Articles by Nicole M. De Jesus in JoVE
Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart Lianguo Wang1, Nicole M. De Jesus2, Crystal M. Ripplinger1 1Department of Pharmacology, University of California Davis, 2Departments of Pharmacology and Biomedical Engineering, University of California Davis This article describes the detailed protocol and equipment necessary for dual optical mapping of transmembrane potential (Vm) and free intra-sarcoplasmic reticulum (SR) Ca2+ in the Langendorff-perfused rabbit heart. This method allows for direct observation and quantification of Vm and SR Ca2+ dynamics in the intact heart.
Other articles by Nicole M. De Jesus on PubMed
Optical Mapping of Sarcoplasmic Reticulum Ca2+ in the Intact Heart: Ryanodine Receptor Refractoriness During Alternans and Fibrillation Circulation Research. Apr, 2014 | Pubmed ID: 24568740 Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia.
Atherosclerosis Exacerbates Arrhythmia Following Myocardial Infarction: Role of Myocardial Inflammation Heart Rhythm : the Official Journal of the Heart Rhythm Society. Jan, 2015 | Pubmed ID: 25304682 Atherosclerotic animal models show increased recruitment of inflammatory cells to the heart after myocardial infarction (MI), which impacts ventricular function and remodeling.