Mitchell B. Schaffler Department of Biomedical Engineering The City College of New York Biography Publications Institution JoVE Articles Mitchell B. Schaffler has not added a biography. If you are Mitchell B. Schaffler and would like to personalize this page please email our Author Liaison for assistance. Publications Reply To: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation JBMR Plus. Jul, 2021 | Pubmed ID: 34258501 Estrogen Depletion on In Vivo Osteocyte Calcium Signaling Responses to Mechanical Loading Bone. Nov, 2021 | Pubmed ID: 34171514 A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation JBMR Plus. Apr, 2021 | Pubmed ID: 33869992 Apoptotic Osteocytes Induce RANKL Production in Bystanders Via Purinergic Signaling and Activation of Pannexin Channels Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. May, 2020 | Pubmed ID: 31910292 CITED2 Mediates the Cross-talk Between Mechanical Loading and IL-4 to Promote Chondroprotection Annals of the New York Academy of Sciences. Apr, 2019 | Pubmed ID: 30891766 Correction To: Green Tea Polyphenol Treatment is Chondroprotective, Anti-inflammatory and Palliative in a Mouse Posttraumatic Osteoarthritis Model Arthritis Research & Therapy. Jan, 2019 | Pubmed ID: 30606217 Potential Role for a Specialized β Integrin-based Structure on Osteocyte Processes in Bone Mechanosensation Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Feb, 2018 | Pubmed ID: 29087614 Osteocyte Calcium Signals Encode Strain Magnitude and Loading Frequency in Vivo Proceedings of the National Academy of Sciences of the United States of America. Oct, 2017 | Pubmed ID: 29078317 Microdamage Induced by in Vivo Reference Point Indentation in Mice is Repaired by Osteocyte-apoptosis Mediated Remodeling Bone. Feb, 2017 | Pubmed ID: 27919734 Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2017 | Pubmed ID: 27859586 Thermally Induced Osteocyte Damage Initiates Pro-osteoclastogenic Gene Expression in Vivo Journal of the Royal Society, Interface. Jun, 2016 | Pubmed ID: 27335224 Regional Differences in Oxidative Metabolism and Mitochondrial Activity Among Cortical Bone Osteocytes Bone. Sep, 2016 | Pubmed ID: 27260646 Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2016 | Pubmed ID: 26852281 Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2016 | Pubmed ID: 26553756 Bone Microdamage, Remodeling and Bone Fragility: How Much Damage is Too Much Damage? BoneKEy Reports. 2015 | Pubmed ID: 25848533 Green Tea Polyphenol Treatment is Chondroprotective, Anti-inflammatory and Palliative in a Mouse Post-traumatic Osteoarthritis Model Arthritis Research & Therapy. Dec, 2014 | Pubmed ID: 25516005 Authors Response to Letter from Plotkin and Bellido Calcified Tissue International. Oct, 2014 | Pubmed ID: 25108470 Structural and Mechanical Repair of Diffuse Damage in Cortical Bone in Vivo Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Dec, 2014 | Pubmed ID: 25042459 Osteocyte Apoptosis is Required for Production of Osteoclastogenic Signals Following Bone Fatigue in Vivo Bone. Jul, 2014 | Pubmed ID: 24709687 Osteocytes: Master Orchestrators of Bone Calcified Tissue International. Jan, 2014 | Pubmed ID: 24042263 Serum IGF-1 is Insufficient to Restore Skeletal Size in the Total Absence of the Growth Hormone Receptor Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2013 | Pubmed ID: 23456957 Osteocyte Signaling in Bone Current Osteoporosis Reports. Jun, 2012 | Pubmed ID: 22552701 Activation of Resorption in Fatigue-loaded Bone Involves Both Apoptosis and Active Pro-osteoclastogenic Signaling by Distinct Osteocyte Populations Bone. May, 2012 | Pubmed ID: 22342796 Tibial Compression is Anabolic in the Adult Mouse Skeleton Despite Reduced Responsiveness with Aging Bone. Sep, 2011 | Pubmed ID: 21642027 Cancellous Bone Adaptation to Tibial Compression is Not Sex Dependent in Growing Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2010 | Pubmed ID: 20576844 The Dependency of Solute Diffusion on Molecular Weight and Shape in Intact Bone Bone. Nov, 2009 | Pubmed ID: 19647808 Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2009 | Pubmed ID: 19049324 A Model for the Role of Integrins in Flow Induced Mechanotransduction in Osteocytes Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17895377 A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes Karl J. Lewis1, James F. Boorman-Padgett3, Macy Castaneda2, David C. Spray4, Mia M. Thi5,6, Mitchell B. Schaffler3 1Meinig School of Biomedical Engineering, Cornell University, 2Sibley School of Mechanical and Aerospace Engineering, Cornell University, 3Department of Biomedical Engineering, The City College of New York, 4Department of Neuroscience, Albert Einstein College of Medicine, 5Department of Orthopaedic Surgery, Albert Einstein College of Medicine, 6Department of Molecular Pharmacology, Albert Einstein College of Medicine JoVE 64366 Bioengineering
A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes Karl J. Lewis1, James F. Boorman-Padgett3, Macy Castaneda2, David C. Spray4, Mia M. Thi5,6, Mitchell B. Schaffler3 1Meinig School of Biomedical Engineering, Cornell University, 2Sibley School of Mechanical and Aerospace Engineering, Cornell University, 3Department of Biomedical Engineering, The City College of New York, 4Department of Neuroscience, Albert Einstein College of Medicine, 5Department of Orthopaedic Surgery, Albert Einstein College of Medicine, 6Department of Molecular Pharmacology, Albert Einstein College of Medicine JoVE 64366 Bioengineering
