Michele Vendruscolo Centre for Misfolding Diseases, Department of Chemistry University of Cambridge Biography Publications Institution JoVE Articles Michele Vendruscolo has not added a biography. If you are Michele Vendruscolo and would like to personalize this page please email our Author Liaison for assistance. Publications Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification ACS Central Science. Aug, 2019 | Pubmed ID: 31482124 A Practical Guide to the Simultaneous Determination of Protein Structure and Dynamics Using Metainference Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31396909 The Hsp70 Chaperone System Stabilizes a Thermo-sensitive Subproteome in E. coli Cell Reports. Jul, 2019 | Pubmed ID: 31365874 Soluble Aggregates Present in Cerebrospinal Fluid Change in Size and Mechanism of Toxicity During Alzheimer's Disease Progression Acta Neuropathologica Communications. Jul, 2019 | Pubmed ID: 31349874 Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers ACS Chemical Neuroscience. Aug, 2019 | Pubmed ID: 31313906 Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging ACS Chemical Biology. Jul, 2019 | Pubmed ID: 31246415 Expression of the Amyloid-β Peptide in a Single Pair of C. Elegans Sensory Neurons Modulates the Associated Behavioural Response PloS One. 2019 | Pubmed ID: 31150491 Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation Cell Reports. May, 2019 | Pubmed ID: 31141697 Effects of α-tubulin Acetylation on Microtubule Structure and Stability Proceedings of the National Academy of Sciences of the United States of America. May, 2019 | Pubmed ID: 31072936 Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies ACS Chemical Biology. Jun, 2019 | Pubmed ID: 31050886 Intrinsically Aggregation-prone Proteins Form Amyloid-like Aggregates and Contribute to Tissue Aging in ELife. May, 2019 | Pubmed ID: 31050339 Secondary Nucleation and Elongation Occur at Different Sites on Alzheimer's Amyloid-β Aggregates Science Advances. Apr, 2019 | Pubmed ID: 31001578 Identifying A- and P-site Locations on Ribosome-protected MRNA Fragments Using Integer Programming Scientific Reports. Apr, 2019 | Pubmed ID: 31000737 The Free Energy Landscape of the Oncogene Protein E7 of Human Papillomavirus Type 16 Reveals a Complex Interplay Between Ordered and Disordered Regions Scientific Reports. Apr, 2019 | Pubmed ID: 30967564 The Metastability of the Proteome of Spinal Motor Neurons Underlies Their Selective Vulnerability in ALS Neuroscience Letters. Jun, 2019 | Pubmed ID: 30953736 Different Soluble Aggregates of Aβ42 Can Give Rise to Cellular Toxicity Through Different Mechanisms Nature Communications. 04, 2019 | Pubmed ID: 30948723 The Amyloid Phenomenon and Its Significance in Biology and Medicine Cold Spring Harbor Perspectives in Biology. Apr, 2019 | Pubmed ID: 30936117 A Method of Predicting the in Vitro Fibril Formation Propensity of Aβ40 Mutants Based on Their Inclusion Body Levels in E. Coli Scientific Reports. Mar, 2019 | Pubmed ID: 30842594 Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis Cold Spring Harbor Perspectives in Biology. Mar, 2019 | Pubmed ID: 30833455 Atomic Force Microscopy for Single Molecule Characterisation of Protein Aggregation Archives of Biochemistry and Biophysics. Mar, 2019 | Pubmed ID: 30742801 Trodusquemine Enhances Aβ Aggregation but Suppresses Its Toxicity by Displacing Oligomers from Cell Membranes Nature Communications. 01, 2019 | Pubmed ID: 30644384 Chemical and Mechanistic Analysis of Photodynamic Inhibition of Alzheimer's β-amyloid Aggregation Chemical Communications (Cambridge, England). Jan, 2019 | Pubmed ID: 30632567 A Superposition Free Method for Protein Conformational Ensemble Analyses and Local Clustering Based on a Differential Geometry Representation of Backbone Proteins. Apr, 2019 | Pubmed ID: 30582223 A Tau Homeostasis Signature is Linked with the Cellular and Regional Vulnerability of Excitatory Neurons to Tau Pathology Nature Neuroscience. 01, 2019 | Pubmed ID: 30559469 In Vitro and in Silico Assessment of the Developability of a Designed Monoclonal Antibody Library MAbs. Feb/Mar, 2019 | Pubmed ID: 30523762 Determination of Protein Structural Ensembles Using Cryo-electron Microscopy Current Opinion in Structural Biology. Jun, 2019 | Pubmed ID: 30502729 Determination of Structural Ensembles of Proteins: Restraining Vs Reweighting Journal of Chemical Theory and Computation. Dec, 2018 | Pubmed ID: 30428663 Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling Structure (London, England : 1993). Oct, 2018 | Pubmed ID: 30393052 Third Generation Antibody Discovery Methods: in Silico Rational Design Chemical Society Reviews. Oct, 2018 | Pubmed ID: 30298157 SAR by Kinetics for Drug Discovery in Protein Misfolding Diseases Proceedings of the National Academy of Sciences of the United States of America. 10, 2018 | Pubmed ID: 30257937 Microfluidic Deposition for Resolving Single-molecule Protein Architecture and Heterogeneity Nature Communications. Sep, 2018 | Pubmed ID: 30250131 Systematic Mapping of Free Energy Landscapes of a Growing Filamin Domain During Biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 09, 2018 | Pubmed ID: 30201720 Author Correction: The Molecular Chaperones DNAJB6 and Hsp70 Cooperate to Suppress α-synuclein Aggregation Scientific Reports. Aug, 2018 | Pubmed ID: 30068912 Determination of the Conformational States of Strychnine in Solution Using NMR Residual Dipolar Couplings in a Tensor-free Approach Methods (San Diego, Calif.). Sep, 2018 | Pubmed ID: 30036639 Structural Differences Between Toxic and Nontoxic HypF-N Oligomers Chemical Communications (Cambridge, England). Aug, 2018 | Pubmed ID: 30020284 Molecular Dynamics Ensemble Refinement of the Heterogeneous Native State of NCBD Using Chemical Shifts and NOEs PeerJ. 2018 | Pubmed ID: 30013831 Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions ACS Chemical Neuroscience. Aug, 2018 | Pubmed ID: 29986583 Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine ACS Chemical Biology. Aug, 2018 | Pubmed ID: 29953201 Reversible Inhibition of the ClpP Protease Via an N-terminal Conformational Switch Proceedings of the National Academy of Sciences of the United States of America. 07, 2018 | Pubmed ID: 29941580 A Method for Partitioning the Information Contained in a Protein Sequence Between Its Structure and Function Proteins. Sep, 2018 | Pubmed ID: 29790601 Cooperative Assembly of Hsp70 Subdomain Clusters Biochemistry. Jul, 2018 | Pubmed ID: 29763298 A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells International Journal of Molecular Sciences. May, 2018 | Pubmed ID: 29757200 Cholesterol Catalyses Aβ42 Aggregation Through a Heterogeneous Nucleation Pathway in the Presence of Lipid Membranes Nature Chemistry. Jun, 2018 | Pubmed ID: 29736006 FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions Cell. Apr, 2018 | Pubmed ID: 29677515 Parapred: Antibody Paratope Prediction Using Convolutional and Recurrent Neural Networks Bioinformatics (Oxford, England). Sep, 2018 | Pubmed ID: 29672675 Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy Biophysical Journal. Apr, 2018 | Pubmed ID: 29642030 Exploring the Role of Post-translational Modifications in Regulating α-synuclein Interactions by Studying the Effects of Phosphorylation on Nanobody Binding Protein Science : a Publication of the Protein Society. Jul, 2018 | Pubmed ID: 29603451 Molecular Determinants of the Interaction of EGCG with Ordered and Disordered Proteins Biopolymers. Aug, 2018 | Pubmed ID: 29603125 Structural Ensemble Modulation Upon Small-Molecule Binding to Disordered Proteins Journal of Molecular Biology. Aug, 2018 | Pubmed ID: 29596915 Distinct Thermodynamic Signatures of Oligomer Generation in the Aggregation of the Amyloid-β Peptide Nature Chemistry. May, 2018 | Pubmed ID: 29581486 Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation Annual Review of Physical Chemistry. 04, 2018 | Pubmed ID: 29490200 Massively Parallel C. Elegans Tracking Provides Multi-dimensional Fingerprints for Phenotypic Discovery Journal of Neuroscience Methods. Aug, 2018 | Pubmed ID: 29452179 MobiDB 3.0: More Annotations for Intrinsic Disorder, Conformational Diversity and Interactions in Proteins Nucleic Acids Research. Jan, 2018 | Pubmed ID: 29136219 Structural Basis of Membrane Disruption and Cellular Toxicity by α-synuclein Oligomers Science (New York, N.Y.). 12, 2017 | Pubmed ID: 29242346 Scaling Behaviour and Rate-determining Steps in Filamentous Self-assembly Chemical Science. Oct, 2017 | Pubmed ID: 29147538 Delivery of Native Proteins into C. Elegans Using a Transduction Protocol Based on Lipid Vesicles Scientific Reports. Nov, 2017 | Pubmed ID: 29118344 Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo Angewandte Chemie (International Ed. in English). Nov, 2017 | Pubmed ID: 28968001 The Molecular Chaperones DNAJB6 and Hsp70 Cooperate to Suppress α-synuclein Aggregation Scientific Reports. Aug, 2017 | Pubmed ID: 28831037 Rapid and Accurate in Silico Solubility Screening of a Monoclonal Antibody Library Scientific Reports. Aug, 2017 | Pubmed ID: 28811609 Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide Journal of Molecular Biology. Sep, 2017 | Pubmed ID: 28743590 Monomeric and Fibrillar α-synuclein Exert Opposite Effects on the Catalytic Cycle That Promotes the Proliferation of Aβ42 Aggregates Proceedings of the National Academy of Sciences of the United States of America. 07, 2017 | Pubmed ID: 28698377 Selective Targeting of Primary and Secondary Nucleation Pathways in Aβ42 Aggregation Using a Rational Antibody Scanning Method Science Advances. Jun, 2017 | Pubmed ID: 28691099 Nanobodies Raised Against Monomeric ɑ-synuclein Inhibit Fibril Formation and Destabilize Toxic Oligomeric Species BMC Biology. 07, 2017 | Pubmed ID: 28673288 Protein Homeostasis of a Metastable Subproteome Associated with Alzheimer's Disease Proceedings of the National Academy of Sciences of the United States of America. 07, 2017 | Pubmed ID: 28652376 Methods of Probing the Interactions Between Small Molecules and Disordered Proteins Cellular and Molecular Life Sciences : CMLS. 09, 2017 | Pubmed ID: 28631009 Phage Display and Kinetic Selection of Antibodies That Specifically Inhibit Amyloid Self-replication Proceedings of the National Academy of Sciences of the United States of America. 06, 2017 | Pubmed ID: 28584111 Amyloid-like Fibrils from an α-Helical Transmembrane Protein Biochemistry. 06, 2017 | Pubmed ID: 28493669 The RNF168 Paralog RNF169 Defines a New Class of Ubiquitylated Histone Reader Involved in the Response to DNA Damage ELife. 04, 2017 | Pubmed ID: 28406400 Structural Characterization of the Early Events in the Nucleation-Condensation Mechanism in a Protein Folding Process Journal of the American Chemical Society. 05, 2017 | Pubmed ID: 28401755 Emergence and Evolution of an Interaction Between Intrinsically Disordered Proteins ELife. 04, 2017 | Pubmed ID: 28398197 Spinal Motor Neuron Protein Supersaturation Patterns Are Associated with Inclusion Body Formation in ALS Proceedings of the National Academy of Sciences of the United States of America. 05, 2017 | Pubmed ID: 28396410 MOAG-4 Promotes the Aggregation of α-synuclein by Competing with Self-protective Electrostatic Interactions The Journal of Biological Chemistry. 05, 2017 | Pubmed ID: 28336532 Simultaneous Quantification of Protein Order and Disorder Nature Chemical Biology. 03, 2017 | Pubmed ID: 28328918 Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation Molecular Cell. Mar, 2017 | Pubmed ID: 28306505 Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition Between α-Synuclein Species Biochemistry. 03, 2017 | Pubmed ID: 28230968 A Natural Product Inhibits the Initiation of α-synuclein Aggregation and Suppresses Its Toxicity Proceedings of the National Academy of Sciences of the United States of America. 02, 2017 | Pubmed ID: 28096355 Networks of Dynamic Allostery Regulate Enzyme Function Structure (London, England : 1993). 02, 2017 | Pubmed ID: 28089447 Simultaneous NMR Characterisation of Multiple Minima in the Free Energy Landscape of an RNA UUCG Tetraloop Physical Chemistry Chemical Physics : PCCP. Jan, 2017 | Pubmed ID: 28067358 Principles of Protein Structural Ensemble Determination Current Opinion in Structural Biology. 02, 2017 | Pubmed ID: 28063280 Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Aβ42 Aggregation in Alzheimer's Disease Proceedings of the National Academy of Sciences of the United States of America. 01, 2017 | Pubmed ID: 28011763 β-Synuclein Suppresses Both the Initiation and Amplification Steps of α-synuclein Aggregation Via Competitive Binding to Surfaces Scientific Reports. 11, 2016 | Pubmed ID: 27808107 Structural Basis of Synaptic Vesicle Assembly Promoted by α-synuclein Nature Communications. 09, 2016 | Pubmed ID: 27640673 Mutations Associated with Familial Parkinson's Disease Alter the Initiation and Amplification Steps of α-synuclein Aggregation Proceedings of the National Academy of Sciences of the United States of America. 09, 2016 | Pubmed ID: 27573854 Metadynamic Metainference: Enhanced Sampling of the Metainference Ensemble Using Metadynamics Scientific Reports. 08, 2016 | Pubmed ID: 27561930 A Protein Homeostasis Signature in Healthy Brains Recapitulates Tissue Vulnerability to Alzheimer's Disease Science Advances. 08, 2016 | Pubmed ID: 27532054 Towards a Structural Biology of the Hydrophobic Effect in Protein Folding Scientific Reports. 07, 2016 | Pubmed ID: 27461719 Chemical Properties of Lipids Strongly Affect the Kinetics of the Membrane-induced Aggregation of α-synuclein Proceedings of the National Academy of Sciences of the United States of America. 06, 2016 | Pubmed ID: 27298346 Structure of a Low-population Binding Intermediate in Protein-RNA Recognition Proceedings of the National Academy of Sciences of the United States of America. 06, 2016 | Pubmed ID: 27286828 Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity Scientific Reports. 06, 2016 | Pubmed ID: 27273030 Rational Design of Mutations That Change the Aggregation Rate of a Protein While Maintaining Its Native Structure and Stability Scientific Reports. 05, 2016 | Pubmed ID: 27150430 Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein Biochemistry. 06, 2016 | Pubmed ID: 27096466 Structural Characterization of the Interaction of α-synuclein Nascent Chains with the Ribosomal Surface and Trigger Factor Proceedings of the National Academy of Sciences of the United States of America. May, 2016 | Pubmed ID: 27092002 A Transcriptional Signature of Alzheimer's Disease is Associated with a Metastable Subproteome at Risk for Aggregation Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016 | Pubmed ID: 27071083 Kinetic Analysis Reveals the Diversity of Microscopic Mechanisms Through Which Molecular Chaperones Suppress Amyloid Formation Nature Communications. Mar, 2016 | Pubmed ID: 27009901 Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain The Journal of Biological Chemistry. May, 2016 | Pubmed ID: 27002146 An Anticancer Drug Suppresses the Primary Nucleation Reaction That Initiates the Production of the Toxic Aβ42 Aggregates Linked with Alzheimer's Disease Science Advances. Feb, 2016 | Pubmed ID: 26933687 A Structural Ensemble of a Ribosome-nascent Chain Complex During Cotranslational Protein Folding Nature Structural & Molecular Biology. Apr, 2016 | Pubmed ID: 26926436 A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins ACS Combinatorial Science. Mar, 2016 | Pubmed ID: 26923286 Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein Scientific Reports. Feb, 2016 | Pubmed ID: 26912067 Hamiltonian Dynamics of Protein Filament Formation Physical Review Letters. Jan, 2016 | Pubmed ID: 26849615 Metainference: A Bayesian Inference Method for Heterogeneous Systems Science Advances. Jan, 2016 | Pubmed ID: 26844300 Molecular Mechanisms of Protein Aggregation from Global Fitting of Kinetic Models Nature Protocols. Feb, 2016 | Pubmed ID: 26741409 Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins Under Native Solution Conditions ACS Nano. Jan, 2016 | Pubmed ID: 26678709 Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurements Biochemistry. Jan, 2016 | Pubmed ID: 26618792 Parmbsc1: a Refined Force Field for DNA Simulations Nature Methods. Jan, 2016 | Pubmed ID: 26569599 Using Pseudocontact Shifts and Residual Dipolar Couplings As Exact NMR Restraints for the Determination of Protein Structural Ensembles Biochemistry. Dec, 2015 | Pubmed ID: 26624789 ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function Neuron. Nov, 2015 | Pubmed ID: 26526393 Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies Current Alzheimer Research. 2015 | Pubmed ID: 26510979 Mapping the Protein Fold Universe Using the CamTube Force Field in Molecular Dynamics Simulations PLoS Computational Biology. Oct, 2015 | Pubmed ID: 26505754 The Inverted Free Energy Landscape of an Intrinsically Disordered Peptide by Simulations and Experiments Scientific Reports. Oct, 2015 | Pubmed ID: 26498066 Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins Biochemistry. Nov, 2015 | Pubmed ID: 26479087 Latent Analysis of Unmodified Biomolecules and Their Complexes in Solution with Attomole Detection Sensitivity Nature Chemistry. Oct, 2015 | Pubmed ID: 26391079 Druggability of Intrinsically Disordered Proteins Advances in Experimental Medicine and Biology. 2015 | Pubmed ID: 26387110 Structure and Dynamics of Intrinsically Disordered Proteins Advances in Experimental Medicine and Biology. 2015 | Pubmed ID: 26387099 Biophysical Approaches for the Study of Interactions Between Molecular Chaperones and Protein Aggregates Chemical Communications (Cambridge, England). Oct, 2015 | Pubmed ID: 26328629 Targeting Disordered Proteins with Small Molecules Using Entropy Trends in Biochemical Sciences. Sep, 2015 | Pubmed ID: 26275458 Rational Design of Antibodies Targeting Specific Epitopes Within Intrinsically Disordered Proteins Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26216991 Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study Journal of the American Chemical Society. Aug, 2015 | Pubmed ID: 26192632 A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone Toward a Target Substrate Biochemistry. Aug, 2015 | Pubmed ID: 26192230 Probing the Residual Structure of the Low Populated Denatured State of ADA2h Under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy Biochemistry. Aug, 2015 | Pubmed ID: 26115097 Dynamic Binding Mode of a Synaptotagmin-1-SNARE Complex in Solution Nature Structural & Molecular Biology. Jul, 2015 | Pubmed ID: 26030874 Analysis of the Performance of the CHESHIRE and YAPP Methods at CASD-NMR Round 3 Journal of Biomolecular NMR. Aug, 2015 | Pubmed ID: 25990018 Widespread Proteome Remodeling and Aggregation in Aging C. Elegans Cell. May, 2015 | Pubmed ID: 25957690 Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures Biochemistry. May, 2015 | Pubmed ID: 25923019 Structure and Dynamics of the Integrin LFA-1 I-domain in the Inactive State Underlie Its Inside-out/outside-in Signaling and Allosteric Mechanisms Structure (London, England : 1993). Apr, 2015 | Pubmed ID: 25773142 A Molecular Chaperone Breaks the Catalytic Cycle That Generates Toxic Aβ Oligomers Nature Structural & Molecular Biology. Mar, 2015 | Pubmed ID: 25686087 Lipid Vesicles Trigger α-synuclein Aggregation by Stimulating Primary Nucleation Nature Chemical Biology. Mar, 2015 | Pubmed ID: 25643172 Supersaturation is a Major Driving Force for Protein Aggregation in Neurodegenerative Diseases Trends in Pharmacological Sciences. Feb, 2015 | Pubmed ID: 25636813 Structure of a Low-population Intermediate State in the Release of an Enzyme Product ELife. Jan, 2015 | Pubmed ID: 25575179 The S2D Method: Simultaneous Sequence-based Prediction of the Statistical Populations of Ordered and Disordered Regions in Proteins Journal of Molecular Biology. Feb, 2015 | Pubmed ID: 25534081 The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-synuclein The Journal of Biological Chemistry. Jan, 2015 | Pubmed ID: 25505181 The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility Journal of Molecular Biology. Jan, 2015 | Pubmed ID: 25451785 Identification and Characterization of PKCγ, a Kinase Associated with SCA14, As an Amyloidogenic Protein Human Molecular Genetics. Jan, 2015 | Pubmed ID: 25217572 A Tensor-free Method for the Structural and Dynamical Refinement of Proteins Using Residual Dipolar Couplings The Journal of Physical Chemistry. B. Jan, 2015 | Pubmed ID: 24824082 Characterization of the Conformational Fluctuations in the Josephin Domain of Ataxin-3 Biophysical Journal. Dec, 2014 | Pubmed ID: 25517158 A Relationship Between the Transient Structure in the Monomeric State and the Aggregation Propensities of α-synuclein and β-synuclein Biochemistry. Nov, 2014 | Pubmed ID: 25389903 Understanding the Frustration Arising from the Competition Between Function, Misfolding, and Aggregation in a Globular Protein Proceedings of the National Academy of Sciences of the United States of America. Sep, 2014 | Pubmed ID: 25228761 Equilibrium Simulations of Proteins Using Molecular Fragment Replacement and NMR Chemical Shifts Proceedings of the National Academy of Sciences of the United States of America. Sep, 2014 | Pubmed ID: 25192938 NMR Characterization of the Conformational Fluctuations of the Human Lymphocyte Function-associated Antigen-1 I-domain Protein Science : a Publication of the Protein Society. Nov, 2014 | Pubmed ID: 25147050 Cyclophilin A Catalyzes Proline Isomerization by an Electrostatic Handle Mechanism Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 24982184 Statistical Mechanics of the Denatured State of a Protein Using Replica-averaged Metadynamics Journal of the American Chemical Society. Jun, 2014 | Pubmed ID: 24884637 Direct Observation of the Three Regions in α-synuclein That Determine Its Membrane-bound Behaviour Nature Communications. May, 2014 | Pubmed ID: 24871041 The Amyloid State and Its Association with Protein Misfolding Diseases Nature Reviews. Molecular Cell Biology. Jun, 2014 | Pubmed ID: 24854788 Archaeal MBF1 Binds to 30S and 70S Ribosomes Via Its Helix-turn-helix Domain The Biochemical Journal. May, 2014 | Pubmed ID: 24825021 Solution Conditions Determine the Relative Importance of Nucleation and Growth Processes in α-synuclein Aggregation Proceedings of the National Academy of Sciences of the United States of America. May, 2014 | Pubmed ID: 24817693 Understanding the Influence of Codon Translation Rates on Cotranslational Protein Folding Accounts of Chemical Research. May, 2014 | Pubmed ID: 24784899 ALMOST: an All Atom Molecular Simulation Toolkit for Protein Structure Determination Journal of Computational Chemistry. May, 2014 | Pubmed ID: 24676684 Chemical Kinetics for Drug Discovery to Combat Protein Aggregation Diseases Trends in Pharmacological Sciences. Mar, 2014 | Pubmed ID: 24560688 Targeting the Intrinsically Disordered Structural Ensemble of α-synuclein by Small Molecules As a Potential Therapeutic Strategy for Parkinson's Disease PloS One. 2014 | Pubmed ID: 24551051 Determination of the Individual Roles of the Linker Residues in the Interdomain Motions of Calmodulin Using NMR Chemical Shifts Journal of Molecular Biology. Apr, 2014 | Pubmed ID: 24530797 A Conformational Ensemble Derived Using NMR Methyl Chemical Shifts Reveals a Mechanical Clamping Transition That Gates the Binding of the HU Protein to DNA Journal of the American Chemical Society. Feb, 2014 | Pubmed ID: 24517490 A Simple Lattice Model That Captures Protein Folding, Aggregation and Amyloid Formation PloS One. 2014 | Pubmed ID: 24454816 Kinetic Modelling Indicates That Fast-translating Codons Can Coordinate Cotranslational Protein Folding by Avoiding Misfolded Intermediates Nature Communications. 2014 | Pubmed ID: 24394622 PE-DB: a Database of Structural Ensembles of Intrinsically Disordered and of Unfolded Proteins Nucleic Acids Research. Jan, 2014 | Pubmed ID: 24174539 Replica-Averaged Metadynamics Journal of Chemical Theory and Computation. Dec, 2013 | Pubmed ID: 26592295 A Clear View of Polymorphism, Twist, and Chirality in Amyloid Fibril Formation ACS Nano. Dec, 2013 | Pubmed ID: 24359171 Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy Journal of the American Chemical Society. Dec, 2013 | Pubmed ID: 24304221 Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins Cell Reports. Nov, 2013 | Pubmed ID: 24183671 Subdomain Architecture and Stability of a Giant Repeat Protein The Journal of Physical Chemistry. B. Oct, 2013 | Pubmed ID: 24053231 In-cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-synuclein Within E. Coli Cells PloS One. 2013 | Pubmed ID: 23991082 Structures of the Excited States of Phospholamban and Shifts in Their Populations Upon Phosphorylation Biochemistry. Sep, 2013 | Pubmed ID: 23968132 Characterization of the Interdomain Motions in Hen Lysozyme Using Residual Dipolar Couplings As Replica-averaged Structural Restraints in Molecular Dynamics Simulations Biochemistry. Sep, 2013 | Pubmed ID: 23941501 A Relationship Between the Aggregation Rates of α-synuclein Variants and the β-sheet Populations in Their Monomeric Forms The Journal of Physical Chemistry. B. Sep, 2013 | Pubmed ID: 23941114 Identification of Small-molecule Binding Pockets in the Soluble Monomeric Form of the Aβ42 Peptide The Journal of Chemical Physics. Jul, 2013 | Pubmed ID: 23883055 A Geometrical Parametrization of C1'-C5' RNA Ribose Chemical Shifts Calculated by Density Functional Theory The Journal of Chemical Physics. Jul, 2013 | Pubmed ID: 23883004 Single-molecule Measurements of Transient Biomolecular Complexes Through Microfluidic Dilution Analytical Chemistry. Jul, 2013 | Pubmed ID: 23782428 A Method of Determining RNA Conformational Ensembles Using Structure-based Calculations of Residual Dipolar Couplings The Journal of Chemical Physics. Jun, 2013 | Pubmed ID: 23758399 Proliferation of Amyloid-β42 Aggregates Occurs Through a Secondary Nucleation Mechanism Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23703910 Characterization of the Free-energy Landscapes of Proteins by NMR-guided Metadynamics Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23572592 Nanobodies Raised Against Monomeric α-synuclein Distinguish Between Fibrils at Different Maturation Stages Journal of Molecular Biology. Jul, 2013 | Pubmed ID: 23557833 Atomic Structure and Hierarchical Assembly of a Cross-β Amyloid Fibril Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23513222 Molecular Dynamics Simulations with Replica-averaged Structural Restraints Generate Structural Ensembles According to the Maximum Entropy Principle The Journal of Chemical Physics. Mar, 2013 | Pubmed ID: 23485282 Analysis of the Contributions of Ring Current and Electric Field Effects to the Chemical Shifts of RNA Bases The Journal of Physical Chemistry. B. Feb, 2013 | Pubmed ID: 23398371 Assessment of the Use of NMR Chemical Shifts As Replica-averaged Structural Restraints in Molecular Dynamics Simulations to Characterize the Dynamics of Proteins The Journal of Physical Chemistry. B. Feb, 2013 | Pubmed ID: 23327201 In Vivo Translation Rates Can Substantially Delay the Cotranslational Folding of the Escherichia Coli Cytosolic Proteome Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23256155 Twisting Transition Between Crystalline and Fibrillar Phases of Aggregated Peptides Physical Review Letters. Oct, 2012 | Pubmed ID: 23102370 ADP Ribosylation Adapts an ER Chaperone Response to Short-term Fluctuations in Unfolded Protein Load The Journal of Cell Biology. Aug, 2012 | Pubmed ID: 22869598 Determination of Structural Fluctuations of Proteins from Structure-based Calculations of Residual Dipolar Couplings Journal of Biomolecular NMR. Aug, 2012 | Pubmed ID: 22729708 Trigger Factor Slows Co-translational Folding Through Kinetic Trapping While Sterically Protecting the Nascent Chain from Aberrant Cytosolic Interactions Journal of the American Chemical Society. Jul, 2012 | Pubmed ID: 22680285 Prediction of Variable Translation Rate Effects on Cotranslational Protein Folding Nature Communications. May, 2012 | Pubmed ID: 22643895 Protein Structure Validation Using Side-chain Chemical Shifts The Journal of Physical Chemistry. B. Apr, 2012 | Pubmed ID: 22455760 From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation Journal of Molecular Biology. Aug, 2012 | Pubmed ID: 22406275 Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts Biochemistry. Mar, 2012 | Pubmed ID: 22360139 Blind Testing of Routine, Fully Automated Determination of Protein Structures from NMR Data Structure (London, England : 1993). Feb, 2012 | Pubmed ID: 22325772 Characterization of the Conformational Equilibrium Between the Two Major Substates of RNase A Using NMR Chemical Shifts Journal of the American Chemical Society. Mar, 2012 | Pubmed ID: 22320129 Proteome Folding and Aggregation Current Opinion in Structural Biology. Apr, 2012 | Pubmed ID: 22317916 ALS Mutations in FUS Cause Neuronal Dysfunction and Death in Caenorhabditis Elegans by a Dominant Gain-of-function Mechanism Human Molecular Genetics. Jan, 2012 | Pubmed ID: 21949354 ¹H, ¹³C and ¹⁵N Resonance Assignments of Human Muscle Acylphosphatase Biomolecular NMR Assignments. Apr, 2012 | Pubmed ID: 21643968 Determination of Conformational Equilibria in Proteins Using Residual Dipolar Couplings Journal of Chemical Theory and Computation. Dec, 2011 | Pubmed ID: 22180735 Experimental Free Energy Surfaces Reveal the Mechanisms of Maintenance of Protein Solubility Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22160682 Inversion of the Balance Between Hydrophobic and Hydrogen Bonding Interactions in Protein Folding and Aggregation PLoS Computational Biology. Oct, 2011 | Pubmed ID: 22022239 Nucleated Polymerisation in the Presence of Pre-formed Seed Filaments International Journal of Molecular Sciences. 2011 | Pubmed ID: 22016630 Using Side-chain Aromatic Proton Chemical Shifts for a Quantitative Analysis of Protein Structures Angewandte Chemie (International Ed. in English). Oct, 2011 | Pubmed ID: 21887824 Nucleated Polymerization with Secondary Pathways. III. Equilibrium Behavior and Oligomer Populations The Journal of Chemical Physics. Aug, 2011 | Pubmed ID: 21842956 Nucleated Polymerization with Secondary Pathways. II. Determination of Self-consistent Solutions to Growth Processes Described by Non-linear Master Equations The Journal of Chemical Physics. Aug, 2011 | Pubmed ID: 21842955 Nucleated Polymerization with Secondary Pathways. I. Time Evolution of the Principal Moments The Journal of Chemical Physics. Aug, 2011 | Pubmed ID: 21842954 Protein Solubility and Protein Homeostasis: a Generic View of Protein Misfolding Disorders Cold Spring Harbor Perspectives in Biology. Dec, 2011 | Pubmed ID: 21825020 Structure-based Prediction of Methyl Chemical Shifts in Proteins Journal of Biomolecular NMR. Aug, 2011 | Pubmed ID: 21748266 The A53T Mutation is Key in Defining the Differences in the Aggregation Kinetics of Human and Mouse α-synuclein Journal of the American Chemical Society. Aug, 2011 | Pubmed ID: 21721555 The IFly Tracking System for an Automated Locomotor and Behavioural Analysis of Drosophila Melanogaster Integrative Biology : Quantitative Biosciences from Nano to Macro. Jul, 2011 | Pubmed ID: 21698336 Metastability of Native Proteins and the Phenomenon of Amyloid Formation Journal of the American Chemical Society. Sep, 2011 | Pubmed ID: 21650202 Using Chemical Shifts to Determine Structural Changes in Proteins Upon Complex Formation The Journal of Physical Chemistry. B. Aug, 2011 | Pubmed ID: 21639128 Detection of Early Locomotor Abnormalities in a Drosophila Model of Alzheimer's Disease Journal of Neuroscience Methods. Apr, 2011 | Pubmed ID: 21315762 Protein Dynamics: Moore's Law in Molecular Biology Current Biology : CB. Jan, 2011 | Pubmed ID: 21256436 New Scenarios of Protein Folding Can Occur on the Ribosome Journal of the American Chemical Society. Jan, 2011 | Pubmed ID: 21204555 Transient Tertiary Structure Formation Within the Ribosome Exit Port Journal of the American Chemical Society. Dec, 2010 | Pubmed ID: 21062068 Translationally Optimal Codons Associate with Aggregation-prone Sites in Proteins Proteomics. Dec, 2010 | Pubmed ID: 21046618 Derivation of a Solubility Condition for Proteins from an Analysis of the Competition Between Folding and Aggregation Molecular BioSystems. Dec, 2010 | Pubmed ID: 20957252 Enzymatic Activity in Disordered States of Proteins Current Opinion in Chemical Biology. Oct, 2010 | Pubmed ID: 20832351 Proteome-level Interplay Between Folding and Aggregation Propensities of Proteins Journal of Molecular Biology. Oct, 2010 | Pubmed ID: 20709078 Using NMR Chemical Shifts As Structural Restraints in Molecular Dynamics Simulations of Proteins Structure (London, England : 1993). Aug, 2010 | Pubmed ID: 20696393 Physicochemical Determinants of Chaperone Requirements Journal of Molecular Biology. Jul, 2010 | Pubmed ID: 20416322 Intrinsic Determinants of Neurotoxic Aggregate Formation by the Amyloid Beta Peptide Biophysical Journal. Apr, 2010 | Pubmed ID: 20409489 Time Averaging of NMR Chemical Shifts in the MLF Peptide in the Solid State Journal of the American Chemical Society. May, 2010 | Pubmed ID: 20387894 Quantitative Approaches to Defining Normal and Aberrant Protein Homeostasis Faraday Discussions. 2009 | Pubmed ID: 20334107 Determination of the Free Energy Landscape of Alpha-synuclein Using Spin Label Nuclear Magnetic Resonance Measurements Journal of the American Chemical Society. Dec, 2009 | Pubmed ID: 20028147 An Analytical Solution to the Kinetics of Breakable Filament Assembly Science (New York, N.Y.). Dec, 2009 | Pubmed ID: 20007899 Analysis of Sub-tauc and Supra-tauc Motions in Protein Gbeta1 Using Molecular Dynamics Simulations Biophysical Journal. Nov, 2009 | Pubmed ID: 19883594 Accurate Random Coil Chemical Shifts from an Analysis of Loop Regions in Native States of Proteins Journal of the American Chemical Society. Nov, 2009 | Pubmed ID: 19852475 Correlation Between MRNA Expression Levels and Protein Aggregation Propensities in Subcellular Localisations Molecular BioSystems. Dec, 2009 | Pubmed ID: 19763336 Fast and Accurate Predictions of Protein NMR Chemical Shifts from Interatomic Distances Journal of the American Chemical Society. Oct, 2009 | Pubmed ID: 19739624 A Condensation-ordering Mechanism in Nanoparticle-catalyzed Peptide Aggregation PLoS Computational Biology. Aug, 2009 | Pubmed ID: 19680431 On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of Alpha-synuclein with Congo Red and Lacmoid Biochemistry. Sep, 2009 | Pubmed ID: 19645507 Physicochemical Principles That Regulate the Competition Between Functional and Dysfunctional Association of Proteins Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19502422 Folding of Small Proteins by Monte Carlo Simulations with Chemical Shift Restraints Without the Use of Molecular Fragment Replacement or Structural Homology The Journal of Physical Chemistry. B. Jun, 2009 | Pubmed ID: 19425536 Position-dependent Electrostatic Protection Against Protein Aggregation Chembiochem : a European Journal of Chemical Biology. May, 2009 | Pubmed ID: 19415709 Competition Between Intramolecular and Intermolecular Interactions in an Amyloid-forming Protein Journal of Molecular Biology. Jun, 2009 | Pubmed ID: 19393661 Toward an Accurate Determination of Free Energy Landscapes in Solution States of Proteins Journal of the American Chemical Society. Mar, 2009 | Pubmed ID: 19292482 A Relationship Between MRNA Expression Levels and Protein Solubility in E. Coli Journal of Molecular Biology. May, 2009 | Pubmed ID: 19281824 The Mechanism of Folding of Im7 Reveals Competition Between Functional and Kinetic Evolutionary Constraints Nature Structural & Molecular Biology. Mar, 2009 | Pubmed ID: 19252485 Mutational Analysis of the Aggregation-prone and Disaggregation-prone Regions of Acylphosphatase Journal of Molecular Biology. Apr, 2009 | Pubmed ID: 18809411 Towards Quantitative Predictions in Cell Biology Using Chemical Properties of Proteins Molecular BioSystems. Dec, 2008 | Pubmed ID: 19396379 Stochastic Reconstruction of Protein Structures from Effective Connectivity Profiles PMC Biophysics. Nov, 2008 | Pubmed ID: 19351427 Determination of Protein Structures in the Solid State from NMR Chemical Shifts Structure (London, England : 1993). Dec, 2008 | Pubmed ID: 19081052 Comparison of Successive Transition States for Folding Reveals Alternative Early Folding Pathways of Two Homologous Proteins Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19033470 A Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric Aggregates PLoS Computational Biology. Nov, 2008 | Pubmed ID: 19008938 Structure Determination of Protein-protein Complexes Using NMR Chemical Shifts: Case of an Endonuclease Colicin-immunity Protein Complex Journal of the American Chemical Society. Nov, 2008 | Pubmed ID: 18980319 Inhibition of Alpha-synuclein Fibrillization by Dopamine is Mediated by Interactions with Five C-terminal Residues and with E83 in the NAC Region PloS One. 2008 | Pubmed ID: 18852892 Prediction by Graph Theoretic Measures of Structural Effects in Proteins Arising from Non-synonymous Single Nucleotide Polymorphisms PLoS Computational Biology. Jul, 2008 | Pubmed ID: 18654622 Protein Dynamics Under Light Control Nature Chemical Biology. Aug, 2008 | Pubmed ID: 18641621 The Zyggregator Method for Predicting Protein Aggregation Propensities Chemical Society Reviews. Jul, 2008 | Pubmed ID: 18568165 Mapping of Two Networks of Residues That Exhibit Structural and Dynamical Changes Upon Binding in a PDZ Domain Protein Journal of the American Chemical Society. Jul, 2008 | Pubmed ID: 18558679 Prediction of Aggregation-prone Regions in Structured Proteins Journal of Molecular Biology. Jul, 2008 | Pubmed ID: 18514226 Calculation of the Free Energy Barriers in the Oligomerisation of Abeta Peptide Fragments Frontiers in Bioscience : a Journal and Virtual Library. May, 2008 | Pubmed ID: 18508610 A Coupled Equilibrium Shift Mechanism in Calmodulin-mediated Signal Transduction Structure (London, England : 1993). May, 2008 | Pubmed ID: 18462678 Biological Function in a Non-native Partially Folded State of a Protein The EMBO Journal. May, 2008 | Pubmed ID: 18451804 Molecular Determinants of the Aggregation Behavior of Alpha- and Beta-synuclein Protein Science : a Publication of the Protein Society. May, 2008 | Pubmed ID: 18436957 Characterisation of Transition State Structures for Protein Folding Using 'high', 'medium' and 'low' {Phi}-values Protein Engineering, Design & Selection : PEDS. Mar, 2008 | Pubmed ID: 18299294 Systematic in Vivo Analysis of the Intrinsic Determinants of Amyloid Beta Pathogenicity PLoS Biology. Oct, 2007 | Pubmed ID: 17973577 Structural Reorganisation and Potential Toxicity of Oligomeric Species Formed During the Assembly of Amyloid Fibrils PLoS Computational Biology. Sep, 2007 | Pubmed ID: 17941703 The Distribution of Residues in a Polypeptide Sequence is a Determinant of Aggregation Optimized by Evolution Biophysical Journal. Dec, 2007 | Pubmed ID: 17766358 Similarities in the Thermodynamics and Kinetics of Aggregation of Disease-related Abeta(1-40) Peptides Protein Science : a Publication of the Protein Society. Jun, 2007 | Pubmed ID: 17525469 A PDZ Domain Recapitulates a Unifying Mechanism for Protein Folding Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17179214 BPPred: a Web-based Computational Tool for Predicting Biophysical Parameters of Proteins Protein Science : a Publication of the Protein Society. Jan, 2007 | Pubmed ID: 17123959 A Protein Evolution Model with Independent Sites That Reproduces Site-specific Amino Acid Distributions from the Protein Data Bank BMC Evolutionary Biology. May, 2006 | Pubmed ID: 16737532 Structural Comparison of the Two Alternative Transition States for Folding of TI I27 Biophysical Journal. Jul, 2006 | Pubmed ID: 16603501 Determination of an Ensemble of Structures Representing the Intermediate State of the Bacterial Immunity Protein Im7 Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16371468 Determination of the Folding Transition States of Barnase by Using PhiI-value-restrained Simulations Validated by Double Mutant PhiIJ-values Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16116084 A Glimpse at the Organization of the Protein Universe Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005 | Pubmed ID: 15827120 Comparison of Sequence-based and Structure-based Energy Functions for the Reversible Folding of a Peptide Biophysical Journal. May, 2005 | Pubmed ID: 15749768 Structures and Relative Free Energies of Partially Folded States of Proteins Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14657374 Calculation of Mutational Free Energy Changes in Transition States for Protein Folding Biophysical Journal. Aug, 2003 | Pubmed ID: 12885664 Analysis of the Distributed Computing Approach Applied to the Folding of a Small Beta Peptide Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12815104 Self-consistent Determination of the Transition State for Protein Folding: Application to a Fibronectin Type III Domain Proceedings of the National Academy of Sciences of the United States of America. Jan, 2003 | Pubmed ID: 12515856 Bireysel Protein Agregalarının Kızılötesi Nanospektroskopi ve Atomik Kuvvet Mikroskobu ile Karakterizeleştirilmesi Francesco Simone Ruggeri1, Tomas Šneideris1,2, Sean Chia1, Michele Vendruscolo1, Tuomas P. J. Knowles1,3 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2Institute of Biotechnology, Life Sciences Center, Vilnius University, 3Cavendish Laboratory, Department of Physics, University of Cambridge JoVE 60108 Biochemistry Otomatik davranış analizi büyük C. elegans nüfus kullanarak bir geniş alan bakış açısı izleme platformu Michele Perni1, Sam Casford1, Francesco A. Aprile1, Ellen A. Nollen2, Tuomas P.J. Knowles1, Michele Vendruscolo1, Christopher M. Dobson1 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2European Research Institute for the Biology of Aging, University Medical Centre Groningen JoVE 58643 Immunology and Infection
Bireysel Protein Agregalarının Kızılötesi Nanospektroskopi ve Atomik Kuvvet Mikroskobu ile Karakterizeleştirilmesi Francesco Simone Ruggeri1, Tomas Šneideris1,2, Sean Chia1, Michele Vendruscolo1, Tuomas P. J. Knowles1,3 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2Institute of Biotechnology, Life Sciences Center, Vilnius University, 3Cavendish Laboratory, Department of Physics, University of Cambridge JoVE 60108 Biochemistry
Otomatik davranış analizi büyük C. elegans nüfus kullanarak bir geniş alan bakış açısı izleme platformu Michele Perni1, Sam Casford1, Francesco A. Aprile1, Ellen A. Nollen2, Tuomas P.J. Knowles1, Michele Vendruscolo1, Christopher M. Dobson1 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2European Research Institute for the Biology of Aging, University Medical Centre Groningen JoVE 58643 Immunology and Infection
