The Journal of Experimental Medicine. Oct, 2004 | Pubmed ID: 15466619 K+ Channels As Targets for Specific Immunomodulation Trends in Pharmacological Sciences. May, 2004 | Pubmed ID: 15120495 A Store-operated Calcium Channel in Drosophila S2 Cells The Journal of General Physiology. Feb, 2004 | Pubmed ID: 14744989 T Cell Repertoire Scanning is Promoted by Dynamic Dendritic Cell Behavior and Random T Cell Motility in the Lymph Node Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14722354 SK3-1C, a Dominant-negative Suppressor of SKCa and IKCa Channels The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14638680 Regulation of Membrane Trafficking and Subcellular Organization of Endocytic Compartments Revealed with FM1-43 in Resting and Activated Human T Cells Experimental Cell Research. Nov, 2003 | Pubmed ID: 14597416 A Stochastic View of Lymphocyte Motility and Trafficking Within the Lymph Node Immunological Reviews. Oct, 2003 | Pubmed ID: 12969316 Real-time Imaging of Lymphocytes in Vivo Current Opinion in Immunology. Aug, 2003 | Pubmed ID: 12900266 Polyvalent Cations As Permeant Probes of MIC and TRPM7 Pores Biophysical Journal. Apr, 2003 | Pubmed ID: 12668438 Autonomous T Cell Trafficking Examined in Vivo with Intravital Two-photon Microscopy Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12601158 MIC Channels Are Inhibited by Internal Divalent Cations but Not ATP Biophysical Journal. Feb, 2003 | Pubmed ID: 12547774 A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T Lymphocytes The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12511563 Two-photon Tissue Imaging: Seeing the Immune System in a Fresh Light Nature Reviews. Immunology. Nov, 2002 | Pubmed ID: 12415310 Two-photon Imaging in Intact Lymphoid Tissue Advances in Experimental Medicine and Biology. 2002 | Pubmed ID: 12405205 Distinct Properties of CRAC and MIC Channels in RBL Cells The Journal of General Physiology. Aug, 2002 | Pubmed ID: 12149283 Two-photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node Science (New York, N.Y.). Jun, 2002 | Pubmed ID: 12016203 The Ins and Outs of Polycystin-2 As a Calcium Release Channel Nature Cell Biology. Mar, 2002 | Pubmed ID: 11875447 Modulation of Mouse Paneth Cell Alpha-defensin Secretion by MIKCa1, a Ca2+-activated, Intermediate Conductance Potassium Channel The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11724775 Imaging Effector Memory T cells in the Ear After Induction of Adoptive DTH JoVE 907 Biology Murine Skin Transplantation JoVE 634 Biology
