Articles by Noopur Bhore in JoVE
Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms Bo-Jeng Wang*1, Pei-Yi Wu*1, Yun-Wen Chen*1, Yu-Tzu Chang1, Noopur Bhore1, Po-Fan Wu1, Yung-Feng Liao1 1Laboratory of Molecular Neurobiology, Institute of Cellular and Organismic Biology, Academia Sinica We have successfully generated two substrate-specific γ-secretase assays. Both cell-based assays presented here are designed to quantify γ-secretase enzymatic activities via the output of firefly luciferase reporters.
Other articles by Noopur Bhore on PubMed
Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases International Journal of Molecular Sciences. | Pubmed ID: 28902166 Protein homeostasis or proteostasis is a fundamental cellular property that encompasses the dynamic balancing of processes in the proteostasis network (PN). Such processes include protein synthesis, folding, and degradation in both non-stressed and stressful conditions. The role of the PN in neurodegenerative disease is well-documented, where it is known to respond to changes in protein folding states or toxic gain-of-function protein aggregation. Dual-specificity phosphatases have recently emerged as important participants in maintaining balance within the PN, acting through modulation of cellular signaling pathways that are involved in neurodegeneration. In this review, we will summarize recent findings describing the roles of dual-specificity phosphatases in neurodegeneration and offer perspectives on future therapeutic directions.