Publications

• Analysis of Macroautophagy Related Proteins in G2019S LRRK2 Parkinson's Disease Brains with Lewy Body Pathology
  Brain Research. Jul, 2018  |   Pubmed ID: 30055128
• Stratification of Candidate Genes for Parkinson's Disease Using Weighted Protein-protein Interaction Network Analysis
  BMC Genomics. Jun, 2018  |   Pubmed ID: 29898659
• LRRK2 is a Negative Regulator of Phagosome Maturation in Macrophages
  The EMBO Journal. Jun, 2018  |   Pubmed ID: 29789389
• Mutations in LRRK2 Amplify Cell-to-cell Protein Aggregate Propagation: a Hypothesis
  Acta Neuropathologica. Jun, 2018  |   Pubmed ID: 29600398
• MTOR Independent Alteration in ULK1 Ser758 Phosphorylation Following Chronic LRRK2 Kinase Inhibition
  Bioscience Reports. Apr, 2018  |   Pubmed ID: 29563162
• Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins
  Proteomics. May, 2018  |   Pubmed ID: 29513927
• The LRRK2 Signalling System
  Cell and Tissue Research. Jul, 2018  |   Pubmed ID: 29308544
• Genome, Transcriptome and Proteome: the Rise of Omics Data and Their Integration in Biomedical Sciences
  Briefings in Bioinformatics. Mar, 2018  |   Pubmed ID: 27881428
• PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2
  Frontiers in Molecular Neuroscience. 2017  |   Pubmed ID: 29311810
• Estimating the Causal Influence of Body Mass Index on Risk of Parkinson Disease: A Mendelian Randomisation Study
  PLoS Medicine. Jun, 2017  |   Pubmed ID: 28609445
• Leucine Rich Repeat Kinase 2: Beyond Parkinson's and Beyond Kinase Inhibitors
  Expert Opinion on Therapeutic Targets. 08, 2017  |   Pubmed ID: 28609155
• Increased Brain Expression of GPNMB is Associated with Genome Wide Significant Risk for Parkinson's Disease on Chromosome 7p15.3
  Neurogenetics. Jul, 2017  |   Pubmed ID: 28391543
• LRRK2 and Autophagy
  Advances in Neurobiology. 2017  |   Pubmed ID: 28353280
• Weighted Protein Interaction Network Analysis of Frontotemporal Dementia
  Journal of Proteome Research. 02, 2017  |   Pubmed ID: 28004582
• Additional Rare Variant Analysis in Parkinson's Disease Cases with and Without Known Pathogenic Mutations: Evidence for Oligogenic Inheritance
  Human Molecular Genetics. Oct, 2016  |   Pubmed ID: 27798102
• MTOR Independent Regulation of Macroautophagy by Leucine Rich Repeat Kinase 2 Via Beclin-1
  Scientific Reports. 10, 2016  |   Pubmed ID: 27731364
• Genetic and Phenotypic Characterization of Complex Hereditary Spastic Paraplegia
  Brain : a Journal of Neurology. 07, 2016  |   Pubmed ID: 27217339
• Parkinson's Disease: From Human Genetics to Clinical Trials
  Science Translational Medicine. Sep, 2015  |   Pubmed ID: 26378242
• Leucine-rich Repeat Kinase 2 Interacts with P21-activated Kinase 6 to Control Neurite Complexity in Mammalian Brain
  Journal of Neurochemistry. Sep, 2015  |   Pubmed ID: 26375402
• Distinct Clinical and Neuropathological Features of G51D SNCA Mutation Cases Compared with SNCA Duplication and H50Q Mutation
  Molecular Neurodegeneration. Aug, 2015  |   Pubmed ID: 26306801
• Computational Analysis of the LRRK2 Interactome
  PeerJ. 2015  |   Pubmed ID: 25737818
• Genetic, Structural, and Molecular Insights into the Function of Ras of Complex Proteins Domains
  Chemistry & Biology. Jul, 2014  |   Pubmed ID: 24981771
• Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution
  The Journal of Biological Chemistry. Aug, 2014  |   Pubmed ID: 24942733
• Parkinson's Disease-linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration
  Human Molecular Genetics. Sep, 2014  |   Pubmed ID: 24740878
• Rare Variants in LRRK1 and Parkinson's Disease
  Neurogenetics. Mar, 2014  |   Pubmed ID: 24241507
• Pathogenic Parkinson's Disease Mutations Across the Functional Domains of LRRK2 Alter the Autophagic/lysosomal Response to Starvation
  Biochemical and Biophysical Research Communications. Nov, 2013  |   Pubmed ID: 24211199
• Fine-mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus
  PloS One. 2013  |   Pubmed ID: 23967090
• LRRK2: Cause, Risk, and Mechanism
  Journal of Parkinson's Disease. 2013  |   Pubmed ID: 23938341
• Inhibition of LRRK2 Kinase Activity Stimulates Macroautophagy
  Biochimica Et Biophysica Acta. Dec, 2013  |   Pubmed ID: 23916833
• Divergent α-synuclein Solubility and Aggregation Properties in G2019S LRRK2 Parkinson's Disease Brains with Lewy Body Pathology Compared to Idiopathic Cases
  Neurobiology of Disease. Oct, 2013  |   Pubmed ID: 23747310
• Dysfunction of the Autophagy/lysosomal Degradation Pathway is a Shared Feature of the Genetic Synucleinopathies
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2013  |   Pubmed ID: 23682122
• α-Synuclein Mutations Cluster Around a Putative Protein Loop
  Neuroscience Letters. Jun, 2013  |   Pubmed ID: 23669636
• GTP Binding and Intramolecular Regulation by the ROC Domain of Death Associated Protein Kinase 1
  Scientific Reports. 2012  |   Pubmed ID: 23019516
• Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue
  PloS One. 2012  |   Pubmed ID: 22303433
• LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?
  Science Signaling. 2012  |   Pubmed ID: 22253261
• Gene Expression in the Parkinson's Disease Brain
  Brain Research Bulletin. Dec, 2011  |   Pubmed ID: 22173063
• Parkinson's Disease Induced Pluripotent Stem Cells with Triplication of the α-synuclein Locus
  Nature Communications. 2011  |   Pubmed ID: 21863007
• Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue
  PloS One. 2011  |   Pubmed ID: 21799870
• A Tangled Web - Tau and Sporadic Parkinson's Disease
  Frontiers in Psychiatry / Frontiers Research Foundation. 2010  |   Pubmed ID: 21423457
• Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea
  PLoS Genetics. 2010  |   Pubmed ID: 21203498
• The R1441C Mutation Alters the Folding Properties of the ROC Domain of LRRK2
  Biochimica Et Biophysica Acta. Dec, 2009  |   Pubmed ID: 19781641
• The Function of ROCO Proteins in Health and Disease
  Biology of the Cell / Under the Auspices of the European Cell Biology Organization. Mar, 2009  |   Pubmed ID: 19152505
• Emerging Pathways in Genetic Parkinson's Disease: Tangles, Lewy Bodies and LRRK2
  The FEBS Journal. Dec, 2008  |   Pubmed ID: 19021752
• Emerging Pathways in Genetic Parkinson's Disease
  The FEBS Journal. Dec, 2008  |   Pubmed ID: 19021751
• Genetic Neuropathology of Parkinson's Disease
  International Journal of Clinical and Experimental Pathology. 2008  |   Pubmed ID: 18784814
• Structure of the ROC Domain from the Parkinson's Disease-associated Leucine-rich Repeat Kinase 2 Reveals a Dimeric GTPase
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18230735
• The Metalloprotease Inhibitor TIMP-3 Regulates Amyloid Precursor Protein and Apolipoprotein E Receptor Proteolysis
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2007  |   Pubmed ID: 17913923
• The R1441C Mutation of LRRK2 Disrupts GTP Hydrolysis
  Biochemical and Biophysical Research Communications. Jun, 2007  |   Pubmed ID: 17442267
• Mutations in LRRK2/dardarin Associated with Parkinson Disease Are More Toxic Than Equivalent Mutations in the Homologous Kinase LRRK1
  Journal of Neurochemistry. Jul, 2007  |   Pubmed ID: 17394548
• Codon 129 Polymorphism of the Human Prion Protein Influences the Kinetics of Amyloid Formation
  The Journal of General Virology. Aug, 2006  |   Pubmed ID: 16847141
• Removal of the Glycosylphosphatidylinositol Anchor from PrP(Sc) by Cathepsin D Does Not Reduce Prion Infectivity
  The Biochemical Journal. Apr, 2006  |   Pubmed ID: 16441239
• A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits Gamma-secretase Cleavage of APP and Notch
  Neurobiology of Disease. Mar, 2002  |   Pubmed ID: 11895378