Patrick H. Maxwell

Publications

• Extension of Saccharomyces Paradoxus Chronological Lifespan by Retrotransposons in Certain Media Conditions Is Associated with Changes in Reactive Oxygen Species
  Genetics. Aug, 2014  |   Pubmed ID: 25106655
• HIF-1 Reduces Ischaemia-reperfusion Injury in the Heart by Targeting the Mitochondrial Permeability Transition Pore
  Cardiovascular Research. Oct, 2014  |   Pubmed ID: 25063991
• The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
  The Journal of Biological Chemistry. Feb, 2014  |   Pubmed ID: 24371136
• Renal Cell Carcinoma: Translational Aspects of Metabolism and Therapeutic Consequences
  Kidney International. Oct, 2013  |   Pubmed ID: 23823604
• The Hypoxia Factor Hif-1α Controls Neural Crest Chemotaxis and Epithelial to Mesenchymal Transition
  The Journal of Cell Biology. May, 2013  |   Pubmed ID: 23712262
• Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination
  Circulation Research. Jun, 2013  |   Pubmed ID: 23564640
• Epistatic Role of the MYH9/APOL1 Region on Familial Hematuria Genes
  PloS One. 2013  |   Pubmed ID: 23516419
• Incidence of End-stage Renal Disease in the Turkish-Cypriot Population of Northern Cyprus: a Population Based Study
  PloS One. 2013  |   Pubmed ID: 23349874
• C3 Glomerulonephritis and CFHR5 Nephropathy
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Feb, 2013  |   Pubmed ID: 23125424
• What Happens to Clinical Training Fellows? A Retrospective Study of the 20 Years Outcome of a Medical Research Council UK Cohort
  BMJ Open. 2012  |   Pubmed ID: 22936819
• Increasing Evidence That Genetic Variation in Complement Factor H Related 5 (CFHR5) Causes Disease: a Commentary on 'Atypical Haemolytic Uremic Syndrome and Genetic Aberrations in the Complement Factor-H-related 5 Gene'
  Journal of Human Genetics. Aug, 2012  |   Pubmed ID: 22739721
• Von Hippel-Lindau Protein in the RPE is Essential for Normal Ocular Growth and Vascular Development
  Development (Cambridge, England). Jul, 2012  |   Pubmed ID: 22627278
• Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy
  The American Journal of Pathology. Apr, 2012  |   Pubmed ID: 22342523
• The ERA-EDTA Working Group on Inherited Kidney Disorders
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jan, 2012  |   Pubmed ID: 22287704
• Tumor Strengths and Frailties: Aspiring to Prevent Colon Cancer
  Nature Medicine. Jan, 2012  |   Pubmed ID: 22227665
• Human CHCHD4 Mitochondrial Proteins Regulate Cellular Oxygen Consumption Rate and Metabolism and Provide a Critical Role in Hypoxia Signaling and Tumor Progression
  The Journal of Clinical Investigation. Feb, 2012  |   Pubmed ID: 22214851
• Retrotransposition is Associated with Genome Instability During Chronological Aging
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011  |   Pubmed ID: 22021441
• Renal Cyst Formation in Fh1-deficient Mice is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
  Cancer Cell. Oct, 2011  |   Pubmed ID: 22014577
• Hypoxia-inducible Transcription Factors Stabilization in the Thick Ascending Limb Protects Against Ischemic Acute Kidney Injury
  Journal of the American Society of Nephrology : JASN. Nov, 2011  |   Pubmed ID: 21921145
• Dimethyloxalyglycine Stimulates the Early Stages of Gastrointestinal Repair Processes Through VEGF-dependent Mechanisms
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2011  |   Pubmed ID: 21876537
• Seeing the Smoking Gun: a Sensitive and Specific Method to Visualize Loss of the Tumour Suppressor, Fumarate Hydratase, in Human Tissues
  The Journal of Pathology. Sep, 2011  |   Pubmed ID: 21792933
• Inactivation of the Von Hippel-Lindau Tumour Suppressor Gene Induces Neuromedin U Expression in Renal Cancer Cells
  Molecular Cancer. 2011  |   Pubmed ID: 21791076
• Familial C3 Glomerulopathy Associated with CFHR5 Mutations: Clinical Characteristics of 91 Patients in 16 Pedigrees
  Clinical Journal of the American Society of Nephrology : CJASN. Jun, 2011  |   Pubmed ID: 21566112
• Developmentally Arrested Structures Preceding Cerebellar Tumors in Von Hippel-Lindau Disease
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Aug, 2011  |   Pubmed ID: 21499240
• Copy Number Profiling in Von Hippel-Lindau Disease Renal Cell Carcinoma
  Genes, Chromosomes & Cancer. Jul, 2011  |   Pubmed ID: 21456047
• Dysregulation of the HIF Pathway Due to VHL Mutation Causing Severe Erythrocytosis and Pulmonary Arterial Hypertension
  Blood. Mar, 2011  |   Pubmed ID: 21454469
• Cardiopulmonary Function in Two Human Disorders of the Hypoxia-inducible Factor (HIF) Pathway: Von Hippel-Lindau Disease and HIF-2alpha Gain-of-function Mutation
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2011  |   Pubmed ID: 21389259
• Prolyl Hydroxylase 3 (PHD3) is Essential for Hypoxic Regulation of Neutrophilic Inflammation in Humans and Mice
  The Journal of Clinical Investigation. Mar, 2011  |   Pubmed ID: 21317538
• Expression Profiling in Progressive Stages of Fumarate-hydratase Deficiency: the Contribution of Metabolic Changes to Tumorigenesis
  Cancer Research. Nov, 2010  |   Pubmed ID: 20978192
• Hypoxia and Upregulation of Hypoxia-inducible Factor 1{alpha} Stimulate Venous Thrombus Recanalization
  Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2010  |   Pubmed ID: 20930171
• VHL Inactivation Induces HEF1 and Aurora Kinase A
  Journal of the American Society of Nephrology : JASN. Dec, 2010  |   Pubmed ID: 20864688
• Differentiation in Neuroblastoma: Diffusion-limited Hypoxia Induces Neuro-endocrine Secretory Protein 55 and Other Markers of a Chromaffin Phenotype
  PloS One. 2010  |   Pubmed ID: 20862257
• Identification of a Mutation in Complement Factor H-related Protein 5 in Patients of Cypriot Origin with Glomerulonephritis
  Lancet. Sep, 2010  |   Pubmed ID: 20800271
• Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function
  Gastroenterology. Dec, 2010  |   Pubmed ID: 20600011
• HLA Has Strongest Association with IgA Nephropathy in Genome-wide Analysis
  Journal of the American Society of Nephrology : JASN. Oct, 2010  |   Pubmed ID: 20595679
• HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia
  PloS One. 2010  |   Pubmed ID: 20559438
• Genetic Loci Influencing Kidney Function and Chronic Kidney Disease
  Nature Genetics. May, 2010  |   Pubmed ID: 20383145
• Variation in IGHMBP2 is Not Associated with IgA Nephropathy in Independent Studies of UK Caucasian and Chinese Han Patients
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. May, 2010  |   Pubmed ID: 20031928
• The Role of HIF in Immunity
  The International Journal of Biochemistry & Cell Biology. Apr, 2010  |   Pubmed ID: 19840863
• Erythropoietin Administration in Humans Causes a Marked and Prolonged Reduction in Circulating Hepcidin
  Haematologica. Mar, 2010  |   Pubmed ID: 19833632
• Prolyl Hydroxylase Domain Inhibitors: a Route to HIF Activation and Neuroprotection
  Antioxidants & Redox Signaling. Apr, 2010  |   Pubmed ID: 19737089
• Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-inducible Factors
  PloS One. 2009  |   Pubmed ID: 19924283
• Genome-wide Association Study Identifies Variants in TMPRSS6 Associated with Hemoglobin Levels
  Nature Genetics. Nov, 2009  |   Pubmed ID: 19820698
• Novel Insights into the Role of the Tumor Suppressor Von Hippel Lindau in Cellular Differentiation, Ciliary Biology, and Cyst Repression
  Journal of Molecular Medicine (Berlin, Germany). Sep, 2009  |   Pubmed ID: 19629420
• Rrm3 Protects the Saccharomyces Cerevisiae Genome from Instability at Nascent Sites of Retrotransposition
  Genetics. Jul, 2009  |   Pubmed ID: 19414561
• Oxygen Availability SHIFts the Cell Cycle
  Cell Cycle (Georgetown, Tex.). May, 2009  |   Pubmed ID: 19377302
• Plasma Hepcidin Levels Are Elevated but Responsive to Erythropoietin Therapy in Renal Disease
  Kidney International. May, 2009  |   Pubmed ID: 19212416
• Identification of Novel VHL Regulated Genes by Transcriptomic Analysis of RCC10 Renal Carcinoma Cells
  Advances in Enzyme Regulation. 2009  |   Pubmed ID: 19162062
• Xenon Preconditioning Protects Against Renal Ischemic-reperfusion Injury Via HIF-1alpha Activation
  Journal of the American Society of Nephrology : JASN. Apr, 2009  |   Pubmed ID: 19144758
• Regulation of Renal Epithelial Tight Junctions by the Von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and is Independent of E-cadherin
  Molecular Biology of the Cell. Feb, 2009  |   Pubmed ID: 19073886
• Deletion of the Von Hippel-Lindau Gene in Pancreatic Beta Cells Impairs Glucose Homeostasis in Mice
  The Journal of Clinical Investigation. Jan, 2009  |   Pubmed ID: 19065050
• Variations Within Oxygen-regulated Gene Expression in Humans
  Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2009  |   Pubmed ID: 19008490
• The A20 Gene Protects Kidneys from Ischaemia/reperfusion Injury by Suppressing Pro-inflammatory Activation
  Journal of Molecular Medicine (Berlin, Germany). Dec, 2008  |   Pubmed ID: 18813897
• Progression of Epididymal Maldevelopment into Hamartoma-like Neoplasia in VHL Disease
  Neoplasia (New York, N.Y.). Oct, 2008  |   Pubmed ID: 18813354
• Incorporation of Y'-Ty1 CDNA Destabilizes Telomeres in Saccharomyces Cerevisiae Telomerase-negative Mutants
  Genetics. Aug, 2008  |   Pubmed ID: 18660531
• Autosomal Dominant Erythrocytosis and Pulmonary Arterial Hypertension Associated with an Activating HIF2 Alpha Mutation
  Blood. Aug, 2008  |   Pubmed ID: 18650473
• Developmental and Tissue-specific Accumulation Pattern for the Drosophila Melanogaster TART ORF1 Protein
  Gene. May, 2008  |   Pubmed ID: 18406546
• Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice
  Molecular and Cellular Biology. May, 2008  |   Pubmed ID: 18332118
• The Von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress
  Molecular and Cellular Biology. Apr, 2008  |   Pubmed ID: 18285459
• Role of Gas6 in Erythropoiesis and Anemia in Mice
  The Journal of Clinical Investigation. Feb, 2008  |   Pubmed ID: 18188450
• Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-reperfusion Injury
  Journal of the American Society of Nephrology : JASN. Jan, 2008  |   Pubmed ID: 18178798
• Expression of Hypoxia-inducible Factors in Normal Human Lung Development
  Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. May-Jun, 2008  |   Pubmed ID: 17990921
• Retrosequence Formation Restructures the Yeast Genome
  Genes & Development. Dec, 2007  |   Pubmed ID: 18079177
• Inadvertent Postdialysis Anticoagulation Due to Heparin Line Locks
  Hemodialysis International. International Symposium on Home Hemodialysis. Oct, 2007  |   Pubmed ID: 17922740
• Erythropoietin Gene Expression in Renal Carcinoma is Considerably More Frequent Than Paraneoplastic Polycythemia
  International Journal of Cancer. Journal International Du Cancer. Dec, 2007  |   Pubmed ID: 17640059
• Host Factors That Control Long Terminal Repeat Retrotransposons in Saccharomyces Cerevisiae: Implications for Regulation of Mammalian Retroviruses
  Eukaryotic Cell. Jul, 2007  |   Pubmed ID: 17496126
• Reactivation of Snail Genes in Renal Fibrosis and Carcinomas: a Process of Reversed Embryogenesis?
  Cell Cycle (Georgetown, Tex.). Mar, 2007  |   Pubmed ID: 17374993
• Genetic Insights into the Hypoxia-inducible Factor (HIF) Pathway
  Advances in Enzyme Regulation. 2007  |   Pubmed ID: 17335877
• Lack of Endothelial Cell Survivin Causes Embryonic Defects in Angiogenesis, Cardiogenesis, and Neural Tube Closure
  Blood. Jun, 2007  |   Pubmed ID: 17299096
• Snail Activation Disrupts Tissue Homeostasis and Induces Fibrosis in the Adult Kidney
  The EMBO Journal. Nov, 2006  |   Pubmed ID: 17093497
• Identification of Multiple Transcription Initiation, Polyadenylation, and Splice Sites in the Drosophila Melanogaster TART Family of Telomeric Retrotransposons
  Nucleic Acids Research. 2006  |   Pubmed ID: 17020919
• Statin-induced Expression of CD59 on Vascular Endothelium in Hypoxia: a Potential Mechanism for the Anti-inflammatory Actions of Statins in Rheumatoid Arthritis
  Arthritis Research & Therapy. 2006  |   Pubmed ID: 16859540
• Low Oxygen Stimulates the Intellect. Symposium on Hypoxia and Development, Physiology and Disease
  EMBO Reports. Jul, 2006  |   Pubmed ID: 16799463
• Formation of Primary Cilia in the Renal Epithelium is Regulated by the Von Hippel-Lindau Tumor Suppressor Protein
  Journal of the American Society of Nephrology : JASN. Jul, 2006  |   Pubmed ID: 16775032
• Mutation of Von Hippel-Lindau Tumour Suppressor and Human Cardiopulmonary Physiology
  PLoS Medicine. Jul, 2006  |   Pubmed ID: 16768548
• HIF Prolyl Hydroxylases in the Rat; Organ Distribution and Changes in Expression Following Hypoxia and Coronary Artery Ligation
  Journal of Molecular and Cellular Cardiology. Jul, 2006  |   Pubmed ID: 16765982
• Venular Basement Membranes Contain Specific Matrix Protein Low Expression Regions That Act As Exit Points for Emigrating Neutrophils
  The Journal of Experimental Medicine. Jun, 2006  |   Pubmed ID: 16754715
• Regulation of E-cadherin Expression by VHL and Hypoxia-inducible Factor
  Cancer Research. Apr, 2006  |   Pubmed ID: 16585181
• Correction of Severe Anaemia Using Immuno-regulated Gene Therapy is Achieved by Restoring the Early Erythroblast Compartment
  British Journal of Haematology. Mar, 2006  |   Pubmed ID: 16445835
• Association of MEGSIN 2093C-2180T Haplotype at the 3' Untranslated Region with Disease Severity and Progression of IgA Nephropathy
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jun, 2006  |   Pubmed ID: 16431886
• A Family with Erythrocytosis Establishes a Role for Prolyl Hydroxylase Domain Protein 2 in Oxygen Homeostasis
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006  |   Pubmed ID: 16407130
• Genetic Studies of IgA Nephropathy
  Nephron. Experimental Nephrology. 2006  |   Pubmed ID: 16282702
• Tumor Cell Plasticity in Ewing Sarcoma, an Alternative Circulatory System Stimulated by Hypoxia
  Cancer Research. Dec, 2005  |   Pubmed ID: 16357161
• Effects of VHL Deficiency on Endolymphatic Duct and Sac
  Cancer Research. Dec, 2005  |   Pubmed ID: 16322231
• HIF, a Missing Link Between Metabolism and Cancer
  Nature Medicine. Oct, 2005  |   Pubmed ID: 16211034
• Hypoxia-inducible Factor As a Physiological Regulator
  Experimental Physiology. Nov, 2005  |   Pubmed ID: 16157658
• The HIF Pathway in Cancer
  Seminars in Cell & Developmental Biology. Aug-Oct, 2005  |   Pubmed ID: 16144689
• Genetic Evidence for a Tumor Suppressor Role of HIF-2alpha
  Cancer Cell. Aug, 2005  |   Pubmed ID: 16098466
• A Common Pathway for Genetic Events Leading to Pheochromocytoma
  Cancer Cell. Aug, 2005  |   Pubmed ID: 16098460
• Manipulation of Oxygen Tensions for in Vitro Cell Culture Using a Hypoxic Workstation
  Expert Review of Proteomics. Jun, 2005  |   Pubmed ID: 16000078
• Contrasting Properties of Hypoxia-inducible Factor 1 (HIF-1) and HIF-2 in Von Hippel-Lindau-associated Renal Cell Carcinoma
  Molecular and Cellular Biology. Jul, 2005  |   Pubmed ID: 15964822
• Is It Rejection? Be on the Lookout for 'decoys'
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Sep, 2005  |   Pubmed ID: 15919691
• Distinct Novel Mutations Affecting the Same Base in the NIPA1 Gene Cause Autosomal Dominant Hereditary Spastic Paraplegia in Two Chinese Families
  Human Mutation. Feb, 2005  |   Pubmed ID: 15643603
• The Prolyl Hydroxylase Enzymes That Act As Oxygen Sensors Regulating Destruction of Hypoxia-inducible Factor Alpha
  Advances in Enzyme Regulation. 2004  |   Pubmed ID: 15581484
• Ty1 Mobilizes Subtelomeric Y' Elements in Telomerase-negative Saccharomyces Cerevisiae Survivors
  Molecular and Cellular Biology. Nov, 2004  |   Pubmed ID: 15509791
• Persistent Induction of HIF-1alpha and -2alpha in Cardiomyocytes and Stromal Cells of Ischemic Myocardium
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2004  |   Pubmed ID: 15247145
• Family-based Association Study Showing That Immunoglobulin A Nephropathy is Associated with the Polymorphisms 2093C and 2180T in the 3' Untranslated Region of the Megsin Gene
  Journal of the American Society of Nephrology : JASN. Jul, 2004  |   Pubmed ID: 15213261
• HIF-1's Relationship to Oxygen: Simple Yet Sophisticated
  Cell Cycle (Georgetown, Tex.). Feb, 2004  |   Pubmed ID: 14712080
• HIF and Oxygen Sensing; As Important to Life As the Air We Breathe?
  Annals of Medicine. 2003  |   Pubmed ID: 12822740
• Heterozygous Deficiency of Hypoxia-inducible Factor-2alpha Protects Mice Against Pulmonary Hypertension and Right Ventricular Dysfunction During Prolonged Hypoxia
  The Journal of Clinical Investigation. May, 2003  |   Pubmed ID: 12750401
• Evidence for Hypoxia-induced Neuronal-to-chromaffin Metaplasia in Neuroblastoma
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2003  |   Pubmed ID: 12665472
• Widespread Hypoxia-inducible Expression of HIF-2alpha in Distinct Cell Populations of Different Organs
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2003  |   Pubmed ID: 12490539
• Disruption of Oxygen Homeostasis Underlies Congenital Chuvash Polycythemia
  Nature Genetics. Dec, 2002  |   Pubmed ID: 12415268
• Long-term Reversal of Chronic Anemia Using a Hypoxia-regulated Erythropoietin Gene Therapy
  Blood. Oct, 2002  |   Pubmed ID: 12239150
• Delivery of Erythropoietin by Encapsulated Myoblasts in a Genetic Model of Severe Anemia
  Kidney International. Oct, 2002  |   Pubmed ID: 12234311
• Oxygen Homeostasis and Cancer: Insights from a Rare Disease
  Clinical Medicine (London, England). Jul-Aug, 2002  |   Pubmed ID: 12195866
• Peptide Blockade of HIFalpha Degradation Modulates Cellular Metabolism and Angiogenesis
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002  |   Pubmed ID: 12149454
• HIF Activation Identifies Early Lesions in VHL Kidneys: Evidence for Site-specific Tumor Suppressor Function in the Nephron
  Cancer Cell. Jun, 2002  |   Pubmed ID: 12124175
• Regulation of the HIF Pathway: Enzymatic Hydroxylation of a Conserved Prolyl Residue in Hypoxia-inducible Factor Alpha Subunits Governs Capture by the PVHL E3 Ubiquitin Ligase Complex
  Advances in Enzyme Regulation. 2002  |   Pubmed ID: 12123724
• Expression of Hypoxia-inducible Factor-1alpha and -2alpha in Hypoxic and Ischemic Rat Kidneys
  Journal of the American Society of Nephrology : JASN. Jul, 2002  |   Pubmed ID: 12089367
• Structural Basis for the Recognition of Hydroxyproline in HIF-1 Alpha by PVHL
  Nature. Jun, 2002  |   Pubmed ID: 12050673
• The Use of Dioxygen by HIF Prolyl Hydroxylase (PHD1)
  Bioorganic & Medicinal Chemistry Letters. Jun, 2002  |   Pubmed ID: 12039559
• Expression of Hypoxia-inducible Factors in Human Renal Cancer: Relationship to Angiogenesis and to the Von Hippel-Lindau Gene Mutation
  Cancer Research. May, 2002  |   Pubmed ID: 12019178
• Oxygen Sensors and Angiogenesis
  Seminars in Cell & Developmental Biology. Feb, 2002  |   Pubmed ID: 11969369
• Hypoxia-induced, Perinecrotic Expression of Endothelial Per-ARNT-Sim Domain Protein-1/hypoxia-inducible Factor-2alpha Correlates with Tumor Progression, Vascularization, and Focal Macrophage Infiltration in Bladder Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2002  |   Pubmed ID: 11839666