Nicholas E. Leadbeater

Publications

• Toward a Unified Mechanism for Oxoammonium Salt-Mediated Oxidation Reactions: A Theoretical and Experimental Study Using a Hydride Transfer Model
  The Journal of Organic Chemistry. Aug, 2015  |   Pubmed ID: 26167866
• Oxidative Cleavage of Allyl Ethers by an Oxoammonium Salt
  Organic & Biomolecular Chemistry. Apr, 2015  |   Pubmed ID: 25748071
• Access to Nitriles from Aldehydes Mediated by an Oxoammonium Salt
  Angewandte Chemie (International Ed. in English). Mar, 2015  |   Pubmed ID: 25665019
• Methylenation of Perfluoroalkyl Ketones Using a Peterson Olefination Approach
  The Journal of Organic Chemistry. Feb, 2014  |   Pubmed ID: 24410210
• Opening an Aladdin's Cave: the Suzuki Coupling in a Room-temperature Ionic Liquid
  Chemical Communications (Cambridge, England). Feb, 2014  |   Pubmed ID: 24383065
• Trifluoromethyl Ketones: Properties, Preparation, and Application
  Chemical Communications (Cambridge, England). Dec, 2013  |   Pubmed ID: 24162741
• Raman Spectroscopy As a Tool for Monitoring Mesoscale Continuous-flow Organic Synthesis: Equipment Interface and Assessment in Four Medicinally-relevant Reactions
  Beilstein Journal of Organic Chemistry. 2013  |   Pubmed ID: 24062851
• Oxidative Esterification of Aldehydes Using a Recyclable Oxoammonium Salt
  Organic Letters. May, 2013  |   Pubmed ID: 23614873
• Synthesis of 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium Tetrafluoroborate and 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl and Their Use in Oxidative Reactions
  Nature Protocols. Apr, 2013  |   Pubmed ID: 23471111
• The Central Role of Chemistry in 'quality by Design' Approaches to Drug Development
  Future Medicinal Chemistry. Sep, 2012  |   Pubmed ID: 23043477
• Ask the Experts: the Challenges and Benefits of Flow Chemistry to Optimize Drug Development
  Future Medicinal Chemistry. Sep, 2012  |   Pubmed ID: 23043475
• Oxidation of α-trifluoromethyl Alcohols Using a Recyclable Oxoammonium Salt
  The Journal of Organic Chemistry. Sep, 2012  |   Pubmed ID: 22931546
• A Weinreb Amide Approach to the Synthesis of Trifluoromethylketones
  Chemical Communications (Cambridge, England). Oct, 2012  |   Pubmed ID: 22911019
• Access to Dienophilic Ene-triketone Synthons by Oxidation of Diketones with an Oxoammonium Salt
  Organic Letters. Jan, 2012  |   Pubmed ID: 22206582
• Continuous-flow, Palladium-catalysed Alkoxycarbonylation Reactions Using a Prototype Reactor in Which It is Possible to Load Gas and Heat Simultaneously
  Organic & Biomolecular Chemistry. Oct, 2011  |   Pubmed ID: 21850299
• Titanium-catalyzed Esterification and Transesterification Reactions Facilitated Using Microwave Heating
  Future Medicinal Chemistry. Feb, 2010  |   Pubmed ID: 21426189
• Cross Coupling: When is Free Really Free?
  Nature Chemistry. Dec, 2010  |   Pubmed ID: 21107360
• In Situ Reaction Monitoring of Microwave-mediated Reactions Using IR Spectroscopy
  Chemical Communications (Cambridge, England). Sep, 2010  |   Pubmed ID: 20717594
• Probing "microwave Effects" Using Raman Spectroscopy
  Organic & Biomolecular Chemistry. Sep, 2009  |   Pubmed ID: 19707691
• Assessment and Use of Two Silicon Carbide Multi-well Plates for Library Synthesis and Proteolytic Digests Using Microwave Heating
  Organic & Biomolecular Chemistry. Jun, 2009  |   Pubmed ID: 19462057
• Palladium-catalyzed Synthesis of Diarylmethanes: Exploitation of Carbanionic Leaving Groups
  Organic Letters. Jun, 2009  |   Pubmed ID: 19456122
• Testing the Validity of Microwave-interfaced, in Situ Raman Spectroscopy As a Tool for Kinetic Studies
  Organic Letters. Jan, 2009  |   Pubmed ID: 19072323
• Palladium-catalyzed Decarboxylative Coupling of Aromatic Acids with Aryl Halides or Unactivated Arenes Using Microwave Heating
  Chemical Communications (Cambridge, England). Dec, 2008  |   Pubmed ID: 19048139
• Use of Raman Spectroscopy As an in Situ Tool to Obtain Kinetic Data for Organic Transformations
  Chemistry (Weinheim an Der Bergstrasse, Germany). 2008  |   Pubmed ID: 18830985
• Preparation of Nonsymmetrically Substituted Stilbenes in a One-pot Two-step Heck Strategy Using Ethene As a Reagent
  The Journal of Organic Chemistry. May, 2008  |   Pubmed ID: 18410149
• Microwave-promoted Insertion of Group 10 Metals into Free Base Porphyrins and Chlorins: Scope and Limitations
  Dalton Transactions (Cambridge, England : 2003). Mar, 2008  |   Pubmed ID: 18305846
• Use of Raman Spectroscopy As a Tool for in Situ Monitoring of Microwave-promoted Reactions
  Nature Protocols. 2008  |   Pubmed ID: 18193016
• Spectroscopie Raman in Situ Comme Sonde Pour L'effet De Puissance Sur Suzuki Favorisée Sur Les Micro-ondes, Les Réactions De Couplage
  Organic & Biomolecular Chemistry. Sep, 2007  |   Pubmed ID: 17700844
• Microwave Energy: a Versatile Tool for the Biosciences
  Organic & Biomolecular Chemistry. Apr, 2007  |   Pubmed ID: 17406708
• Probing the Effects of Microwave Irradiation on Enzyme-catalysed Organic Transformations: the Case of Lipase-catalysed Transesterification Reactions
  Organic & Biomolecular Chemistry. Apr, 2007  |   Pubmed ID: 17377658
• À L'aide De Raman in Situ Suivi Comme Un Outil D'optimisation Rapide Et Intensification De La Synthèse Organique Micro-ondes-promu : Estérification à Titre D'exemple
  Organic & Biomolecular Chemistry. Mar, 2007  |   Pubmed ID: 17315069
• Alkoxycarbonylation of Aryl Iodides Using Gaseous Carbon Monoxide and Pre-pressurized Reaction Vessels in Conjunction with Microwave Heating
  Organic & Biomolecular Chemistry. Jan, 2007  |   Pubmed ID: 17164908
• Real-time Monitoring of Microwave-promoted Organometallic Ligand-substitution Reactions Using in Situ Raman Spectroscopy
  Chemical Communications (Cambridge, England). Sep, 2006  |   Pubmed ID: 17047782
• Surveillance En Temps Réel Des Micro-ondes-promu à L'aide De La Spectroscopie Raman in Situ Les Réactions De Couplage De Suzuki
  Organic Letters. Sep, 2006  |   Pubmed ID: 16986957
• Fast, Easy, Clean Chemistry by Using Water As a Solvent and Microwave Heating: the Suzuki Coupling As an Illustration
  Chemical Communications (Cambridge, England). Jun, 2005  |   Pubmed ID: 15957019
• Suzuki Coupling of Aryl Chlorides with Phenylboronic Acid in Water, Using Microwave Heating with Simultaneous Cooling
  Organic Letters. May, 2005  |   Pubmed ID: 15901144
• Microwave-promoted Heck Coupling Using Ultralow Metal Catalyst Concentrations
  The Journal of Organic Chemistry. Mar, 2005  |   Pubmed ID: 15730302
• A Reassessment of the Transition-metal Free Suzuki-type Coupling Methodology
  The Journal of Organic Chemistry. Jan, 2005  |   Pubmed ID: 15624918
• Microwave-assisted Mannich-type Three-component Reactions
  Molecular Diversity. 2003  |   Pubmed ID: 14870842
• Rapid, Easy Cyanation of Aryl Bromides and Chlorides Using Nickel Salts in Conjunction with Microwave Promotion
  The Journal of Organic Chemistry. Nov, 2003  |   Pubmed ID: 14604393
• First Examples of Transition-metal Free Sonogashira-type Couplings
  Organic Letters. Oct, 2003  |   Pubmed ID: 14535743
• Rapid Cyanation of Aryl Iodides in Water Using Microwave Promotion
  Organic & Biomolecular Chemistry. Apr, 2003  |   Pubmed ID: 12926385
• Transition-metal-free Suzuki-type Coupling Reactions: Scope and Limitations of the Methodology
  The Journal of Organic Chemistry. Jul, 2003  |   Pubmed ID: 12839459
• Transition-metal-free Suzuki-type Coupling Reactions
  Angewandte Chemie (International Ed. in English). Mar, 2003  |   Pubmed ID: 12671982
• Rapid and Amenable Suzuki Coupling Reaction in Water Using Microwave and Conventional Heating
  The Journal of Organic Chemistry. Feb, 2003  |   Pubmed ID: 12558412
• Polymer-supported Metal-phosphine Complexes for Use As Catalysts or Linkers in Medicinally-oriented Organic Synthesis
  Current Medicinal Chemistry. Dec, 2002  |   Pubmed ID: 12470252
• Preparation of Polymer-supported Ligands and Metal Complexes for Use in Catalysis
  Chemical Reviews. Oct, 2002  |   Pubmed ID: 12371884
• Ligand-free Palladium Catalysis of the Suzuki Reaction in Water Using Microwave Heating
  Organic Letters. Aug, 2002  |   Pubmed ID: 12182602
• Polymer-bound 1-aryl-3-alkyltriazenes As Modular Ligands for Catalysis. Part 2: Screening Immobilized Metal Complexes for Catalytic Activity
  Bioorganic & Medicinal Chemistry Letters. Jul, 2002  |   Pubmed ID: 12086832
• Polymer-bound 1-aryl-3-alkyltriazenes As Modular Ligands for Catalysis. Part 1: Synthesis and Metal Coordination
  Bioorganic & Medicinal Chemistry Letters. Jul, 2002  |   Pubmed ID: 12086831
• Microencapsulated VO(acac)2: Preparation and Use in Allylic Alcohol Epoxidation
  Organic Letters. May, 2002  |   Pubmed ID: 11975618
• A Study of the Ionic Liquid Mediated Microwave Heating of Organic Solvents
  The Journal of Organic Chemistry. May, 2002  |   Pubmed ID: 11975584