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Articles by Mike O'Donnell in JoVE
Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase Richard T. Pomerantz1, Mike O'Donnell1 1Howard Hughes Medical Institute, Rockefeller University The fate of the replisome following a collision with a head-on RNA polymerase (RNAP) is unknown. We find that the replisome stalls upon collision with a head-on RNAP, but resumes elongation after displacing the RNAP from DNA. Mfd promotes replication restart by facilitating displacement of the RNAP after the collision.