Michelle Sargent

Publications

• MCUb Induction Protects the Heart From Postischemic Remodeling
  Circulation Research. 07, 2020  |   Pubmed ID: 32299299
• Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart Via Direct Injection but Not by Vascular Infusion
  Circulation. 03, 2020  |   Pubmed ID: 32202933
• An Acute Immune Response Underlies the Benefit of Cardiac Stem cell Therapy
  Nature. 01, 2020  |   Pubmed ID: 31775156
• Disruption of Valosin-containing Protein Activity Causes Cardiomyopathy and Reveals Pleiotropic Functions in Cardiac Homeostasis
  The Journal of Biological Chemistry. 05, 2019  |   Pubmed ID: 31006653
• ERK1/2 Signaling Induces Skeletal Muscle Slow Fiber-type Switching and Reduces Muscular Dystrophy Disease Severity
  JCI Insight. 04, 2019  |   Pubmed ID: 30964448
• Thrombospondin-3 Augments Injury-induced Cardiomyopathy by Intracellular Integrin Inhibition and Sarcolemmal Instability
  Nature Communications. 01, 2019  |   Pubmed ID: 30622267
• Genetic Lineage Tracing of Sca-1 Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart
  Circulation. 12, 2018  |   Pubmed ID: 29991486
• Defective Flux of Thrombospondin-4 Through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy
  Molecular and Cellular Biology. 07, 2018  |   Pubmed ID: 29712757
• Specialized Fibroblast Differentiated States Underlie Scar Formation in the Infarcted Mouse Heart
  The Journal of Clinical Investigation. 05, 2018  |   Pubmed ID: 29664017
• Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure
  Circulation. 09, 2018  |   Pubmed ID: 29653926
• Autophagic Cell Death is Dependent on Lysosomal Membrane Permeability Through Bax and Bak
  ELife. 11, 2017  |   Pubmed ID: 29148970
• Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression
  Journal of the American College of Cardiology. Aug, 2017  |   Pubmed ID: 28818206
• TGFBI Functions Similar to Periostin but is Uniquely Dispensable During Cardiac Injury
  PloS One. 2017  |   Pubmed ID: 28750100
• Mitsugumin 29 Regulates T-tubule Architecture in the Failing Heart
  Scientific Reports. 07, 2017  |   Pubmed ID: 28706255
• Caveolae-localized L-type Ca2+ Channels Do Not Contribute to Function or Hypertrophic Signalling in the Mouse Heart
  Cardiovascular Research. Jun, 2017  |   Pubmed ID: 28402392
• Fibroblast-Specific Genetic Manipulation of P38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis
  Circulation. Aug, 2017  |   Pubmed ID: 28356446
• Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart
  PloS One. 2016  |   Pubmed ID: 27764156
• Thrombospondin Expression in Myofibers Stabilizes Muscle Membranes
  ELife. 09, 2016  |   Pubmed ID: 27669143
• Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice
  The Journal of Biological Chemistry. May, 2016  |   Pubmed ID: 26966179
• Genetic Overexpression of Serpina3n Attenuates Muscular Dystrophy in Mice
  Human Molecular Genetics. Mar, 2016  |   Pubmed ID: 26744329
• Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling
  Molecular and Cellular Biology. Jan, 2016  |   Pubmed ID: 26459760
• Cardiac-specific Deletion of Protein Phosphatase 1β Promotes Increased Myofilament Protein Phosphorylation and Contractile Alterations
  Journal of Molecular and Cellular Cardiology. Oct, 2015  |   Pubmed ID: 26334248
• STIM1 Elevation in the Heart Results in Aberrant Ca²⁺ Handling and Cardiomyopathy
  Journal of Molecular and Cellular Cardiology. Oct, 2015  |   Pubmed ID: 26241845
• The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart
  Cell Reports. Jul, 2015  |   Pubmed ID: 26119742
• Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death
  PloS One. 2015  |   Pubmed ID: 26061004
• Genetic Analysis of Connective Tissue Growth Factor As an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling
  Molecular and Cellular Biology. Jun, 2015  |   Pubmed ID: 25870108
• P38α MAPK Underlies Muscular Dystrophy and Myofiber Death Through a Bax-dependent Mechanism
  Human Molecular Genetics. Oct, 2014  |   Pubmed ID: 24876160
• Enhanced Ca²⁺ Influx from STIM1-Orai1 Induces Muscle Pathology in Mouse Models of Muscular Dystrophy
  Human Molecular Genetics. Jul, 2014  |   Pubmed ID: 24556214
• Bax and Bak Function As the Outer Membrane Component of the Mitochondrial Permeability Pore in Regulating Necrotic Cell Death in Mice
  ELife. Aug, 2013  |   Pubmed ID: 23991283
• A Thrombospondin-dependent Pathway for a Protective ER Stress Response
  Cell. Jun, 2012  |   Pubmed ID: 22682248
• L 型 Ca²⁺ 通道活动减少心脏诱导肥大和小鼠心脏衰竭。
  The Journal of Clinical Investigation. Jan, 2012  |   Pubmed ID: 22133878
• 肌营养不良症小鼠骨骼肌 SERCA 表达的缓解措施。
  The Journal of Clinical Investigation. Mar, 2011  |   Pubmed ID: 21285509
• Genetic Deletion of Myostatin from the Heart Prevents Skeletal Muscle Atrophy in Heart Failure
  Circulation. Jan, 2010  |   Pubmed ID: 20065166
• Calcineurin Protects the Heart in a Murine Model of Dilated Cardiomyopathy
  Journal of Molecular and Cellular Cardiology. Jun, 2010  |   Pubmed ID: 19854199
• Calcium Influx is Sufficient to Induce Muscular Dystrophy Through a TRPC-dependent Mechanism
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009  |   Pubmed ID: 19864620
• 在骨骼肌中 Dysferlin 表达的基因操纵： 肌营养不良症的新见解。
  The American Journal of Pathology. Nov, 2009  |   Pubmed ID: 19834057
• ASK1 Regulates Cardiomyocyte Death but Not Hypertrophy in Transgenic Mice
  Circulation Research. Nov, 2009  |   Pubmed ID: 19815822
• Plasma Membrane Ca2+-ATPase Isoform 4 Antagonizes Cardiac Hypertrophy in Association with Calcineurin Inhibition in Rodents
  The Journal of Clinical Investigation. Apr, 2009  |   Pubmed ID: 19287093
• Cardiac Myosin Binding Protein-C Phosphorylation in a {beta}-myosin Heavy Chain Background
  Circulation. Mar, 2009  |   Pubmed ID: 19237661
• Genetic Manipulation of Periostin Expression in the Heart Does Not Affect Myocyte Content, Cell Cycle Activity, or Cardiac Repair
  Circulation Research. Jan, 2009  |   Pubmed ID: 19038863
• DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility
  The Journal of Biological Chemistry. Nov, 2008  |   Pubmed ID: 18753132
• 遗传与药理活性抑制缺血性坏死线粒体依赖减弱肌营养不良症。
  Nature Medicine. Apr, 2008  |   Pubmed ID: 18345011
• Cardiomyocyte GATA4 Functions As a Stress-responsive Regulator of Angiogenesis in the Murine Heart
  The Journal of Clinical Investigation. Nov, 2007  |   Pubmed ID: 17975667
• Inducible and Myocyte-specific Inhibition of PKCalpha Enhances Cardiac Contractility and Protects Against Infarction-induced Heart Failure
  American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2007  |   Pubmed ID: 17921332
• Genetic Disruption of Calcineurin Improves Skeletal Muscle Pathology and Cardiac Disease in a Mouse Model of Limb-girdle Muscular Dystrophy
  The Journal of Biological Chemistry. Mar, 2007  |   Pubmed ID: 17289669
• Cardiac Myosin Binding Protein C Phosphorylation is Cardioprotective
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006  |   Pubmed ID: 17075052
• Age-dependent Effect of Myostatin Blockade on Disease Severity in a Murine Model of Limb-girdle Muscular Dystrophy
  The American Journal of Pathology. Jun, 2006  |   Pubmed ID: 16723712