Miguel Quiros Department of Pathology, Michigan Medicine University of Michigan Biography Publications Institution JoVE Articles Miguel Quiros Dr. Miguel Quiros did his undergrad studies in microbiology at the University of Costa Rica. He obtained his PhD in Molecular and Cellular Physiology at the Center for Research and Advanced Studies in Mexico City, Mexico. During his PhD he specialized in epithelial cell junctions and their physiological regulation. His research focuses on the resolution phase of intestinal inflammation. His current projects include: (a) establishing a defined matrix to grow mini-guts with the potential to be engrafted into ulcerated tissue from IBD patients and promote epithelial recovery; (b) characterizing the kinetics of cytokine release during the resolution phase of inflammation and describe the cascade of events that lead to recovery of homeostasis; (c) studying the effect of specialized pro-resolution mediators on intestinal epithelial wound healing. Dr. Quiros was awarded with the CCFA 2016 Shanti Sitaraman, MD, PhD, Young IBD Investigator Award for his research on the role of Resolvin E1 on intestinal epithelial wound healing. Publications Therapeutic Opportunities for Repair GPCRs During Intestinal Mucosal Wound Healing Trends in Molecular Medicine. Nov, 2020 | Pubmed ID: 32958405 Neutrophil Expressed CD47 Regulates CD11b/CD18-dependent Neutrophil Transepithelial Migration in the Intestine in Vivo Mucosal Immunology. Jun, 2020 | Pubmed ID: 32561828 Innate Immune Cell-epithelial Crosstalk During Wound Repair The Journal of Clinical Investigation. 07, 2019 | Pubmed ID: 31329162 Synthetic Hydrogels for Human Intestinal Organoid Generation and Colonic Wound Repair Nature Cell Biology. Nov, 2017 | Pubmed ID: 29058719 Inflammation-induced Desmoglein-2 Ectodomain Shedding Compromises the Mucosal Barrier Molecular Biology of the Cell. Sep, 2015 | Pubmed ID: 26224314 Annexin A1-containing Extracellular Vesicles and Polymeric Nanoparticles Promote Epithelial Wound Repair The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25664854 Targeting Epithelial Expressed Sialyl Lewis Glycans Improves Colonic Mucosal Wound Healing and Protects Against Colitis JCI Insight. Month, | Pubmed ID: 32427587 Resolvin E1 is a Pro-repair Molecule That Promotes Intestinal Epithelial Wound Healing Proceedings of the National Academy of Sciences of the United States of America. Month, | Pubmed ID: 32300016 Erythroid Differentiation Regulator-1 Induced by Microbiota in Early Life Drives Intestinal Stem Cell Proliferation and Regeneration Nature Communications. Month, | Pubmed ID: 31980634 Epithelial CD47 is Critical for Mucosal Repair in the Murine Intestine in Vivo Nature Communications. Month, | Pubmed ID: 31676794 Formyl Peptide Receptor 2 Regulates Monocyte Recruitment to Promote Intestinal Mucosal Wound Repair FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Month, | Pubmed ID: 31585047 IFN-γ-tethered Hydrogels Enhance Mesenchymal Stem Cell-based Immunomodulation and Promote Tissue Repair Biomaterials. Month, | Pubmed ID: 31401468 TNFα Promotes Mucosal Wound Repair Through Enhanced Platelet Activating Factor Receptor Signaling in the Epithelium Mucosal Immunology. Month, | Pubmed ID: 30971752 IL-10 Produced by Macrophages Regulates Epithelial Integrity in the Small Intestine Scientific Reports. Month, | Pubmed ID: 30718924 Saving Problematic Mucosae: SPMs in Intestinal Mucosal Inflammation and Repair Trends in Molecular Medicine. Month, | Pubmed ID: 30642681 Publisher Correction: PEG-4MAL Hydrogels for Human Organoid Generation, Culture, and in Vivo Delivery Nature Protocols. Month, | Pubmed ID: 30356140 Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair Annual Review of Physiology. Month, | Pubmed ID: 30354933 PEG-4MAL Hydrogels for Human Organoid Generation, Culture, and in Vivo Delivery Nature Protocols. Month, | Pubmed ID: 30190557 Intracellular Desmoglein-2 Cleavage Sensitizes Epithelial Cells to Apoptosis in Response to Pro-inflammatory Cytokines Cell Death & Disease. Month, | Pubmed ID: 29523777 Macrophage-derived IL-10 Mediates Mucosal Repair by Epithelial WISP-1 Signaling The Journal of Clinical Investigation. Month, | Pubmed ID: 28783045 Intestinal Epithelial Claudins: Expression and Regulation in Homeostasis and Inflammation Annals of the New York Academy of Sciences. Month, | Pubmed ID: 28493289 The Microenvironment of Injured Murine Gut Elicits a Local Pro-restitutive Microbiota Nature Microbiology. Month, | Pubmed ID: 27571978 Generation af Murine Primary Colon Epitel Monolayers fra Tarmkrypter Chithra K Muraleedharan1, Jay Mierzwiak1, Darius Feier1, Asma Nusrat1, Miguel Quiros1 1Department of Pathology, School of Medicine, University of Michigan JoVE 62156 Biology
Generation af Murine Primary Colon Epitel Monolayers fra Tarmkrypter Chithra K Muraleedharan1, Jay Mierzwiak1, Darius Feier1, Asma Nusrat1, Miguel Quiros1 1Department of Pathology, School of Medicine, University of Michigan JoVE 62156 Biology
