Pablo Hernansanz-Agustín

I initiated my studies in Biology at the University of Alcalá de Henares, specialized in Molecular Biology, Biochemistry and Biotechnology, and finished my degree performing a two-years stay at the University of Hertfordshire (United Kingdom, 2008-2010). I obtained my PhD with Cum Laude and International Mentions in 2017 by the Autonomous University of Madrid (UAM), after completing several short-term stays at the University of Zurich (Switzerland) and the University of Cambridge (United Kingdom). Later, I was contracted as postdoctoral researcher by the Institute of Medical Research La Princesa (IISP) and then by the Spanish Centre for Cardiovascular Research (CNIC), which is my current position.

My main scientific interests are to study the involvement of mitochondrial sodium and oxygen homeostasis in metabolism, physiology and redox signalling, particularly under the scope of cardiovascular diseases. I am main author of high impact factor journals, such as Nature or Science Advances, among which the most relevant contributions can be summarized as follows: (i) the elucidation of the mitochondrial ROS paradox during hypoxia (Free Rad Biol Med, 2014), (ii) the implication of mitochondrial complex I active/deactive (A/D) transition and sodium chelators in hypoxic ROS production and adaptation (Redox Biology, 2017), the confirmation of new supercomplexes in the mitochondrial electron transport chain and the metabolic significance of the I+III supercomplex (Science Advances, 2020), (iv) and the discovery of sodium as a second messenger in the cell and its role during acute hypoxic responses (Nature, 2020).