Ole Isacson McLean Hospital, Harvard Stem Cell Institute Harvard Medical School Biography Publications Institution JoVE Articles Ole Isacson has not added a biography. If you are Ole Isacson and would like to personalize this page please email our Author Liaison for assistance. Publications Sorting the Wheat from the Chaff in Dopamine Neuron-based Cell Therapies Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25848026 A Nurr1 Agonist Causes Neuroprotection in a Parkinson's Disease Lesion Model Primed with the Toll-Like Receptor 3 DsRNA Inflammatory Stimulant Poly(I:C) PloS One. 2015 | Pubmed ID: 25815475 Successful Function of Autologous IPSC-Derived Dopamine Neurons Following Transplantation in a Non-Human Primate Model of Parkinson's Disease Cell Stem Cell. Mar, 2015 | Pubmed ID: 25732245 Long-term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients Cell Reports. Jun, 2014 | Pubmed ID: 24910427 ALS-associated Peripherin Spliced Transcripts Form Distinct Protein Inclusions That Are Neuroprotective Against Oxidative Stress Experimental Neurology. Nov, 2014 | Pubmed ID: 24907400 Widespread Neuron-specific Transgene Expression in Brain and Spinal Cord Following Synapsin Promoter-driven AAV9 Neonatal Intracerebroventricular Injection Neuroscience Letters. Jul, 2014 | Pubmed ID: 24882721 Progressive Axonal Transport and Synaptic Protein Changes Correlate with Behavioral and Neuropathological Abnormalities in the Heterozygous Q175 KI Mouse Model of Huntington's Disease Human Molecular Genetics. Sep, 2014 | Pubmed ID: 24728190 Motor Impairments, Striatal Degeneration, and Altered Dopamine-glutamate Interplay in Mice Lacking PSD-95 Journal of Neurogenetics. Mar-Jun, 2014 | Pubmed ID: 24702501 Advances in Stem-cell--generated Transplantation Therapy for Parkinson's Disease Expert Opinion on Biological Therapy. Apr, 2014 | Pubmed ID: 24437368 Enhanced Ubiquitin-dependent Degradation by Nedd4 Protects Against α-synuclein Accumulation and Toxicity in Animal Models of Parkinson's Disease Neurobiology of Disease. Apr, 2014 | Pubmed ID: 24388974 LRRK2 Mutations Cause Mitochondrial DNA Damage in IPSC-derived Neural Cells from Parkinson's Disease Patients: Reversal by Gene Correction Neurobiology of Disease. Feb, 2014 | Pubmed ID: 24148854 Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of HESC-, HiPSC-, and Non-human Primate IPSC-derived Dopaminergic Neurons Stem Cells (Dayton, Ohio). Aug, 2013 | Pubmed ID: 23666606 Characterization and Criteria of Embryonic Stem and Induced Pluripotent Stem Cells for a Dopamine Replacement Therapy Progress in Brain Research. 2012 | Pubmed ID: 23195423 Stem Cells for Parkinson's Disease: Advancing Science but Protecting Patients Movement Disorders : Official Journal of the Movement Disorder Society. Oct, 2012 | Pubmed ID: 23032987 Creation of an Open-access, Mutation-defined Fibroblast Resource for Neurological Disease Research PloS One. 2012 | Pubmed ID: 22952635 The Search for Genetic Mouse Models of Prodromal Parkinson's Disease Experimental Neurology. Oct, 2012 | Pubmed ID: 22819262 Pharmacological Rescue of Mitochondrial Deficits in IPSC-derived Neural Cells from Patients with Familial Parkinson's Disease Science Translational Medicine. Jul, 2012 | Pubmed ID: 22764206 α-Synuclein Overexpressing Transgenic Mice Show Internal Organ Pathology and Autonomic Deficits Neurobiology of Disease. Aug, 2012 | Pubmed ID: 22549133 Viral and Inflammatory Triggers of Neurodegenerative Diseases Science Translational Medicine. Feb, 2012 | Pubmed ID: 22344685 神経変性疾患における幹細胞の臨床翻訳 Cell Stem Cell. Feb, 2012 | Pubmed ID: 22305565 パーキンソン病の新しい治療法を発見するために幹細胞やiPS細胞を用いた Parkinsonism & Related Disorders. Jan, 2012 | Pubmed ID: 22166414 フルレングスのα-シヌクレインとパーキンソン病の脳領域とα-シヌクレインの過剰発現のトランスジェニックマウスモデルでその3つのスプライシングバリアントの転写発現レベル Molecular and Cellular Neurosciences. Feb, 2012 | Pubmed ID: 22155155 Oct4の誘発性リプログラミングは、中脳ドーパミン作動性ニューロンへの大人の脳の神経幹細胞の分化に必要である PloS One. 2011 | Pubmed ID: 21655272 神経移植用の組織適合性霊長類によって誘導される多能性幹細胞の開発 Stem Cells (Dayton, Ohio). Jul, 2011 | Pubmed ID: 21608081 黒質線条体ドーパミン作動性シナプスの機能とパーキンソン病の神経移植の利用 Journal of Neurology. Aug, 2011 | Pubmed ID: 21544566 IPSと幹細胞を用いたPDのNeurorestorative治療の機会 RinshÅ Shinkeigaku = Clinical Neurology. Nov, 2010 | Pubmed ID: 21921494 Toll様受容体3アゴニストポリイノシン：ポリシチジル酸は、黒質線条体ドーパミン変性をトリガ The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010 | Pubmed ID: 21123556 別の脆弱性と体性運動ニューロン集団のグローバルな遺伝子発現プロファイリングは、退化と保護分子と経路を識別 Brain : a Journal of Neurology. Aug, 2010 | Pubmed ID: 20826431 シヌクレインの介在物についてあまりにも包括的である Nature Medicine. Sep, 2010 | Pubmed ID: 20823871 分化したパーキンソン患者由来の誘導多能性幹細胞は、成体齧歯類の脳で成長し、モーターがパーキンソン病ラットにおける非対称性の削減 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20798034 ハップ-YACトランスジェニックモデルでは、アルツハイマー病とダウン症候群と同様に前頭皮質に上昇UPS活性を有する Journal of Neurochemistry. Sep, 2010 | Pubmed ID: 20698932 腹側中脳のドーパミン作動性ニューロンへのヒトESおよびパーキンソン病のiPS細胞の分化には、レチノイン酸によるSHH、FGF8aの高活性フォームと特定の地域化が必要 Molecular and Cellular Neurosciences. Nov, 2010 | Pubmed ID: 20603216 転写因子Orthodenticleホメオボックス2は、軸索投射、中脳ドーパミン作動性ニューロンの脆弱性に影響を与える Brain : a Journal of Neurology. Jul, 2010 | Pubmed ID: 20573704 高いRegulatabilityはSLC18A2、生活に欠かせない小胞モノアミントランスポーターの遺伝子選択を支持 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2010 | Pubmed ID: 20181938 RAB3B過剰発現によるドーパミン端末の高機能化と保護 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 20007772 パーキンソン病のための先行細胞療法 Science (New York, N.Y.). Nov, 2009 | Pubmed ID: 19965408 げっ歯類の脳から腹側中脳前駆細胞およびドーパミン作動性ニューロンの単離および培養 Current Protocols in Stem Cell Biology. Dec, 2009 | Pubmed ID: 19960452 Wnt1-lmx1a小説自己調節ループを形成し、SHH-FoxA2経路と相乗的に中脳のドーパミン作動性分化を制御する Cell Stem Cell. Dec, 2009 | Pubmed ID: 19951692 胎児移植の疾患のようなプロセスのための証拠はない Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805203 細胞治療のためのES細胞由来ドーパミン神経細胞を生成するための分子や細胞の決定要因 Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 19731556 CD15、CD24、CD29とは、幹細胞の神経系統分化のために表面マーカーコードを定義します。 Stem Cells (Dayton, Ohio). Dec, 2009 | Pubmed ID: 19725119 パーキンソン病患者の移植で隔離された細胞損傷の機能的関連性の欠如 Journal of Neurology. Aug, 2009 | Pubmed ID: 19711122 血液脳関門は、パーキンソン病霊長類におけるレボドパ誘発性ジスキネジア後、無傷である - 生体の脳画像研究からの証拠 Neurobiology of Disease. Sep, 2009 | Pubmed ID: 19501164 線条体神経炎症と組み合わせることでシナプスと軸索輸送タンパク質の動的な変更は、AAVアルファsynucleinopathyモデルラットにおけるドーパミン神経細胞の損失の前に The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2009 | Pubmed ID: 19295143 パーキンソン病ウイルスの初期化因子の無料患者由来の誘導多能性幹細胞 Cell. Mar, 2009 | Pubmed ID: 19269371 D1/PSD-95/NMDA受容体複合体のPSD-95 Uncouplesドーパミン-グルタミン酸の相互作用 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2009 | Pubmed ID: 19261890 軸索ガイダンスとシナプスメンテナンス：神経変性疾患と治療のための臨床マーカー Trends in Neurosciences. Mar, 2009 | Pubmed ID: 19162339 パーキンソン病のための細胞と遺伝子治療の将来 Annals of Neurology. Dec, 2008 | Pubmed ID: 19127583 ALSモデルのグリア細胞は、ヒト胚性幹細胞由来運動ニューロンへの毒性を媒介することができる Cell Stem Cell. Dec, 2008 | Pubmed ID: 19041769 霊長類胚性幹細胞からの単為生殖ドーパミンニューロンは、実験的パーキンソン病の機能を回復させる Brain : a Journal of Neurology. Aug, 2008 | Pubmed ID: 18669499 ユビキチン - プロテアソーム系の代償変更、YAC72及びR6 / 2トランスジェニックマウスの脳由来神経栄養因子とミトコンドリア複合体II / III部分的モデルハンチントン病患者 Human Molecular Genetics. Oct, 2008 | Pubmed ID: 18640989 運命のマッピングおよび系統解析は、ドーパミン欠乏線条体に成長因子アルファおよびノギン線条体注入を変換した後の線条体神経芽細胞の多数の生産を実証 Stem Cells (Dayton, Ohio). Sep, 2008 | Pubmed ID: 18556510 ノシセプチン/判り受容体の遮断は、MPTP誘発性パーキンソニズムを減衰 Neurobiology of Disease. Jun, 2008 | Pubmed ID: 18413287 14年にパーキンソン病の病理学なしには生き残れを持つ人々に注入しドーパミンニューロン Nature Medicine. May, 2008 | Pubmed ID: 18391961 書き換え線維芽細胞由来のニューロンが機能的には胎児の脳への統合とパーキンソン病ラットの症状を改善する Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18391196 胚性幹細胞由来Pitx3強化緑色蛍光タンパク質中脳ドーパミンニューロンはパーキンソン病の動物モデルにおける蛍光活性化細胞選別と機能によって濃縮を生き残れる Stem Cells (Dayton, Ohio). Jun, 2008 | Pubmed ID: 18388307 パーキンソン病のための細胞ベースの治療における最近の進歩 Neurosurgical Focus. 2008 | Pubmed ID: 18341409 IL-1βによって媒介される神経炎症は、パーキンソン病の動物モデルで変性するドーパミンニューロンの感受性を増加させる Journal of Neuroinflammation. 2008 | Pubmed ID: 18304357 ヒト胚性幹細胞由来神経前駆細胞は、ドーパミン作動性ニューロンを含む全ての三神経系に分化する能力を失うことなく長期的な増殖を維持 Journal of Neurochemistry. Jan, 2008 | Pubmed ID: 17944878 運動ニューロン疾患の動物モデルにおける細胞療法と幹細胞 The European Journal of Neuroscience. Oct, 2007 | Pubmed ID: 17897390 アルツハイマー病の新しい治療アプローチ：安部田分解プロテアーゼのex Vivoでの遺伝子送達を介してアミロイド斑の負担を軽減 PLoS Medicine. Aug, 2007 | Pubmed ID: 17760499 ロイシンリッチリピート蛋白質LINGO-1の阻害は、パーキンソン病モデルにおけるドーパミン作動性ニューロンの生存、構造、および機能を強化 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17726113 内因性のセリン/スレオニンプロテインホスファターゼ阻害剤、G-基質は、パーキンソン病のモデルでの脆弱性を軽減 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2007 | Pubmed ID: 17670978 未熟と神経を差別化マウス胚性幹細胞は、機能のFas / Fasリガンドシステムの発現しない Stem Cells (Dayton, Ohio). Oct, 2007 | Pubmed ID: 17615270 マウス胚性幹細胞のインビトロ分化の各段階でレンチウイルスベクターにおける種々のプロモーターの機能解析 Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2007 | Pubmed ID: 17609656 ヒト胚性幹細胞由来の神経細胞集団の細胞ソーティングのマーカーおよび方法 Stem Cells (Dayton, Ohio). Sep, 2007 | Pubmed ID: 17588935 L-DOPA誘発ジスキネジアとパーキンソン霊長類とげっ歯類のD3ドーパミン受容体の感作性のin Vivoの証拠で Neurobiology of Disease. Aug, 2007 | Pubmed ID: 17588764 PSD-95によるシグナリングドーパミンD1受容体の阻害 The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17369255 プロテアソームアクチベーターは、ハンチントン病神経モデル細胞の生存率を高める PloS One. 2007 | Pubmed ID: 17327906 チロシンヒドロキシラーゼプロモーターを用いて胚性幹細胞由来の強化緑色蛍光タンパク質陽性のドーパミンニューロンの選択は、未熟な細胞集団におけるレポーター遺伝子の発現によって混同されてい Stem Cells (Dayton, Ohio). May, 2007 | Pubmed ID: 17234989 上皮細胞の前駆体と中脳のようなドーパミン作動性ニューロン骨形成タンパク質の拮抗薬手おけを用いたヒト胚性幹細胞からの収量を確保。 Stem Cells (Dayton, Ohio). Feb, 2007 | Pubmed ID: 17038668 霊長類ES細胞由来の移植ドーパミンニューロンが優先的にグラフト内DARPP-32線条体前駆体を支配する The European Journal of Neuroscience. Oct, 2006 | Pubmed ID: 17067292 What Are the Long-term Effects of Neural Grafting in Patients with Huntington's Disease? Nature Clinical Practice. Neurology. Sep, 2006 | Pubmed ID: 16932607 Neuroblast Protuberances in the Subventricular Zone of the Regenerative MRL/MpJ Mouse The Journal of Comparative Neurology. Oct, 2006 | Pubmed ID: 16927265 Axonal Growth Regulation of Fetal and Embryonic Stem Cell-derived Dopaminergic Neurons by Netrin-1 and Slits Stem Cells (Dayton, Ohio). Nov, 2006 | Pubmed ID: 16840550 Genetic Selection of Sox1GFP-expressing Neural Precursors Removes Residual Tumorigenic Pluripotent Stem Cells and Attenuates Tumor Formation After Transplantation Journal of Neurochemistry. Jun, 2006 | Pubmed ID: 16696855 Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion in Vitro Stem Cells (Dayton, Ohio). Jun, 2006 | Pubmed ID: 16543488 特定のマイクロRNAは、胚性幹細胞由来のニューロン新生を変調 Stem Cells (Dayton, Ohio). Apr, 2006 | Pubmed ID: 16357340 間質細胞由来誘導活性、Nurr1、および相乗的シグナル分子マウス胚性幹細胞からのドーパミン作動性ニューロンを誘導します。 Stem Cells (Dayton, Ohio). Mar, 2006 | Pubmed ID: 16123386 Insights into Parkinson's Disease Models and Neurotoxicity Using Non-invasive Imaging Toxicology and Applied Pharmacology. Sep, 2005 | Pubmed ID: 15979668 Long-term Survival of Dopamine Neurons Derived from Parthenogenetic Primate Embryonic Stem Cells (cyno-1) After Transplantation Stem Cells (Dayton, Ohio). Aug, 2005 | Pubmed ID: 15941857 Cell Type-specific Gene Expression of Midbrain Dopaminergic Neurons Reveals Molecules Involved in Their Vulnerability and Protection Human Molecular Genetics. Jul, 2005 | Pubmed ID: 15888489 Cell Type Analysis of Functional Fetal Dopamine Cell Suspension Transplants in the Striatum and Substantia Nigra of Patients with Parkinson's Disease Brain : a Journal of Neurology. Jul, 2005 | Pubmed ID: 15872020 Abnormal APP, Cholinergic and Cognitive Function in Ts65Dn Down's Model Mice Experimental Neurology. Jun, 2005 | Pubmed ID: 15869949 Stem Cells May Reshape the Prospect of Parkinson's Disease Therapy Brain Research. Molecular Brain Research. Mar, 2005 | Pubmed ID: 15790528 Netrin-1 and Slit-2 Regulate and Direct Neurite Growth of Ventral Midbrain Dopaminergic Neurons Molecular and Cellular Neurosciences. Mar, 2005 | Pubmed ID: 15737744 コンテキストに依存した神経細胞の分化と胚芽層誘導 Smad4/- と Cripto-/- 萌芽期の幹細胞。 Molecular and Cellular Neurosciences. Mar, 2005 | Pubmed ID: 15737733 The Homeodomain Transcription Factor Pitx3 Facilitates Differentiation of Mouse Embryonic Stem Cells into AHD2-expressing Dopaminergic Neurons Molecular and Cellular Neurosciences. Feb, 2005 | Pubmed ID: 15691706 Mapping Dopamine Function in Primates Using Pharmacologic Magnetic Resonance Imaging The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2004 | Pubmed ID: 15509742 Intrastriatal Transforming Growth Factor Alpha Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells Without Differentiation into Dopaminergic Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2004 | Pubmed ID: 15483111 Region-specific Cell Grafting into Cervical and Lumbar Spinal Cord in Rat: a Qualitative and Quantitative Stereological Study Experimental Neurology. Nov, 2004 | Pubmed ID: 15473986 Generalized Brain and Skin Proteasome Inhibition in Huntington's Disease Annals of Neurology. Sep, 2004 | Pubmed ID: 15349858 Selective COX-2 Inhibition Prevents Progressive Dopamine Neuron Degeneration in a Rat Model of Parkinson's Disease Journal of Neuroinflammation. May, 2004 | Pubmed ID: 15285796 Problems and Solutions for Circuits and Synapses in Parkinson's Disease Neuron. Jul, 2004 | Pubmed ID: 15260952 Temporally Induced Nurr1 Can Induce a Non-neuronal Dopaminergic Cell Type in Embryonic Stem Cell Differentiation The European Journal of Neuroscience. Mar, 2004 | Pubmed ID: 15016073 Estrogen Alters Amyloid Precursor Protein As Well As Dendritic and Cholinergic Markers in a Mouse Model of Down Syndrome Hippocampus. 2003 | Pubmed ID: 14750653 霊長類パーキンソン病モデルにおけるMPTP誘発神経毒性後の脳機能のマッピング NeuroImage. Oct, 2003 | Pubmed ID: 14568476 The Production and Use of Cells As Therapeutic Agents in Neurodegenerative Diseases The Lancet. Neurology. Jul, 2003 | Pubmed ID: 12849120 Orphan Nuclear Receptor Nurr1 Directly Transactivates the Promoter Activity of the Tyrosine Hydroxylase Gene in a Cell-specific Manner Journal of Neurochemistry. May, 2003 | Pubmed ID: 12694388 Toward Full Restoration of Synaptic and Terminal Function of the Dopaminergic System in Parkinson's Disease by Stem Cells Annals of Neurology. 2003 | Pubmed ID: 12666105 Regional Alterations in Amyloid Precursor Protein and Nerve Growth Factor Across Age in a Mouse Model of Down's Syndrome Neuroscience Research. Apr, 2003 | Pubmed ID: 12657457 Altered Proteasomal Function in Sporadic Parkinson's Disease Experimental Neurology. Jan, 2003 | Pubmed ID: 12504866 Genetic Engineering of Mouse Embryonic Stem Cells by Nurr1 Enhances Differentiation and Maturation into Dopaminergic Neurons The European Journal of Neuroscience. Nov, 2002 | Pubmed ID: 12453046 Regulation of Dopamine Cell Type and Transmitter Function in Fetal and Stem Cell Transplantation for Parkinson's Disease Progress in Brain Research. 2002 | Pubmed ID: 12432781 Proteasome Inhibition Causes Nigral Degeneration with Inclusion Bodies in Rats Neuroreport. Aug, 2002 | Pubmed ID: 12167769 Spatial Memory Testing Decreases Hippocampal Amyloid Precursor Protein in Young, but Not Aged, Female Rats Neuroscience Letters. Aug, 2002 | Pubmed ID: 12123857 Selective Loss of 20S Proteasome Alpha-subunits in the Substantia Nigra Pars Compacta in Parkinson's Disease Neuroscience Letters. Jul, 2002 | Pubmed ID: 12095645 Models of Repair Mechanisms for Future Treatment Modalities of Parkinson's Disease Brain Research Bulletin. Apr, 2002 | Pubmed ID: 12031282 Herpes Simplex Virus/adeno-associated Virus Hybrid Vectors for Gene Transfer to Neurons. Preparation and Use Methods in Molecular Medicine. 2002 | Pubmed ID: 11987795 ノルアドレナリン神経伝達物質のアイデンティティの決定にホメオドメインタンパク質のPhox2a/2bの直接的な役割 Journal of Neurochemistry. Mar, 2002 | Pubmed ID: 11948255 マウス胚性幹細胞株における効率的な導入遺伝子の発現のために異なるプロモーターシステムの分析 Stem Cells (Dayton, Ohio). 2002 | Pubmed ID: 11897870 Cortico-hippocampal APP and NGF Levels Are Dynamically Altered by Cholinergic Muscarinic Antagonist or M1 Agonist Treatment in Normal Mice The European Journal of Neuroscience. Feb, 2002 | Pubmed ID: 11876777 Alzheimer's Disease and Down's Syndrome: Roles of APP, Trophic Factors and ACh Trends in Neurosciences. Feb, 2002 | Pubmed ID: 11814559 Embryonic Stem Cells Develop into Functional Dopaminergic Neurons After Transplantation in a Parkinson Rat Model Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11782534 オレIsacson：パーキンソン病に対する新しい治療法の開発 Ole Isacson1 1McLean Hospital, Harvard Stem Cell Institute, Harvard Medical School JoVE 189 Biology ES細胞由来の神経上皮細胞の培養 Shreeya Karki1, Jan Pruszak1, Ole Isacson1, Kai C Sonntag1 1McLean Hospital, Harvard Medical School JoVE 118 Biology
オレIsacson：パーキンソン病に対する新しい治療法の開発 Ole Isacson1 1McLean Hospital, Harvard Stem Cell Institute, Harvard Medical School JoVE 189 Biology
ES細胞由来の神経上皮細胞の培養 Shreeya Karki1, Jan Pruszak1, Ole Isacson1, Kai C Sonntag1 1McLean Hospital, Harvard Medical School JoVE 118 Biology
