Nikolaus Rajewsky Biography Publications JoVE Articles Nikolaus Rajewsky has not added a biography. If you are Nikolaus Rajewsky and would like to personalize this page please email our Author Liaison for assistance. Publications CiRS-7 and MiR-7 Regulate Ischemia-induced Neuronal Death Via Glutamatergic Signaling Cell Reports. Mar, 2024 | Pubmed ID: 38446664 Spatiotemporal, Optogenetic Control of Gene Expression in Organoids Nature Methods. Oct, 2023 | Pubmed ID: 37735569 Defining the Landscape of Circular RNAs in Neuroblastoma Unveils a Global Suppressive Function of MYCN Nature Communications. Jul, 2023 | Pubmed ID: 37402719 Modelling Viral Encephalitis Caused by Herpes Simplex Virus 1 Infection in Cerebral Organoids Nature Microbiology. Jul, 2023 | Pubmed ID: 37349587 Establishment of Gastrointestinal Assembloids to Study the Interplay Between Epithelial Crypts and Their Mesenchymal Niche Nature Communications. May, 2023 | Pubmed ID: 37230989 Prox2 and Runx3 Vagal Sensory Neurons Regulate Esophageal Motility Neuron. Jul, 2023 | Pubmed ID: 37192624 Long-term Imaging Reveals Behavioral Plasticity During C. Elegans Dauer Exit BMC Biology. Dec, 2022 | Pubmed ID: 36514066 SARS-CoV-2 Infection Dynamics Revealed by Wastewater Sequencing Analysis and Deconvolution The Science of the Total Environment. Dec, 2022 | Pubmed ID: 36228784 Urinary Single-cell Sequencing Captures Kidney Injury and Repair Processes in Human Acute Kidney Injury Kidney International. Dec, 2022 | Pubmed ID: 36049643 Spacemake: Processing and Analysis of Large-scale Spatial Transcriptomics Data GigaScience. Jul, 2022 | Pubmed ID: 35852420 NovoSpaRc: Flexible Spatial Reconstruction of Single-cell Gene Expression with Optimal Transport Nature Protocols. Sep, 2021 | Pubmed ID: 34349282 Parallel Genetics of Regulatory Sequences Using Scalable Genome Editing In vivo Cell Reports. Apr, 2021 | Pubmed ID: 33852857 Defective Metabolic Programming Impairs Early Neuronal Morphogenesis in Neural Cultures and an Organoid Model of Leigh Syndrome Nature Communications. 03, 2021 | Pubmed ID: 33771987 Publisher Correction: LifeTime and Improving European Healthcare Through Cell-based Interceptive Medicine Nature. Apr, 2021 | Pubmed ID: 33731935 Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients Journal of the American Society of Nephrology : JASN. Feb, 2021 | Pubmed ID: 33239393 LifeTime and Improving European Healthcare Through Cell-based Interceptive Medicine Nature. 11, 2020 | Pubmed ID: 32894860 CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia Molecular Therapy : the Journal of the American Society of Gene Therapy. 12, 2020 | Pubmed ID: 32822592 Functional Interplay of Epstein-Barr Virus Oncoproteins in a Mouse Model of B Cell Lymphomagenesis Proceedings of the National Academy of Sciences of the United States of America. 06, 2020 | Pubmed ID: 32522871 Tracing Tumorigenesis in a Solid Tumor Model at Single-cell Resolution Nature Communications. 02, 2020 | Pubmed ID: 32080185 A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain Cell Reports. 02, 2020 | Pubmed ID: 32075758 Gene Expression Cartography Nature. 12, 2019 | Pubmed ID: 31748748 Single-cell RNA-sequencing of Herpes Simplex Virus 1-infected Cells Connects NRF2 Activation to an Antiviral Program Nature Communications. Oct, 2019 | Pubmed ID: 31653857 Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells Cell Reports. Sep, 2019 | Pubmed ID: 31553918 Identification of Proteins and MiRNAs That Specifically Bind an MRNA in Vivo Nature Communications. 09, 2019 | Pubmed ID: 31527589 FLAM-seq: Full-length MRNA Sequencing Reveals Principles of Poly(A) Tail Length Control Nature Methods. 09, 2019 | Pubmed ID: 31384046 The Translational Landscape of the Human Heart Cell. Jun, 2019 | Pubmed ID: 31155234 BCR-dependent Lineage Plasticity in Mature B Cells Science (New York, N.Y.). 02, 2019 | Pubmed ID: 30765568 Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis Cell Reports. 11, 2018 | Pubmed ID: 30485812 Spatiotemporal M(i)RNA Architecture and 3' UTR Regulation in the C. elegans Germline Developmental Cell. 12, 2018 | Pubmed ID: 30416012 A Single-Cell Transcriptome Atlas of the Mouse Glomerulus Journal of the American Society of Nephrology : JASN. 08, 2018 | Pubmed ID: 29794128 Cell Type Atlas and Lineage Tree of a Whole Complex Animal by Single-cell Transcriptomics Science (New York, N.Y.). 05, 2018 | Pubmed ID: 29674432 Post-transcriptional Regulation by 3' UTRs Can Be Masked by Regulatory Elements in 5' UTRs Cell Reports. 03, 2018 | Pubmed ID: 29562178 Single-Molecule Fluorescence In Situ Hybridization (FISH) of Circular RNA CDR1as Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29322442 Signaling by the Epstein-Barr Virus LMP1 Protein Induces Potent Cytotoxic CD4 and CD8 T Cell Responses Proceedings of the National Academy of Sciences of the United States of America. 01, 2018 | Pubmed ID: 29311309 Widespread Activation of Antisense Transcription of the Host Genome During Herpes Simplex Virus 1 Infection Genome Biology. Oct, 2017 | Pubmed ID: 29089033 RNA Localization is a Key Determinant of Neurite-enriched Proteome Nature Communications. Sep, 2017 | Pubmed ID: 28928394 The Embryo at Single-cell Transcriptome Resolution Science (New York, N.Y.). 10, 2017 | Pubmed ID: 28860209 A Map of Human Circular RNAs in Clinically Relevant Tissues Journal of Molecular Medicine (Berlin, Germany). Nov, 2017 | Pubmed ID: 28842720 Loss of a Mammalian Circular RNA Locus Causes MiRNA Deregulation and Affects Brain Function Science (New York, N.Y.). Sep, 2017 | Pubmed ID: 28798046 Cell Fixation and Preservation for Droplet-based Single-cell Transcriptomics BMC Biology. 05, 2017 | Pubmed ID: 28526029 RCAS: an RNA Centric Annotation System for Transcriptome-wide Regions of Interest Nucleic Acids Research. Jun, 2017 | Pubmed ID: 28334930 Extensive Identification and Analysis of Conserved Small ORFs in Animals Genome Biology. Sep, 2015 | Pubmed ID: 26364619 Translational Regulation Shapes the Molecular Landscape of Complex Disease Phenotypes Nature Communications. May, 2015 | Pubmed ID: 26007203 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed Molecular Cell. Jun, 2015 | Pubmed ID: 25921068 Insm1 Cooperates with Neurod1 and Foxa2 to Maintain Mature Pancreatic β-cell Function The EMBO Journal. May, 2015 | Pubmed ID: 25828096 Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals Cell Reports. Jan, 2015 | Pubmed ID: 25558066 A Variety of Dicer Substrates in Human and C. Elegans Cell. Nov, 2014 | Pubmed ID: 25416952 CircRNA Biogenesis Competes with Pre-mRNA Splicing Molecular Cell. Oct, 2014 | Pubmed ID: 25242144 CircBase: a Database for Circular RNAs RNA (New York, N.Y.). Nov, 2014 | Pubmed ID: 25234927 Mixed Messages: Re-initiation Factors Regulate Translation of Animal MRNAs Cell Research. Dec, 2014 | Pubmed ID: 25145358 Widespread Changes in Protein Synthesis Induced by MicroRNAs Nature. Sep, 2008 | Pubmed ID: 18668040 Generation and Downstream Analysis of Single-Cell and Single-Nuclei Transcriptomes in Brain Organoids JoVE 66225 Developmental Biology Aislamiento de núcleos de riñón de ratón adulto para secuenciación de ARN de un solo núcleo Janna Leiz*1,2, Christian Hinze*1,2, Anastasiya Boltengagen3, Caroline Braeuning4, Christine Kocks3, Nikolaus Rajewsky3, Kai M. Schmidt-Ott1,2 1Department of Nephrology and Medical Intensive Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 2Molecular and Translational Kidney Research, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 3Berlin Institute of Medical Systems Biology (BIMSB), Systems Biology of Gene Regulatory Elements, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 4Berlin Institute of Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) JoVE 62901 Biology Generación de organoides cerebrales humanos para el modelado de enfermedades mitocondriales Stephanie Le1, Laura Petersilie2, Gizem Inak1,4, Carmen Menacho-Pando1, Karl W. Kafitz2, Agnieszka Rybak-Wolf3, Nikolaus Rajewsky3, Christine R. Rose2, Alessandro Prigione1,5 1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, 2Institute of Neurobiology, Heinrich Heine University, 3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrueck Center for Molecular Medicine (MDC), 4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, 5Max Delbrueck Center for Molecular Medicine (MDC) JoVE 62756 Neuroscience
Generation and Downstream Analysis of Single-Cell and Single-Nuclei Transcriptomes in Brain Organoids JoVE 66225 Developmental Biology
Aislamiento de núcleos de riñón de ratón adulto para secuenciación de ARN de un solo núcleo Janna Leiz*1,2, Christian Hinze*1,2, Anastasiya Boltengagen3, Caroline Braeuning4, Christine Kocks3, Nikolaus Rajewsky3, Kai M. Schmidt-Ott1,2 1Department of Nephrology and Medical Intensive Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 2Molecular and Translational Kidney Research, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 3Berlin Institute of Medical Systems Biology (BIMSB), Systems Biology of Gene Regulatory Elements, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 4Berlin Institute of Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) JoVE 62901 Biology
Generación de organoides cerebrales humanos para el modelado de enfermedades mitocondriales Stephanie Le1, Laura Petersilie2, Gizem Inak1,4, Carmen Menacho-Pando1, Karl W. Kafitz2, Agnieszka Rybak-Wolf3, Nikolaus Rajewsky3, Christine R. Rose2, Alessandro Prigione1,5 1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, 2Institute of Neurobiology, Heinrich Heine University, 3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrueck Center for Molecular Medicine (MDC), 4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, 5Max Delbrueck Center for Molecular Medicine (MDC) JoVE 62756 Neuroscience
