Nicholas R. Lemoine Center for Molecular Oncology, Barts Cancer Institute Queen Mary University of London Biography Publications Institution JoVE Articles Nicholas R. Lemoine has not added a biography. If you are Nicholas R. Lemoine and would like to personalize this page please email our Author Liaison for assistance. Publications Anti-stromal Treatment Together with Chemotherapy Targets Multiple Signalling Pathways in Pancreatic Adenocarcinoma The Journal of Pathology. Jul, 2016 | Pubmed ID: 27061193 Vaccinia Virus, a Promising New Therapeutic Agent for Pancreatic Cancer Immunotherapy. 2015 | Pubmed ID: 26595180 New Role of Interleukin-10 in Enhancing the Antitumor Efficacy of Oncolytic Vaccinia Virus for Treatment of Pancreatic Cancer Oncoimmunology. Sep, 2015 | Pubmed ID: 26405610 A Vaccinia Virus Armed with Interleukin-10 is a Promising Therapeutic Agent for Treatment of Murine Pancreatic Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2015 | Pubmed ID: 25416195 A Multi-gene Signature Predicts Outcome in Patients with Pancreatic Ductal Adenocarcinoma Genome Medicine. 2014 | Pubmed ID: 25587357 Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Facilitates Pancreatic Cancer Cell Invasion EMBO Molecular Medicine. Apr, 2014 | Pubmed ID: 24503018 STAT1 Interaction with E3-14.7K in Monocytes Affects the Efficacy of Oncolytic Adenovirus Journal of Virology. Feb, 2014 | Pubmed ID: 24335311 Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer As Monitored Longitudinally by PET Imaging Cancer Research. Feb, 2014 | Pubmed ID: 24285724 The Pancreatic Expression Database: Recent Extensions and Updates Nucleic Acids Research. Jan, 2014 | Pubmed ID: 24163255 A Practical Guide for the Functional Annotation of Genetic Variations Using SNPnexus Briefings in Bioinformatics. Jul, 2013 | Pubmed ID: 23395730 Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer PloS One. 2013 | Pubmed ID: 23372777 Vascular Endothelial Growth Factor A Promotes Vaccinia Virus Entry into Host Cells Via Activation of the Akt Pathway Journal of Virology. Mar, 2013 | Pubmed ID: 23269798 S100P is a Metastasis-associated Gene That Facilitates Transendothelial Migration of Pancreatic Cancer Cells Clinical & Experimental Metastasis. Mar, 2013 | Pubmed ID: 23007696 A Novel Therapeutic Regimen to Eradicate Established Solid Tumors with an Effective Induction of Tumor-specific Immunity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2012 | Pubmed ID: 23091113 O-miner: an Integrative Platform for Automated Analysis and Mining of -omics Data Nucleic Acids Research. Jul, 2012 | Pubmed ID: 22600742 SNPnexus: a Web Server for Functional Annotation of Novel and Publicly Known Genetic Variants (2012 Update) Nucleic Acids Research. Jul, 2012 | Pubmed ID: 22544707 Systemic Delivery of Oncolytic Viruses: Hopes and Hurdles Advances in Virology. 2012 | Pubmed ID: 22400027 Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11 Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2012 | Pubmed ID: 22086234 AGR2 is a Novel Surface Antigen That Promotes the Dissemination of Pancreatic Cancer Cells Through Regulation of Cathepsins B and D Cancer Research. Nov, 2011 | Pubmed ID: 21948970 A Global Insight into a Cancer Transcriptional Space Using Pancreatic Data: Importance, Findings and Flaws Nucleic Acids Research. Oct, 2011 | Pubmed ID: 21724610 Using BioMart As a Framework to Manage and Query Pancreatic Cancer Data Database : the Journal of Biological Databases and Curation. 2011 | Pubmed ID: 21666272 The Pancreatic Expression Database: 2011 Update Nucleic Acids Research. Jan, 2011 | Pubmed ID: 20959292 Online Resources of Cancer Data: Barriers, Benefits and Lessons Briefings in Bioinformatics. Jan, 2011 | Pubmed ID: 20348133 Novel Therapies for Pancreatic Cancer: Setbacks and Progress Future Oncology (London, England). Jul, 2010 | Pubmed ID: 20624116 Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles Viruses. Jan, 2010 | Pubmed ID: 20543907 Efficacy of Oncolytic Mutants Targeting PRb and P53 Pathways is Synergistically Enhanced when Combined with Cytotoxic Drugs in Prostate Cancer Cells and Tumor Xenografts Human Gene Therapy. Oct, 2010 | Pubmed ID: 20497039 Arginine Deprivation and Argininosuccinate Synthetase Expression in the Treatment of Cancer International Journal of Cancer. Jun, 2010 | Pubmed ID: 20104527 Pancreatic Cancer: Molecular Pathogenesis and New Therapeutic Targets Nature Reviews. Gastroenterology & Hepatology. Jul, 2009 | Pubmed ID: 19506583 A Web-based Platform for Mining Pancreatic Expression Datasets Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]. 2009 | Pubmed ID: 19451743 AKT/mTOR Pathway Activation and BCL-2 Family Proteins Modulate the Sensitivity of Human Small Cell Lung Cancer Cells to RAD001 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2009 | Pubmed ID: 19228731 SNPnexus: a Web Database for Functional Annotation of Newly Discovered and Public Domain Single Nucleotide Polymorphisms Bioinformatics (Oxford, England). Mar, 2009 | Pubmed ID: 19098027 Genome-wide Analysis of Pancreatic Cancer Using Microarray-based Techniques Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]. 2009 | Pubmed ID: 19077451 Analysis of the Urine Proteome in Patients with Pancreatic Ductal Adenocarcinoma Proteomics. Clinical Applications. Jul, 2008 | Pubmed ID: 21136905 Therapeutic Potential of Replication-selective Oncolytic Adenoviruses on Cells from Familial and Sporadic Desmoid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2008 | Pubmed ID: 18829497 Biological Approaches to Therapy of Pancreatic Cancer Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]. 2008 | Pubmed ID: 18724071 Pancreatic Expression Database: a Generic Model for the Organization, Integration and Mining of Complex Cancer Datasets BMC Genomics. Nov, 2007 | Pubmed ID: 18045474 The Role of S100P in the Invasion of Pancreatic Cancer Cells is Mediated Through Cytoskeletal Changes and Regulation of Cathepsin D Cancer Research. Sep, 2007 | Pubmed ID: 17875703 S100A4 Contributes to the Suppression of BNIP3 Expression, Chemoresistance, and Inhibition of Apoptosis in Pancreatic Cancer Cancer Research. Jul, 2007 | Pubmed ID: 17638890 Cytotoxic Action of Phorbol Esters on Human Pancreatic Cancer Cells International Journal of Cancer. Oct, 2007 | Pubmed ID: 17582609 The Expression of S100A8 in Pancreatic Cancer-associated Monocytes is Associated with the Smad4 Status of Pancreatic Cancer Cells Proteomics. Jun, 2007 | Pubmed ID: 17469085 Quantifying the Activity of Adenoviral E1A CR2 Deletion Mutants Using Renilla Luciferase Bioluminescence and 3'-deoxy-3'-[18F]fluorothymidine Positron Emission Tomography Imaging Cancer Research. Sep, 2006 | Pubmed ID: 16982761 Analysis of P53 Mutations for a Mutational Signature in Human Intrahepatic Cholangiocarcinoma International Journal of Oncology. May, 2006 | Pubmed ID: 16596244 Proteomic Analysis of Chronic Pancreatitis and Pancreatic Adenocarcinoma Gastroenterology. Nov, 2005 | Pubmed ID: 16285947 Doxazosin Induces Apoptosis in LNCaP Prostate Cancer Cell Line Through DNA Binding and DNA-dependent Protein Kinase Down-regulation International Journal of Oncology. Dec, 2005 | Pubmed ID: 16273218 Peanut-like 1 (septin 5) Gene Expression in Normal and Neoplastic Human Endocrine Pancreas Neuroendocrinology. 2005 | Pubmed ID: 16179808 Intrinsic Chemoresistance to Gemcitabine is Associated with Decreased Expression of BNIP3 in Pancreatic Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2005 | Pubmed ID: 15837765 Antithrombotic Therapy in Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2005 | Pubmed ID: 15699474 Growth Delay of Human Pancreatic Cancer Cells by Methylase Inhibitor 5-aza-2'-deoxycytidine Treatment is Associated with Activation of the Interferon Signalling Pathway Oncogene. Jan, 2005 | Pubmed ID: 15637593 Salmonella Enterica Serovar Typhimurium Interaction with Dendritic Cells: Impact of the SifA Gene Cellular Microbiology. Nov, 2004 | Pubmed ID: 15469435 Silencing of Androgen-regulated Genes Using a Fusion of AR with the PLZF Transcriptional Repressor Oncogene. Sep, 2004 | Pubmed ID: 15334066 Analysis of Gene Expression in Cancer Cell Lines Identifies Candidate Markers for Pancreatic Tumorigenesis and Metastasis International Journal of Cancer. Oct, 2004 | Pubmed ID: 15305381 Noninvasive Imaging of the Transcriptional Activities of Human Telomerase Promoter Fragments in Mice Cancer Research. Jul, 2004 | Pubmed ID: 15256462 Interleukin-1beta and Tumour Necrosis Factor-alpha Promote the Transformation of Human Immortalised Mesothelial Cells by Erionite International Journal of Oncology. Jul, 2004 | Pubmed ID: 15202003 Low Molecular Weight Heparin, Therapy with Dalteparin, and Survival in Advanced Cancer: the Fragmin Advanced Malignancy Outcome Study (FAMOUS) Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2004 | Pubmed ID: 15143088 A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/neu Oncogene Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2004 | Pubmed ID: 15131034 Quantitative Imaging of Na/I Symporter Transgene Expression Using Positron Emission Tomography in the Living Animal Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2004 | Pubmed ID: 15006611 Role of Bim in the Survival Pathway Induced by Raf in Epithelial Cells Oncogene. Apr, 2004 | Pubmed ID: 14676826 Clinical Trials with GDEPT: Cytosine Deaminase and 5-fluorocytosine Methods in Molecular Medicine. 2004 | Pubmed ID: 14657578 Application of Laser Capture Microdissection Combined with Two-dimensional Electrophoresis for the Discovery of Differentially Regulated Proteins in Pancreatic Ductal Adenocarcinoma Proteomics. Oct, 2003 | Pubmed ID: 14625861 Fibroblast Growth Factor 2-mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells Molecular and Cellular Biology. Nov, 2003 | Pubmed ID: 14560006 Molecular Alterations in Pancreatic Carcinoma: Expression Profiling Shows That Dysregulated Expression of S100 Genes is Highly Prevalent The Journal of Pathology. Sep, 2003 | Pubmed ID: 12950018 Combination of Microdissection and Microarray Analysis to Identify Gene Expression Changes Between Differentially Located Tumour Cells in Breast Cancer Oncogene. Jun, 2003 | Pubmed ID: 12802281 Procaspase 3 Expression in Ovarian Carcinoma Cells Increases Survivin Transcription Which Can Be Countered with a Dominant-negative Mutant, Survivin T34A; a Combination Gene Therapy Strategy Oncogene. Jun, 2003 | Pubmed ID: 12789262 Sodium Iodide Symporter: a New Strategy to Target Cancer? Lancet (London, England). May, 2003 | Pubmed ID: 12788591 Recombinant E. Coli Efficiently Delivers Antigen and Maturation Signals to Human Dendritic Cells: Presentation of MART1 to CD8+ T Cells International Journal of Cancer. Jul, 2003 | Pubmed ID: 12767067 DNA Fingerprinting from Cells Captured by Laser Microdissection Methods in Enzymology. 2002 | Pubmed ID: 12418207 Adenovirus Biodistribution and Noninvasive Imaging of Gene Expression in Vivo by Positron Emission Tomography Using Human Sodium/iodide Symporter As Reporter Gene Human Gene Therapy. Sep, 2002 | Pubmed ID: 12396625 Expression Profiling of Microdissected Pancreatic Adenocarcinomas Oncogene. Jul, 2002 | Pubmed ID: 12085237 Characterization of Gene Expression Profiles in Intraductal Papillary-mucinous Tumors of the Pancreas The American Journal of Pathology. May, 2002 | Pubmed ID: 12000726 Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax to Trigger Apoptosis Molecular and Cellular Biology. Jun, 2002 | Pubmed ID: 11997495 Dpc4 is Expressed in Virtually All Primary and Metastatic Pancreatic Endocrine Carcinomas Virchows Archiv : an International Journal of Pathology. Feb, 2002 | Pubmed ID: 11964045 Sex Chromosome Anomalies in Pancreatic Endocrine Tumors International Journal of Cancer. Apr, 2002 | Pubmed ID: 11920612 Use of DNA Fingerprinting to Detect Genetic Rearrangements in Human Cancer Methods in Molecular Medicine. 2002 | Pubmed ID: 11901496 The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP Through a Reaper-like Motif The Journal of Biological Chemistry. Jan, 2002 | Pubmed ID: 11602612 Uma abordagem simples e eficiente para construir vectores de vírus mutante Vaccinia Ming Yuan*1, Pengju Wang*2,3, Louisa S. Chard1, Nicholas R. Lemoine1,2,3, Yaohe Wang1,2,3 1Center for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, 2Sino-British Research Centre for Molecular Oncology, National Center for International Research in Cell and Gene Therapy, Zhengzhou University, 3School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University JoVE 54171 Immunology and Infection
Uma abordagem simples e eficiente para construir vectores de vírus mutante Vaccinia Ming Yuan*1, Pengju Wang*2,3, Louisa S. Chard1, Nicholas R. Lemoine1,2,3, Yaohe Wang1,2,3 1Center for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, 2Sino-British Research Centre for Molecular Oncology, National Center for International Research in Cell and Gene Therapy, Zhengzhou University, 3School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University JoVE 54171 Immunology and Infection
