Ole Isacson McLean Hospital, Harvard Stem Cell Institute Harvard Medical School Biography Publications Institution JoVE Articles Ole Isacson has not added a biography. If you are Ole Isacson and would like to personalize this page please email our Author Liaison for assistance. Publications Sorting the Wheat from the Chaff in Dopamine Neuron-based Cell Therapies Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25848026 A Nurr1 Agonist Causes Neuroprotection in a Parkinson's Disease Lesion Model Primed with the Toll-Like Receptor 3 DsRNA Inflammatory Stimulant Poly(I:C) PloS One. 2015 | Pubmed ID: 25815475 Successful Function of Autologous IPSC-Derived Dopamine Neurons Following Transplantation in a Non-Human Primate Model of Parkinson's Disease Cell Stem Cell. Mar, 2015 | Pubmed ID: 25732245 Long-term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients Cell Reports. Jun, 2014 | Pubmed ID: 24910427 ALS-associated Peripherin Spliced Transcripts Form Distinct Protein Inclusions That Are Neuroprotective Against Oxidative Stress Experimental Neurology. Nov, 2014 | Pubmed ID: 24907400 Widespread Neuron-specific Transgene Expression in Brain and Spinal Cord Following Synapsin Promoter-driven AAV9 Neonatal Intracerebroventricular Injection Neuroscience Letters. Jul, 2014 | Pubmed ID: 24882721 Progressive Axonal Transport and Synaptic Protein Changes Correlate with Behavioral and Neuropathological Abnormalities in the Heterozygous Q175 KI Mouse Model of Huntington's Disease Human Molecular Genetics. Sep, 2014 | Pubmed ID: 24728190 Motor Impairments, Striatal Degeneration, and Altered Dopamine-glutamate Interplay in Mice Lacking PSD-95 Journal of Neurogenetics. Mar-Jun, 2014 | Pubmed ID: 24702501 Advances in Stem-cell--generated Transplantation Therapy for Parkinson's Disease Expert Opinion on Biological Therapy. Apr, 2014 | Pubmed ID: 24437368 Enhanced Ubiquitin-dependent Degradation by Nedd4 Protects Against α-synuclein Accumulation and Toxicity in Animal Models of Parkinson's Disease Neurobiology of Disease. Apr, 2014 | Pubmed ID: 24388974 LRRK2 Mutations Cause Mitochondrial DNA Damage in IPSC-derived Neural Cells from Parkinson's Disease Patients: Reversal by Gene Correction Neurobiology of Disease. Feb, 2014 | Pubmed ID: 24148854 Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of HESC-, HiPSC-, and Non-human Primate IPSC-derived Dopaminergic Neurons Stem Cells (Dayton, Ohio). Aug, 2013 | Pubmed ID: 23666606 Characterization and Criteria of Embryonic Stem and Induced Pluripotent Stem Cells for a Dopamine Replacement Therapy Progress in Brain Research. 2012 | Pubmed ID: 23195423 Stem Cells for Parkinson's Disease: Advancing Science but Protecting Patients Movement Disorders : Official Journal of the Movement Disorder Society. Oct, 2012 | Pubmed ID: 23032987 Creation of an Open-access, Mutation-defined Fibroblast Resource for Neurological Disease Research PloS One. 2012 | Pubmed ID: 22952635 The Search for Genetic Mouse Models of Prodromal Parkinson's Disease Experimental Neurology. Oct, 2012 | Pubmed ID: 22819262 Pharmacological Rescue of Mitochondrial Deficits in IPSC-derived Neural Cells from Patients with Familial Parkinson's Disease Science Translational Medicine. Jul, 2012 | Pubmed ID: 22764206 α-Synuclein Overexpressing Transgenic Mice Show Internal Organ Pathology and Autonomic Deficits Neurobiology of Disease. Aug, 2012 | Pubmed ID: 22549133 Viral and Inflammatory Triggers of Neurodegenerative Diseases Science Translational Medicine. Feb, 2012 | Pubmed ID: 22344685 干细胞在神经退行性疾病的临床翻译。 Cell Stem Cell. Feb, 2012 | Pubmed ID: 22305565 使用干细胞和 IPS 细胞来发现帕金森病新的治疗方法。 Parkinsonism & Related Disorders. Jan, 2012 | Pubmed ID: 22166414 全长 α-synuclein 和其三个剪接变体在帕金森病的大脑区域和 α-synuclein 过表达转基因小鼠模型中的谈话内容表达水平。 Molecular and Cellular Neurosciences. Feb, 2012 | Pubmed ID: 22155155 需要成人脑组织神经干细胞分化为脑多巴胺能神经元诱导 Oct4 重新编程。 PloS One. 2011 | Pubmed ID: 21655272 相容性的灵长类动物诱导多能干细胞神经移植的发展。 Stem Cells (Dayton, Ohio). Jul, 2011 | Pubmed ID: 21608081 黑质纹状体的多巴胺能突触和神经移植在帕金森病中的使用功能。 Journal of Neurology. Aug, 2011 | Pubmed ID: 21544566 使用干细胞和 IPS 的局部放电中的各种疗法的机会。 RinshÅ Shinkeigaku = Clinical Neurology. Nov, 2010 | Pubmed ID: 21921494 Toll 样受体 3 激动剂 Polyinosinic:polycytidylic 酸触发黑质纹状体多巴胺能变性。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010 | Pubmed ID: 21123556 全球基因表达谱的躯体运动神经元人口与不同的漏洞识别分子和退行性变和保护的途径。 Brain : a Journal of Neurology. Aug, 2010 | Pubmed ID: 20826431 正太包容 Synuclein 夹杂物有关。 Nature Medicine. Sep, 2010 | Pubmed ID: 20823871 有区别的帕金森病人派生诱导的胚胎干细胞在成年鼠脑中成长和减少帕金森病大鼠的电机不对称。 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20798034 大力青年转基因模型具有更高的 UPS 类似于唐氏综合征和阿尔茨海默病的额叶皮层的活动。 Journal of Neurochemistry. Sep, 2010 | Pubmed ID: 20698932 人类 ES 和帕金森病的 IPS 细胞分化为脑腹侧多巴胺能神经元甲酸所需要 SHH、 FGF8a 和特定区域化高活性形式。 Molecular and Cellular Neurosciences. Nov, 2010 | Pubmed ID: 20603216 转录因子 Orthodenticle 同源盒 2 影响轴突预测和中脑多巴胺能神经元的漏洞。 Brain : a Journal of Neurology. Jul, 2010 | Pubmed ID: 20573704 高 Regulatability 看好遗传选择在 SLC18A2,囊泡单胺转运体生命的根本。 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2010 | Pubmed ID: 20181938 功能增强和保护多巴胺能码头由 RAB3B 表达。 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 20007772 单元格前面的帕金森病的治疗。 Science (New York, N.Y.). Nov, 2009 | Pubmed ID: 19965408 隔离和腹侧中脑神经前体细胞和啮齿动物的大脑多巴胺能神经元的文化。 Current Protocols in Stem Cell Biology. Dec, 2009 | Pubmed ID: 19960452 Wnt1 Lmx1a 构成新型自动调节循环和控制协同与 SHH FoxA2 通路中脑多巴胺能分化。 Cell Stem Cell. Dec, 2009 | Pubmed ID: 19951692 在胚胎移植中类似疾病的进程没有证据。 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805203 用于生成 ES 细胞的分子和细胞决定因素派生的多巴胺神经元细胞疗法。 Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 19731556 CD15、 CD24 和 CD29 定义神经分化干细胞的表面标志代码。 Stem Cells (Dayton, Ohio). Dec, 2009 | Pubmed ID: 19725119 缺少的功能隔离的细胞受损的帕金森病患者移植的相关性。 Journal of Neurology. Aug, 2009 | Pubmed ID: 19711122 血脑屏障完好无损后在帕金森病的灵长类动物 — — 左旋多巴诱导的异动来自体内神经影像学研究的证据。 Neurobiology of Disease. Sep, 2009 | Pubmed ID: 19501164 腺相关病毒 Alpha Synucleinopathy 大鼠模型中的突触前和轴突运输蛋白结合纹状体 Neuroinflammation 中的动态变化前面多巴胺能神经元丢失。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2009 | Pubmed ID: 19295143 帕金森病病人派生诱导多能干细胞免费的病毒编程因素。 Cell. Mar, 2009 | Pubmed ID: 19269371 PSD-95 Uncouples 中复杂的 D1/PSD-95/NMDA 受体的多巴胺-谷氨酸互动。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2009 | Pubmed ID: 19261890 轴突导向和突触维护: 神经退行性疾病和治疗的临床前标记。 Trends in Neurosciences. Mar, 2009 | Pubmed ID: 19162339 帕金森病的细胞和基因治疗的未来。 Annals of Neurology. Dec, 2008 | Pubmed ID: 19127583 ALS 模型胶质可以调解对源自人类胚胎干细胞的运动神经元的毒性。 Cell Stem Cell. Dec, 2008 | Pubmed ID: 19041769 孤雌生殖的多巴胺神经元从灵长类胚胎干细胞恢复功能实验帕金森病。 Brain : a Journal of Neurology. Aug, 2008 | Pubmed ID: 18669499 泛素蛋白酶体系统、 脑源性神经营养因子和线粒体复杂 II/III YAC72 和 R6/2 的转基因小鼠的补偿性变化部分型号亨廷顿氏舞蹈病患者。 Human Molecular Genetics. Oct, 2008 | Pubmed ID: 18640989 命运映射和沿袭分析表明经过转化生长因子 α 和脑袋纹状体注入到多巴胺枯竭的纹状体的纹状体的细胞悬液一大批生产。 Stem Cells (Dayton, Ohio). Sep, 2008 | Pubmed ID: 18556510 孤啡肽/孤啡肽 FQ 受体封锁衰减 MPTP 致帕金森综合征。 Neurobiology of Disease. Jun, 2008 | Pubmed ID: 18413287 植入帕金森病患者的多巴胺神经元存活 14 年无病理。 Nature Medicine. May, 2008 | Pubmed ID: 18391961 神经元功能编程成纤维细胞从派生融入于胎儿的大脑,并改善症状的治疗帕金森病大鼠。 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18391196 胚胎干细胞源性 Pitx3 增强绿色荧光蛋白中脑多巴胺神经元生存富集荧光激活细胞分选和帕金森病动物模型中的函数。 Stem Cells (Dayton, Ohio). Jun, 2008 | Pubmed ID: 18388307 基于单元格的帕金森病治疗的最新进展。 Neurosurgical Focus. 2008 | Pubmed ID: 18341409 Neuroinflammation 介导 IL 1beta 增加变性帕金森病动物模型的多巴胺神经元的易感性。 Journal of Neuroinflammation. 2008 | Pubmed ID: 18304357 来自人类胚胎干细胞的神经前体保持长期的扩散而不会丢失所有三个神经谱系,包括多巴胺能神经元分化的潜力。 Journal of Neurochemistry. Jan, 2008 | Pubmed ID: 17944878 细胞治疗和干细胞的运动神经元疾病的动物模型。 The European Journal of Neuroscience. Oct, 2007 | Pubmed ID: 17897390 通过事后的 Abeta 有辱人格的蛋白酶体内基因传递的减少淀粉样斑块负担: 对阿尔茨海默病的一种新型的治疗方法。 PLoS Medicine. Aug, 2007 | Pubmed ID: 17760499 富亮氨酸重复蛋白 LINGO-1 的抑制作用增强了生存、 结构和功能的帕金森病模型中的多巴胺能神经元。 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17726113 内源性丝氨酸/苏氨酸蛋白磷酸酶抑制剂,G-基板,减少了对帕金森病模型中的漏洞。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2007 | Pubmed ID: 17670978 未成熟和神经性差别小鼠胚胎干细胞不能代表一个功能性 Fas/Fas 配体系统。 Stem Cells (Dayton, Ohio). Oct, 2007 | Pubmed ID: 17615270 不同启动子在不同阶段的小鼠胚胎干细胞体外诱导分化的慢病毒载体的功能分析。 Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2007 | Pubmed ID: 17609656 标记和单元格的人类胚胎干细胞源性神经细胞群体进行排序的方法。 Stem Cells (Dayton, Ohio). Sep, 2007 | Pubmed ID: 17588935 帕金森病灵长类和啮齿类动物与 L-多巴诱导的异动 D3 多巴胺受体敏感性的体内证据。 Neurobiology of Disease. Aug, 2007 | Pubmed ID: 17588764 信号由 PSD 95 多巴胺 D1 受体的抑制作用。 The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17369255 蛋白酶体活化剂增强了生存的亨廷顿氏舞蹈病细胞神经元的模型。 PloS One. 2007 | Pubmed ID: 17327906 选择的胚胎干细胞增强的绿色荧光蛋白抗体阳性多巴胺神经元使用酪氨酸羟化酶基因的启动把混杂在一起的记者在不成熟的细胞群体中的基因表达。 Stem Cells (Dayton, Ohio). May, 2007 | Pubmed ID: 17234989 神经上皮前体和从人类胚胎干细胞使用骨人骨形成蛋白拮抗剂脑袋样中脑多巴胺能神经元的收益增加。 Stem Cells (Dayton, Ohio). Feb, 2007 | Pubmed ID: 17038668 优先从灵长类动物 ES 细胞移植的多巴胺神经元支配 DARPP 32 纹状体祖细胞在移植物内。 The European Journal of Neuroscience. Oct, 2006 | Pubmed ID: 17067292 What Are the Long-term Effects of Neural Grafting in Patients with Huntington's Disease? Nature Clinical Practice. Neurology. Sep, 2006 | Pubmed ID: 16932607 Neuroblast Protuberances in the Subventricular Zone of the Regenerative MRL/MpJ Mouse The Journal of Comparative Neurology. Oct, 2006 | Pubmed ID: 16927265 Axonal Growth Regulation of Fetal and Embryonic Stem Cell-derived Dopaminergic Neurons by Netrin-1 and Slits Stem Cells (Dayton, Ohio). Nov, 2006 | Pubmed ID: 16840550 Genetic Selection of Sox1GFP-expressing Neural Precursors Removes Residual Tumorigenic Pluripotent Stem Cells and Attenuates Tumor Formation After Transplantation Journal of Neurochemistry. Jun, 2006 | Pubmed ID: 16696855 Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion in Vitro Stem Cells (Dayton, Ohio). Jun, 2006 | Pubmed ID: 16543488 特定 Microrna 调节胚胎神经干细胞的再生。 Stem Cells (Dayton, Ohio). Apr, 2006 | Pubmed ID: 16357340 间质细胞诱导活动、 相关因子 1,并协同信号分子诱使从小鼠胚胎干细胞的多巴胺能神经元。 Stem Cells (Dayton, Ohio). Mar, 2006 | Pubmed ID: 16123386 Insights into Parkinson's Disease Models and Neurotoxicity Using Non-invasive Imaging Toxicology and Applied Pharmacology. Sep, 2005 | Pubmed ID: 15979668 Long-term Survival of Dopamine Neurons Derived from Parthenogenetic Primate Embryonic Stem Cells (cyno-1) After Transplantation Stem Cells (Dayton, Ohio). Aug, 2005 | Pubmed ID: 15941857 Cell Type-specific Gene Expression of Midbrain Dopaminergic Neurons Reveals Molecules Involved in Their Vulnerability and Protection Human Molecular Genetics. Jul, 2005 | Pubmed ID: 15888489 Cell Type Analysis of Functional Fetal Dopamine Cell Suspension Transplants in the Striatum and Substantia Nigra of Patients with Parkinson's Disease Brain : a Journal of Neurology. Jul, 2005 | Pubmed ID: 15872020 Abnormal APP, Cholinergic and Cognitive Function in Ts65Dn Down's Model Mice Experimental Neurology. Jun, 2005 | Pubmed ID: 15869949 Stem Cells May Reshape the Prospect of Parkinson's Disease Therapy Brain Research. Molecular Brain Research. Mar, 2005 | Pubmed ID: 15790528 Netrin-1 and Slit-2 Regulate and Direct Neurite Growth of Ventral Midbrain Dopaminergic Neurons Molecular and Cellular Neurosciences. Mar, 2005 | Pubmed ID: 15737744 上下文相关神经元分化及胚层诱导的 Smad4 /-和 Cripto-/-胚胎干细胞。 Molecular and Cellular Neurosciences. Mar, 2005 | Pubmed ID: 15737733 The Homeodomain Transcription Factor Pitx3 Facilitates Differentiation of Mouse Embryonic Stem Cells into AHD2-expressing Dopaminergic Neurons Molecular and Cellular Neurosciences. Feb, 2005 | Pubmed ID: 15691706 Mapping Dopamine Function in Primates Using Pharmacologic Magnetic Resonance Imaging The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2004 | Pubmed ID: 15509742 Intrastriatal Transforming Growth Factor Alpha Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells Without Differentiation into Dopaminergic Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2004 | Pubmed ID: 15483111 Region-specific Cell Grafting into Cervical and Lumbar Spinal Cord in Rat: a Qualitative and Quantitative Stereological Study Experimental Neurology. Nov, 2004 | Pubmed ID: 15473986 Generalized Brain and Skin Proteasome Inhibition in Huntington's Disease Annals of Neurology. Sep, 2004 | Pubmed ID: 15349858 Selective COX-2 Inhibition Prevents Progressive Dopamine Neuron Degeneration in a Rat Model of Parkinson's Disease Journal of Neuroinflammation. May, 2004 | Pubmed ID: 15285796 Problems and Solutions for Circuits and Synapses in Parkinson's Disease Neuron. Jul, 2004 | Pubmed ID: 15260952 Temporally Induced Nurr1 Can Induce a Non-neuronal Dopaminergic Cell Type in Embryonic Stem Cell Differentiation The European Journal of Neuroscience. Mar, 2004 | Pubmed ID: 15016073 Estrogen Alters Amyloid Precursor Protein As Well As Dendritic and Cholinergic Markers in a Mouse Model of Down Syndrome Hippocampus. 2003 | Pubmed ID: 14750653 脑功能后 Mptp 神经毒性作用灵长类帕金森病模型中的映射。 NeuroImage. Oct, 2003 | Pubmed ID: 14568476 The Production and Use of Cells As Therapeutic Agents in Neurodegenerative Diseases The Lancet. Neurology. Jul, 2003 | Pubmed ID: 12849120 Orphan Nuclear Receptor Nurr1 Directly Transactivates the Promoter Activity of the Tyrosine Hydroxylase Gene in a Cell-specific Manner Journal of Neurochemistry. May, 2003 | Pubmed ID: 12694388 Toward Full Restoration of Synaptic and Terminal Function of the Dopaminergic System in Parkinson's Disease by Stem Cells Annals of Neurology. 2003 | Pubmed ID: 12666105 Regional Alterations in Amyloid Precursor Protein and Nerve Growth Factor Across Age in a Mouse Model of Down's Syndrome Neuroscience Research. Apr, 2003 | Pubmed ID: 12657457 Altered Proteasomal Function in Sporadic Parkinson's Disease Experimental Neurology. Jan, 2003 | Pubmed ID: 12504866 基因工程小鼠胚胎干细胞的相关因子 1 增强了分化和成熟为多巴胺能神经元。 The European Journal of Neuroscience. Nov, 2002 | Pubmed ID: 12453046 Regulation of Dopamine Cell Type and Transmitter Function in Fetal and Stem Cell Transplantation for Parkinson's Disease Progress in Brain Research. 2002 | Pubmed ID: 12432781 Proteasome Inhibition Causes Nigral Degeneration with Inclusion Bodies in Rats Neuroreport. Aug, 2002 | Pubmed ID: 12167769 Spatial Memory Testing Decreases Hippocampal Amyloid Precursor Protein in Young, but Not Aged, Female Rats Neuroscience Letters. Aug, 2002 | Pubmed ID: 12123857 Selective Loss of 20S Proteasome Alpha-subunits in the Substantia Nigra Pars Compacta in Parkinson's Disease Neuroscience Letters. Jul, 2002 | Pubmed ID: 12095645 Models of Repair Mechanisms for Future Treatment Modalities of Parkinson's Disease Brain Research Bulletin. Apr, 2002 | Pubmed ID: 12031282 Herpes Simplex Virus/adeno-associated Virus Hybrid Vectors for Gene Transfer to Neurons. Preparation and Use Methods in Molecular Medicine. 2002 | Pubmed ID: 11987795 Homeodomain 蛋白 Phox2a/2b 的去甲肾上腺素神经递质确定身份的直接作用。 Journal of Neurochemistry. Mar, 2002 | Pubmed ID: 11948255 不同启动子的高效转基因小鼠胚胎干细胞系中的表达系统的分析。 Stem Cells (Dayton, Ohio). 2002 | Pubmed ID: 11897870 Cortico-hippocampal APP and NGF Levels Are Dynamically Altered by Cholinergic Muscarinic Antagonist or M1 Agonist Treatment in Normal Mice The European Journal of Neuroscience. Feb, 2002 | Pubmed ID: 11876777 Alzheimer's Disease and Down's Syndrome: Roles of APP, Trophic Factors and ACh Trends in Neurosciences. Feb, 2002 | Pubmed ID: 11814559 Embryonic Stem Cells Develop into Functional Dopaminergic Neurons After Transplantation in a Parkinson Rat Model Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11782534 OLE Isacson:帕金森氏病的新疗法的发展 Ole Isacson1 1McLean Hospital, Harvard Stem Cell Institute, Harvard Medical School JoVE 189 Biology ES细胞源性神经上皮细胞培养 Shreeya Karki1, Jan Pruszak1, Ole Isacson1, Kai C Sonntag1 1McLean Hospital, Harvard Medical School JoVE 118 Biology
OLE Isacson:帕金森氏病的新疗法的发展 Ole Isacson1 1McLean Hospital, Harvard Stem Cell Institute, Harvard Medical School JoVE 189 Biology
ES细胞源性神经上皮细胞培养 Shreeya Karki1, Jan Pruszak1, Ole Isacson1, Kai C Sonntag1 1McLean Hospital, Harvard Medical School JoVE 118 Biology