Muthiah Manoharan Alnylam Pharmaceuticals, Inc. Biography Publications Institution JoVE Articles Muthiah Manoharan has not added a biography. If you are Muthiah Manoharan and would like to personalize this page please email our Author Liaison for assistance. Publications Angewandte Chemie (International Ed. in English). Jul, 2012 | Pubmed ID: 22782619 Molecularly Self-assembled Nucleic Acid Nanoparticles for Targeted in Vivo SiRNA Delivery Nature Nanotechnology. 2012 | Pubmed ID: 22659608 RNA (New York, N.Y.). Mar, 2012 | Pubmed ID: 22294662 Mechanistic Insights into LDL Nanoparticle-mediated SiRNA Delivery Bioconjugate Chemistry. Jan, 2012 | Pubmed ID: 22142191 Experimental Neurology. Jan, 2012 | Pubmed ID: 22119622 マイクロ Rna 194 転写因子 1 のターゲット (Tcf1, HNF1α) でジリジリ 6 の成人の肝臓およびコントロールの式です。 Hepatology (Baltimore, Md.). Jan, 2012 | Pubmed ID: 21887698 Bioconjugate Chemistry. Aug, 2011 | Pubmed ID: 21755983 Angewandte Chemie (International Ed. in English). Mar, 2011 | Pubmed ID: 21351337 Nucleic Acids Research. Jun, 2011 | Pubmed ID: 21345934 The Journal of Organic Chemistry. Mar, 2011 | Pubmed ID: 21299239 Nucleic Acids Research. Apr, 2011 | Pubmed ID: 21183463 Chemistry & Biology. Dec, 2010 | Pubmed ID: 21168770 Organic Letters. Dec, 2010 | Pubmed ID: 21049912 Nucleic Acids Research. Nov, 2010 | Pubmed ID: 20610434 Analytical Biochemistry. Oct, 2010 | Pubmed ID: 20599656 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20534471 Targeted Delivery of RNAi Therapeutics with Endogenous and Exogenous Ligand-based Mechanisms Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2010 | Pubmed ID: 20461061 Organic Letters. May, 2010 | Pubmed ID: 20420425 Nucleic Acids Research. Aug, 2010 | Pubmed ID: 20403811 Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2010 | Pubmed ID: 20170694 Analytical Biochemistry. Jun, 2010 | Pubmed ID: 20156415 Rational Design of Cationic Lipids for SiRNA Delivery Nature Biotechnology. Feb, 2010 | Pubmed ID: 20081866 Antimicrobial Agents and Chemotherapy. Sep, 2009 | Pubmed ID: 19506055 Chemical Communications (Cambridge, England). Apr, 2009 | Pubmed ID: 19333476 肝臓への全身性の配信 Lipidoid SiRNA 製剤の開発 Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2009 | Pubmed ID: 19259063 Durable Protection from Herpes Simplex Virus-2 Transmission Following Intravaginal Application of SiRNAs Targeting Both a Viral and Host Gene Cell Host & Microbe. Jan, 2009 | Pubmed ID: 19154990 Oligonucleotides. Mar, 2009 | Pubmed ID: 19093781 齧歯動物の血漿コレステロールおよび LDL のコレステロール霊長類における PCSK9 を鋭くターゲット治療 RNAi を下げます。 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18695239 RNAi 治療薬の配信のための脂質のような材料のコンビナトリアル ライブラリ。 Nature Biotechnology. May, 2008 | Pubmed ID: 18438401 Journal of Medicinal Chemistry. May, 2008 | Pubmed ID: 18399648 A Viral MicroRNA Functions As an Orthologue of Cellular MiR-155 Nature. Dec, 2007 | Pubmed ID: 18075594 効果的な RNAi による遺伝子の内因性マイクロ Rna 経路の中断することがなく沈黙。 Nature. Oct, 2007 | Pubmed ID: 17898712 Nucleic Acids Research. 2007 | Pubmed ID: 17881374 Nature Biotechnology. Oct, 2007 | Pubmed ID: 17873866 特異性、二重劣化とAntagomirsの細胞内局在 Nucleic Acids Research. 2007 | Pubmed ID: 17439965 Cell. Apr, 2007 | Pubmed ID: 17382377 Nucleosides, Nucleotides & Nucleic Acids. 2007 | Pubmed ID: 17365794 ACS Chemical Biology. Apr, 2006 | Pubmed ID: 17163665 Nature Chemical Biology. Dec, 2006 | Pubmed ID: 17108989 Journal of Medicinal Chemistry. Apr, 2006 | Pubmed ID: 16610796 Biochemistry. Apr, 2006 | Pubmed ID: 16566588 Nature. May, 2006 | Pubmed ID: 16565705 'antagomirs'を用いたin VivoにおけるマイクロRNAのサイレンシング Nature. Dec, 2005 | Pubmed ID: 16258535 Journal of Medicinal Chemistry. Oct, 2005 | Pubmed ID: 16220989 Nucleic Acids Research. 2005 | Pubmed ID: 16170156 プロービングのスルホンアミド オリゴヌクレオチドの生物物理特性に及ぼす影響: RNA のアフィニティ、ヌクレアーゼ耐性、および 10 の 2'--O リボ核酸変更の結晶構造の包括的な分析。 Biochemistry. Jun, 2005 | Pubmed ID: 15966728 Nature Medicine. Mar, 2005 | Pubmed ID: 15723075 Methods in Enzymology. 2005 | Pubmed ID: 15644187 Nucleic Acids Research. 2004 | Pubmed ID: 15602001 Current Opinion in Chemical Biology. Dec, 2004 | Pubmed ID: 15556399 Journal of the American Chemical Society. Nov, 2004 | Pubmed ID: 15547979 Nature. Nov, 2004 | Pubmed ID: 15538359 The Journal of Gene Medicine. Oct, 2004 | Pubmed ID: 15386737 Nucleic Acids Research. 2004 | Pubmed ID: 15247346 2'-O-[2-(グアニジ) エチル]-オリゴヌクレオチドを修正: 二重および三重の構造に及ぼす安定化します。 Organic Letters. Jun, 2004 | Pubmed ID: 15176796 Nucleic Acids Research. 2004 | Pubmed ID: 14762210 Nucleic Acids Research. Supplement (2001). 2003 | Pubmed ID: 14510407 C 5 プロピニル ピリミジンを含むオリゴヌクレオチド in Vitro および in Vivo の評価。 Antisense & Nucleic Acid Drug Development. 2003 | Pubmed ID: 12954113 Organic Letters. Aug, 2003 | Pubmed ID: 12916967 Organic Letters. Jun, 2003 | Pubmed ID: 12790517 Nucleic Acids Research. Apr, 2003 | Pubmed ID: 12682357 Journal of the American Chemical Society. Mar, 2003 | Pubmed ID: 12603111 2'-O-[2-(amino)-2-oxoethyl] オリゴヌクレオチド。 Organic Letters. Feb, 2003 | Pubmed ID: 12583729 Bioconjugate Chemistry. Jan-Feb, 2003 | Pubmed ID: 12526688 RNA (New York, N.Y.). Dec, 2002 | Pubmed ID: 12515389 Angewandte Chemie (International Ed. in English). Jan, 2002 | Pubmed ID: 12491456 高親和性ペプチド核酸オリゴマー三環系シトシン アナログ。 Organic Letters. Dec, 2002 | Pubmed ID: 12465896 アンチセンス オリゴヌクレオチド バインディングひと血清アルブミンの改善: イブプロフェン抱合の劇的な効果。 Chembiochem : a European Journal of Chemical Biology. Dec, 2002 | Pubmed ID: 12465035 Nature Biotechnology. Dec, 2002 | Pubmed ID: 12426578 2'-O-[2-(メチルチオ) エチル]-オリゴヌクレオチドを変更: 2'-O-[2-(methoxy)-ethyl]-modified のオリゴヌクレオチド バインディング プロパティと高いバインディング ターゲット RNA への親和性の改良蛋白質でのアナログ。 Biochemistry. Oct, 2002 | Pubmed ID: 12269806 The Journal of Pharmacology and Experimental Therapeutics. Aug, 2002 | Pubmed ID: 12130724 Antisense & Nucleic Acid Drug Development. Apr, 2002 | Pubmed ID: 12074364 European Journal of Biochemistry / FEBS. May, 2002 | Pubmed ID: 12027896 Biochemistry. Jan, 2002 | Pubmed ID: 11802733 The Journal of Organic Chemistry. Jan, 2002 | Pubmed ID: 11798305 同所性膀胱腫瘍モデルと膀胱内Sarnaの治療の評価 Moo Rim Kang*1, Glen Yang*1, Klaus Charisse2, Hila Epstein-Barash2, Muthiah Manoharan2, Long-Cheng Li1 1Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 2Alnylam Pharmaceuticals, Inc. JoVE 4207 Medicine
同所性膀胱腫瘍モデルと膀胱内Sarnaの治療の評価 Moo Rim Kang*1, Glen Yang*1, Klaus Charisse2, Hila Epstein-Barash2, Muthiah Manoharan2, Long-Cheng Li1 1Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 2Alnylam Pharmaceuticals, Inc. JoVE 4207 Medicine