Nicole F. Liachko Geriatrics Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System Biography Publications Institution JoVE Articles Nicole F. Liachko has not added a biography. If you are Nicole F. Liachko and would like to personalize this page please email our Author Liaison for assistance. Publications Tau and TDP-43 Synergy: a Novel Therapeutic Target for Sporadic Late-onset Alzheimer's Disease GeroScience. Jun, 2021 | Pubmed ID: 34185246 Regulation of TDP-43 Phosphorylation in Aging and Disease GeroScience. May, 2021 | Pubmed ID: 34032984 Targeting Nuclear Protein TDP-43 by Cell Division Cycle Kinase 7 Inhibitors: A New Therapeutic Approach for Amyotrophic Lateral Sclerosis European Journal of Medicinal Chemistry. Jan, 2021 | Pubmed ID: 33139113 Adult Onset Pan-neuronal Human Tau Tubulin Kinase 1 Expression Causes Severe Cerebellar Neurodegeneration in Mice Acta Neuropathologica Communications. 11, 2020 | Pubmed ID: 33228809 ARENA-based Activity Profiling of Tau and TDP-43 Transgenic MicroPublication Biology. Jul, 2020 | Pubmed ID: 32724897 Activity of the Poly(A) Binding Protein MSUT2 Determines Susceptibility to Pathological Tau in the Mammalian Brain Science Translational Medicine. Dec, 2019 | Pubmed ID: 31852801 Genome Wide Analysis Reveals Heparan Sulfate Epimerase Modulates TDP-43 Proteinopathy PLoS Genetics. 12, 2019 | Pubmed ID: 31834878 Constitutive XBP-1s-mediated Activation of the Endoplasmic Reticulum Unfolded Protein Response Protects Against Pathological Tau Nature Communications. 09, 2019 | Pubmed ID: 31570707 Resistance and Resilience to Alzheimer's Disease Pathology Are Associated with Reduced Cortical PTau and Absence of Limbic-predominant Age-related TDP-43 Encephalopathy in a Community-based Cohort Acta Neuropathologica Communications. 06, 2019 | Pubmed ID: 31174609 Tau Tubulin Kinases in Proteinopathy The FEBS Journal. 07, 2019 | Pubmed ID: 31034749 Motor Neuron Disease-associated Loss of Nuclear TDP-43 is Linked to DNA Double-strand Break Repair Defects Proceedings of the National Academy of Sciences of the United States of America. 03, 2019 | Pubmed ID: 30770445 Preventive Action of Benztropine on Platinum-induced Peripheral Neuropathies and Tumor Growth Acta Neuropathologica Communications. 01, 2019 | Pubmed ID: 30657060 Pathological Phosphorylation of Tau and TDP-43 by TTBK1 and TTBK2 Drives Neurodegeneration Molecular Neurodegeneration. 02, 2018 | Pubmed ID: 29409526 Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing Scientific Reports. 01, 2018 | Pubmed ID: 29343694 TDP-43/FUS in Motor Neuron Disease: Complexity and Challenges Progress in Neurobiology. Oct - Nov, 2016 | Pubmed ID: 27693252 The Phosphatase Calcineurin Regulates Pathological TDP-43 Phosphorylation Acta Neuropathologica. 10, 2016 | Pubmed ID: 27473149 Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2015 | Pubmed ID: 26490867 The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43 PLoS Genetics. Dec, 2014 | Pubmed ID: 25473830 Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis Journal of Medicinal Chemistry. Mar, 2014 | Pubmed ID: 24592867 CDC7 Inhibition Blocks Pathological TDP-43 Phosphorylation and Neurodegeneration Annals of Neurology. Jul, 2013 | Pubmed ID: 23424178 Dopamine D2 Receptor Antagonism Suppresses Tau Aggregation and Neurotoxicity Biological Psychiatry. Mar, 2013 | Pubmed ID: 23140663 Phosphorylation Promotes Neurotoxicity in a Caenorhabditis Elegans Model of TDP-43 Proteinopathy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010 | Pubmed ID: 21123567 Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis Heather N. Currey1, Nicole F. Liachko1,2 1Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 2Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington JoVE 62699 Neuroscience
Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis Heather N. Currey1, Nicole F. Liachko1,2 1Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 2Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington JoVE 62699 Neuroscience
