In JoVE (1)
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Articles by Nicholas Venetos in JoVE
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury Allyson L. Huttinger1, Debra G. Wheeler1, Surya Gnyawali2, David Dornbos III1, Juliana M. Layzer3, Nicholas Venetos1, Spencer Talentino1, Nicholas J. Musgrave1, Cheyenne Jones1, Camille Bratton1, Matthew E. Joseph4, Chandan Sen2, Bruce A. Sullenger3, Shahid M. Nimjee1 1Department of Neurological Surgery, Ohio State University, 2Department of Surgery, Ohio State University, 3Department of Surgery, Duke University, 4Department of Internal Medicine, Ohio State University Here, we present the modifications necessary to a well characterized and commonly used small animal ferric chloride-induced (FeCl3) carotid artery injury model for use in a large animal vascular injury model. The resulting model can be utilized for pre-clinical trial assessment of both prophylactic and thrombolytic pharmacological and mechanical interventions.