Articles by Nicholas Eustace in JoVE
Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing Ashley N. Gilbert1, Rachael S. Shevin4, Joshua C. Anderson2, Catherine P. Langford3, Nicholas Eustace2, G. Yancey Gillespie3, Raj Singh4, Christopher D. Willey2 1Biomedical Engineering, University of Alabama at Birmingham, 2Radiation Oncology, University of Alabama at Birmingham, 3Neurosurgery, University of Alabama at Birmingham, 4Vivo Biosciences, Inc. Patient-derived xenografts of glioblastoma multiforme can be miniaturized into living microtumors using 3D human biogel culture system. This in vivo-like 3D tumor assay is suitable for drug response testing and molecular profiling, including kinomic analysis.
Other articles by Nicholas Eustace on PubMed
Use of Nonsteroidal Anti-inflammatory Drugs in Infants. A Survey of Members of the Association of Paediatric Anaesthetists of Great Britain and Ireland Paediatric Anaesthesia. May, 2007 | Pubmed ID: 17474954 Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as perioperative analgesics. Many are currently used off label. Diclofenac is currently licensed for use in children over 1 year of age for the treatment of juvenile rheumatoid arthritis, while ibuprofen is licensed for use in children weighing over 7 kg. The dose and interval in children is currently extrapolated from adult studies, as the pharmacokinetic (PK) and pharmacodynamic (PD) data are lacking in infants.
Sternoplasty and Rib Distraction in Neonatal Jeune Syndrome Journal of Pediatric Orthopedics. Sep, 2010 | Pubmed ID: 20733414 A 12-week-old boy with Jeune syndrome (asphyxiating thoracic dystrophy) was referred to the orthopaedic unit with progressive respiratory failure, recurrent respiratory tract infections, and recurrent admissions to the intensive care unit for ventilatory support. His chest x-ray revealed a small and narrow thoracic cage with short broad ribs and abnormal costal cartilages. His chest expansion was impaired by the short, horizontally positioned ribs resulting in alveolar hypoventilation. Without surgical intervention to expand his thoracic cage, he would die of respiratory failure.