Other Publications (1)
Articles by Michelle J. Veite-Schmahl in JoVE
Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling Michelle J. Veite-Schmahl1, Daniel P. Regan1, Adam C. Rivers1, Joseph F. Nowatzke1,2, Michael A. Kennedy1 1Department of Chemistry & Biochemistry, Miami University, 2College of Medicine, Central Michigan University This video article provides a detailed demonstration of the procedures required to successfully remove the pancreas from a mouse by dissection for histological analysis and metabolic profiling.
Other articles by Michelle J. Veite-Schmahl on PubMed
HMGA1 Expression Levels Are Elevated in Pancreatic Intraepithelial Neoplasia Cells in the Ptf1a-Cre; LSL-KrasG12D Transgenic Mouse Model of Pancreatic Cancer British Journal of Cancer. Jul, 2017 | Pubmed ID: 28697176 Pancreatic cancer is currently the third leading cause of cancer deaths in the United States and it is predicted to become the second by the year 2030. High-mobility group A1 protein (HMGA1) is an oncogenic transcription factor, localised and active in cell nuclei, that is linked to tumour progression in many human cancers, including pancreatic cancer. Overexpression of HMGA1 renders cancer cells resistant to chemotherapy. Although the Ptf1a-Cre; LSL-KrasG12D transgenic mouse is perhaps the most widely utilised animal model for human pancreatic cancer, expression levels of HMGA1 in pancreata from this mouse model have not been characterised.