Ottavio Arancio

Publications

• β- but Not γ-secretase Proteolysis of APP Causes Synaptic and Memory Deficits in a Mouse Model of Dementia
  EMBO Molecular Medicine. Dec, 2011  |   Pubmed ID: 22170863
• APP Heterozygosity Averts Memory Deficit in Knockin Mice Expressing the Danish Dementia BRI2 Mutant
  The EMBO Journal. Jun, 2011  |   Pubmed ID: 21587206
• Endogenous Amyloid-β is Necessary for Hippocampal Synaptic Plasticity and Memory
  Annals of Neurology. May, 2011  |   Pubmed ID: 21472769
• A Selective Role for ARMS/Kidins220 Scaffold Protein in Spatial Memory and Trophic Support of Entorhinal and Frontal Cortical Neurons
  Experimental Neurology. Jun, 2011  |   Pubmed ID: 21419124
• Inhibition of Amyloid-beta (Abeta) Peptide-binding Alcohol Dehydrogenase-Abeta Interaction Reduces Abeta Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011  |   Pubmed ID: 21307267
• Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-linked Synaptic Dysfunction and Cognitive Deficits
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010  |   Pubmed ID: 21147981
• Danish Dementia Mice Suggest That Loss of Function and Not the Amyloid Cascade Causes Synaptic Plasticity and Memory Deficits
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010  |   Pubmed ID: 21098268
• Memory Deficits Due to Familial British Dementia BRI2 Mutation Are Caused by Loss of BRI2 Function Rather Than Amyloidosis
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2010  |   Pubmed ID: 21048150
• The Ankyrin Repeat-rich Membrane Spanning (ARMS)/Kidins220 Scaffold Protein is Regulated by Activity-dependent Calpain Proteolysis and Modulates Synaptic Plasticity
  The Journal of Biological Chemistry. Dec, 2010  |   Pubmed ID: 20943655
• Microglial Receptor for Advanced Glycation End Product-dependent Signal Pathway Drives Beta-amyloid-induced Synaptic Depression and Long-term Depression Impairment in Entorhinal Cortex
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2010  |   Pubmed ID: 20739563
• The ARMS/Kidins220 Scaffold Protein Modulates Synaptic Transmission
  Molecular and Cellular Neurosciences. Oct, 2010  |   Pubmed ID: 20547223
• MAPK, Beta-amyloid and Synaptic Dysfunction: the Role of RAGE
  Expert Review of Neurotherapeutics. Nov, 2009  |   Pubmed ID: 19903023
• Reversal of Long-term Dendritic Spine Alterations in Alzheimer Disease Models
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009  |   Pubmed ID: 19805389
• Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease
  Journal of Alzheimer's Disease : JAD. 2009  |   Pubmed ID: 19625751
• Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-beta Load in an Alzheimer's Disease Mouse Model
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2009  |   Pubmed ID: 19553447
• Glutaminase-deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2009  |   Pubmed ID: 19516252
• Endocannabinoid System: Emerging Role from Neurodevelopment to Neurodegeneration
  Mini Reviews in Medicinal Chemistry. Apr, 2009  |   Pubmed ID: 19356123
• Abeta-dependent Inhibition of LTP in Different Intracortical Circuits of the Visual Cortex: the Role of RAGE
  Journal of Alzheimer's Disease : JAD. 2009  |   Pubmed ID: 19221410
• Protection Against Beta-amyloid Induced Abnormal Synaptic Function and Cell Death by Ginkgolide J
  Neurobiology of Aging. Feb, 2009  |   Pubmed ID: 17640772
• PIP2: a New Key Player in Alzheimer's Disease
  Cellscience. Jul, 2008  |   Pubmed ID: 20577650
• Picomolar Amyloid-beta Positively Modulates Synaptic Plasticity and Memory in Hippocampus
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008  |   Pubmed ID: 19118188
• Small Molecule, Non-peptide P75 Ligands Inhibit Abeta-induced Neurodegeneration and Synaptic Impairment
  PloS One. 2008  |   Pubmed ID: 18978948
• Cyclophilin D Deficiency Attenuates Mitochondrial and Neuronal Perturbation and Ameliorates Learning and Memory in Alzheimer's Disease
  Nature Medicine. Oct, 2008  |   Pubmed ID: 18806802
• Acute Ethanol Suppresses Glutamatergic Neurotransmission Through Endocannabinoids in Hippocampal Neurons
  Journal of Neurochemistry. Nov, 2008  |   Pubmed ID: 18796007
• Role of Phosphodiesterase 5 in Synaptic Plasticity and Memory
  Neuropsychiatric Disease and Treatment. Apr, 2008  |   Pubmed ID: 18728748
• A Role for CGMP-dependent Protein Kinase II in AMPA Receptor Trafficking and Synaptic Plasticity
  Channels (Austin, Tex.). Jul-Aug, 2008  |   Pubmed ID: 18728399
• Inhibition of Calpains Improves Memory and Synaptic Transmission in a Mouse Model of Alzheimer Disease
  The Journal of Clinical Investigation. Aug, 2008  |   Pubmed ID: 18596919
• Synaptojanin 1-linked Phosphoinositide Dyshomeostasis and Cognitive Deficits in Mouse Models of Down's Syndrome
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008  |   Pubmed ID: 18591654
• Isolation and Characterization of "Reprotoxin", a Novel Protein Complex from Daboia Russelii Snake Venom
  Biochimie. Oct, 2008  |   Pubmed ID: 18573307
• A Transgenic Rat That Develops Alzheimer's Disease-like Amyloid Pathology, Deficits in Synaptic Plasticity and Cognitive Impairment
  Neurobiology of Disease. Jul, 2008  |   Pubmed ID: 18504134
• Retromer Deficiency Observed in Alzheimer's Disease Causes Hippocampal Dysfunction, Neurodegeneration, and Abeta Accumulation
  Proceedings of the National Academy of Sciences of the United States of America. May, 2008  |   Pubmed ID: 18480253
• Oligomeric Amyloid-beta Peptide Disrupts Phosphatidylinositol-4,5-bisphosphate Metabolism
  Nature Neuroscience. May, 2008  |   Pubmed ID: 18391946
• Receptor for Advanced Glycation End Product-dependent Activation of P38 Mitogen-activated Protein Kinase Contributes to Amyloid-beta-mediated Cortical Synaptic Dysfunction
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2008  |   Pubmed ID: 18367618
• A Neuronal Microtubule-interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease
  The Journal of Pharmacology and Experimental Therapeutics. Apr, 2008  |   Pubmed ID: 18199809
• RAGE: a Potential Target for Abeta-mediated Cellular Perturbation in Alzheimer's Disease
  Current Molecular Medicine. Dec, 2007  |   Pubmed ID: 18331231
• Oligomers of Beta-amyloid Peptide Inhibit BDNF-induced Arc Expression in Cultured Cortical Neurons
  Current Alzheimer Research. Dec, 2007  |   Pubmed ID: 18220514
• A GluR1-cGKII Interaction Regulates AMPA Receptor Trafficking
  Neuron. Nov, 2007  |   Pubmed ID: 18031684
• Alpha-synuclein Involvement in Hippocampal Synaptic Plasticity: Role of NO, CGMP, CGK and CaMKII
  The European Journal of Neuroscience. Jun, 2007  |   Pubmed ID: 17610578
• Neurotrophins, Synaptic Plasticity and Dementia
  Current Opinion in Neurobiology. Jun, 2007  |   Pubmed ID: 17419049
• Involvement of the Nitric Oxide Pathway in Synaptic Dysfunction Following Amyloid Elevation in Alzheimer's Disease
  Reviews in the Neurosciences. 2006  |   Pubmed ID: 17180876
• Estimation of the Mean from Sums with Unknown Numbers of Summands
  Biometrics. Sep, 2006  |   Pubmed ID: 16984336
• Early Presynaptic Changes During Plasticity in Cultured Hippocampal Neurons
  The EMBO Journal. Sep, 2006  |   Pubmed ID: 16957772
• Ubiquitin Hydrolase Uch-L1 Rescues Beta-amyloid-induced Decreases in Synaptic Function and Contextual Memory
  Cell. Aug, 2006  |   Pubmed ID: 16923396
• Fibrillar Beta-amyloid Impairs the Late Phase of Long Term Potentiation
  Current Alzheimer Research. Jul, 2006  |   Pubmed ID: 16842092
• BDNF-mediated Neurotransmission Relies Upon a Myosin VI Motor Complex
  Nature Neuroscience. Aug, 2006  |   Pubmed ID: 16819522
• Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2006  |   Pubmed ID: 16399702
• Amyloid-beta Peptide Inhibits Activation of the Nitric Oxide/cGMP/cAMP-responsive Element-binding Protein Pathway During Hippocampal Synaptic Plasticity
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2005  |   Pubmed ID: 16033898
• Synaptic Fatigue is More Pronounced in the APP/PS1 Transgenic Mouse Model of Alzheimer's Disease
  Current Alzheimer Research. Apr, 2005  |   Pubmed ID: 15974910
• ABAD Enhances Abeta-induced Cell Stress Via Mitochondrial Dysfunction
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2005  |   Pubmed ID: 15665036
• Persistent Improvement in Synaptic and Cognitive Functions in an Alzheimer Mouse Model After Rolipram Treatment
  The Journal of Clinical Investigation. Dec, 2004  |   Pubmed ID: 15578094
• Alpha-Synuclein Produces a Long-lasting Increase in Neurotransmitter Release
  The EMBO Journal. Nov, 2004  |   Pubmed ID: 15510220
• RAGE Potentiates Abeta-induced Perturbation of Neuronal Function in Transgenic Mice
  The EMBO Journal. Oct, 2004  |   Pubmed ID: 15457210
• Calpain Mediates Calcium-induced Activation of the Erk1,2 MAPK Pathway and Cytoskeletal Phosphorylation in Neurons: Relevance to Alzheimer's Disease
  The American Journal of Pathology. Sep, 2004  |   Pubmed ID: 15331404
• Cell Cultures from Animal Models of Alzheimer's Disease As a Tool for Faster Screening and Testing of Drug Efficacy
  Journal of Molecular Neuroscience : MN. 2004  |   Pubmed ID: 15314245
• Progressive Age-related Development of Alzheimer-like Pathology in APP/PS1 Mice
  Annals of Neurology. Jun, 2004  |   Pubmed ID: 15174014
• ABAD Directly Links Abeta to Mitochondrial Toxicity in Alzheimer's Disease
  Science (New York, N.Y.). Apr, 2004  |   Pubmed ID: 15087549
• Presynaptic CaMKII is Necessary for Synaptic Plasticity in Cultured Hippocampal Neurons
  Neuron. Apr, 2004  |   Pubmed ID: 15066270
• Calpain Inhibitors, a Treatment for Alzheimer's Disease: Position Paper
  Journal of Molecular Neuroscience : MN. 2003  |   Pubmed ID: 14501020
• Receptor Protein Tyrosine Phosphatase Alpha is Essential for Hippocampal Neuronal Migration and Long-term Potentiation
  The EMBO Journal. Aug, 2003  |   Pubmed ID: 12912911
• Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
  Science (New York, N.Y.). Aug, 2003  |   Pubmed ID: 12907793
• Usefulness of Behavioral and Electrophysiological Studies in Transgenic Models of Alzheimer's Disease
  Neurochemical Research. Jul, 2003  |   Pubmed ID: 12737525
• Amyloid Beta -peptide Inhibition of the PKA/CREB Pathway and Long-term Potentiation: Reversibility by Drugs That Enhance CAMP Signaling
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002  |   Pubmed ID: 12244210
• Calpain Inhibitors: a Treatment for Alzheimer's Disease
  Journal of Molecular Neuroscience : MN. Aug-Oct, 2002  |   Pubmed ID: 12212771