Mitchell J. Weiss

Publications

• UBE2O Remodels the Proteome During Terminal Erythroid Differentiation
  Science (New York, N.Y.). Aug, 2017  |   Pubmed ID: 28774900
• MiR-144 Attenuates the Host Response to Influenza Virus by Targeting the TRAF6-IRF7 Signaling Axis
  PLoS Pathogens. Apr, 2017  |   Pubmed ID: 28380049
• A Genome-editing Strategy to Treat β-hemoglobinopathies That Recapitulates a Mutation Associated with a Benign Genetic Condition
  Nature Medicine. Sep, 2016  |   Pubmed ID: 27525524
• The Severity of Hereditary Porphyria is Modulated by the Porphyrin Exporter and Lan Antigen ABCB6
  Nature Communications. Aug, 2016  |   Pubmed ID: 27507172
• Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease
  Pediatrics. Jul, 2016  |   Pubmed ID: 27335380
• Welcoming a New Age for Gene Therapy in Hematology
  Blood. May, 2016  |   Pubmed ID: 27053534
• Unlinking an LncRNA from Its Associated Cis Element
  Molecular Cell. Apr, 2016  |   Pubmed ID: 27041223
• Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells
  Cell Stem Cell. Jan, 2016  |   Pubmed ID: 26607381
• Amelioration of Murine Sickle Cell Disease by Nonablative Conditioning and γ-globin Gene-corrected Bone Marrow Cells
  Molecular Therapy. Methods & Clinical Development. 2015  |   Pubmed ID: 26665131
• The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development
  Molecular and Cellular Biology. Nov, 2015  |   Pubmed ID: 26527618
• Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia
  PloS One. 2015  |   Pubmed ID: 26258650
• Occupancy by Key Transcription Factors is a More Accurate Predictor of Enhancer Activity Than Histone Modifications or Chromatin Accessibility
  Epigenetics & Chromatin. 2015  |   Pubmed ID: 25984238
• Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells
  The Journal of Clinical Investigation. Jun, 2015  |   Pubmed ID: 25961454
• Anemia: Progress in Molecular Mechanisms and Therapies
  Nature Medicine. Mar, 2015  |   Pubmed ID: 25742458
• Dynamics of GATA1 Binding and Expression Response in a GATA1-induced Erythroid Differentiation System
  Genomics Data. Jun, 2015  |   Pubmed ID: 25729644
• Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus
  The Journal of Clinical Investigation. Mar, 2015  |   Pubmed ID: 25621499
• MicroRNA-486-5p is an Erythroid OncomiR of the Myeloid Leukemias of Down Syndrome
  Blood. Feb, 2015  |   Pubmed ID: 25533034
• Level of RUNX1 Activity is Critical for Leukemic Predisposition but Not for Thrombocytopenia
  Blood. Feb, 2015  |   Pubmed ID: 25490895
• A Comparative Encyclopedia of DNA Elements in the Mouse Genome
  Nature. Nov, 2014  |   Pubmed ID: 25409824
• Divergent Functions of Hematopoietic Transcription Factors in Lineage Priming and Differentiation During Erythro-megakaryopoiesis
  Genome Research. Dec, 2014  |   Pubmed ID: 25319996
• Dynamic Shifts in Occupancy by TAL1 Are Guided by GATA Factors and Drive Large-scale Reprogramming of Gene Expression During Hematopoiesis
  Genome Research. Dec, 2014  |   Pubmed ID: 25319994
• Trim58 Degrades Dynein and Regulates Terminal Erythropoiesis
  Developmental Cell. Sep, 2014  |   Pubmed ID: 25241935
• Hematopoietic Differentiation of Pluripotent Stem Cells in Culture
  Methods in Molecular Biology (Clifton, N.J.). 2014  |   Pubmed ID: 25062629
• Update on the Diagnosis and Management of Thalassemia
  Clinical Advances in Hematology & Oncology : H&O. Jan, 2014  |   Pubmed ID: 25000317
• Post-translational Transformation of Methionine to Aspartate is Catalyzed by Heme Iron and Driven by Peroxide: a Novel Subunit-specific Mechanism in Hemoglobin
  The Journal of Biological Chemistry. Aug, 2014  |   Pubmed ID: 24939847
• MiR-451 Deficiency is Associated with Altered Endometrial Fibrinogen Alpha Chain Expression and Reduced Endometriotic Implant Establishment in an Experimental Mouse Model
  PloS One. 2014  |   Pubmed ID: 24937656
• Immune Hemolytic Anemia with Drug-induced Antibodies to Carboplatin and Vincristine in a Pediatric Patient with an Optic Pathway Glioma
  Transfusion. Nov, 2014  |   Pubmed ID: 24860959
• Personalized Platelet Transfusions: One Step Closer to the Clinic
  Cell Stem Cell. Apr, 2014  |   Pubmed ID: 24702993
• Erythro-megakaryocytic Transcription Factors Associated with Hereditary Anemia
  Blood. May, 2014  |   Pubmed ID: 24652993
• Iron-laden Macrophage in Autoimmune Disease
  Blood. Jan, 2014  |   Pubmed ID: 24605366
• Lineage and Species-specific Long Noncoding RNAs During Erythro-megakaryocytic Development
  Blood. Mar, 2014  |   Pubmed ID: 24497530
• Development of Acute Megakaryoblastic Leukemia in Down Syndrome is Associated with Sequential Epigenetic Changes
  Blood. Oct, 2013  |   Pubmed ID: 23980066
• Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines
  Blood. Sep, 2013  |   Pubmed ID: 23940280
• Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients
  Blood. Aug, 2013  |   Pubmed ID: 23744582
• Congenital Dyserythropoietic Anemias: III's a Charm
  Blood. Jun, 2013  |   Pubmed ID: 23744492
• α-Hemoglobin-stabilizing Protein (AHSP) Perturbs the Proximal Heme Pocket of Oxy-α-hemoglobin and Weakens the Iron-oxygen Bond
  The Journal of Biological Chemistry. Jul, 2013  |   Pubmed ID: 23696640
• Long Noncoding RNAs in Biology and Hematopoiesis
  Blood. Jun, 2013  |   Pubmed ID: 23645840
• Patient-derived Induced Pluripotent Stem Cells Recapitulate Hematopoietic Abnormalities of Juvenile Myelomonocytic Leukemia
  Blood. Apr, 2013  |   Pubmed ID: 23620576
• The Calcineurin-NFAT Pathway Negatively Regulates Megakaryopoiesis
  Blood. Apr, 2013  |   Pubmed ID: 23446734
• The Secreted Lymphangiogenic Factor CCBE1 is Essential for Fetal Liver Erythropoiesis
  Blood. Apr, 2013  |   Pubmed ID: 23426945
• Hemoglobin Variants: Biochemical Properties and Clinical Correlates
  Cold Spring Harbor Perspectives in Medicine. Mar, 2013  |   Pubmed ID: 23388674
• α-Hemoglobin Stabilizing Protein (AHSP) Markedly Decreases the Redox Potential and Reactivity of α-subunits of Human HbA with Hydrogen Peroxide
  The Journal of Biological Chemistry. Feb, 2013  |   Pubmed ID: 23264625
• MiR-451 Regulates Dendritic Cell Cytokine Responses to Influenza Infection
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2012  |   Pubmed ID: 23169590
• Trisomy 21-associated Defects in Human Primitive Hematopoiesis Revealed Through Induced Pluripotent Stem Cells
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012  |   Pubmed ID: 23045704
• Perturbation of Fetal Liver Hematopoietic Stem and Progenitor Cell Development by Trisomy 21
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012  |   Pubmed ID: 23045701
• α-Hemoglobin-stabilizing Protein is a Sensitive and Specific Marker of Erythroid Precursors
  The American Journal of Surgical Pathology. Oct, 2012  |   Pubmed ID: 22982896
• An Encyclopedia of Mouse DNA Elements (Mouse ENCODE)
  Genome Biology. Aug, 2012  |   Pubmed ID: 22889292
• What's in a Name?
  The Journal of Clinical Investigation. Jul, 2012  |   Pubmed ID: 22706300
• SLC35D3 Delivery from Megakaryocyte Early Endosomes is Required for Platelet Dense Granule Biogenesis and is Differentially Defective in Hermansky-Pudlak Syndrome Models
  Blood. Jul, 2012  |   Pubmed ID: 22611153
• CD19 is a Major B Cell Receptor-independent Activator of MYC-driven B-lymphomagenesis
  The Journal of Clinical Investigation. Jun, 2012  |   Pubmed ID: 22546857
• Self-renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells
  Cell Stem Cell. Apr, 2012  |   Pubmed ID: 22482503
• Integrated Protein Quality-control Pathways Regulate Free α-globin in Murine β-thalassemia
  Blood. May, 2012  |   Pubmed ID: 22427201
• Loss of the MiR-144/451 Cluster Impairs Ischaemic Preconditioning-mediated Cardioprotection by Targeting Rac-1
  Cardiovascular Research. May, 2012  |   Pubmed ID: 22354898
• Kinetics of α-globin Binding to α-hemoglobin Stabilizing Protein (AHSP) Indicate Preferential Stabilization of Hemichrome Folding Intermediate
  The Journal of Biological Chemistry. Mar, 2012  |   Pubmed ID: 22298770
• Insights into Hemoglobin Assembly Through in Vivo Mutagenesis of α-hemoglobin Stabilizing Protein
  The Journal of Biological Chemistry. Mar, 2012  |   Pubmed ID: 22287545
• Functional Regulation of Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1/HPIP) in Erythroid Differentiation
  The Journal of Biological Chemistry. Feb, 2012  |   Pubmed ID: 22187427
• A New 'Linc' Between Noncoding RNAs and Blood Development
  Genes & Development. Dec, 2011  |   Pubmed ID: 22190456
• Dynamics of the Epigenetic Landscape During Erythroid Differentiation After GATA1 Restoration
  Genome Research. Oct, 2011  |   Pubmed ID: 21795386
• A Hemoglobin Variant Associated with Neonatal Cyanosis and Anemia
  The New England Journal of Medicine. May, 2011  |   Pubmed ID: 21561349
• Identification of Distal Cis-regulatory Elements at Mouse Mitoferrin Loci Using Zebrafish Transgenesis
  Molecular and Cellular Biology. Apr, 2011  |   Pubmed ID: 21248200
• Protein Quality Control During Erythropoiesis and Hemoglobin Synthesis
  Hematology/oncology Clinics of North America. Dec, 2010  |   Pubmed ID: 21075281
• AHSP (α-haemoglobin-stabilizing Protein) Stabilizes Apo-α-haemoglobin in a Partially Folded State
  The Biochemical Journal. Dec, 2010  |   Pubmed ID: 20860551
• Analysis of Alpha Hemoglobin Stabilizing Protein Overexpression in Murine β-thalassemia
  American Journal of Hematology. Oct, 2010  |   Pubmed ID: 20815047
• MicroRNA Expression in Maturing Murine Megakaryocytes
  Blood. Dec, 2010  |   Pubmed ID: 20720187
• MiR-451 Protects Against Erythroid Oxidant Stress by Repressing 14-3-3zeta
  Genes & Development. Aug, 2010  |   Pubmed ID: 20679398
• MicroRNAs in Erythropoiesis
  Current Opinion in Hematology. May, 2010  |   Pubmed ID: 20216213
• Getting by with a Little Help from Our Friends
  Current Opinion in Pediatrics. Feb, 2010  |   Pubmed ID: 20068412
• The Role of Alpha-hemoglobin Stabilizing Protein in Redox Chemistry, Denaturation, and Hemoglobin Assembly
  Antioxidants & Redox Signaling. Feb, 2010  |   Pubmed ID: 19659437
• Insights into GATA-1-mediated Gene Activation Versus Repression Via Genome-wide Chromatin Occupancy Analysis
  Molecular Cell. Nov, 2009  |   Pubmed ID: 19941827
• Erythroid GATA1 Function Revealed by Genome-wide Analysis of Transcription Factor Occupancy, Histone Modifications, and MRNA Expression
  Genome Research. Dec, 2009  |   Pubmed ID: 19887574
• LRF is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-dependent Apoptosis
  Developmental Cell. Oct, 2009  |   Pubmed ID: 19853566
• Mammalian Casein Kinase 1alpha and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling
  Molecular and Cellular Biology. Dec, 2009  |   Pubmed ID: 19805514
• A Cis-proline in Alpha-hemoglobin Stabilizing Protein Directs the Structural Reorganization of Alpha-hemoglobin
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19706593
• Stem Cells Unscramble Yolk Sac Hematopoiesis
  Blood. Aug, 2009  |   Pubmed ID: 19696206
• Graded Repression of PU.1/Sfpi1 Gene Transcription by GATA Factors Regulates Hematopoietic Cell Fate
  Blood. Jul, 2009  |   Pubmed ID: 19491391
• Analysis of Human Alpha Globin Gene Mutations That Impair Binding to the Alpha Hemoglobin Stabilizing Protein
  Blood. Jun, 2009  |   Pubmed ID: 19349619
• Chaperoning Erythropoiesis
  Blood. Mar, 2009  |   Pubmed ID: 19109556
• Transcriptional Enhancement by GATA1-occupied DNA Segments is Strongly Associated with Evolutionary Constraint on the Binding Site Motif
  Genome Research. Dec, 2008  |   Pubmed ID: 18818370
• Trisomy 21 Enhances Human Fetal Erythro-megakaryocytic Development
  Blood. Dec, 2008  |   Pubmed ID: 18812473
• An Iron Responsive Element-like Stem-loop Regulates Alpha-hemoglobin-stabilizing Protein MRNA
  The Journal of Biological Chemistry. Oct, 2008  |   Pubmed ID: 18676996
• A GATA-1-regulated MicroRNA Locus Essential for Erythropoiesis
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008  |   Pubmed ID: 18303114
• Population Analysis of the Alpha Hemoglobin Stabilizing Protein (AHSP) Gene Identifies Sequence Variants That Alter Expression and Function
  American Journal of Hematology. Feb, 2008  |   Pubmed ID: 17874450
• STAT1 Promotes Megakaryopoiesis Downstream of GATA-1 in Mice
  The Journal of Clinical Investigation. Dec, 2007  |   Pubmed ID: 18060035
• Diseased Red Blood Cells Topple Iron Balance
  Nature Medicine. Sep, 2007  |   Pubmed ID: 17828218
• An Erythroid Chaperone That Facilitates Folding of Alpha-globin Subunits for Hemoglobin Synthesis
  The Journal of Clinical Investigation. Jul, 2007  |   Pubmed ID: 17607360
• Assembly of Recently Translated Full-length and C-terminal Truncated Human Gamma-globin Chains with a Pool of Alpha-globin Chains to Form Hb F in a Cell-free System
  Archives of Biochemistry and Biophysics. Jul, 2007  |   Pubmed ID: 17418086
• Experimental Validation of Predicted Mammalian Erythroid Cis-regulatory Modules
  Genome Research. Dec, 2006  |   Pubmed ID: 17038566
• A Novel Haem-binding Interface in the 22 KDa Haem-binding Protein P22HBP
  Journal of Molecular Biology. Sep, 2006  |   Pubmed ID: 16905148
• Biochemical Fates of Alpha Hemoglobin Bound to Alpha Hemoglobin-stabilizing Protein AHSP
  The Journal of Biological Chemistry. Oct, 2006  |   Pubmed ID: 16901899
• Alpha-haemoglobin Stabilising Protein is a Quantitative Trait Gene That Modifies the Phenotype of Beta-thalassaemia
  British Journal of Haematology. Jun, 2006  |   Pubmed ID: 16704446
• Mitoferrin is Essential for Erythroid Iron Assimilation
  Nature. Mar, 2006  |   Pubmed ID: 16511496
• Designer Blood: Creating Hematopoietic Lineages from Embryonic Stem Cells
  Blood. Feb, 2006  |   Pubmed ID: 16254136
• Early Block to Erythromegakaryocytic Development Conferred by Loss of Transcription Factor GATA-1
  Blood. Jan, 2006  |   Pubmed ID: 16144799
• Role of Alpha-hemoglobin-stabilizing Protein in Normal Erythropoiesis and Beta-thalassemia
  Annals of the New York Academy of Sciences. 2005  |   Pubmed ID: 16339656
• Megakaryocyte Biology and Related Disorders
  The Journal of Clinical Investigation. Dec, 2005  |   Pubmed ID: 16322777
• GATA-1 and Oct-1 Are Required for Expression of the Human Alpha-hemoglobin-stabilizing Protein Gene
  The Journal of Biological Chemistry. Nov, 2005  |   Pubmed ID: 16186125
• Repression of C-kit and Its Downstream Substrates by GATA-1 Inhibits Cell Proliferation During Erythroid Maturation
  Molecular and Cellular Biology. Aug, 2005  |   Pubmed ID: 16024808
• Structure of Oxidized Alpha-haemoglobin Bound to AHSP Reveals a Protective Mechanism for Haem
  Nature. Jun, 2005  |   Pubmed ID: 15931225
• Proximity Among Distant Regulatory Elements at the Beta-globin Locus Requires GATA-1 and FOG-1
  Molecular Cell. Feb, 2005  |   Pubmed ID: 15694345
• Molecular Mechanism of AHSP-mediated Stabilization of Alpha-hemoglobin
  Cell. Nov, 2004  |   Pubmed ID: 15550245
• Loss of Alpha-hemoglobin-stabilizing Protein Impairs Erythropoiesis and Exacerbates Beta-thalassemia
  The Journal of Clinical Investigation. Nov, 2004  |   Pubmed ID: 15545996
• Global Regulation of Erythroid Gene Expression by Transcription Factor GATA-1
  Blood. Nov, 2004  |   Pubmed ID: 15297311
• Evaluation of Alpha Hemoglobin Stabilizing Protein (AHSP) As a Genetic Modifier in Patients with Beta Thalassemia
  Blood. May, 2004  |   Pubmed ID: 14715623
• Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene
  The Journal of Biological Chemistry. Feb, 2004  |   Pubmed ID: 14613934
• New Insights into Erythropoietin and Epoetin Alfa: Mechanisms of Action, Target Tissues, and Clinical Applications
  The Oncologist. 2003  |   Pubmed ID: 14671225
• GATA-1-dependent Transcriptional Repression of GATA-2 Via Disruption of Positive Autoregulation and Domain-wide Chromatin Remodeling
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003  |   Pubmed ID: 12857954
• GATA-1-mediated Proliferation Arrest During Erythroid Maturation
  Molecular and Cellular Biology. Jul, 2003  |   Pubmed ID: 12832487
• Formation of a Tissue-specific Histone Acetylation Pattern by the Hematopoietic Transcription Factor GATA-1
  Molecular and Cellular Biology. Feb, 2003  |   Pubmed ID: 12556492
• Cooperative Activities of Hematopoietic Regulators Recruit RNA Polymerase II to a Tissue-specific Chromatin Domain
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2002  |   Pubmed ID: 12193659
• Biophysical Characterization of the Alpha-globin Binding Protein Alpha-hemoglobin Stabilizing Protein
  The Journal of Biological Chemistry. Oct, 2002  |   Pubmed ID: 12192002
• An Abundant Erythroid Protein That Stabilizes Free Alpha-haemoglobin
  Nature. Jun, 2002  |   Pubmed ID: 12066189